Dr. Adam Mechler, PhD, FRSC
La Trobe University
Research Expertise
About
Publications
Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma
PROTEOMICS / Oct 18, 2013
Kalra, H., Adda, C. G., Liem, M., Ang, C., Mechler, A., Simpson, R. J., Hulett, M. D., & Mathivanan, S. (2013). Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. PROTEOMICS, 13(22), 3354–3364. Portico. https://doi.org/10.1002/pmic.201300282
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Oncotarget / Apr 12, 2015
Keerthikumar, S., Gangoda, L., Liem, M., Fonseka, P., Atukorala, I., Ozcitti, C., Mechler, A., Adda, C. G., Ang, C.-S., & Mathivanan, S. (2015). Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. Oncotarget, 6(17), 15375–15396. https://doi.org/10.18632/oncotarget.3801
Calcium-dependent Open/Closed Conformations and Interfacial Energy Maps of Reconstituted Hemichannels
Journal of Biological Chemistry / Mar 01, 2005
Thimm, J., Mechler, A., Lin, H., Rhee, S., & Lal, R. (2005). Calcium-dependent Open/Closed Conformations and Interfacial Energy Maps of Reconstituted Hemichannels. Journal of Biological Chemistry, 280(11), 10646–10654. https://doi.org/10.1074/jbc.m412749200
Semiconductive Polymer Blends: Correlating Structure with Transport Properties at the Nanoscale
Advanced Materials / Mar 05, 2004
Ionescu‐Zanetti, C., Mechler, A., Carter, S. A., & Lal, R. (2004). Semiconductive Polymer Blends: Correlating Structure with Transport Properties at the Nanoscale. Advanced Materials, 16(5), 385–389. Portico. https://doi.org/10.1002/adma.200305747
Specific and Selective Peptide-Membrane Interactions Revealed Using Quartz Crystal Microbalance
Biophysical Journal / Dec 01, 2007
Mechler, A., Praporski, S., Atmuri, K., Boland, M., Separovic, F., & Martin, L. L. (2007). Specific and Selective Peptide-Membrane Interactions Revealed Using Quartz Crystal Microbalance. Biophysical Journal, 93(11), 3907–3916. https://doi.org/10.1529/biophysj.107.116525
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens
Journal of Medicinal Chemistry / Jun 21, 2010
Knappe, D., Piantavigna, S., Hansen, A., Mechler, A., Binas, A., Nolte, O., Martin, L. L., & Hoffmann, R. (2010). Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens. Journal of Medicinal Chemistry, 53(14), 5240–5247. https://doi.org/10.1021/jm100378b
Evaporative self-assembly assisted synthesis of polymeric nanoparticles by surface acoustic wave atomization
Nanotechnology / Mar 04, 2008
Friend, J. R., Yeo, L. Y., Arifin, D. R., & Mechler, A. (2008). Evaporative self-assembly assisted synthesis of polymeric nanoparticles by surface acoustic wave atomization. Nanotechnology, 19(14), 145301. https://doi.org/10.1088/0957-4484/19/14/145301
Theoretical and Experimental Studies of the Antioxidant and Antinitrosant Activity of Syringic Acid
The Journal of Organic Chemistry / Nov 05, 2020
Vo, Q. V., Bay, M. V., Nam, P. C., Quang, D. T., Flavel, M., Hoa, N. T., & Mechler, A. (2020). Theoretical and Experimental Studies of the Antioxidant and Antinitrosant Activity of Syringic Acid. The Journal of Organic Chemistry, 85(23), 15514–15520. https://doi.org/10.1021/acs.joc.0c02258
Transthyretin oligomers induce calcium influx via voltage‐gated calcium channels
Journal of Neurochemistry / Aug 25, 2006
Hou, X., Parkington, H. C., Coleman, H. A., Mechler, A., Martin, L. L., Aguilar, M., & Small, D. H. (2006). Transthyretin oligomers induce calcium influx via voltage‐gated calcium channels. Journal of Neurochemistry, 100(2), 446–457. Portico. https://doi.org/10.1111/j.1471-4159.2006.04210.x
Synthesis of Ag and Au nanostructures in an ionic liquid: thermodynamic and kinetic effects underlying nanoparticle, cluster and nanowire formation
Journal of Materials Chemistry / Jan 01, 2007
Bhatt, A. I., Mechler, ?d?m, Martin, L. L., & Bond, A. M. (2007). Synthesis of Ag and Au nanostructures in an ionic liquid: thermodynamic and kinetic effects underlying nanoparticle, cluster and nanowire formation. Journal of Materials Chemistry, 17(21), 2241. https://doi.org/10.1039/b618036a
Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation
Scientific Reports / Nov 30, 2016
Shahmiri, M., Enciso, M., Adda, C. G., Smith, B. J., Perugini, M. A., & Mechler, A. (2016). Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation. Scientific Reports, 6(1). https://doi.org/10.1038/srep38184
Supramolecular Self‐Assembly of N‐Acetyl‐Capped β‐Peptides Leads to Nano‐ to Macroscale Fiber Formation
Angewandte Chemie International Edition / Jun 19, 2013
