Dr. Adam Mechler, PhD, FRSC

La Trobe University

Melbourne, Victoria, Australia

Research Expertise

physical chemistry
membrane biophysics
nanoscience
nanoarchitecture and molecular machines

About

Prof. Adam Mechler is a renowned physical chemist academic, specializing in the field of intermolecular interactions. He was born and raised in Hungary and developed a passion for science at a young age. He pursued his education in physics and chemistry and earned his PhD from the University of Szeged in 2001. During his PhD studies, Dr. Mechler focused on characterization of carbon nanostructures with an emphasis of graphite-diamond transformation. His research was recognized for its innovation and impact, and he was awarded the prestigious NATO Science for Peace Fellowship to continue his work at the University of California Santa Barbara, where he he found his inspiration from world leading experts and set his focus on the area of intermolecular interactions and self-assembly. In 2004 he moved to Australia as a Research Fellow at Monash University. Dr. Mechler joined the faculty at La Trobe University as tenured academic in 2009. He has since become a leading authority in his field, publishing numerous well received papers and receiving international recognition and accolades for his work. In 2012, Dr. Mechler was elected as a Fellow of the Royal Society of Chemistry (FRSC) in recognition of his contributions to the field of self-assembled nanomaterials. He is also a member of several other prestigious scientific organizations, including the American Chemical Society and the Australian Society for Biophysics. In addition to his research, Dr. Mechler is also a dedicated teacher and mentor. He has supervised numerous graduate and undergraduate students, and is known for his passion and enthusiasm in the classroom. Dr. Mechler continues to push the boundaries of our understanding of intermolecular interactions and self-organized systems and his work has significant implications for a wide range of fields, including materials science, biophysics, and physical chemistry. His dedication to scientific research and education has made him a highly respected figure in the scientific community.

Publications

Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

PROTEOMICS / Oct 18, 2013

Kalra, H., Adda, C. G., Liem, M., Ang, C., Mechler, A., Simpson, R. J., Hulett, M. D., & Mathivanan, S. (2013). Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. PROTEOMICS, 13(22), 3354–3364. Portico. https://doi.org/10.1002/pmic.201300282

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

Oncotarget / Apr 12, 2015

Keerthikumar, S., Gangoda, L., Liem, M., Fonseka, P., Atukorala, I., Ozcitti, C., Mechler, A., Adda, C. G., Ang, C.-S., & Mathivanan, S. (2015). Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. Oncotarget, 6(17), 15375–15396. https://doi.org/10.18632/oncotarget.3801

Calcium-dependent Open/Closed Conformations and Interfacial Energy Maps of Reconstituted Hemichannels

Journal of Biological Chemistry / Mar 01, 2005

Thimm, J., Mechler, A., Lin, H., Rhee, S., & Lal, R. (2005). Calcium-dependent Open/Closed Conformations and Interfacial Energy Maps of Reconstituted Hemichannels. Journal of Biological Chemistry, 280(11), 10646–10654. https://doi.org/10.1074/jbc.m412749200

Semiconductive Polymer Blends: Correlating Structure with Transport Properties at the Nanoscale

Advanced Materials / Mar 05, 2004

Ionescu‐Zanetti, C., Mechler, A., Carter, S. A., & Lal, R. (2004). Semiconductive Polymer Blends: Correlating Structure with Transport Properties at the Nanoscale. Advanced Materials, 16(5), 385–389. Portico. https://doi.org/10.1002/adma.200305747

Specific and Selective Peptide-Membrane Interactions Revealed Using Quartz Crystal Microbalance

Biophysical Journal / Dec 01, 2007

Mechler, A., Praporski, S., Atmuri, K., Boland, M., Separovic, F., & Martin, L. L. (2007). Specific and Selective Peptide-Membrane Interactions Revealed Using Quartz Crystal Microbalance. Biophysical Journal, 93(11), 3907–3916. https://doi.org/10.1529/biophysj.107.116525

Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens

Journal of Medicinal Chemistry / Jun 21, 2010

Knappe, D., Piantavigna, S., Hansen, A., Mechler, A., Binas, A., Nolte, O., Martin, L. L., & Hoffmann, R. (2010). Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens. Journal of Medicinal Chemistry, 53(14), 5240–5247. https://doi.org/10.1021/jm100378b

Evaporative self-assembly assisted synthesis of polymeric nanoparticles by surface acoustic wave atomization

Nanotechnology / Mar 04, 2008

Friend, J. R., Yeo, L. Y., Arifin, D. R., & Mechler, A. (2008). Evaporative self-assembly assisted synthesis of polymeric nanoparticles by surface acoustic wave atomization. Nanotechnology, 19(14), 145301. https://doi.org/10.1088/0957-4484/19/14/145301

Theoretical and Experimental Studies of the Antioxidant and Antinitrosant Activity of Syringic Acid

The Journal of Organic Chemistry / Nov 05, 2020

Vo, Q. V., Bay, M. V., Nam, P. C., Quang, D. T., Flavel, M., Hoa, N. T., & Mechler, A. (2020). Theoretical and Experimental Studies of the Antioxidant and Antinitrosant Activity of Syringic Acid. The Journal of Organic Chemistry, 85(23), 15514–15520. https://doi.org/10.1021/acs.joc.0c02258

Transthyretin oligomers induce calcium influx via voltage‐gated calcium channels

Journal of Neurochemistry / Aug 25, 2006

Hou, X., Parkington, H. C., Coleman, H. A., Mechler, A., Martin, L. L., Aguilar, M., & Small, D. H. (2006). Transthyretin oligomers induce calcium influx via voltage‐gated calcium channels. Journal of Neurochemistry, 100(2), 446–457. Portico. https://doi.org/10.1111/j.1471-4159.2006.04210.x

Synthesis of Ag and Au nanostructures in an ionic liquid: thermodynamic and kinetic effects underlying nanoparticle, cluster and nanowire formation

