Martin Tsui
University of California, San Francisco
Research Expertise
About
Publications
Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification
Briefings in Bioinformatics / Sep 11, 2020
Khan, A. A., & Khan, Z. (2020). Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification. Briefings in Bioinformatics, 22(2), 1206–1214. https://doi.org/10.1093/bib/bbaa207
An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
Aug 10, 2020
Schoof, M., Faust, B., Saunders, R. A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesbølle, C. B., Puchades, C., Azumaya, C. M., Kratochvil, H. T., Zimanyi, M., Deshpande, I., Liang, J., Dickinson, S., Nguyen, H. C., Chio, C. M., Merz, G. E., … Thompson, M. C. (2020). An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. https://doi.org/10.1101/2020.08.08.238469
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2
Jun 28, 2022
Gahbauer, S., Correy, G. J., Schuller, M., Ferla, M. P., Doruk, Y. U., Rachman, M., Wu, T., Diolaiti, M., Wang, S., Neitz, R. J., Fearon, D., Radchenko, D., Moroz, Y., Irwin, J. J., Renslo, A. R., Taylor, J. C., Gestwicki, J. E., von Delft, F., Ashworth, A., … Fraser, J. S. (2022). Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2. https://doi.org/10.1101/2022.06.27.497816
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike
Aug 10, 2020
Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Zhou, X. X., Leung, K. K., & Wells, J. A. (2020). Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. https://doi.org/10.1101/2020.08.08.242511
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
May 19, 2021
Verba, K., Gupta, M., Azumaya, C., Moritz, M., Pourmal, S., Diallo, A., Merz, G., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A., Diwanji, D., Hernandez, E., Herrera, N., Kratochvil, H., Lam, V., Li, F., Li, Y., Nguyen, H., … Rosenberg, O. (2021). CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. https://doi.org/10.21203/rs.3.rs-515215/v1
The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9
ACS Synthetic Biology / Mar 20, 2017
Tsui, T. K. M., Hand, T. H., Duboy, E. C., & Li, H. (2017). The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9. ACS Synthetic Biology, 6(6), 1103–1113. https://doi.org/10.1021/acssynbio.7b00050
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
Annual Review of Biophysics / Jun 22, 2015
Tsui, T. K. M., & Li, H. (2015). Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annual Review of Biophysics, 44(1), 229–255. https://doi.org/10.1146/annurev-biophys-060414-033939
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Structure / Mar 01, 2023
Remesh, S. G., Merz, G. E., Brilot, A. F., Chio, U. S., Rizo, A. N., Pospiech, T. H., Lui, I., Laurie, M. T., Glasgow, J., Le, C. Q., Zhang, Y., Diwanji, D., Hernandez, E., Lopez, J., Mehmood, H., Pawar, K. I., Pourmal, S., Smith, A. M., Zhou, F., … Verba, K. A. (2023). Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure, 31(3), 253-264.e6. https://doi.org/10.1016/j.str.2023.01.009
The Impact of DNA Topology on Target Selection by a Cytosine-Specific Cas9
Biophysical Journal / Feb 01, 2017
Kin Martin Tsui, T., Hand, T. H., & Li, H. (2017). The Impact of DNA Topology on Target Selection by a Cytosine-Specific Cas9. Biophysical Journal, 112(3), 71a. https://doi.org/10.1016/j.bpj.2016.11.431
Phosphate Lock Residues of Acidothermus cellulolyticus Cas9 Are Critical to Its Substrate Specificity
Phosphate Lock Residues of Acidothermus cellulolyticus Cas9 Are Critical to Its Substrate Specificity. (n.d.). American Chemical Society (ACS). https://doi.org/10.1021/acssynbio.8b00455.s001
Stability of a Transient Protein Complex in a Charged Aqueous Droplet with Variable pH
Stability of a Transient Protein Complex in a Charged Aqueous Droplet with Variable pH. (n.d.). American Chemical Society (ACS). https://doi.org/10.1021/acs.jpclett.6b02319.s001
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
May 12, 2021
Gupta, M., Azumaya, C. M., Moritz, M., Pourmal, S., Diallo, A., Merz, G. E., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A. F., Diwanji, D., Hernandez, E., Herrera, N., Kratochvil, H. T., Lam, V. L., Li, F., Li, Y., Nguyen, H. C., … Nowotny, C. (2021). CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. https://doi.org/10.1101/2021.05.10.443524
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
Science Advances / Apr 16, 2021
Schuller, M., Correy, G. J., Gahbauer, S., Fearon, D., Wu, T., Díaz, R. E., Young, I. D., Carvalho Martins, L., Smith, D. H., Schulze-Gahmen, U., Owens, T. W., Deshpande, I., Merz, G. E., Thwin, A. C., Biel, J. T., Peters, J. K., Moritz, M., Herrera, N., … Kratochvil, H. T. (2021). Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science Advances, 7(16). https://doi.org/10.1126/sciadv.abf8711
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Science / Dec 18, 2020
Schoof, M., Faust, B., Saunders, R. A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesbølle, C. B., Puchades, C., Azumaya, C. M., Kratochvil, H. T., Zimanyi, M., Deshpande, I., Liang, J., Dickinson, S., Nguyen, H. C., Chio, C. M., Merz, G. E., … Thompson, M. C. (2020). An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science, 370(6523), 1473–1479. https://doi.org/10.1126/science.abe3255
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
Nature Chemical Biology / Oct 20, 2020
Bracken, C. J., Lim, S. A., Solomon, P., Rettko, N. J., Nguyen, D. P., Zha, B. S., Schaefer, K., Byrnes, J. R., Zhou, J., Lui, I., Liu, J., Pance, K., Azumaya, C. M., Braxton, J. R., Brilot, A. F., Gupta, M., Li, F., Lopez, K. E., … Melo, A. (2020). Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature Chemical Biology, 17(1), 113–121. https://doi.org/10.1038/s41589-020-00679-1
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
Science / Dec 04, 2020
Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., Kaake, R. M., Weckstein, A. R., Owens, T. W., Gupta, M., Pourmal, S., Titus, E. W., Cakir, M., Soucheray, M., … McGregor, M. (2020). Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521). https://doi.org/10.1126/science.abe9403
Education
Florida State University
Ph.D., Molecular Biophysics / July, 2017
University of California, San Diego
B.S., Chemistry / June, 2012
Experience
Stealth
Founder & CEO / January, 2023 — Present
Genome engineering
Amazon
Senior Scientist / December, 2021 — February, 2023
Molecular Diagnostics
Van Andel Institute
Postdoctoral Fellow / September, 2020 — April, 2021
Cryo-EM of membrane proteins
University of California, San Francisco
Postdoctoral Scholar / October, 2017 — August, 2020
Biochemistry and structural characterization of HIV proteins,
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