Del Borgo, M. P., Mechler, A. I., Traore, D., Forsyth, C., Wilce, J. A., Wilce, M. C. J., Aguilar, M., & Perlmutter, P. (2013). Supramolecular Self‐Assembly of N‐Acetyl‐Capped β‐Peptides Leads to Nano‐ to Macroscale Fiber Formation. Angewandte Chemie International Edition, 52(32), 8266–8270. Portico. https://doi.org/10.1002/anie.201303175
Density functional theory study of the role of benzylic hydrogen atoms in the antioxidant properties of lignans
Scientific Reports / Aug 17, 2018
Vo, Q. V., Nam, P. C., Bay, M. V., Thong, N. M., Cuong, N. D., & Mechler, A. (2018). Density functional theory study of the role of benzylic hydrogen atoms in the antioxidant properties of lignans. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-30860-5
Electrochemical reactions of cytochrome c on electrodes modified by fullerene films
Journal of Electroanalytical Chemistry / Feb 01, 2001
Csiszár, M., Szűcs, Á., Tölgyesi, M., Mechler, Á., Nagy, J. B., & Novák, M. (2001). Electrochemical reactions of cytochrome c on electrodes modified by fullerene films. Journal of Electroanalytical Chemistry, 497(1–2), 69–74. https://doi.org/10.1016/s0022-0728(00)00453-8
High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1–40) of Alzheimer’s disease suggests a novel mechanism of oligomer assembly
Journal of Structural Biology / Jul 01, 2006
Losic, D., Martin, L. L., Mechler, A., Aguilar, M.-I., & Small, D. H. (2006). High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1–40) of Alzheimer’s disease suggests a novel mechanism of oligomer assembly. Journal of Structural Biology, 155(1), 104–110. https://doi.org/10.1016/j.jsb.2006.02.013
Geometrically Precise Building Blocks: the Self-Assembly of β-Peptides
Chemistry & Biology / Nov 01, 2015
Gopalan, R. D., Del Borgo, M. P., Mechler, A. I., Perlmutter, P., & Aguilar, M.-I. (2015). Geometrically Precise Building Blocks: the Self-Assembly of β-Peptides. Chemistry & Biology, 22(11), 1417–1423. https://doi.org/10.1016/j.chembiol.2015.10.005
Antioxidant Motifs in Flavonoids: O–H versus C–H Bond Dissociation
ACS Omega / May 22, 2019
Vo, Q. V., Nam, P. C., Thong, N. M., Trung, N. T., Phan, C.-T. D., & Mechler, A. (2019). Antioxidant Motifs in Flavonoids: O–H versus C–H Bond Dissociation. ACS Omega, 4(5), 8935–8942. https://doi.org/10.1021/acsomega.9b00677
Real-time Measurement of Membrane Conformational States Induced by Antimicrobial Peptides: Balance Between Recovery and Lysis
Scientific Reports / Jun 27, 2014
Hall, K., Lee, T.-H., Mechler, A. I., Swann, M. J., & Aguilar, M.-I. (2014). Real-time Measurement of Membrane Conformational States Induced by Antimicrobial Peptides: Balance Between Recovery and Lysis. Scientific Reports, 4(1). https://doi.org/10.1038/srep05479
The formation of gold nanoparticles using hydroquinone as a reducing agent through a localized pH change upon addition of NaOH to a solution of HAuCl4
Colloids and Surfaces A: Physicochemical and Engineering Aspects / Nov 01, 2010
Sirajuddin, Mechler, A., Torriero, A. A. J., Nafady, A., Lee, C.-Y., Bond, A. M., O’Mullane, A. P., & Bhargava, S. K. (2010). The formation of gold nanoparticles using hydroquinone as a reducing agent through a localized pH change upon addition of NaOH to a solution of HAuCl4. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 370(1–3), 35–41. https://doi.org/10.1016/j.colsurfa.2010.08.041
A resonance Raman spectroscopic investigation into the effects of fixation and dehydration on heme environment of hemoglobin
Journal of Raman Spectroscopy / May 11, 2009
Asghari‐Khiavi, M., Mechler, A., Bambery, K. R., McNaughton, D., & Wood, B. R. (2009). A resonance Raman spectroscopic investigation into the effects of fixation and dehydration on heme environment of hemoglobin. Journal of Raman Spectroscopy, 40(11), 1668–1674. Portico. https://doi.org/10.1002/jrs.2317
Exploring the origin of tip‐enhanced Raman scattering; preparation of efficient TERS probes with high yield
Journal of Raman Spectroscopy / Aug 02, 2011
Asghari‐Khiavi, M., Wood, B. R., Hojati‐Talemi, P., Downes, A., McNaughton, D., & Mechler, A. (2011). Exploring the origin of tip‐enhanced Raman scattering; preparation of efficient TERS probes with high yield. Journal of Raman Spectroscopy, 43(2), 173–180. Portico. https://doi.org/10.1002/jrs.3021
Controls and constrains of the membrane disrupting action of Aurein 1.2
Scientific Reports / Nov 17, 2015