Journal of Materials Chemistry / Jan 01, 2007

Bhatt, A. I., Mechler, ?d?m, Martin, L. L., & Bond, A. M. (2007). Synthesis of Ag and Au nanostructures in an ionic liquid: thermodynamic and kinetic effects underlying nanoparticle, cluster and nanowire formation. Journal of Materials Chemistry, 17(21), 2241. https://doi.org/10.1039/b618036a

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation

Scientific Reports / Nov 30, 2016

Shahmiri, M., Enciso, M., Adda, C. G., Smith, B. J., Perugini, M. A., & Mechler, A. (2016). Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation. Scientific Reports, 6(1). https://doi.org/10.1038/srep38184

Supramolecular Self‐Assembly of N‐Acetyl‐Capped β‐Peptides Leads to Nano‐ to Macroscale Fiber Formation

Angewandte Chemie International Edition / Jun 19, 2013

Del Borgo, M. P., Mechler, A. I., Traore, D., Forsyth, C., Wilce, J. A., Wilce, M. C. J., Aguilar, M., & Perlmutter, P. (2013). Supramolecular Self‐Assembly of N‐Acetyl‐Capped β‐Peptides Leads to Nano‐ to Macroscale Fiber Formation. Angewandte Chemie International Edition, 52(32), 8266–8270. Portico. https://doi.org/10.1002/anie.201303175

Density functional theory study of the role of benzylic hydrogen atoms in the antioxidant properties of lignans

Scientific Reports / Aug 17, 2018

Vo, Q. V., Nam, P. C., Bay, M. V., Thong, N. M., Cuong, N. D., & Mechler, A. (2018). Density functional theory study of the role of benzylic hydrogen atoms in the antioxidant properties of lignans. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-30860-5

Electrochemical reactions of cytochrome c on electrodes modified by fullerene films

Journal of Electroanalytical Chemistry / Feb 01, 2001

Csiszár, M., Szűcs, Á., Tölgyesi, M., Mechler, Á., Nagy, J. B., & Novák, M. (2001). Electrochemical reactions of cytochrome c on electrodes modified by fullerene films. Journal of Electroanalytical Chemistry, 497(1–2), 69–74. https://doi.org/10.1016/s0022-0728(00)00453-8

High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1–40) of Alzheimer’s disease suggests a novel mechanism of oligomer assembly

Journal of Structural Biology / Jul 01, 2006

Losic, D., Martin, L. L., Mechler, A., Aguilar, M.-I., & Small, D. H. (2006). High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1–40) of Alzheimer’s disease suggests a novel mechanism of oligomer assembly. Journal of Structural Biology, 155(1), 104–110. https://doi.org/10.1016/j.jsb.2006.02.013

Geometrically Precise Building Blocks: the Self-Assembly of β-Peptides

Chemistry & Biology / Nov 01, 2015

Gopalan, R. D., Del Borgo, M. P., Mechler, A. I., Perlmutter, P., & Aguilar, M.-I. (2015). Geometrically Precise Building Blocks: the Self-Assembly of β-Peptides. Chemistry & Biology, 22(11), 1417–1423. https://doi.org/10.1016/j.chembiol.2015.10.005

Antioxidant Motifs in Flavonoids: O–H versus C–H Bond Dissociation

ACS Omega / May 22, 2019

Vo, Q. V., Nam, P. C., Thong, N. M., Trung, N. T., Phan, C.-T. D., & Mechler, A. (2019). Antioxidant Motifs in Flavonoids: O–H versus C–H Bond Dissociation. ACS Omega, 4(5), 8935–8942. https://doi.org/10.1021/acsomega.9b00677

Real-time Measurement of Membrane Conformational States Induced by Antimicrobial Peptides: Balance Between Recovery and Lysis

Scientific Reports / Jun 27, 2014

Hall, K., Lee, T.-H., Mechler, A. I., Swann, M. J., & Aguilar, M.-I. (2014). Real-time Measurement of Membrane Conformational States Induced by Antimicrobial Peptides: Balance Between Recovery and Lysis. Scientific Reports, 4(1). https://doi.org/10.1038/srep05479

The formation of gold nanoparticles using hydroquinone as a reducing agent through a localized pH change upon addition of NaOH to a solution of HAuCl4

Colloids and Surfaces A: Physicochemical and Engineering Aspects / Nov 01, 2010

Sirajuddin, Mechler, A., Torriero, A. A. J., Nafady, A., Lee, C.-Y., Bond, A. M., O’Mullane, A. P., & Bhargava, S. K. (2010). The formation of gold nanoparticles using hydroquinone as a reducing agent through a localized pH change upon addition of NaOH to a solution of HAuCl4. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 370(1–3), 35–41. https://doi.org/10.1016/j.colsurfa.2010.08.041

A resonance Raman spectroscopic investigation into the effects of fixation and dehydration on heme environment of hemoglobin

Journal of Raman Spectroscopy / May 11, 2009

Asghari‐Khiavi, M., Mechler, A., Bambery, K. R., McNaughton, D., & Wood, B. R. (2009). A resonance Raman spectroscopic investigation into the effects of fixation and dehydration on heme environment of hemoglobin. Journal of Raman Spectroscopy, 40(11), 1668–1674. Portico. https://doi.org/10.1002/jrs.2317

Exploring the origin of tip‐enhanced Raman scattering; preparation of efficient TERS probes with high yield

Journal of Raman Spectroscopy / Aug 02, 2011

Asghari‐Khiavi, M., Wood, B. R., Hojati‐Talemi, P., Downes, A., McNaughton, D., & Mechler, A. (2011). Exploring the origin of tip‐enhanced Raman scattering; preparation of efficient TERS probes with high yield. Journal of Raman Spectroscopy, 43(2), 173–180. Portico. https://doi.org/10.1002/jrs.3021

