Dr. Adam Mechler, PhD, FRSC

La Trobe University

Melbourne, Victoria, Australia

Research Expertise

physical chemistry
membrane biophysics
nanoscience
nanoarchitecture and molecular machines

About

Prof. Adam Mechler is a renowned physical chemist academic, specializing in the field of intermolecular interactions. He was born and raised in Hungary and developed a passion for science at a young age. He pursued his education in physics and chemistry and earned his PhD from the University of Szeged in 2001. During his PhD studies, Dr. Mechler focused on characterization of carbon nanostructures with an emphasis of graphite-diamond transformation. His research was recognized for its innovation and impact, and he was awarded the prestigious NATO Science for Peace Fellowship to continue his work at the University of California Santa Barbara, where he he found his inspiration from world leading experts and set his focus on the area of intermolecular interactions and self-assembly. In 2004 he moved to Australia as a Research Fellow at Monash University. Dr. Mechler joined the faculty at La Trobe University as tenured academic in 2009. He has since become a leading authority in his field, publishing numerous well received papers and receiving international recognition and accolades for his work. In 2012, Dr. Mechler was elected as a Fellow of the Royal Society of Chemistry (FRSC) in recognition of his contributions to the field of self-assembled nanomaterials. He is also a member of several other prestigious scientific organizations, including the American Chemical Society and the Australian Society for Biophysics. In addition to his research, Dr. Mechler is also a dedicated teacher and mentor. He has supervised numerous graduate and undergraduate students, and is known for his passion and enthusiasm in the classroom. Dr. Mechler continues to push the boundaries of our understanding of intermolecular interactions and self-organized systems and his work has significant implications for a wide range of fields, including materials science, biophysics, and physical chemistry. His dedication to scientific research and education has made him a highly respected figure in the scientific community.