Shahmiri, M., Enciso, M., & Mechler, A. (2015). Controls and constrains of the membrane disrupting action of Aurein 1.2. Scientific Reports, 5(1). https://doi.org/10.1038/srep16378
Correlation of atomic force microscopy and Raman micro-spectroscopy to study the effects of ex vivo treatment procedures on human red blood cells
The Analyst / Jan 01, 2010
Asghari-Khiavi, M., Wood, B. R., Mechler, A., Bambery, K. R., Buckingham, D. W., Cooke, B. M., & McNaughton, D. (2010). Correlation of atomic force microscopy and Raman micro-spectroscopy to study the effects of ex vivo treatment procedures on human red blood cells. The Analyst, 135(3), 525. https://doi.org/10.1039/b919245j
Metal organic framework-supported N -heterocyclic carbene palladium complex: A highly efficient and reusable heterogeneous catalyst for Suzuki-Miyaura C-C coupling reaction
Microporous and Mesoporous Materials / Nov 01, 2017
Bahadori, M., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor-Baltork, I., & Zadehahmadi, F. (2017). Metal organic framework-supported N -heterocyclic carbene palladium complex: A highly efficient and reusable heterogeneous catalyst for Suzuki-Miyaura C-C coupling reaction. Microporous and Mesoporous Materials, 253, 102–111. https://doi.org/10.1016/j.micromeso.2017.06.048
Structure and homogeneity of pseudo-physiological phospholipid bilayers and their deposition characteristics on carboxylic acid terminated self-assembled monolayers
Biomaterials / Feb 01, 2009
Mechler, A., Praporski, S., Piantavigna, S., Heaton, S. M., Hall, K. N., Aguilar, M.-I., & Martin, L. L. (2009). Structure and homogeneity of pseudo-physiological phospholipid bilayers and their deposition characteristics on carboxylic acid terminated self-assembled monolayers. Biomaterials, 30(4), 682–689. https://doi.org/10.1016/j.biomaterials.2008.10.016
Solution Structure and Membrane Interactions of the Antimicrobial Peptide Fallaxidin 4.1a: An NMR and QCM Study
Biochemistry / Nov 13, 2009
Sherman, P. J., Jackway, R. J., Gehman, J. D., Praporski, S., McCubbin, G. A., Mechler, A., Martin, L. L., Separovic, F., & Bowie, J. H. (2009). Solution Structure and Membrane Interactions of the Antimicrobial Peptide Fallaxidin 4.1a: An NMR and QCM Study. Biochemistry, 48(50), 11892–11901. https://doi.org/10.1021/bi901668y
Organization of Cytochrome P450 Enzymes Involved in Sex Steroid Synthesis
Journal of Biological Chemistry / Nov 01, 2009
Praporski, S., Ng, S. M., Nguyen, A. D., Corbin, C. J., Mechler, A., Zheng, J., Conley, A. J., & Martin, L. L. (2009). Organization of Cytochrome P450 Enzymes Involved in Sex Steroid Synthesis. Journal of Biological Chemistry, 284(48), 33224–33232. https://doi.org/10.1074/jbc.m109.006064
Novel amplitude and frequency demodulation algorithm for a virtual dynamic atomic force microscope
Nanotechnology / Mar 10, 2006
Kokavecz, J., Tóth, Z., Horváth, Z. L., Heszler, P., & Mechler, Á. (2006). Novel amplitude and frequency demodulation algorithm for a virtual dynamic atomic force microscope. Nanotechnology, 17(7), S173–S177. https://doi.org/10.1088/0957-4484/17/7/s12
Anomalies in nanostructure size measurements by AFM
Physical Review B / Sep 02, 2005
Mechler, Á., Kopniczky, J., Kokavecz, J., Hoel, A., Granqvist, C.-G., & Heszler, P. (2005). Anomalies in nanostructure size measurements by AFM. Physical Review B, 72(12). https://doi.org/10.1103/physrevb.72.125407
Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights
New Journal of Chemistry / Jan 01, 2020
Boulebd, H., Mechler, A., Hoa, N. T., & Vo, Q. V. (2020). Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights. New Journal of Chemistry, 44(23), 9863–9869. https://doi.org/10.1039/d0nj01567a
Surface Immobilization of Bio-Functionalized Cubosomes: Sensing of Proteins by Quartz Crystal Microbalance
Langmuir / Dec 09, 2011
Fraser, S. J., Mulet, X., Martin, L., Praporski, S., Mechler, A., Hartley, P. G., Polyzos, A., & Separovic, F. (2011). Surface Immobilization of Bio-Functionalized Cubosomes: Sensing of Proteins by Quartz Crystal Microbalance. Langmuir, 28(1), 620–627. https://doi.org/10.1021/la2032994
Surface energy maps of nanostructures: Atomic force microscopy and numerical simulation study
Applied Physics Letters / May 26, 2003
Mechler, Á., Kokavecz, J., Heszler, P., & Lal, R. (2003). Surface energy maps of nanostructures: Atomic force microscopy and numerical simulation study. Applied Physics Letters, 82(21), 3740–3742. https://doi.org/10.1063/1.1577392
Is Indolinonic Hydroxylamine a Promising Artificial Antioxidant?