Controls and constrains of the membrane disrupting action of Aurein 1.2

Scientific Reports / Nov 17, 2015

Shahmiri, M., Enciso, M., & Mechler, A. (2015). Controls and constrains of the membrane disrupting action of Aurein 1.2. Scientific Reports, 5(1). https://doi.org/10.1038/srep16378

Correlation of atomic force microscopy and Raman micro-spectroscopy to study the effects of ex vivo treatment procedures on human red blood cells

The Analyst / Jan 01, 2010

Asghari-Khiavi, M., Wood, B. R., Mechler, A., Bambery, K. R., Buckingham, D. W., Cooke, B. M., & McNaughton, D. (2010). Correlation of atomic force microscopy and Raman micro-spectroscopy to study the effects of ex vivo treatment procedures on human red blood cells. The Analyst, 135(3), 525. https://doi.org/10.1039/b919245j

Metal organic framework-supported N -heterocyclic carbene palladium complex: A highly efficient and reusable heterogeneous catalyst for Suzuki-Miyaura C-C coupling reaction

Microporous and Mesoporous Materials / Nov 01, 2017

Bahadori, M., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor-Baltork, I., & Zadehahmadi, F. (2017). Metal organic framework-supported N -heterocyclic carbene palladium complex: A highly efficient and reusable heterogeneous catalyst for Suzuki-Miyaura C-C coupling reaction. Microporous and Mesoporous Materials, 253, 102–111. https://doi.org/10.1016/j.micromeso.2017.06.048

Structure and homogeneity of pseudo-physiological phospholipid bilayers and their deposition characteristics on carboxylic acid terminated self-assembled monolayers

Biomaterials / Feb 01, 2009

Mechler, A., Praporski, S., Piantavigna, S., Heaton, S. M., Hall, K. N., Aguilar, M.-I., & Martin, L. L. (2009). Structure and homogeneity of pseudo-physiological phospholipid bilayers and their deposition characteristics on carboxylic acid terminated self-assembled monolayers. Biomaterials, 30(4), 682–689. https://doi.org/10.1016/j.biomaterials.2008.10.016

Solution Structure and Membrane Interactions of the Antimicrobial Peptide Fallaxidin 4.1a: An NMR and QCM Study

Biochemistry / Nov 13, 2009

Sherman, P. J., Jackway, R. J., Gehman, J. D., Praporski, S., McCubbin, G. A., Mechler, A., Martin, L. L., Separovic, F., & Bowie, J. H. (2009). Solution Structure and Membrane Interactions of the Antimicrobial Peptide Fallaxidin 4.1a: An NMR and QCM Study. Biochemistry, 48(50), 11892–11901. https://doi.org/10.1021/bi901668y

Organization of Cytochrome P450 Enzymes Involved in Sex Steroid Synthesis

Journal of Biological Chemistry / Nov 01, 2009

Praporski, S., Ng, S. M., Nguyen, A. D., Corbin, C. J., Mechler, A., Zheng, J., Conley, A. J., & Martin, L. L. (2009). Organization of Cytochrome P450 Enzymes Involved in Sex Steroid Synthesis. Journal of Biological Chemistry, 284(48), 33224–33232. https://doi.org/10.1074/jbc.m109.006064

Novel amplitude and frequency demodulation algorithm for a virtual dynamic atomic force microscope

Nanotechnology / Mar 10, 2006

Kokavecz, J., Tóth, Z., Horváth, Z. L., Heszler, P., & Mechler, Á. (2006). Novel amplitude and frequency demodulation algorithm for a virtual dynamic atomic force microscope. Nanotechnology, 17(7), S173–S177. https://doi.org/10.1088/0957-4484/17/7/s12

Anomalies in nanostructure size measurements by AFM

Physical Review B / Sep 02, 2005

Mechler, Á., Kopniczky, J., Kokavecz, J., Hoel, A., Granqvist, C.-G., & Heszler, P. (2005). Anomalies in nanostructure size measurements by AFM. Physical Review B, 72(12). https://doi.org/10.1103/physrevb.72.125407

Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights

New Journal of Chemistry / Jan 01, 2020

Boulebd, H., Mechler, A., Hoa, N. T., & Vo, Q. V. (2020). Thermodynamic and kinetic studies of the antiradical activity of 5-hydroxymethylfurfural: computational insights. New Journal of Chemistry, 44(23), 9863–9869. https://doi.org/10.1039/d0nj01567a

Surface Immobilization of Bio-Functionalized Cubosomes: Sensing of Proteins by Quartz Crystal Microbalance

Langmuir / Dec 09, 2011

Fraser, S. J., Mulet, X., Martin, L., Praporski, S., Mechler, A., Hartley, P. G., Polyzos, A., & Separovic, F. (2011). Surface Immobilization of Bio-Functionalized Cubosomes: Sensing of Proteins by Quartz Crystal Microbalance. Langmuir, 28(1), 620–627. https://doi.org/10.1021/la2032994

Surface energy maps of nanostructures: Atomic force microscopy and numerical simulation study

Applied Physics Letters / May 26, 2003

Mechler, Á., Kokavecz, J., Heszler, P., & Lal, R. (2003). Surface energy maps of nanostructures: Atomic force microscopy and numerical simulation study. Applied Physics Letters, 82(21), 3740–3742. https://doi.org/10.1063/1.1577392

Is Indolinonic Hydroxylamine a Promising Artificial Antioxidant?

