Pranshu Sahgal, Ph.D.
Cell and Molecular biologist in cancer biology
Research Expertise
About
Publications
Integrin traffic – the update
Journal of Cell Science / Jan 01, 2015
De Franceschi, N., Hamidi, H., Alanko, J., Sahgal, P., & Ivaska, J. (2015). Integrin traffic – the update. Journal of Cell Science. https://doi.org/10.1242/jcs.161653
AMPK negatively regulates tensin-dependent integrin activity
Journal of Cell Biology / Mar 13, 2017
Georgiadou, M., Lilja, J., Jacquemet, G., Guzmán, C., Rafaeva, M., Alibert, C., Yan, Y., Sahgal, P., Lerche, M., Manneville, J.-B., Mäkelä, T. P., & Ivaska, J. (2017). AMPK negatively regulates tensin-dependent integrin activity. Journal of Cell Biology, 216(4), 1107–1121. https://doi.org/10.1083/jcb.201609066
Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells
Developmental Cell / May 01, 2014
Muharram, G., Sahgal, P., Korpela, T., De Franceschi, N., Kaukonen, R., Clark, K., Tulasne, D., Carpén, O., & Ivaska, J. (2014). Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells. Developmental Cell, 29(4), 421–436. https://doi.org/10.1016/j.devcel.2014.03.024
SORLA regulates endosomal trafficking and oncogenic fitness of HER2
Nature Communications / May 28, 2019
Pietilä, M., Sahgal, P., Peuhu, E., Jäntti, N. Z., Paatero, I., Närvä, E., Al-Akhrass, H., Lilja, J., Georgiadou, M., Andersen, O. M., Padzik, A., Sihto, H., Joensuu, H., Blomqvist, M., Saarinen, I., Boström, P. J., Taimen, P., & Ivaska, J. (2019). SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nature Communications, 10(1). https://doi.org/10.1038/s41467-019-10275-0
Regulation of Cell Migration and β1
Integrin Trafficking by the Endosomal
Adaptor GGA3
Traffic / Apr 05, 2016
Ratcliffe, C. D. H., Sahgal, P., Parachoniak, C. A., Ivaska, J., & Park, M. (2016). Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor <scp>GGA3</scp>. Traffic, 17(6), 670–688. Portico. https://doi.org/10.1111/tra.12390
GGA2 and RAB13 promote activity-dependent β1-integrin recycling
Jun 22, 2018
Sahgal, P., Alanko, J., Icha, J., Paatero, I., Hamidi, H., Arjonen, A., Pietilä, M., Rokka, A., & Ivaska, J. (2018). GGA2 and RAB13 promote activity-dependent β1-integrin recycling. https://doi.org/10.1101/353086
An Enhancer-Driven Stem Cell–Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer
Gastroenterology / Jan 01, 2022
Liang, X., Duronio, G. N., Yang, Y., Bala, P., Hebbar, P., Spisak, S., Sahgal, P., Singh, H., Zhang, Y., Xie, Y., Cejas, P., Long, H. W., Bass, A. J., & Sethi, N. S. (2022). An Enhancer-Driven Stem Cell–Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer. Gastroenterology, 162(1), 209–222. https://doi.org/10.1053/j.gastro.2021.09.044
Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration
Journal of Cell Science / Jan 01, 2017
Mygind, K. J., Schwarz, J., Sahgal, P., Ivaska, J., & Kveiborg, M. (2017). Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration. Journal of Cell Science. https://doi.org/10.1242/jcs.205393
Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses
The Journal of Infection in Developing Countries / Nov 26, 2009
Saxena, S. K., Mishra, N., Saxena, R., Swamy, M. A., Sahgal, P., Saxena, S., Tiwari, S., Mathur, A., & Nair, M. P. (2009). Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses. The Journal of Infection in Developing Countries, 4(01), 001–006. https://doi.org/10.3855/jidc.546
Early TP53 Alterations Shape Gastric and Esophageal Cancer Development
Cancers / Nov 24, 2021
Sahgal, P., Huffman, B. M., Patil, D. T., Chatila, W. K., Yaeger, R., Cleary, J. M., & Sethi, N. S. (2021). Early TP53 Alterations Shape Gastric and Esophageal Cancer Development. Cancers, 13(23), 5915. https://doi.org/10.3390/cancers13235915
Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma
Scientific Reports / Nov 23, 2023