The Journal of Physical Chemistry B / Aug 28, 2019
Vo, Q. V., Bay, M. V., Nam, P. C., & Mechler, A. (2019). Is Indolinonic Hydroxylamine a Promising Artificial Antioxidant? The Journal of Physical Chemistry B, 123(37), 7777–7784. https://doi.org/10.1021/acs.jpcb.9b05160
A theoretical study of the radical scavenging activity of natural stilbenes
RSC Advances / Jan 01, 2019
Vo, Q. V., Cam Nam, P., Bay, M. V., Minh Thong, N., Hieu, L. T., & Mechler, A. (2019). A theoretical study of the radical scavenging activity of natural stilbenes. RSC Advances, 9(72), 42020–42028. https://doi.org/10.1039/c9ra08381b
Dynamical properties of the Q-controlled atomic force microscope
Applied Physics Letters / Oct 11, 2004
Kokavecz, J., Horváth, Z. L., & Mechler, Á. (2004). Dynamical properties of the Q-controlled atomic force microscope. Applied Physics Letters, 85(15), 3232–3234. https://doi.org/10.1063/1.1785863
Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes / Jan 01, 2008
Hou, X., Mechler, A., Martin, L. L., Aguilar, M.-I., & Small, D. H. (2008). Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1778(1), 198–205. https://doi.org/10.1016/j.bbamem.2007.09.018
Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells
The FASEB Journal / Apr 24, 2009
Glover, D. J., Ng, S. M., Mechler, A., Martin, L. L., & Jans, D. A. (2009). Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells. The FASEB Journal, 23(9), 2996–3006. Portico. https://doi.org/10.1096/fj.09-131425
Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane
Advanced Functional Materials / Jan 08, 2009
Battle, A. R., Valenzuela, S. M., Mechler, A., Nichols, R. J., Praporski, S., di Maio, I. L., Islam, H., Girard‐Egrot, A. P., Cornell, B. A., Prashar, J., Caruso, F., Martin, L. L., & Martin, D. K. (2009). Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane. Advanced Functional Materials, 19(2), 201–208. Portico. https://doi.org/10.1002/adfm.200800483
A brief overview of global biotechnology
Biotechnology & Biotechnological Equipment / Feb 07, 2021
Martin, D. K., Vicente, O., Beccari, T., Kellermayer, M., Koller, M., Lal, R., Marks, R. S., Marova, I., Mechler, A., Tapaloaga, D., Žnidaršič-Plazl, P., & Dundar, M. (2021). A brief overview of global biotechnology. Biotechnology & Biotechnological Equipment, 35(sup1), S5–S14. https://doi.org/10.1080/13102818.2021.1878933
Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study
Journal of Inorganic Biochemistry / Dec 01, 2011
Asghari-Khiavi, M., Vongsvivut, J., Perepichka, I., Mechler, A., Wood, B. R., McNaughton, D., & Bohle, D. S. (2011). Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study. Journal of Inorganic Biochemistry, 105(12), 1662–1669. https://doi.org/10.1016/j.jinorgbio.2011.08.005
In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols
Journal of Chemical Information and Modeling / Dec 16, 2019
Vo, Q. V., & Mechler, A. (2019). In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols. Journal of Chemical Information and Modeling, 60(1), 316–321. https://doi.org/10.1021/acs.jcim.9b00917
Raman spectroscopic and atomic force microscopic study of graphite ablation at 193 and 248 nm
Applied Surface Science / Feb 01, 2000
Mechler, Á., Heszler, P., Márton, Z., Kovács, M., Szörényi, T., & Bor, Z. (2000). Raman spectroscopic and atomic force microscopic study of graphite ablation at 193 and 248 nm. Applied Surface Science, 154–155, 22–28. https://doi.org/10.1016/s0169-4332(99)00473-0
Phenylalanine residues act as membrane anchors in the antimicrobial action of Aurein 1.2
Biointerphases / Oct 26, 2017
Shahmiri, M., Cornell, B., & Mechler, A. (2017). Phenylalanine residues act as membrane anchors in the antimicrobial action of Aurein 1.2. Biointerphases, 12(5). https://doi.org/10.1116/1.4995674
Imaging bandwidth of the tapping mode atomic force microscope probe
Physical Review B / Apr 04, 2006
Kokavecz, J., Marti, O., Heszler, P., & Mechler, Á. (2006). Imaging bandwidth of the tapping mode atomic force microscope probe. Physical Review B, 73(15). https://doi.org/10.1103/physrevb.73.155403
Organogels Derived from Tetranitrated Crown Ethers
Organic Letters / Feb 28, 2006
Langford, S. J., Latter, M. J., Lau, V.-L., Martin, L. L., & Mechler, A. (2006). Organogels Derived from Tetranitrated Crown Ethers. Organic Letters, 8(7), 1371–1373. https://doi.org/10.1021/ol060142j
A thermodynamic and kinetic study of the antioxidant activity of natural hydroanthraquinones
RSC Advances / Jan 01, 2020
Vo, Q. V., Thong, N. M., Le Huyen, T., Nam, P. C., Tam, N. M., Hoa, N. T., & Mechler, A. (2020). A thermodynamic and kinetic study of the antioxidant activity of natural hydroanthraquinones. RSC Advances, 10(34), 20089–20097. https://doi.org/10.1039/d0ra04013d
Cell Penetrating Apidaecin Peptide Interactions with Biomimetic Phospholipid Membranes
International Journal of Peptide Research and Therapeutics / Apr 01, 2009
Piantavigna, S., Czihal, P., Mechler, A., Richter, M., Hoffmann, R., & Martin, L. L. (2009). Cell Penetrating Apidaecin Peptide Interactions with Biomimetic Phospholipid Membranes. International Journal of Peptide Research and Therapeutics, 15(2), 139–146. https://doi.org/10.1007/s10989-009-9175-2