The Journal of Physical Chemistry B / Aug 28, 2019

Vo, Q. V., Bay, M. V., Nam, P. C., & Mechler, A. (2019). Is Indolinonic Hydroxylamine a Promising Artificial Antioxidant? The Journal of Physical Chemistry B, 123(37), 7777–7784. https://doi.org/10.1021/acs.jpcb.9b05160

A theoretical study of the radical scavenging activity of natural stilbenes

RSC Advances / Jan 01, 2019

Vo, Q. V., Cam Nam, P., Bay, M. V., Minh Thong, N., Hieu, L. T., & Mechler, A. (2019). A theoretical study of the radical scavenging activity of natural stilbenes. RSC Advances, 9(72), 42020–42028. https://doi.org/10.1039/c9ra08381b

Dynamical properties of the Q-controlled atomic force microscope

Applied Physics Letters / Oct 11, 2004

Kokavecz, J., Horváth, Z. L., & Mechler, Á. (2004). Dynamical properties of the Q-controlled atomic force microscope. Applied Physics Letters, 85(15), 3232–3234. https://doi.org/10.1063/1.1785863

Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes / Jan 01, 2008

Hou, X., Mechler, A., Martin, L. L., Aguilar, M.-I., & Small, D. H. (2008). Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1778(1), 198–205. https://doi.org/10.1016/j.bbamem.2007.09.018

Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells

The FASEB Journal / Apr 24, 2009

Glover, D. J., Ng, S. M., Mechler, A., Martin, L. L., & Jans, D. A. (2009). Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells. The FASEB Journal, 23(9), 2996–3006. Portico. https://doi.org/10.1096/fj.09-131425

Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

Advanced Functional Materials / Jan 08, 2009

Battle, A. R., Valenzuela, S. M., Mechler, A., Nichols, R. J., Praporski, S., di Maio, I. L., Islam, H., Girard‐Egrot, A. P., Cornell, B. A., Prashar, J., Caruso, F., Martin, L. L., & Martin, D. K. (2009). Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane. Advanced Functional Materials, 19(2), 201–208. Portico. https://doi.org/10.1002/adfm.200800483

A brief overview of global biotechnology

Biotechnology & Biotechnological Equipment / Feb 07, 2021

Martin, D. K., Vicente, O., Beccari, T., Kellermayer, M., Koller, M., Lal, R., Marks, R. S., Marova, I., Mechler, A., Tapaloaga, D., Žnidaršič-Plazl, P., & Dundar, M. (2021). A brief overview of global biotechnology. Biotechnology & Biotechnological Equipment, 35(sup1), S5–S14. https://doi.org/10.1080/13102818.2021.1878933

Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study

Journal of Inorganic Biochemistry / Dec 01, 2011

Asghari-Khiavi, M., Vongsvivut, J., Perepichka, I., Mechler, A., Wood, B. R., McNaughton, D., & Bohle, D. S. (2011). Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study. Journal of Inorganic Biochemistry, 105(12), 1662–1669. https://doi.org/10.1016/j.jinorgbio.2011.08.005

In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols

Journal of Chemical Information and Modeling / Dec 16, 2019

Vo, Q. V., & Mechler, A. (2019). In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols. Journal of Chemical Information and Modeling, 60(1), 316–321. https://doi.org/10.1021/acs.jcim.9b00917

Raman spectroscopic and atomic force microscopic study of graphite ablation at 193 and 248 nm

Applied Surface Science / Feb 01, 2000

Mechler, Á., Heszler, P., Márton, Z., Kovács, M., Szörényi, T., & Bor, Z. (2000). Raman spectroscopic and atomic force microscopic study of graphite ablation at 193 and 248 nm. Applied Surface Science, 154–155, 22–28. https://doi.org/10.1016/s0169-4332(99)00473-0

Phenylalanine residues act as membrane anchors in the antimicrobial action of Aurein 1.2

Biointerphases / Oct 26, 2017

Shahmiri, M., Cornell, B., & Mechler, A. (2017). Phenylalanine residues act as membrane anchors in the antimicrobial action of Aurein 1.2. Biointerphases, 12(5). https://doi.org/10.1116/1.4995674

Imaging bandwidth of the tapping mode atomic force microscope probe

Physical Review B / Apr 04, 2006

Kokavecz, J., Marti, O., Heszler, P., & Mechler, Á. (2006). Imaging bandwidth of the tapping mode atomic force microscope probe. Physical Review B, 73(15). https://doi.org/10.1103/physrevb.73.155403

Organogels Derived from Tetranitrated Crown Ethers

Organic Letters / Feb 28, 2006

Langford, S. J., Latter, M. J., Lau, V.-L., Martin, L. L., & Mechler, A. (2006). Organogels Derived from Tetranitrated Crown Ethers. Organic Letters, 8(7), 1371–1373. https://doi.org/10.1021/ol060142j

A thermodynamic and kinetic study of the antioxidant activity of natural hydroanthraquinones

RSC Advances / Jan 01, 2020

Vo, Q. V., Thong, N. M., Le Huyen, T., Nam, P. C., Tam, N. M., Hoa, N. T., & Mechler, A. (2020). A thermodynamic and kinetic study of the antioxidant activity of natural hydroanthraquinones. RSC Advances, 10(34), 20089–20097. https://doi.org/10.1039/d0ra04013d

Cell Penetrating Apidaecin Peptide Interactions with Biomimetic Phospholipid Membranes

International Journal of Peptide Research and Therapeutics / Apr 01, 2009

Piantavigna, S., Czihal, P., Mechler, A., Richter, M., Hoffmann, R., & Martin, L. L. (2009). Cell Penetrating Apidaecin Peptide Interactions with Biomimetic Phospholipid Membranes. International Journal of Peptide Research and Therapeutics, 15(2), 139–146. https://doi.org/10.1007/s10989-009-9175-2

Time-resolved shock-wave photography above 193-nm excimer laser-ablated graphite surface

Applied Physics A Materials Science & Processing / Dec 01, 1999

Márton, Zs., Heszler, P., Mechler, Á., Hopp, B., Kántor, Z., & Bor, Zs. (1999). Time-resolved shock-wave photography above 193-nm excimer laser-ablated graphite surface. Applied Physics A Materials Science & Processing, 69(S1), S133–S136. https://doi.org/10.1007/s003399900293

Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights

The Journal of Physical Chemistry B / Apr 21, 2020

Boulebd, H., Khodja, I. A., Bay, M. V., Hoa, N. T., Mechler, A., & Vo, Q. V. (2020). Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights. The Journal of Physical Chemistry B, 124(20), 4123–4131. https://doi.org/10.1021/acs.jpcb.0c02439

Growth ofCaenorhabditis elegansin Defined Media Is Dependent on Presence of Particulate Matter

G3 Genes|Genomes|Genetics / Feb 01, 2018

Flavel, M. R., Mechler, A., Shahmiri, M., Mathews, E. R., Franks, A. E., Chen, W., Zanker, D., Xian, B., Gao, S., Luo, J., Tegegne, S., Doneski, C., & Jois, M. (2018). Growth ofCaenorhabditis elegansin Defined Media Is Dependent on Presence of Particulate Matter. G3 Genes|Genomes|Genetics, 8(2), 567–575. https://doi.org/10.1534/g3.117.300325

The antioxidant activity of natural diterpenes: theoretical insights

RSC Advances / Jan 01, 2020

Vo, Q. V., Tam, N. M., Hieu, L. T., Van Bay, M., Thong, N. M., Le Huyen, T., Hoa, N. T., & Mechler, A. (2020). The antioxidant activity of natural diterpenes: theoretical insights. RSC Advances, 10(25), 14937–14943. https://doi.org/10.1039/d0ra02681f

Nano-viscosimetry analysis of the membrane disrupting action of the bee venom peptide melittin

Scientific Reports / Jul 25, 2019

Pandidan, S., & Mechler, A. (2019). Nano-viscosimetry analysis of the membrane disrupting action of the bee venom peptide melittin. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-47325-y

Supramolecular self-assembly of 14-helical nanorods with tunable linear and dendritic hierarchical morphologies

New Journal of Chemistry / Jan 01, 2015

Seoudi, R. S., Del Borgo, M. P., Kulkarni, K., Perlmutter, P., Aguilar, M.-I., & Mechler, A. (2015). Supramolecular self-assembly of 14-helical nanorods with tunable linear and dendritic hierarchical morphologies. New Journal of Chemistry, 39(5), 3280–3287. https://doi.org/10.1039/c4nj01926a

A QCM‐D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA

ChemBioChem / Apr 03, 2017

Tajik‐Ahmadabad, B., Mechler, A., Muir, B. W., McLean, K., Hinton, T. M., Separovic, F., & Polyzos, A. (2017). A QCM‐D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA. ChemBioChem, 18(10), 921–930. Portico. https://doi.org/10.1002/cbic.201600613

Investigation of fluid cell resonances in intermittent contact mode atomic force microscopy

Applied Physics Letters / Jul 09, 2007

Kokavecz, J., & Mechler, A. (2007). Investigation of fluid cell resonances in intermittent contact mode atomic force microscopy. Applied Physics Letters, 91(2). https://doi.org/10.1063/1.2753104

Nanoscale velocity–drag force relationship in thin liquid layers measured by atomic force microscopy

Applied Physics Letters / Oct 25, 2004

Mechler, Á., Piorek, B., Lal, R., & Banerjee, S. (2004). Nanoscale velocity–drag force relationship in thin liquid layers measured by atomic force microscopy. Applied Physics Letters, 85(17), 3881–3883. https://doi.org/10.1063/1.1808504

Amino acid sequence controls the self-assembled superstructure morphology of N-acetylated tri-β3-peptides

Pure and Applied Chemistry / Sep 08, 2015

Seoudi, R. S., Dowd, A., Del Borgo, M., Kulkarni, K., Perlmutter, P., Aguilar, M.-I., & Mechler, A. (2015). Amino acid sequence controls the self-assembled superstructure morphology of N-acetylated tri-β3-peptides. Pure and Applied Chemistry, 87(9–10), 1021–1028. https://doi.org/10.1515/pac-2015-0108

Antioxidant Activities of Monosubstituted Indolinonic Hydroxylamines: A Thermodynamic and Kinetic Study

The Journal of Physical Chemistry B / Nov 25, 2019

Vo, Q. V., Gon, T. V., Bay, M. V., & Mechler, A. (2019). Antioxidant Activities of Monosubstituted Indolinonic Hydroxylamines: A Thermodynamic and Kinetic Study. The Journal of Physical Chemistry B, 123(50), 10672–10679. https://doi.org/10.1021/acs.jpcb.9b08912

β3-tripeptides act as sticky ends to self-assemble into a bioscaffold

APL Bioengineering / May 01, 2018

Del Borgo, M. P., Kulkarni, K., Tonta, M. A., Ratcliffe, J. L., Seoudi, R., Mechler, A. I., Perlmutter, P., Parkington, H. C., & Aguilar, M.-I. (2018). β3-tripeptides act as sticky ends to self-assemble into a bioscaffold. APL Bioengineering, 2(2). https://doi.org/10.1063/1.5020105

Viscoelastic changes measured in partially suspended single bilayer membranes

Soft Matter / Jan 01, 2015

Hasan, I. Y., & Mechler, A. (2015). Viscoelastic changes measured in partially suspended single bilayer membranes. Soft Matter, 11(27), 5571–5579. https://doi.org/10.1039/c5sm00278h

Electrochemiluminescence of surface bound microparticles of ruthenium complexes

J. Mater. Chem. / Jan 01, 2010

Barbante, G. J., Hogan, C. F., Mechler, A., & Hughes, A. B. (2010). Electrochemiluminescence of surface bound microparticles of ruthenium complexes. J. Mater. Chem., 20(5), 891–899. https://doi.org/10.1039/b918799p

Spring constant of microcantilevers in fundamental and higher eigenmodes

Physical Review B / Nov 04, 2008

Kokavecz, J., & Mechler, A. (2008). Spring constant of microcantilevers in fundamental and higher eigenmodes. Physical Review B, 78(17). https://doi.org/10.1103/physrevb.78.172101

