Wenting Zhao

Postdoctoral Research Scientist at Columbia University

Research Expertise

Biotechnology
Synthetic Biology
Protein Engineering
Drug Screening
Cancer Research
Oncology
Molecular Medicine
Genetics
Genetics (clinical)
Molecular Biology
Biomedical Engineering
Neurology (clinical)
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing
Immunology
Immunology and Allergy
Biochemistry
Bioengineering

About

Wenting Zhao is a highly educated and experienced individual in the field of Chemical and Biomolecular Engineering. She received her Bachelor of Science degree in Chemical and Bioengineering from Zhejiang University in 2010. She then went on to pursue her passion for research and obtained her PhD in Chemical and Biomolecular Engineering from Rice University in 2017. After completing her PhD, Wenting continued to expand her knowledge and skills as a Postdoctoral Research Scientist at Columbia University. She has been involved in numerous research projects and has published several papers in reputable scientific journals. Wenting's areas of expertise include biotechnology, drug discovery, synthetic biology, and next-generation sequencing. She is dedicated to finding innovative solutions to complex engineering problems and has a strong passion for making a positive impact through her research. In her free time, Wenting enjoys hiking, traveling, and trying new cuisines. She also enjoys mentoring and volunteering in STEM programs to inspire and empower young students to pursue careers in science and engineering.

Publications

Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

Nature Cancer / Jan 11, 2021

Garofano, L., Migliozzi, S., Oh, Y. T., D’Angelo, F., Najac, R. D., Ko, A., Frangaj, B., Caruso, F. P., Yu, K., Yuan, J., Zhao, W., Di Stefano, A. L., Bielle, F., Jiang, T., Sims, P., Suvà, M. L., Tang, F., Su, X.-D., Ceccarelli, M., … Iavarone, A. (2021). Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities. Nature Cancer, 2(2), 141–156. https://doi.org/10.1038/s43018-020-00159-4

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

Genome Medicine / May 19, 2021

Chen, A. X., Gartrell, R. D., Zhao, J., Upadhyayula, P. S., Zhao, W., Yuan, J., Minns, H. E., Dovas, A., Bruce, J. N., Lasorella, A., Iavarone, A., Canoll, P., Sims, P. A., & Rabadan, R. (2021). Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker. Genome Medicine, 13(1). https://doi.org/10.1186/s13073-021-00906-x

Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq

Genome Medicine / May 11, 2021

Zhao, W., Dovas, A., Spinazzi, E. F., Levitin, H. M., Banu, M. A., Upadhyayula, P., Sudhakar, T., Marie, T., Otten, M. L., Sisti, M. B., Bruce, J. N., Canoll, P., & Sims, P. A. (2021). Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq. Genome Medicine, 13(1). https://doi.org/10.1186/s13073-021-00894-y

ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Nature Cancer / Nov 29, 2021

Arrieta, V. A., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K. B., Upadhyayula, P. S., Lee-Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2021). ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nature Cancer, 2(12), 1372–1386. https://doi.org/10.1038/s43018-021-00260-2

Quantitatively Predictable Control of Cellular Protein Levels through Proteasomal Degradation

ACS Synthetic Biology / Nov 07, 2017

Zhao, W., Pferdehirt, L., & Segatori, L. (2017). Quantitatively Predictable Control of Cellular Protein Levels through Proteasomal Degradation. ACS Synthetic Biology, 7(2), 540–552. https://doi.org/10.1021/acssynbio.7b00325

Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit

Nature Communications / Apr 08, 2014

Zhao, W., Bonem, M., McWhite, C., Silberg, J. J., & Segatori, L. (2014). Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit. Nature Communications, 5(1). https://doi.org/10.1038/ncomms4612

Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial

The Lancet Oncology / Nov 01, 2022

Spinazzi, E. F., Argenziano, M. G., Upadhyayula, P. S., Banu, M. A., Neira, J. A., Higgins, D. M. O., Wu, P. B., Pereira, B., Mahajan, A., Humala, N., Al-Dalahmah, O., Zhao, W., Save, A. V., Gill, B. J. A., Boyett, D. M., Marie, T., Furnari, J. L., Sudhakar, T. D., Stopka, S. A., … Bruce, J. N. (2022). Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial. The Lancet Oncology, 23(11), 1409–1418. https://doi.org/10.1016/s1470-2045(22)00599-x

Input-dependent post-translational control of the reporter output enhances dynamic resolution of mammalian signaling systems

Methods in Enzymology / Jan 01, 2019

Jayanthi, B. E. K., Zhao, W., & Segatori, L. (2019). Input-dependent post-translational control of the reporter output enhances dynamic resolution of mammalian signaling systems. In Chemical and Synthetic Biology Approaches To Understand Cellular Functions – Part B (pp. 1–27). Elsevier. https://doi.org/10.1016/bs.mie.2019.02.013

Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity

Jun 19, 2019

Ding, H., Burgenske, D. M., Zhao, W., Subramaniam, P. S., Bakken, K. K., He, L., Alvarez, M. J., Laise, P., Paull, E. O., Spinazzi, E. F., Dovas, A., Marie, T., Upadhyayula, P., Cruz, F. D., Diolaiti, D., Kung, A., Bruce, J. N., Canoll, P., Sims, P. A., … Califano, A. (2019). Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity. https://doi.org/10.1101/675439

Hysteretic Genetic Circuit for Detection of Proteasomal Degradation in Mammalian Cells

ACS Synthetic Biology / Aug 15, 2019

Zeng, Y., Bhagyashree, B., Zhao, W., Nguyen, T., & Segatori, L. (2019). Hysteretic Genetic Circuit for Detection of Proteasomal Degradation in Mammalian Cells. ACS Synthetic Biology, 8(9), 2025–2035. https://doi.org/10.1021/acssynbio.9b00074

CTNI-25. PHASE IB CLINICAL TRIAL OF CHRONIC CONVECTION-ENHANCED DELIVERY OF TOPOTECAN FOR RECURRENT GLIOBLASTOMA

Neuro-Oncology / Nov 01, 2020

Bruce, J., Spinazzi, E., Lassman, A., Iwamoto, F., Welch, M., Banu, M., Argenziano, M., Upadhyayula, P., Agar, N. Y. R., Humala, N., Marie, T., Pereira, B., Sudhakar, T., Mahajan, A., Neira, J., Lignelli-Dipple, A., Grinband, J., Sims, P., D’Amico, R., & Canoll, P. (2020). CTNI-25. PHASE IB CLINICAL TRIAL OF CHRONIC CONVECTION-ENHANCED DELIVERY OF TOPOTECAN FOR RECURRENT GLIOBLASTOMA. Neuro-Oncology, 22(Supplement_2), ii47–ii48. https://doi.org/10.1093/neuonc/noaa215.192

TAMI-57. INDUCTION OF FERROPTOSIS PROMOTES IMMUNOGENIC CELL DEATH AND ACTIVATION OF THE IMMUNE MICROENVIRONMENT IN GLIOMA

Neuro-Oncology / Nov 02, 2021

Argenziano, M., Banu, M., Dovas, A., Zhao, W., Furnari, J., Higgins, D., Upadhyayula, P., Mahajan, A., Humala, N., Sims, P., Bruce, J. N., & Canoll, P. (2021). TAMI-57. INDUCTION OF FERROPTOSIS PROMOTES IMMUNOGENIC CELL DEATH AND ACTIVATION OF THE IMMUNE MICROENVIRONMENT IN GLIOMA. Neuro-Oncology, 23(Supplement_6), vi210–vi210. https://doi.org/10.1093/neuonc/noab196.839

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

Feb 23, 2023

Banu, M. A., Dovas, A., Argenziano, M. G., Zhao, W., Grajal, H. C., Higgins, D. M. O., Sperring, C. P., Pereira, B., Ye, L. F., Mahajan, A., Humala, N., Furnari, J. L., Upadhyayula, P. S., Zandkarimi, F., Nguyen, T. T. T., Wu, P. B., Hai, L., Karan, C., Razavilar, A., … Canoll, P. D. (2023). A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma. https://doi.org/10.1101/2023.02.22.529581

Consensus scHPF Identifies Cell Type-Specific Drug Responses in Glioma by Integrating Large-Scale scRNA-seq

Dec 07, 2023

Levitin, H. M., Zhao, W., Bruce, J. N., Canoll, P., & Sims, P. A. (2023). Consensus scHPF Identifies Cell Type-Specific Drug Responses in Glioma by Integrating Large-Scale scRNA-seq. https://doi.org/10.1101/2023.12.05.570193

Abstract 102: Microanatomy of Intracranial Human Thrombi by Single Nuclei Transcriptomics

Stroke / Feb 01, 2024

Spinazzi, E. F., Leifer, V. P., Argenziano, M. G., Zhao, W., Alexander, J. E., Mahajan, A., Furnari, J. L., Kotidis, C. P., Canoll, P. D., Sims, P. A., Mandigo, G. K., Connolly, E. S., & Lavine, S. D. (2024). Abstract 102: Microanatomy of Intracranial Human Thrombi by Single Nuclei Transcriptomics. Stroke, 55(Suppl_1). https://doi.org/10.1161/str.55.suppl_1.102

TMIC-24. FERROPTOSIS INDUCES IMMUNOGENIC CELL DEATH AND SYNERGIZES WITH CD47 BLOCKADE TO REPROGRAM THE GLIOMA MICROENVIRONMENT