Time-resolved shock-wave photography above 193-nm excimer laser-ablated graphite surface
Applied Physics A Materials Science & Processing / Dec 01, 1999
Márton, Zs., Heszler, P., Mechler, Á., Hopp, B., Kántor, Z., & Bor, Zs. (1999). Time-resolved shock-wave photography above 193-nm excimer laser-ablated graphite surface. Applied Physics A Materials Science & Processing, 69(S1), S133–S136. https://doi.org/10.1007/s003399900293
Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights
The Journal of Physical Chemistry B / Apr 21, 2020
Boulebd, H., Khodja, I. A., Bay, M. V., Hoa, N. T., Mechler, A., & Vo, Q. V. (2020). Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights. The Journal of Physical Chemistry B, 124(20), 4123–4131. https://doi.org/10.1021/acs.jpcb.0c02439
Growth ofCaenorhabditis elegansin Defined Media Is Dependent on Presence of Particulate Matter
G3 Genes|Genomes|Genetics / Feb 01, 2018
Flavel, M. R., Mechler, A., Shahmiri, M., Mathews, E. R., Franks, A. E., Chen, W., Zanker, D., Xian, B., Gao, S., Luo, J., Tegegne, S., Doneski, C., & Jois, M. (2018). Growth ofCaenorhabditis elegansin Defined Media Is Dependent on Presence of Particulate Matter. G3 Genes|Genomes|Genetics, 8(2), 567–575. https://doi.org/10.1534/g3.117.300325
The antioxidant activity of natural diterpenes: theoretical insights
RSC Advances / Jan 01, 2020
Vo, Q. V., Tam, N. M., Hieu, L. T., Van Bay, M., Thong, N. M., Le Huyen, T., Hoa, N. T., & Mechler, A. (2020). The antioxidant activity of natural diterpenes: theoretical insights. RSC Advances, 10(25), 14937–14943. https://doi.org/10.1039/d0ra02681f
Nano-viscosimetry analysis of the membrane disrupting action of the bee venom peptide melittin
Scientific Reports / Jul 25, 2019
Pandidan, S., & Mechler, A. (2019). Nano-viscosimetry analysis of the membrane disrupting action of the bee venom peptide melittin. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-47325-y
Supramolecular self-assembly of 14-helical nanorods with tunable linear and dendritic hierarchical morphologies
New Journal of Chemistry / Jan 01, 2015
Seoudi, R. S., Del Borgo, M. P., Kulkarni, K., Perlmutter, P., Aguilar, M.-I., & Mechler, A. (2015). Supramolecular self-assembly of 14-helical nanorods with tunable linear and dendritic hierarchical morphologies. New Journal of Chemistry, 39(5), 3280–3287. https://doi.org/10.1039/c4nj01926a
A QCM‐D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA
ChemBioChem / Apr 03, 2017
Tajik‐Ahmadabad, B., Mechler, A., Muir, B. W., McLean, K., Hinton, T. M., Separovic, F., & Polyzos, A. (2017). A QCM‐D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA. ChemBioChem, 18(10), 921–930. Portico. https://doi.org/10.1002/cbic.201600613
Investigation of fluid cell resonances in intermittent contact mode atomic force microscopy
Applied Physics Letters / Jul 09, 2007
Kokavecz, J., & Mechler, A. (2007). Investigation of fluid cell resonances in intermittent contact mode atomic force microscopy. Applied Physics Letters, 91(2). https://doi.org/10.1063/1.2753104
Nanoscale velocity–drag force relationship in thin liquid layers measured by atomic force microscopy
Applied Physics Letters / Oct 25, 2004
Mechler, Á., Piorek, B., Lal, R., & Banerjee, S. (2004). Nanoscale velocity–drag force relationship in thin liquid layers measured by atomic force microscopy. Applied Physics Letters, 85(17), 3881–3883. https://doi.org/10.1063/1.1808504
Amino acid sequence controls the self-assembled superstructure morphology of N-acetylated tri-β3-peptides
Pure and Applied Chemistry / Sep 08, 2015
Seoudi, R. S., Dowd, A., Del Borgo, M., Kulkarni, K., Perlmutter, P., Aguilar, M.-I., & Mechler, A. (2015). Amino acid sequence controls the self-assembled superstructure morphology of N-acetylated tri-β3-peptides. Pure and Applied Chemistry, 87(9–10), 1021–1028. https://doi.org/10.1515/pac-2015-0108
Antioxidant Activities of Monosubstituted Indolinonic Hydroxylamines: A Thermodynamic and Kinetic Study
The Journal of Physical Chemistry B / Nov 25, 2019
Vo, Q. V., Gon, T. V., Bay, M. V., & Mechler, A. (2019). Antioxidant Activities of Monosubstituted Indolinonic Hydroxylamines: A Thermodynamic and Kinetic Study. The Journal of Physical Chemistry B, 123(50), 10672–10679. https://doi.org/10.1021/acs.jpcb.9b08912
β3-tripeptides act as sticky ends to self-assemble into a bioscaffold
APL Bioengineering / May 01, 2018
Del Borgo, M. P., Kulkarni, K., Tonta, M. A., Ratcliffe, J. L., Seoudi, R., Mechler, A. I., Perlmutter, P., Parkington, H. C., & Aguilar, M.-I. (2018). β3-tripeptides act as sticky ends to self-assemble into a bioscaffold. APL Bioengineering, 2(2). https://doi.org/10.1063/1.5020105
Viscoelastic changes measured in partially suspended single bilayer membranes
Soft Matter / Jan 01, 2015
Hasan, I. Y., & Mechler, A. (2015). Viscoelastic changes measured in partially suspended single bilayer membranes. Soft Matter, 11(27), 5571–5579. https://doi.org/10.1039/c5sm00278h
Electrochemiluminescence of surface bound microparticles of ruthenium complexes
J. Mater. Chem. / Jan 01, 2010
Barbante, G. J., Hogan, C. F., Mechler, A., & Hughes, A. B. (2010). Electrochemiluminescence of surface bound microparticles of ruthenium complexes. J. Mater. Chem., 20(5), 891–899. https://doi.org/10.1039/b918799p
