Martin Tsui

University of California, San Francisco

San Francisco, California, United States of America

Research Expertise

Biochemistry
Structural Biology
Cryo-EM
CRISPR
Molecular Assembly and Interaction
Molecular Biology
Information Systems
Biomedical Engineering
Cell Biology
Biophysics
Bioengineering
Cas9
Cas12
Cas13
Protein Engineernig
Genome Engineering

About

Martin Tsui is an accomplished scientist with a strong background in biochemistry. He received his Ph.D. in Molecular Biophysics from Florida State University in 2017, where he conducted research on the structure and function of CRISPR proteins. Prior to that, he obtained his B.S. in Chemistry from the University of California, San Diego in 2012. After completing his graduate studies, Martin founded his own company, Stealth, where he serves as a Founder & CEO. Under his leadership, the company has developed innovative solutions for the biotech industry and has gained recognition for its groundbreaking research. Before starting his company, Martin worked as a Senior Scientist at Amazon, where he applied his expertise in protein biochemistry and CRISPR to improve the company's product development processes and creating new products. He also gained valuable experience as a Postdoctoral Scholar at the University of California, San Francisco and Postdoctoral Fellow at the Van Andel Institute, where he studied cancer proteins, SARS-CoV-2, HIV proteins, and the role of proteins in neurodegenerative diseases, respectively. Martin is a highly driven and passionate individual who is dedicated to advancing the field of biotechnology. His impressive education and diverse experience have equipped him with the skills and knowledge to make significant contributions to the scientific community. He continues to pursue new opportunities to further his research and make a positive impact in the world of science.

Publications

Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Briefings in Bioinformatics / Sep 11, 2020

Khan, A. A., & Khan, Z. (2020). Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification. Briefings in Bioinformatics, 22(2), 1206–1214. https://doi.org/10.1093/bib/bbaa207

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

Aug 10, 2020

Schoof, M., Faust, B., Saunders, R. A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesbølle, C. B., Puchades, C., Azumaya, C. M., Kratochvil, H. T., Zimanyi, M., Deshpande, I., Liang, J., Dickinson, S., Nguyen, H. C., Chio, C. M., Merz, G. E., … Thompson, M. C. (2020). An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. https://doi.org/10.1101/2020.08.08.238469

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2

Jun 28, 2022

Gahbauer, S., Correy, G. J., Schuller, M., Ferla, M. P., Doruk, Y. U., Rachman, M., Wu, T., Diolaiti, M., Wang, S., Neitz, R. J., Fearon, D., Radchenko, D., Moroz, Y., Irwin, J. J., Renslo, A. R., Taylor, J. C., Gestwicki, J. E., von Delft, F., Ashworth, A., … Fraser, J. S. (2022). Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2. https://doi.org/10.1101/2022.06.27.497816

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

Aug 10, 2020

Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Zhou, X. X., Leung, K. K., & Wells, J. A. (2020). Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. https://doi.org/10.1101/2020.08.08.242511

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

May 19, 2021

Verba, K., Gupta, M., Azumaya, C., Moritz, M., Pourmal, S., Diallo, A., Merz, G., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A., Diwanji, D., Hernandez, E., Herrera, N., Kratochvil, H., Lam, V., Li, F., Li, Y., Nguyen, H., … Rosenberg, O. (2021). CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. https://doi.org/10.21203/rs.3.rs-515215/v1

The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9

ACS Synthetic Biology / Mar 20, 2017

Tsui, T. K. M., Hand, T. H., Duboy, E. C., & Li, H. (2017). The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9. ACS Synthetic Biology, 6(6), 1103–1113. https://doi.org/10.1021/acssynbio.7b00050

Structure Principles of CRISPR-Cas Surveillance and Effector Complexes

Annual Review of Biophysics / Jun 22, 2015

Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

Structure / Mar 01, 2023

Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009

The Impact of DNA Topology on Target Selection by a Cytosine-Specific Cas9

Biophysical Journal / Feb 01, 2017

Kin Martin Tsui, T., Hand, T. H., & Li, H. (2017). The Impact of DNA Topology on Target Selection by a Cytosine-Specific Cas9. Biophysical Journal, 112(3), 71a. https://doi.org/10.1016/j.bpj.2016.11.431

Phosphate Lock Residues of Acidothermus cellulolyticus Cas9 Are Critical to Its Substrate Specificity

Phosphate Lock Residues of Acidothermus cellulolyticus Cas9 Are Critical to Its Substrate Specificity. (n.d.). American Chemical Society (ACS). https://doi.org/10.1021/acssynbio.8b00455.s001

Stability of a Transient Protein Complex in a Charged Aqueous Droplet with Variable pH

Stability of a Transient Protein Complex in a Charged Aqueous Droplet with Variable pH. (n.d.). American Chemical Society (ACS). https://doi.org/10.1021/acs.jpclett.6b02319.s001

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

May 12, 2021

Gupta, M., Azumaya, C. M., Moritz, M., Pourmal, S., Diallo, A., Merz, G. E., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A. F., Diwanji, D., Hernandez, E., Herrera, N., Kratochvil, H. T., Lam, V. L., Li, F., Li, Y., Nguyen, H. C., … Nowotny, C. (2021). CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. https://doi.org/10.1101/2021.05.10.443524

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Science Advances / Apr 16, 2021

Schuller, M., Correy, G. J., Gahbauer, S., Fearon, D., Wu, T., Díaz, R. E., Young, I. D., Carvalho Martins, L., Smith, D. H., Schulze-Gahmen, U., Owens, T. W., Deshpande, I., Merz, G. E., Thwin, A. C., Biel, J. T., Peters, J. K., Moritz, M., Herrera, N., … Kratochvil, H. T. (2021). Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science Advances, 7(16). https://doi.org/10.1126/sciadv.abf8711

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Science / Dec 18, 2020

Schoof, M., Faust, B., Saunders, R. A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesbølle, C. B., Puchades, C., Azumaya, C. M., Kratochvil, H. T., Zimanyi, M., Deshpande, I., Liang, J., Dickinson, S., Nguyen, H. C., Chio, C. M., Merz, G. E., … Thompson, M. C. (2020). An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science, 370(6523), 1473–1479. https://doi.org/10.1126/science.abe3255

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Nature Chemical Biology / Oct 20, 2020

Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Azumaya, C. M., Braxton, J. R., Brilot, A. F., Gupta, M., Li, F., Lopez, K. E., … Melo, A. (2020). Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature Chemical Biology, 17(1), 113–121. https://doi.org/10.1038/s41589-020-00679-1

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Science / Dec 04, 2020

Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., Kaake, R. M., Weckstein, A. R., Owens, T. W., Gupta, M., Pourmal, S., Titus, E. W., Cakir, M., Soucheray, M., … McGregor, M. (2020). Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521). https://doi.org/10.1126/science.abe9403

Education

Florida State University

Ph.D., Molecular Biophysics / July, 2017

Tallahassee, Florida, United States of America

University of California, San Diego

B.S., Chemistry / June, 2012

San Diego, California, United States of America

Experience

Stealth

Founder & CEO / January, 2023Present

Genome engineering

Amazon

Senior Scientist / December, 2021February, 2023

Molecular Diagnostics

Van Andel Institute

Postdoctoral Fellow / September, 2020April, 2021

Cryo-EM of membrane proteins

University of California, San Francisco

Postdoctoral Scholar / October, 2017August, 2020

Biochemistry and structural characterization of HIV proteins,

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