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Publications

Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma
PROTEOMICS
2013
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Oncotarget
2015
Calcium-dependent Open/Closed Conformations and Interfacial Energy Maps of Reconstituted Hemichannels
Journal of Biological Chemistry
2005
Semiconductive Polymer Blends: Correlating Structure with Transport Properties at the Nanoscale
Advanced Materials
2004
Specific and Selective Peptide-Membrane Interactions Revealed Using Quartz Crystal Microbalance
Biophysical Journal
2007
Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens
Journal of Medicinal Chemistry
2010
Evaporative self-assembly assisted synthesis of polymeric nanoparticles by surface acoustic wave atomization
Nanotechnology
2008
Theoretical and Experimental Studies of the Antioxidant and Antinitrosant Activity of Syringic Acid
The Journal of Organic Chemistry
2020
Transthyretin oligomers induce calcium influx via voltage‐gated calcium channels
Journal of Neurochemistry
2006
Synthesis of Ag and Au nanostructures in an ionic liquid: thermodynamic and kinetic effects underlying nanoparticle, cluster and nanowire formation
Journal of Materials Chemistry
2007
Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation
Scientific Reports
2016
Supramolecular Self‐Assembly of N‐Acetyl‐Capped β‐Peptides Leads to Nano‐ to Macroscale Fiber Formation
Angewandte Chemie International Edition
2013
Density functional theory study of the role of benzylic hydrogen atoms in the antioxidant properties of lignans
Scientific Reports
2018
Electrochemical reactions of cytochrome c on electrodes modified by fullerene films
Journal of Electroanalytical Chemistry
2001
High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1–40) of Alzheimer’s disease suggests a novel mechanism of oligomer assembly
Journal of Structural Biology
2006
Geometrically Precise Building Blocks: the Self-Assembly of β-Peptides
Chemistry & Biology
2015
Antioxidant Motifs in Flavonoids: O–H versus C–H Bond Dissociation
ACS Omega
2019
Real-time Measurement of Membrane Conformational States Induced by Antimicrobial Peptides: Balance Between Recovery and Lysis
Scientific Reports
2014
The formation of gold nanoparticles using hydroquinone as a reducing agent through a localized pH change upon addition of NaOH to a solution of HAuCl4
Colloids and Surfaces A: Physicochemical and Engineering Aspects
2010
A resonance Raman spectroscopic investigation into the effects of fixation and dehydration on heme environment of hemoglobin
Journal of Raman Spectroscopy
2009
Exploring the origin of tip‐enhanced Raman scattering; preparation of efficient TERS probes with high yield
Journal of Raman Spectroscopy
2011
Controls and constrains of the membrane disrupting action of Aurein 1.2
Scientific Reports
2015
Correlation of atomic force microscopy and Raman micro-spectroscopy to study the effects of ex vivo treatment procedures on human red blood cells
The Analyst
2010
Metal organic framework-supported N -heterocyclic carbene palladium complex: A highly efficient and reusable heterogeneous catalyst for Suzuki-Miyaura C-C coupling reaction
Microporous and Mesoporous Materials
2017
Structure and homogeneity of pseudo-physiological phospholipid bilayers and their deposition characteristics on carboxylic acid terminated self-assembled monolayers
Biomaterials
2009
Solution Structure and Membrane Interactions of the Antimicrobial Peptide Fallaxidin 4.1a: An NMR and QCM Study
Biochemistry
2009
Organization of Cytochrome P450 Enzymes Involved in Sex Steroid Synthesis
Journal of Biological Chemistry
2009
Novel amplitude and frequency demodulation algorithm for a virtual dynamic atomic force microscope
Nanotechnology
2006
Anomalies in nanostructure size measurements by AFM
Physical Review B
2005
Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights
New Journal of Chemistry
2020
Surface Immobilization of Bio-Functionalized Cubosomes: Sensing of Proteins by Quartz Crystal Microbalance
Langmuir
2011
Surface energy maps of nanostructures: Atomic force microscopy and numerical simulation study
Applied Physics Letters
2003
Is Indolinonic Hydroxylamine a Promising Artificial Antioxidant?
The Journal of Physical Chemistry B
2019
A theoretical study of the radical scavenging activity of natural stilbenes
RSC Advances
2019
Dynamical properties of the Q-controlled atomic force microscope
Applied Physics Letters
2004
Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes
2008
Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells
The FASEB Journal
2009
Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane
Advanced Functional Materials
2009
A brief overview of global biotechnology
Biotechnology & Biotechnological Equipment
2021
Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study
Journal of Inorganic Biochemistry
2011
In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols
Journal of Chemical Information and Modeling
2019
Raman spectroscopic and atomic force microscopic study of graphite ablation at 193 and 248 nm
Applied Surface Science
2000
Phenylalanine residues act as membrane anchors in the antimicrobial action of Aurein 1.2
Biointerphases
2017
Imaging bandwidth of the tapping mode atomic force microscope probe
Physical Review B
2006
Organogels Derived from Tetranitrated Crown Ethers
Organic Letters
2006
A thermodynamic and kinetic study of the antioxidant activity of natural hydroanthraquinones
RSC Advances
2020
Cell Penetrating Apidaecin Peptide Interactions with Biomimetic Phospholipid Membranes
International Journal of Peptide Research and Therapeutics
2009
Time-resolved shock-wave photography above 193-nm excimer laser-ablated graphite surface
Applied Physics A Materials Science & Processing
1999
Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights
The Journal of Physical Chemistry B
2020
Growth ofCaenorhabditis elegansin Defined Media Is Dependent on Presence of Particulate Matter
G3 Genes|Genomes|Genetics
2018
The antioxidant activity of natural diterpenes: theoretical insights
RSC Advances
2020
Nano-viscosimetry analysis of the membrane disrupting action of the bee venom peptide melittin
Scientific Reports
2019