Spring constant of microcantilevers in fundamental and higher eigenmodes
Physical Review B / Nov 04, 2008
Kokavecz, J., & Mechler, A. (2008). Spring constant of microcantilevers in fundamental and higher eigenmodes. Physical Review B, 78(17). https://doi.org/10.1103/physrevb.78.172101
AFM study of morphological changes associated with electrochemical solid–solid transformation of three-dimensional crystals of TCNQ to metal derivatives (metal = Cu, Co, Ni; TCNQ = tetracyanoquinodimethane)
Journal of Solid State Electrochemistry / Sep 27, 2007
Qu, X., Nafady, A., Mechler, A., Zhang, J., Harris, A. R., O’Mullane, A. P., Martin, L. L., & Bond, A. M. (2007). AFM study of morphological changes associated with electrochemical solid–solid transformation of three-dimensional crystals of TCNQ to metal derivatives (metal = Cu, Co, Ni; TCNQ = tetracyanoquinodimethane). Journal of Solid State Electrochemistry, 12(6), 739–746. https://doi.org/10.1007/s10008-007-0423-0
Interaction of Small Ionic Species With Phospholipid Membranes: The Role of Metal Coordination
Frontiers in Materials / Jan 07, 2019
Le, C. T. M., Houri, A., Balage, N., Smith, B. J., & Mechler, A. (2019). Interaction of Small Ionic Species With Phospholipid Membranes: The Role of Metal Coordination. Frontiers in Materials, 5. https://doi.org/10.3389/fmats.2018.00080
Labeling phospholipid membranes with lipid mimetic luminescent metal complexes
Biochimica et Biophysica Acta (BBA) - Biomembranes / Nov 01, 2014
Mechler, A., Stringer, B. D., Mubin, M. S. H., Doeven, E. H., Phillips, N. W., Rudd-Schmidt, J., & Hogan, C. F. (2014). Labeling phospholipid membranes with lipid mimetic luminescent metal complexes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1838(11), 2939–2946. https://doi.org/10.1016/j.bbamem.2014.08.005
Time-resolved investigation of the transient surface reflection changes of subpicosecond excimer laser ablated liquids
Applied Physics A Materials Science & Processing / Dec 01, 1999
Hopp, B., Tóth, Z., Gál, K., Mechler, Á., Bor, Zs., Moustaizis, S. D., Georgiou, S., & Fotakis, C. (1999). Time-resolved investigation of the transient surface reflection changes of subpicosecond excimer laser ablated liquids. Applied Physics A Materials Science & Processing, 69(S1), S191–S194. https://doi.org/10.1007/s003399900212
Excimer laser irradiation induced formation of diamond-like carbon layer on graphite
Applied Surface Science / Jan 01, 1999
Mechler, Á., Heszler, P., Kántor, Z., Szörényi, T., & Bor, Z. (1999). Excimer laser irradiation induced formation of diamond-like carbon layer on graphite. Applied Surface Science, 138–139, 174–178. https://doi.org/10.1016/s0169-4332(98)00397-3
Assessment of the free radical scavenging potential of cannabidiol under physiological conditions: Theoretical and experimental investigations
Journal of Molecular Liquids / Jan 01, 2022
Boulebd, H., Pereira, D. M., Amine Khodja, I., Hoa, N. T., Mechler, A., & Vo, Q. V. (2022). Assessment of the free radical scavenging potential of cannabidiol under physiological conditions: Theoretical and experimental investigations. Journal of Molecular Liquids, 346, 118277. https://doi.org/10.1016/j.molliq.2021.118277
Theoretical Study on the Antioxidant Activity of Natural Depsidones
ACS Omega / Mar 31, 2020
Bay, M. V., Nam, P. C., Quang, D. T., Mechler, A., Hien, N. K., Hoa, N. T., & Vo, Q. V. (2020). Theoretical Study on the Antioxidant Activity of Natural Depsidones. ACS Omega, 5(14), 7895–7902. https://doi.org/10.1021/acsomega.9b04179
The radical scavenging activity of natural ramalin: A mechanistic and kinetic study
Chemical Physics Letters / Jan 01, 2020
Vo, Q. V., Tam, N. M., Bay, M. V., & Mechler, A. (2020). The radical scavenging activity of natural ramalin: A mechanistic and kinetic study. Chemical Physics Letters, 739, 137004. https://doi.org/10.1016/j.cplett.2019.137004
Self-assembled nanomaterials based on beta (β3) tetrapeptides
Nanotechnology / Feb 24, 2016
Seoudi, R. S., Hinds, M. G., Wilson, D. J. D., Adda, C. G., Del Borgo, M., Aguilar, M.-I., Perlmutter, P., & Mechler, A. (2016). Self-assembled nanomaterials based on beta (β3) tetrapeptides. Nanotechnology, 27(13), 135606. https://doi.org/10.1088/0957-4484/27/13/135606
The hydroperoxyl and superoxide anion radical scavenging activity of anthocyanidins in physiological environments: Theoretical insights into mechanisms and kinetics
Phytochemistry / Dec 01, 2021
Vo, Q. V., Hoa, N. T., Thong, N. M., & Mechler, A. (2021). The hydroperoxyl and superoxide anion radical scavenging activity of anthocyanidins in physiological environments: Theoretical insights into mechanisms and kinetics. Phytochemistry, 192, 112968. https://doi.org/10.1016/j.phytochem.2021.112968
Biochemical and biophysical characterization of a novel plant protein disulfide isomerase
Peptide Science / Nov 04, 2008
Gruber, C. W., Čemažar, M., Mechler, A., Martin, L. L., & Craik, D. J. (2008). Biochemical and biophysical characterization of a novel plant protein disulfide isomerase. Peptide Science, 92(1), 35–43. Portico. https://doi.org/10.1002/bip.21113
Modelling the mechanism and kinetics of the radical scavenging activity of iminostilbene
