Pranshu Sahgal, Ph.D.

Cell and Molecular biologist in cancer biology

Research Expertise

Cancer Biology
Cancer Signaling
Cancer Genomics
Drug Discovery and Development
Cell Biology
Developmental Biology
Molecular Biology
Genetics
Biochemistry
Structural Biology
Hepatology
Gastroenterology
Microbiology
Virology
Infectious Diseases
Parasitology
Cancer Research
Oncology

About

·         Cell and Molecular Biologist with a robust background in translational research, specializing in identifying novel molecular biomarkers, drug targets, and mechanism of action for advancing early cancer diagnosis and targeted cancer treatment. ·         Recognized for a proven track record of scientific innovation, evidenced by: ○        15+ scientific papers (6 as first/co-first author) having direct clinical development implications; 800+ citations. ○        20+ new collaborations; Presentations of scientific data in 10+ national/international conferences. ○        $350,000 as personal grant award acquisition from 10 foundations. ·         Exemplary collaborator and communicator with deep expertise in latest culture models, molecular biology techniques, assay development and Good Laboratory Practice (GLP). Demonstrated ability to effectively manage multiple projects, exhibiting exceptional organizational skills and keen attention to detail, leveraging innovative thinking to drive research forward. ·         Certified Medical Affairs Specialist with an understanding of clinical study and trials, contributing to regulatory submissions and fostering relationships with Key Opinion Leaders (KOLs), Contract Research Organizations (CROs), and other key stakeholders.

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Publications

Integrin traffic – the update
Journal of Cell Science
2015
AMPK negatively regulates tensin-dependent integrin activity
Journal of Cell Biology
2017
Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells
Developmental Cell
2014
SORLA regulates endosomal trafficking and oncogenic fitness of HER2
Nature Communications
2019
Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3
Traffic
2016
GGA2 and RAB13 promote activity-dependent β1-integrin recycling
Unknown Venue
2018
An Enhancer-Driven Stem Cell–Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer
Gastroenterology
2022
Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration
Journal of Cell Science
2017
Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses
The Journal of Infection in Developing Countries
2009
Early TP53 Alterations Shape Gastric and Esophageal Cancer Development
Cancers
2021
Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma
Scientific Reports
2023
Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer
Clinical Cancer Research
2022
Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
iScience
2023
Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
Unknown Venue
2023
Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
npj Precision Oncology
2024
Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency
Unknown Venue
2024
RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer
Clinical Cancer Research
2024
20P Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
ESMO Open
2023
Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas
Unknown Venue
2022
SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2
Unknown Venue
2018

Education

University of Turku

Ph.D., Cell and molecular biology / November, 2018

Turku

Experience

Dana-Farber Cancer Institute and Harvard Medical School

Links & Social Media

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