Shiyong Peng

National Institute of Health

Research Expertise

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Publications

Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease
Journal of Neurochemistry
2005
Increased proNGF Levels in Subjects with Mild Cognitive Impairment and Mild Alzheimer Disease
Journal of Neuropathology & Experimental Neurology
2004
Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease
The Journal of Neuroscience
2009
Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43
Journal of Biological Chemistry
2013
Early diagnosis and successful treatment of acquired toxoplasmosis infectious retinochoroiditis
Medicine
2018
Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane
Nature Communications
2016
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
Nature Communications
2017
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice
Neurobiology of Aging
2012
Neuroprotection and lifespan extension in Ppt1−/− mice by NtBuHA: therapeutic implications for INCL
Nature Neuroscience
2013
α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals
The Journal of Neuroscience
2016
The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol
Human Molecular Genetics
2012
Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol
Human Molecular Genetics
2010
Chronic olanzapine administration causes metabolic syndrome through inflammatory cytokines in rodent models of insulin resistance
Scientific Reports
2019
Cln1gene disruption in mice reveals a common pathogenic link between two of the most lethal childhood neurodegenerative lysosomal storage disorders
Human Molecular Genetics
2015
Suppression of agrin‐22 production and synaptic dysfunction in Cln1−/− mice
Annals of Clinical and Translational Neurology
2015
Resveratrol derivative excited postsynaptic potentiation specifically via PKCβ-NMDA receptor mediation
Pharmacological Research
2020
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia
International Journal of Molecular Sciences
2022
Enzymatic activity of palmitoyl‐protein thioesterase‐1 in serum from schizophrenia significantly associates with schizophrenia diagnosis scales
Journal of Cellular and Molecular Medicine
2019
Insulin Resistance–Related Proteins Are Overexpressed in Patients and Rats Treated With Olanzapine and Are Reverted by Pueraria in the Rat Model
Journal of Clinical Psychopharmacology
2019
A lysosomal targeting defect of V0a1 suppresses V‐ATPase activity elevating lysosomal pH in Ppt1‐/‐ mice: amelioration by NtBuHA
The FASEB Journal
2015
P1‐345: BDNF mRNA levels are decreased in peripheral blood samples from subjects with Alzheimer's disease
Alzheimer's & Dementia
2008
PPT1 Deficiency-Induced GABAAR Hyperpalmitoylation Impairs Synaptic Transmission and Memory Formation
Unknown Venue
2022
Dysregulation of V‐ATPase Function Impairs Lysosomal Acidification in a Mouse Model of a Rare Lysosomal Storage Disease, INCL
The FASEB Journal
2016
Shift in the Balance of TRKA and ProNGF in Prodromal Alzheimer ’s Disease
Advances in Behavioral Biology
P1–032: Decreased BDNF mRNA levels in mouse models of Alzheimer's disease
Alzheimer's & Dementia
2006
GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation in CLN1 disease
Unknown Venue
2024
Acquisition and extinction of active avoidance compulsive-like behavior in mice
Journal of Psychiatric Research
2023
Prooxidative activity of plumbagin induces apoptosis in human pancreatic ductal adenocarcinoma cells via intrinsic apoptotic pathway
Toxicology in Vitro
2020
Impaired lysosomal maturation of pro‐cathepsin D to active cathepsin D in a childhood neurodegenerative lysosomal storage disease
The FASEB Journal
2012
Brain-Derived Neurotrophic Factor, Food Intake Regulation, and Obesity
Archives of Medical Research
2011
Decreased ProBDNF: The Cause of Alzheimer’s-Associated Neurodegeneration and Cognitive Decline?
Advances in Behavioral Biology
P1-243 BDNF and proBDNF are decreased in the preclinical stages of Alzheimer's disease
Neurobiology of Aging
2004
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