Polymer Degradation and Stability / Mar 01, 2021
Vo, Q. V., Van, L. T. N., Hoa, N. T., & Mechler, A. (2021). Modelling the mechanism and kinetics of the radical scavenging activity of iminostilbene. Polymer Degradation and Stability, 185, 109483. https://doi.org/10.1016/j.polymdegradstab.2021.109483
Synthesis of aromatic and indole alpha-glucosinolates
Carbohydrate Research / Jan 01, 2018
Vo, Q. V., Rochfort, S., Nam, P. C., Nguyen, T. L., Nguyen, T. T., & Mechler, A. (2018). Synthesis of aromatic and indole alpha-glucosinolates. Carbohydrate Research, 455, 45–53. https://doi.org/10.1016/j.carres.2017.11.004
The role of C-terminal amidation in the mechanism of action of the antimicrobial peptide aurein 1.2
The EuroBiotech Journal / Jan 01, 2020
Shahmiri, M., & Mechler, A. (2020). The role of C-terminal amidation in the mechanism of action of the antimicrobial peptide aurein 1.2. The EuroBiotech Journal, 4(1), 25–31. https://doi.org/10.2478/ebtj-2020-0004
Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study
ACS Omega / Nov 08, 2019
Vo, Q. V., Van Bay, M., Nam, P. C., & Mechler, A. (2019). Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study. ACS Omega, 4(21), 19375–19381. https://doi.org/10.1021/acsomega.9b02782
Analytical approaches to study domain formation in biomimetic membranes
The Analyst / Jan 01, 2017
Hasan, I. Y., & Mechler, A. (2017). Analytical approaches to study domain formation in biomimetic membranes. The Analyst, 142(17), 3062–3078. https://doi.org/10.1039/c7an01038a
Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight
ACS Omega / May 13, 2021
Trung, N. Q., Thong, N. M., Cuong, D. H., Manh, T. D., Hoang, L. P., Hien, N. K., Nam, P. C., Quang, D. T., Mechler, A., & Vo, Q. V. (2021). Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight. ACS Omega, 6(20), 13391–13397. https://doi.org/10.1021/acsomega.1c01448
Dodecatungstocobaltate heteropolyanion encapsulation into MIL‐101(Cr) metal–organic framework scaffold provides a highly efficient heterogeneous catalyst for methanolysis of epoxides
Applied Organometallic Chemistry / Oct 11, 2017
Marandi, A., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor‐Baltork, I., & Zadehahmadi, F. (2017). Dodecatungstocobaltate heteropolyanion encapsulation into MIL‐101(Cr) metal–organic framework scaffold provides a highly efficient heterogeneous catalyst for methanolysis of epoxides. Applied Organometallic Chemistry, 32(2). Portico. https://doi.org/10.1002/aoc.4065
Oxidation reactions catalysed by molybdenum(VI) complexes grafted on UiO‐66 metal–organic framework as an elegant nanoreactor
Applied Organometallic Chemistry / Aug 22, 2017
Afzali, N., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor‐Baltork, I., Kardanpour, R., & Zadehahmadi, F. (2017). Oxidation reactions catalysed by molybdenum(VI) complexes grafted on UiO‐66 metal–organic framework as an elegant nanoreactor. Applied Organometallic Chemistry, 32(1). Portico. https://doi.org/10.1002/aoc.3958
Is Usnic Acid a Promising Radical Scavenger?
ACS Omega / Jul 07, 2020
Hoa, N. T., Van Bay, M., Mechler, A., & Vo, Q. V. (2020). Is Usnic Acid a Promising Radical Scavenger? ACS Omega, 5(28), 17715–17720. https://doi.org/10.1021/acsomega.0c02306
Is natural fraxin an overlooked radical scavenger?
RSC Advances / Jan 01, 2021
Nam, P. C., Thong, N. M., Hoa, N. T., Quang, D. T., Hoang, L. P., Mechler, A., & Vo, Q. V. (2021). Is natural fraxin an overlooked radical scavenger? RSC Advances, 11(24), 14269–14275. https://doi.org/10.1039/d1ra01360b
In Silico Evaluation of the Radical Scavenging Mechanism of Mactanamide
ACS Omega / Sep 04, 2020
Vo, Q. V., Hoa, N. T., Nam, P. C., Quang, D. T., & Mechler, A. (2020). In Silico Evaluation of the Radical Scavenging Mechanism of Mactanamide. ACS Omega, 5(37), 24106–24110. https://doi.org/10.1021/acsomega.0c03646
Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements
Analytical Chemistry / May 04, 2016
Hasan, I. Y., & Mechler, A. (2016). Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements. Analytical Chemistry, 88(10), 5037–5041. https://doi.org/10.1021/acs.analchem.6b01045
Subtle Differences in Initial Membrane Interactions Underpin the Selectivity of Small Antimicrobial Peptides
ChemPlusChem / Dec 22, 2014
Praporski, S., Mechler, A., Separovic, F., & Martin, L. L. (2014). Subtle Differences in Initial Membrane Interactions Underpin the Selectivity of Small Antimicrobial Peptides. ChemPlusChem, 80(1), 91–96. Portico. https://doi.org/10.1002/cplu.201402318
Nanoscale resolution microchannel flow velocimetry by atomic force microscopy
Applied Physics Letters / Oct 09, 2006
Piorek, B., Mechler, Á., Lal, R., Freudenthal, P., Meinhart, C., & Banerjee, S. (2006). Nanoscale resolution microchannel flow velocimetry by atomic force microscopy. Applied Physics Letters, 89(15). https://doi.org/10.1063/1.2358966
Local laser-assisted chemical vapor deposition of diamond
Applied Surface Science / Dec 01, 2000
Tóth, Z., Mechler, Á., & Heszler, P. (2000). Local laser-assisted chemical vapor deposition of diamond. Applied Surface Science, 168(1–4), 5–8. https://doi.org/10.1016/s0169-4332(00)00563-8
Insights into the mechanisms and kinetics of the hydroperoxyl radical scavenging activity of Artepillin C