AFM study of morphological changes associated with electrochemical solid–solid transformation of three-dimensional crystals of TCNQ to metal derivatives (metal = Cu, Co, Ni; TCNQ = tetracyanoquinodimethane)

Journal of Solid State Electrochemistry / Sep 27, 2007

Qu, X., Nafady, A., Mechler, A., Zhang, J., Harris, A. R., O’Mullane, A. P., Martin, L. L., & Bond, A. M. (2007). AFM study of morphological changes associated with electrochemical solid–solid transformation of three-dimensional crystals of TCNQ to metal derivatives (metal = Cu, Co, Ni; TCNQ = tetracyanoquinodimethane). Journal of Solid State Electrochemistry, 12(6), 739–746. https://doi.org/10.1007/s10008-007-0423-0

Interaction of Small Ionic Species With Phospholipid Membranes: The Role of Metal Coordination

Frontiers in Materials / Jan 07, 2019

Le, C. T. M., Houri, A., Balage, N., Smith, B. J., & Mechler, A. (2019). Interaction of Small Ionic Species With Phospholipid Membranes: The Role of Metal Coordination. Frontiers in Materials, 5. https://doi.org/10.3389/fmats.2018.00080

Labeling phospholipid membranes with lipid mimetic luminescent metal complexes

Biochimica et Biophysica Acta (BBA) - Biomembranes / Nov 01, 2014

Mechler, A., Stringer, B. D., Mubin, M. S. H., Doeven, E. H., Phillips, N. W., Rudd-Schmidt, J., & Hogan, C. F. (2014). Labeling phospholipid membranes with lipid mimetic luminescent metal complexes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1838(11), 2939–2946. https://doi.org/10.1016/j.bbamem.2014.08.005

Time-resolved investigation of the transient surface reflection changes of subpicosecond excimer laser ablated liquids

Applied Physics A Materials Science & Processing / Dec 01, 1999

Hopp, B., Tóth, Z., Gál, K., Mechler, Á., Bor, Zs., Moustaizis, S. D., Georgiou, S., & Fotakis, C. (1999). Time-resolved investigation of the transient surface reflection changes of subpicosecond excimer laser ablated liquids. Applied Physics A Materials Science & Processing, 69(S1), S191–S194. https://doi.org/10.1007/s003399900212

Excimer laser irradiation induced formation of diamond-like carbon layer on graphite

Applied Surface Science / Jan 01, 1999

Mechler, Á., Heszler, P., Kántor, Z., Szörényi, T., & Bor, Z. (1999). Excimer laser irradiation induced formation of diamond-like carbon layer on graphite. Applied Surface Science, 138–139, 174–178. https://doi.org/10.1016/s0169-4332(98)00397-3

Assessment of the free radical scavenging potential of cannabidiol under physiological conditions: Theoretical and experimental investigations

Journal of Molecular Liquids / Jan 01, 2022

Boulebd, H., Pereira, D. M., Amine Khodja, I., Hoa, N. T., Mechler, A., & Vo, Q. V. (2022). Assessment of the free radical scavenging potential of cannabidiol under physiological conditions: Theoretical and experimental investigations. Journal of Molecular Liquids, 346, 118277. https://doi.org/10.1016/j.molliq.2021.118277

Theoretical Study on the Antioxidant Activity of Natural Depsidones

ACS Omega / Mar 31, 2020

Bay, M. V., Nam, P. C., Quang, D. T., Mechler, A., Hien, N. K., Hoa, N. T., & Vo, Q. V. (2020). Theoretical Study on the Antioxidant Activity of Natural Depsidones. ACS Omega, 5(14), 7895–7902. https://doi.org/10.1021/acsomega.9b04179

The radical scavenging activity of natural ramalin: A mechanistic and kinetic study

Chemical Physics Letters / Jan 01, 2020

Vo, Q. V., Tam, N. M., Bay, M. V., & Mechler, A. (2020). The radical scavenging activity of natural ramalin: A mechanistic and kinetic study. Chemical Physics Letters, 739, 137004. https://doi.org/10.1016/j.cplett.2019.137004

Self-assembled nanomaterials based on beta (β3) tetrapeptides

Nanotechnology / Feb 24, 2016

Seoudi, R. S., Hinds, M. G., Wilson, D. J. D., Adda, C. G., Del Borgo, M., Aguilar, M.-I., Perlmutter, P., & Mechler, A. (2016). Self-assembled nanomaterials based on beta (β3) tetrapeptides. Nanotechnology, 27(13), 135606. https://doi.org/10.1088/0957-4484/27/13/135606

The hydroperoxyl and superoxide anion radical scavenging activity of anthocyanidins in physiological environments: Theoretical insights into mechanisms and kinetics

Phytochemistry / Dec 01, 2021

Vo, Q. V., Hoa, N. T., Thong, N. M., & Mechler, A. (2021). The hydroperoxyl and superoxide anion radical scavenging activity of anthocyanidins in physiological environments: Theoretical insights into mechanisms and kinetics. Phytochemistry, 192, 112968. https://doi.org/10.1016/j.phytochem.2021.112968

Biochemical and biophysical characterization of a novel plant protein disulfide isomerase

Peptide Science / Nov 04, 2008

Gruber, C. W., Čemažar, M., Mechler, A., Martin, L. L., & Craik, D. J. (2008). Biochemical and biophysical characterization of a novel plant protein disulfide isomerase. Peptide Science, 92(1), 35–43. Portico. https://doi.org/10.1002/bip.21113

Modelling the mechanism and kinetics of the radical scavenging activity of iminostilbene

Polymer Degradation and Stability / Mar 01, 2021

Vo, Q. V., Van, L. T. N., Hoa, N. T., & Mechler, A. (2021). Modelling the mechanism and kinetics of the radical scavenging activity of iminostilbene. Polymer Degradation and Stability, 185, 109483. https://doi.org/10.1016/j.polymdegradstab.2021.109483