Supramolecular self-assembly of 14-helical nanorods with tunable linear and dendritic hierarchical morphologies
New Journal of Chemistry
2015
A QCM‐D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA
ChemBioChem
2017
Investigation of fluid cell resonances in intermittent contact mode atomic force microscopy
Applied Physics Letters
2007
Nanoscale velocity–drag force relationship in thin liquid layers measured by atomic force microscopy
Applied Physics Letters
2004
Amino acid sequence controls the self-assembled superstructure morphology of N-acetylated tri-β3-peptides
Pure and Applied Chemistry
2015
Antioxidant Activities of Monosubstituted Indolinonic Hydroxylamines: A Thermodynamic and Kinetic Study
The Journal of Physical Chemistry B
2019
β3-tripeptides act as sticky ends to self-assemble into a bioscaffold
APL Bioengineering
2018
Viscoelastic changes measured in partially suspended single bilayer membranes
Soft Matter
2015
Electrochemiluminescence of surface bound microparticles of ruthenium complexes
J. Mater. Chem.
2010
Spring constant of microcantilevers in fundamental and higher eigenmodes
Physical Review B
2008
AFM study of morphological changes associated with electrochemical solid–solid transformation of three-dimensional crystals of TCNQ to metal derivatives (metal = Cu, Co, Ni; TCNQ = tetracyanoquinodimethane)
Journal of Solid State Electrochemistry
2007
Interaction of Small Ionic Species With Phospholipid Membranes: The Role of Metal Coordination
Frontiers in Materials
2019
Labeling phospholipid membranes with lipid mimetic luminescent metal complexes
Biochimica et Biophysica Acta (BBA) - Biomembranes
2014
Time-resolved investigation of the transient surface reflection changes of subpicosecond excimer laser ablated liquids
Applied Physics A Materials Science & Processing
1999
Excimer laser irradiation induced formation of diamond-like carbon layer on graphite
Applied Surface Science
1999
Assessment of the free radical scavenging potential of cannabidiol under physiological conditions: Theoretical and experimental investigations
Journal of Molecular Liquids
2022
Theoretical Study on the Antioxidant Activity of Natural Depsidones
ACS Omega
2020
The radical scavenging activity of natural ramalin: A mechanistic and kinetic study
Chemical Physics Letters
2020
Self-assembled nanomaterials based on beta (β3) tetrapeptides
Nanotechnology
2016
The hydroperoxyl and superoxide anion radical scavenging activity of anthocyanidins in physiological environments: Theoretical insights into mechanisms and kinetics
Phytochemistry
2021
Biochemical and biophysical characterization of a novel plant protein disulfide isomerase
Peptide Science
2008
Modelling the mechanism and kinetics of the radical scavenging activity of iminostilbene
Polymer Degradation and Stability
2021
Synthesis of aromatic and indole alpha-glucosinolates
Carbohydrate Research
2018
The role of C-terminal amidation in the mechanism of action of the antimicrobial peptide aurein 1.2
The EuroBiotech Journal
2020
Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study
ACS Omega
2019
Analytical approaches to study domain formation in biomimetic membranes
The Analyst
2017
Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight
ACS Omega
2021
Dodecatungstocobaltate heteropolyanion encapsulation into MIL‐101(Cr) metal–organic framework scaffold provides a highly efficient heterogeneous catalyst for methanolysis of epoxides
Applied Organometallic Chemistry
2017
Oxidation reactions catalysed by molybdenum(VI) complexes grafted on UiO‐66 metal–organic framework as an elegant nanoreactor
Applied Organometallic Chemistry
2017
Is Usnic Acid a Promising Radical Scavenger?
ACS Omega
2020
Is natural fraxin an overlooked radical scavenger?
RSC Advances
2021
In Silico Evaluation of the Radical Scavenging Mechanism of Mactanamide
ACS Omega
2020
Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements
Analytical Chemistry
2016
Subtle Differences in Initial Membrane Interactions Underpin the Selectivity of Small Antimicrobial Peptides
ChemPlusChem
2014
Nanoscale resolution microchannel flow velocimetry by atomic force microscopy
Applied Physics Letters
2006
Local laser-assisted chemical vapor deposition of diamond
Applied Surface Science
2000
Insights into the mechanisms and kinetics of the hydroperoxyl radical scavenging activity of Artepillin C
New Journal of Chemistry
2021
Large-Scale Synthesis of Nanosilica from Silica Sand for Plant Stimulant Applications
ACS Omega
2022
The hydroperoxyl radical scavenging activity of natural hydroxybenzoic acids in oil and aqueous environments: Insights into the mechanism and kinetics
Phytochemistry
2022
Molybdenum (VI)‐functionalized UiO‐66 provides an efficient heterogeneous nanocatalyst in oxidation reactions
Applied Organometallic Chemistry
2019
Design Principles of Peptide Based Self-Assembled Nanomaterials
Advances in Experimental Medicine and Biology
2017
Formation of planar unilamellar phospholipid membranes on oxidized gold substrate
Biointerphases
2016
Diamond-like carbon layer formation on graphite by excimer laser irradiation
Applied Physics A: Materials Science & Processing
1998
Calculating bond dissociation energies of X−H (X=C, N, O, S) bonds of aromatic systems via density functional theory: a detailed comparison of methods
Royal Society Open Science
2022
Validating an artificial organelle: Studies of lipid droplet-specific proteins on adiposome platform
iScience
2021
Membrane morphology effects in quartz crystal microbalance characterization of antimicrobial peptide activity
Biophysical Chemistry
2020
Substitution effects on the antiradical activity of hydralazine: a DFT analysis
New Journal of Chemistry
2020
A Study of Protein Electrochemistry on a Supported Membrane Electrode
International Journal of Peptide Research and Therapeutics
2006

Education

University of Szeged

PhD, Physics / 2001

Szeged

Experience

University of California Santa Barbara

NATO Postdoctoral Fellow / 20012004

Monash University

Monash Research Fellow / 20042009

Soft money independent research-only position

La Trobe University

Senior Lecturer (equiv. Assistant Professor in USA) / 20092016

Associate Professor / 20162020

Professor / 2020Present

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