Ummu Guven

Postdoctoral researcher at the University of Milan, I am passionate about advancing the understanding of the molecular mechanisms and therapeutic potential of cancer stem cells.

Research Expertise

stem cell biology
cancer stem cells
cell plasticity
tumor microenvironment

About

As a postdoctoral researcher at the University of Milan, I am passionate about advancing the understanding of the molecular mechanisms and therapeutic potential of cancer stem cells. With over nine years of work experience in stem cell research, I have developed strong skills in flow cytometry, miRNA analysis, and cell culture. I have also contributed to multiple publications in peer-reviewed journals and presented my findings at international conferences. In my current role, I work with a multidisciplinary team of scientists to explore the role of SMYD3 in regulating the stemness and differentiation of cancer stem cells in breast cancer. My goal is to discover novel biomarkers and targets for cancer diagnosis and treatment, and to translate my research into clinical applications. I am motivated by the challenge and the impact of my work, and I value collaboration, innovation, and excellence.

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Publications

Cancer stem cell differentiation: TGFβ1 and versican may trigger molecules for the organization of tumor spheroids
Oncology Reports
2014
Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol
International Journal of Molecular Medicine
2014
Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells
PLOS ONE
2015
Abstract 4072: Wnt1 gene expression alters heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+prostate cancer stem cells.
Cancer Research
2013
Expression of E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in non-small-cell lung carcinoma
Lung Cancer
1996
Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice
Folia Histochemica et Cytobiologica
2017
Combined treatment with resveratrol prevents the atorvastatin-induced myopathy in rat skeletal muscle
African Journal of Pharmacy and Pharmacology
2013
Targeting Epigenetic Regulators with HDAC and BET Inhibitors to Modulate Muscle Wasting
International Journal of Molecular Sciences
2023
Abstract 3686: Regulatory role cancer stem cells (CSCs)-derived exosomal miRNAs in ovarian cancer growth and progression
Cancer Research
2019
Abstract 2591: miR-193b is a novel regulator of Inhibition of Notch signaling by for targeting cancer stem cell and tumor microenvironment
Cancer Research
2019
Kişilerarası ilişkiler ve iletişimde kendini açma
Kişilerarası ilişkiler ve etkili iletişim
2017
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3
European Journal of Medicinal Chemistry
2022
“Double hit” strategy: Removal of sialic acid from the dendritic cell surface and loading with CD44+/CD24-/low cell lysate inhibits tumor growth and metastasis by targeting breast cancer stem cells
International Immunopharmacology
2022
New Psychoactive Substance 5-MeO-MIPT In vivo Acute Toxicity and Hystotoxicological Study
Balkan Medical Journal
2020
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality
iScience
2020
Characterization of CD133+/CD44+human prostate cancer stem cells with ATR-FTIR spectroscopy
The Analyst
2019
Ribosome biogenesis mediates antitumor activity of flavopiridol in CD44+/CD24‑ breast cancer stem cells
Oncology Letters
2017

Education

Ege Üniversitesi

PhD Fllow, Stem Cell / August, 2019

Izmir

Ege University

MSc, Stem Cell / January, 2014

Izmir

Ege University

Bachelor, Biology / June, 2011

Izmir

Experience

Università degli Studi di Milano Dipartimento di Bioscienze

Postdoctoral Fellow / March, 2020Present

University of Texas MD Anderson Cancer Center

Graduate Fellow / February, 2018February, 2019

Ege University

Research Fellow / September, 2015January, 2018

Researcher / June, 2013May, 2015

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