Synthesis of aromatic and indole alpha-glucosinolates

Carbohydrate Research / Jan 01, 2018

Vo, Q. V., Rochfort, S., Nam, P. C., Nguyen, T. L., Nguyen, T. T., & Mechler, A. (2018). Synthesis of aromatic and indole alpha-glucosinolates. Carbohydrate Research, 455, 45–53. https://doi.org/10.1016/j.carres.2017.11.004

The role of C-terminal amidation in the mechanism of action of the antimicrobial peptide aurein 1.2

The EuroBiotech Journal / Jan 01, 2020

Shahmiri, M., & Mechler, A. (2020). The role of C-terminal amidation in the mechanism of action of the antimicrobial peptide aurein 1.2. The EuroBiotech Journal, 4(1), 25–31. https://doi.org/10.2478/ebtj-2020-0004

Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study

ACS Omega / Nov 08, 2019

Vo, Q. V., Van Bay, M., Nam, P. C., & Mechler, A. (2019). Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study. ACS Omega, 4(21), 19375–19381. https://doi.org/10.1021/acsomega.9b02782

Analytical approaches to study domain formation in biomimetic membranes

The Analyst / Jan 01, 2017

Hasan, I. Y., & Mechler, A. (2017). Analytical approaches to study domain formation in biomimetic membranes. The Analyst, 142(17), 3062–3078. https://doi.org/10.1039/c7an01038a

Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight

ACS Omega / May 13, 2021

Trung, N. Q., Thong, N. M., Cuong, D. H., Manh, T. D., Hoang, L. P., Hien, N. K., Nam, P. C., Quang, D. T., Mechler, A., & Vo, Q. V. (2021). Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight. ACS Omega, 6(20), 13391–13397. https://doi.org/10.1021/acsomega.1c01448

Dodecatungstocobaltate heteropolyanion encapsulation into MIL‐101(Cr) metal–organic framework scaffold provides a highly efficient heterogeneous catalyst for methanolysis of epoxides

Applied Organometallic Chemistry / Oct 11, 2017

Marandi, A., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor‐Baltork, I., & Zadehahmadi, F. (2017). Dodecatungstocobaltate heteropolyanion encapsulation into MIL‐101(Cr) metal–organic framework scaffold provides a highly efficient heterogeneous catalyst for methanolysis of epoxides. Applied Organometallic Chemistry, 32(2). Portico. https://doi.org/10.1002/aoc.4065

Oxidation reactions catalysed by molybdenum(VI) complexes grafted on UiO‐66 metal–organic framework as an elegant nanoreactor

Applied Organometallic Chemistry / Aug 22, 2017

Afzali, N., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor‐Baltork, I., Kardanpour, R., & Zadehahmadi, F. (2017). Oxidation reactions catalysed by molybdenum(VI) complexes grafted on UiO‐66 metal–organic framework as an elegant nanoreactor. Applied Organometallic Chemistry, 32(1). Portico. https://doi.org/10.1002/aoc.3958

Is Usnic Acid a Promising Radical Scavenger?

ACS Omega / Jul 07, 2020

Hoa, N. T., Van Bay, M., Mechler, A., & Vo, Q. V. (2020). Is Usnic Acid a Promising Radical Scavenger? ACS Omega, 5(28), 17715–17720. https://doi.org/10.1021/acsomega.0c02306

Is natural fraxin an overlooked radical scavenger?

RSC Advances / Jan 01, 2021

Nam, P. C., Thong, N. M., Hoa, N. T., Quang, D. T., Hoang, L. P., Mechler, A., & Vo, Q. V. (2021). Is natural fraxin an overlooked radical scavenger? RSC Advances, 11(24), 14269–14275. https://doi.org/10.1039/d1ra01360b

In Silico Evaluation of the Radical Scavenging Mechanism of Mactanamide

ACS Omega / Sep 04, 2020

Vo, Q. V., Hoa, N. T., Nam, P. C., Quang, D. T., & Mechler, A. (2020). In Silico Evaluation of the Radical Scavenging Mechanism of Mactanamide. ACS Omega, 5(37), 24106–24110. https://doi.org/10.1021/acsomega.0c03646

Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements

Analytical Chemistry / May 04, 2016

Hasan, I. Y., & Mechler, A. (2016). Cholesterol Rich Domains Identified in Unilamellar Supported Biomimetic Membranes via Nano-Viscosity Measurements. Analytical Chemistry, 88(10), 5037–5041. https://doi.org/10.1021/acs.analchem.6b01045

Subtle Differences in Initial Membrane Interactions Underpin the Selectivity of Small Antimicrobial Peptides

ChemPlusChem / Dec 22, 2014

Praporski, S., Mechler, A., Separovic, F., & Martin, L. L. (2014). Subtle Differences in Initial Membrane Interactions Underpin the Selectivity of Small Antimicrobial Peptides. ChemPlusChem, 80(1), 91–96. Portico. https://doi.org/10.1002/cplu.201402318

Nanoscale resolution microchannel flow velocimetry by atomic force microscopy

Applied Physics Letters / Oct 09, 2006

Piorek, B., Mechler, Á., Lal, R., Freudenthal, P., Meinhart, C., & Banerjee, S. (2006). Nanoscale resolution microchannel flow velocimetry by atomic force microscopy. Applied Physics Letters, 89(15). https://doi.org/10.1063/1.2358966

Local laser-assisted chemical vapor deposition of diamond

Applied Surface Science / Dec 01, 2000

Tóth, Z., Mechler, Á., & Heszler, P. (2000). Local laser-assisted chemical vapor deposition of diamond. Applied Surface Science, 168(1–4), 5–8. https://doi.org/10.1016/s0169-4332(00)00563-8

Insights into the mechanisms and kinetics of the hydroperoxyl radical scavenging activity of Artepillin C