New Journal of Chemistry / Jan 01, 2021
Boulebd, H., Mechler, A., Hoa, N. T., Nam, P. C., Quang, D. T., & Vo, Q. V. (2021). Insights into the mechanisms and kinetics of the hydroperoxyl radical scavenging activity of Artepillin C. New Journal of Chemistry, 45(17), 7774–7780. https://doi.org/10.1039/d1nj00666e
Large-Scale Synthesis of Nanosilica from Silica Sand for Plant Stimulant Applications
ACS Omega / Nov 02, 2022
Hoang, C. V., Thoai, D. N., Cam, N. T. D., Phuong, T. T. T., Lieu, N. T., Hien, T. T. T., Nhiem, D. N., Pham, T.-D., Tung, M. H. T., Tran, N. T. T., Mechler, A., & Vo, Q. V. (2022). Large-Scale Synthesis of Nanosilica from Silica Sand for Plant Stimulant Applications. ACS Omega, 7(45), 41687–41695. https://doi.org/10.1021/acsomega.2c05760
The hydroperoxyl radical scavenging activity of natural hydroxybenzoic acids in oil and aqueous environments: Insights into the mechanism and kinetics
Phytochemistry / Sep 01, 2022
Hang, D. T. N., Hoa, N. T., Bich, H. N., Mechler, A., & Vo, Q. V. (2022). The hydroperoxyl radical scavenging activity of natural hydroxybenzoic acids in oil and aqueous environments: Insights into the mechanism and kinetics. Phytochemistry, 201, 113281. https://doi.org/10.1016/j.phytochem.2022.113281
Molybdenum (VI)‐functionalized UiO‐66 provides an efficient heterogeneous nanocatalyst in oxidation reactions
Applied Organometallic Chemistry / Sep 04, 2019
Afzali, N., Kardanpour, R., Zadehahmadi, F., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor‐Baltork, I., & Bahadori, M. (2019). Molybdenum (VI)‐functionalized UiO‐66 provides an efficient heterogeneous nanocatalyst in oxidation reactions. Applied Organometallic Chemistry, 33(11). Portico. https://doi.org/10.1002/aoc.5225
Design Principles of Peptide Based Self-Assembled Nanomaterials
Advances in Experimental Medicine and Biology / Jan 01, 2017
Seoudi, R. S., & Mechler, A. (2017). Design Principles of Peptide Based Self-Assembled Nanomaterials. In Peptides and Peptide-based Biomaterials and their Biomedical Applications (pp. 51–94). Springer International Publishing. https://doi.org/10.1007/978-3-319-66095-0_4
Formation of planar unilamellar phospholipid membranes on oxidized gold substrate
Biointerphases / Sep 01, 2016
Hasan, I. Y., & Mechler, A. (2016). Formation of planar unilamellar phospholipid membranes on oxidized gold substrate. Biointerphases, 11(3). https://doi.org/10.1116/1.4963188
Diamond-like carbon layer formation on graphite by excimer laser irradiation
Applied Physics A: Materials Science & Processing / Jun 01, 1998
Mechler, Á., Heszler, P., Kántor, Z., Szörényi, T., & Bor, Z. (1998). Diamond-like carbon layer formation on graphite by excimer laser irradiation. Applied Physics A: Materials Science & Processing, 66(6), 659–661. https://doi.org/10.1007/s003390050729
Calculating bond dissociation energies of X−H (X=C, N, O, S) bonds of aromatic systems via density functional theory: a detailed comparison of methods
Royal Society Open Science / Jun 01, 2022
Trung, N. Q., Mechler, A., Hoa, N. T., & Vo, Q. V. (2022). Calculating bond dissociation energies of X−H (X=C, N, O, S) bonds of aromatic systems via density functional theory: a detailed comparison of methods. Royal Society Open Science, 9(6). https://doi.org/10.1098/rsos.220177
Validating an artificial organelle: Studies of lipid droplet-specific proteins on adiposome platform
iScience / Aug 01, 2021
Ma, X., Zhi, Z., Zhang, S., Zhou, C., Mechler, A., & Liu, P. (2021). Validating an artificial organelle: Studies of lipid droplet-specific proteins on adiposome platform. IScience, 24(8), 102834. https://doi.org/10.1016/j.isci.2021.102834
Membrane morphology effects in quartz crystal microbalance characterization of antimicrobial peptide activity
Biophysical Chemistry / Jul 01, 2020
Pandidan, S., & Mechler, A. (2020). Membrane morphology effects in quartz crystal microbalance characterization of antimicrobial peptide activity. Biophysical Chemistry, 262, 106381. https://doi.org/10.1016/j.bpc.2020.106381
Substitution effects on the antiradical activity of hydralazine: a DFT analysis
New Journal of Chemistry / Jan 01, 2020
Boulebd, H., Tam, N. M., Mechler, A., & Vo, Q. V. (2020). Substitution effects on the antiradical activity of hydralazine: a DFT analysis. New Journal of Chemistry, 44(38), 16577–16583. https://doi.org/10.1039/d0nj03753b
A Study of Protein Electrochemistry on a Supported Membrane Electrode
International Journal of Peptide Research and Therapeutics / Apr 12, 2006
Mechler, A., Nawaratna, G., Aguilar, M.-I., & Martin, L. L. (2006). A Study of Protein Electrochemistry on a Supported Membrane Electrode. International Journal of Peptide Research and Therapeutics, 12(3), 217–224. https://doi.org/10.1007/s10989-006-9029-0
Education
University of Szeged
PhD, Physics / 2001
Experience
University of California Santa Barbara
NATO Postdoctoral Fellow / 2001 — 2004
Monash University
Monash Research Fellow / 2004 — 2009
Soft money independent research-only position
La Trobe University
Senior Lecturer (equiv. Assistant Professor in USA) / 2009 — 2016
Associate Professor / 2016 — 2020
Professor / 2020 — Present
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