Prosz, A., Duan, H., Tisza, V., Sahgal, P., Topka, S., Klus, G. T., Börcsök, J., Sztupinszki, Z., Hanlon, T., Diossy, M., Vizkeleti, L., Stormoen, D. R., Csabai, I., Pappot, H., Vijai, J., Offit, K., Ried, T., Sethi, N., Mouw, K. W., … Szallasi, Z. (2023). Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-47946-4
Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer
Clinical Cancer Research / Oct 24, 2022
Peng, K., Zhang, F., Wang, Y., Sahgal, P., Li, T., Zhou, J., Liang, X., Zhang, Y., Sethi, N., Liu, T., Zhang, H., & Bass, A. J. (2022). Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer. Clinical Cancer Research, 29(1), 197–208. https://doi.org/10.1158/1078-0432.ccr-22-1609
Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
iScience / Nov 01, 2023
Sahgal, P., Patil, D. T., Bala, P., Sztupinszki, Z. M., Tisza, V., Spisak, S., Luong, A. G., Huffman, B., Prosz, A., Singh, H., Lazaro, J.-B., Szallasi, Z., Cleary, J. M., & Sethi, N. S. (2023). Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. IScience, 26(11), 108169. https://doi.org/10.1016/j.isci.2023.108169
Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
Mar 28, 2023
Sahgal, P., Patil, D. T., Sztupinszki, Z. M., Tisza, V., Spisak, S., Huffman, B., Prosz, A., Singh, H., Lazaro, J.-B., Szallasi, Z., Cleary, J. M., & Sethi, N. S. (2023). Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. https://doi.org/10.1101/2023.03.27.534412
Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
npj Precision Oncology / Apr 08, 2024
Prosz, A., Sahgal, P., Huffman, B. M., Sztupinszki, Z., Morris, C. X., Chen, D., Börcsök, J., Diossy, M., Tisza, V., Spisak, S., Likasitwatanakul, P., Rusz, O., Csabai, I., Cecchini, M., Baca, Y., Elliot, A., Enzinger, P., Singh, H., Ubellaker, J., … Sethi, N. S. (2024). Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. Npj Precision Oncology, 8(1). https://doi.org/10.1038/s41698-024-00561-6
Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency
Apr 01, 2024
Szallasi, Z., Diossy, M., Tisza, V., Li, H., Sahgal, P., Zhou, J., Sztupinszki, Z., Young, D., Nuosome, D., Kuo, C., Jiang, J., Chen, Y., Ebner, R., Sesterhenn, I., Moncur, J., Chesnut, G., Petrovics, G., T.Klus, G., Valcz, G., … Spisak, S. (2024). Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency. https://doi.org/10.21203/rs.3.rs-3995251/v1
RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer
Clinical Cancer Research / Mar 05, 2024
Singh, H., Sahgal, P., Kapner, K., Corsello, S. M., Gupta, H., Gujrathi, R., Li, Y. Y., Cherniack, A. D., El Alam, R., Kerfoot, J., Andrews, E., Lee, A., Nambiar, C., Hannigan, A. M., Remland, J., Brais, L., Leahy, M. E., Rubinson, D. A., Schlechter, B. L., … Cleary, J. M. (2024). RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer. Clinical Cancer Research, OF1–OF16. https://doi.org/10.1158/1078-0432.ccr-23-2581
20P Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
ESMO Open / Mar 01, 2023
Sahgal, P. (2023). 20P Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. ESMO Open, 8(1), 100986. https://doi.org/10.1016/j.esmoop.2023.100986
Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas
Jul 16, 2022
Prosz, A., Sahgal, P., Morris, C. X., Sztupinszki, Z., Börcsök, J., Diossy, M., Tisza, V., Spisak, S., Rusz, O., Csabai, I., Huffman, B. M., Singh, H., Lazaro, J.-B., Cecchini, M., Cleary, J. M., Szallasi, Z., & Sethi, N. S. (2022). Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas. https://doi.org/10.1101/2022.07.14.500118
SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2
Apr 11, 2018
Pietilä, M., Sahgal, P., Peuhu, E., Jäntti, N., Paatero, I., Andersen, O. M., Padzik, A., Blomqvist, M., Saarinen, I., Boström, P., Taimen, P., & Ivaska, J. (2018). SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2. https://doi.org/10.1101/299586
Education
University of Turku
Ph.D., Cell and molecular biology / November, 2018
Experience
Dana-Farber Cancer Institute and Harvard Medical School
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