New Journal of Chemistry / Jan 01, 2021

Boulebd, H., Mechler, A., Hoa, N. T., Nam, P. C., Quang, D. T., & Vo, Q. V. (2021). Insights into the mechanisms and kinetics of the hydroperoxyl radical scavenging activity of Artepillin C. New Journal of Chemistry, 45(17), 7774–7780. https://doi.org/10.1039/d1nj00666e

Large-Scale Synthesis of Nanosilica from Silica Sand for Plant Stimulant Applications

ACS Omega / Nov 02, 2022

Hoang, C. V., Thoai, D. N., Cam, N. T. D., Phuong, T. T. T., Lieu, N. T., Hien, T. T. T., Nhiem, D. N., Pham, T.-D., Tung, M. H. T., Tran, N. T. T., Mechler, A., & Vo, Q. V. (2022). Large-Scale Synthesis of Nanosilica from Silica Sand for Plant Stimulant Applications. ACS Omega, 7(45), 41687–41695. https://doi.org/10.1021/acsomega.2c05760

The hydroperoxyl radical scavenging activity of natural hydroxybenzoic acids in oil and aqueous environments: Insights into the mechanism and kinetics

Phytochemistry / Sep 01, 2022

Hang, D. T. N., Hoa, N. T., Bich, H. N., Mechler, A., & Vo, Q. V. (2022). The hydroperoxyl radical scavenging activity of natural hydroxybenzoic acids in oil and aqueous environments: Insights into the mechanism and kinetics. Phytochemistry, 201, 113281. https://doi.org/10.1016/j.phytochem.2022.113281

Molybdenum (VI)‐functionalized UiO‐66 provides an efficient heterogeneous nanocatalyst in oxidation reactions

Applied Organometallic Chemistry / Sep 04, 2019

Afzali, N., Kardanpour, R., Zadehahmadi, F., Tangestaninejad, S., Moghadam, M., Mirkhani, V., Mechler, A., Mohammadpoor‐Baltork, I., & Bahadori, M. (2019). Molybdenum (VI)‐functionalized UiO‐66 provides an efficient heterogeneous nanocatalyst in oxidation reactions. Applied Organometallic Chemistry, 33(11). Portico. https://doi.org/10.1002/aoc.5225

Design Principles of Peptide Based Self-Assembled Nanomaterials

Advances in Experimental Medicine and Biology / Jan 01, 2017

Seoudi, R. S., & Mechler, A. (2017). Design Principles of Peptide Based Self-Assembled Nanomaterials. In Peptides and Peptide-based Biomaterials and their Biomedical Applications (pp. 51–94). Springer International Publishing. https://doi.org/10.1007/978-3-319-66095-0_4

Formation of planar unilamellar phospholipid membranes on oxidized gold substrate

Biointerphases / Sep 01, 2016

Hasan, I. Y., & Mechler, A. (2016). Formation of planar unilamellar phospholipid membranes on oxidized gold substrate. Biointerphases, 11(3). https://doi.org/10.1116/1.4963188

Diamond-like carbon layer formation on graphite by excimer laser irradiation

Applied Physics A: Materials Science & Processing / Jun 01, 1998

Mechler, Á., Heszler, P., Kántor, Z., Szörényi, T., & Bor, Z. (1998). Diamond-like carbon layer formation on graphite by excimer laser irradiation. Applied Physics A: Materials Science & Processing, 66(6), 659–661. https://doi.org/10.1007/s003390050729

Calculating bond dissociation energies of X−H (X=C, N, O, S) bonds of aromatic systems via density functional theory: a detailed comparison of methods

Royal Society Open Science / Jun 01, 2022

Trung, N. Q., Mechler, A., Hoa, N. T., & Vo, Q. V. (2022). Calculating bond dissociation energies of X−H (X=C, N, O, S) bonds of aromatic systems via density functional theory: a detailed comparison of methods. Royal Society Open Science, 9(6). https://doi.org/10.1098/rsos.220177

Validating an artificial organelle: Studies of lipid droplet-specific proteins on adiposome platform

iScience / Aug 01, 2021

Ma, X., Zhi, Z., Zhang, S., Zhou, C., Mechler, A., & Liu, P. (2021). Validating an artificial organelle: Studies of lipid droplet-specific proteins on adiposome platform. IScience, 24(8), 102834. https://doi.org/10.1016/j.isci.2021.102834

Membrane morphology effects in quartz crystal microbalance characterization of antimicrobial peptide activity

Biophysical Chemistry / Jul 01, 2020

Pandidan, S., & Mechler, A. (2020). Membrane morphology effects in quartz crystal microbalance characterization of antimicrobial peptide activity. Biophysical Chemistry, 262, 106381. https://doi.org/10.1016/j.bpc.2020.106381

Substitution effects on the antiradical activity of hydralazine: a DFT analysis

New Journal of Chemistry / Jan 01, 2020

Boulebd, H., Tam, N. M., Mechler, A., & Vo, Q. V. (2020). Substitution effects on the antiradical activity of hydralazine: a DFT analysis. New Journal of Chemistry, 44(38), 16577–16583. https://doi.org/10.1039/d0nj03753b

A Study of Protein Electrochemistry on a Supported Membrane Electrode

International Journal of Peptide Research and Therapeutics / Apr 12, 2006

Mechler, A., Nawaratna, G., Aguilar, M.-I., & Martin, L. L. (2006). A Study of Protein Electrochemistry on a Supported Membrane Electrode. International Journal of Peptide Research and Therapeutics, 12(3), 217–224. https://doi.org/10.1007/s10989-006-9029-0

Education

University of Szeged

PhD, Physics / 2001

Szeged

Experience

University of California Santa Barbara

NATO Postdoctoral Fellow / 20012004

Monash University

Monash Research Fellow / 20042009

Soft money independent research-only position

La Trobe University

Senior Lecturer (equiv. Assistant Professor in USA) / 20092016

Associate Professor / 20162020

Professor / 2020Present

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