Jobin Varkey

Research professor at University of Southern California

Research Expertise

Neurodegeneration
Protein Structure
Protein-Membrane interaction
Cell Biology
Biochemistry
Molecular Biology
Catalysis
Colloid and Surface Chemistry
Pharmacology
Infectious Diseases
Pharmacology (medical)
Genetics
Biophysics
Cellular and Molecular Neuroscience
Endocrinology
Physiology
Cognitive Neuroscience
Condensed Matter Physics
Nuclear and High Energy Physics
Virology
Instrumentation

Legacy Map

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Publications

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
Journal of Biological Chemistry
2010
Pericyte degeneration causes white matter dysfunction in the mouse central nervous system
Nature Medicine
2018
Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation
Journal of Biological Chemistry
2012
Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation
Journal of the American Chemical Society
2012
Antibacterial Activity of Human Neutrophil Defensin HNP-1 Analogs without Cysteines
Antimicrobial Agents and Chemotherapy
2005
Rational design of potent domain antibody inhibitors of amyloid fibril assembly
Proceedings of the National Academy of Sciences
2012
Nonaggregated α-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding
Biochemistry
2014
Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces
Proceedings of the National Academy of Sciences
2013
α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles
Journal of Biological Chemistry
2013
α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils
Journal of Biological Chemistry
2016
Gene co-expression network analysis for identifying genetic markers in Parkinson's disease - a three-way comparative approach
Genomics
2019
Membranes as modulators of amyloid protein misfolding and target of toxicity
Biochimica et Biophysica Acta (BBA) - Biomembranes
2018
E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity
Journal of Biological Chemistry
2019
Antibacterial activity of linear peptides spanning the carboxy-terminal β-sheet domain of arthropod defensins
Peptides
2006
Early Sodium Dodecyl Sulfate Induced Collapse of α-Synuclein Correlates with Its Amyloid Formation
ACS Chemical Neuroscience
2014
Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes
Gene
2019
Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR
Journal of Magnetic Resonance
2017
An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles
Viruses
2020
Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils
Biophysical Journal
2020
Molecular basis of Q-length selectivity for the MW1 antibody–huntingtin interaction
Journal of Biological Chemistry
2023
α-Synuclein Amyloid Fibrils Formed of Two Protofibrils
Microscopy and Microanalysis
2015
α Synuclein Amyloid Fibrils With Two Entwined Protofibrils Each With One Subunit Per 4.7 Å Axial Rise
Microscopy and Microanalysis
2013
Hydration Dynamics as a Molecular Ruler for Refining Protein Structure at Lipid Membrane Interfaces
Biophysical Journal
2013
Defensins: antimicrobial peptides of innate immunity
Nature Reviews Immunology
2003

Education

Ph.D., Biochemistry / May, 2008

Hyderabad

Experience

University of Southern California, Los Angeles

Karunya University

Centre for Biotechnology

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