Neuro-Oncology / Nov 01, 2023

Sperring, C., Argenziano, M., Banu, M., Dovas, A., Mela, A., Zhao, W., Furnari, J., Pereira, B., Ager, C., Yeary, M., Shapiro, B., Kotidis, C., Adeyuan, O., Higgins, D., Upadhyayula, P., Mahajan, A., Humala, N., Izar, B., Sims, P., … Canoll, P. (2023). TMIC-24. FERROPTOSIS INDUCES IMMUNOGENIC CELL DEATH AND SYNERGIZES WITH CD47 BLOCKADE TO REPROGRAM THE GLIOMA MICROENVIRONMENT. Neuro-Oncology, 25(Supplement_5), v283–v283. https://doi.org/10.1093/neuonc/noad179.1090

Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma

Sep 12, 2023

Cheng, Y. L., Banu, M. A., Zhao, W., Rosenfeld, S. S., Canoll, P., & Sims, P. A. (2023). Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma. https://doi.org/10.1101/2023.09.09.557001

A lymph node slice culture model to characterize T cell activation dynamics and anti-viral responses in human tissue

The Journal of Immunology / May 01, 2023

George, A., Davis-Porada, J., Weng, S., Zhao, W., Farber, D. L., & Sims, P. (2023). A lymph node slice culture model to characterize T cell activation dynamics and anti-viral responses in human tissue. The Journal of Immunology, 210(1_Supplement), 250.11-250.11. https://doi.org/10.4049/jimmunol.210.supp.250.11

ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

WFNOS 2022 Abstract Book / Jan 01, 2022

Arrieta, V. A., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K. B., Upadhyayula, P., Lee-Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2022). ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. WFNOS 2022 Abstract Book. https://doi.org/10.14791/btrt.2022.10.f-2616

Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Nature Cancer / Feb 11, 2022

Arrieta, V. A., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K. B., Upadhyayula, P. S., Lee-Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2022). Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nature Cancer, 3(3), 373–373. https://doi.org/10.1038/s43018-022-00343-8

TAMI-70. METABOLIC VULNERABILITY TO GPX4 INHIBITION AND FERROPTOSIS OF QUIESCENT ASTROCYTE-LIKE GLIOMA CELL POPULATIONS

Neuro-Oncology / Nov 02, 2021

Banu, M., Dovas, A., Argenziano, M., Zhao, W., Higgins, D., Upadhyayula, P., Mahajan, A., Humala, N., Nguyen, T., Zandkarimi, F., Siegelin, M. D., Brent, S., Sims, P., Bruce, J. N., & Canoll, P. (2021). TAMI-70. METABOLIC VULNERABILITY TO GPX4 INHIBITION AND FERROPTOSIS OF QUIESCENT ASTROCYTE-LIKE GLIOMA CELL POPULATIONS. Neuro-Oncology, 23(Supplement_6), vi212–vi213. https://doi.org/10.1093/neuonc/noab196.852

BIOM-31. ERK1/2 PHOSPHORYLATION PREDICTS SURVIVAL FOLLOWING ANTI-PD-1 IMMUNOTHERAPY IN RECURRENT GLIOBLASTOMA

Neuro-Oncology / Nov 02, 2021

Arrieta, V., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K., Upadhyayula, P., Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2021). BIOM-31. ERK1/2 PHOSPHORYLATION PREDICTS SURVIVAL FOLLOWING ANTI-PD-1 IMMUNOTHERAPY IN RECURRENT GLIOBLASTOMA. Neuro-Oncology, 23(Supplement_6), vi17–vi17. https://doi.org/10.1093/neuonc/noab196.062

MODL-09. FEASIBILITY OF ACUTE SLICE CULTURE-SINGLE CELL SEQUENCING DRUG SCREENING AS A TOOL TO SELECT THERAPY FOR CHILDREN WITH RELAPSED BRAIN TUMORS

Neuro-Oncology / Dec 01, 2020

Gampel, B., Szalontay, L., Zhao, W., Garvin, J., Sethi, C., Stark, E., Sims, P., Canoll, P., & Zacharoulis, S. (2020). MODL-09. FEASIBILITY OF ACUTE SLICE CULTURE-SINGLE CELL SEQUENCING DRUG SCREENING AS A TOOL TO SELECT THERAPY FOR CHILDREN WITH RELAPSED BRAIN TUMORS. Neuro-Oncology, 22(Supplement_3), iii412–iii413. https://doi.org/10.1093/neuonc/noaa222.584

COMP-12. SINGLE-CELL TRANSCRIPTOME PROFILING OF GBM TISSUE ACUTE SLICE CULTURES FOR PERSONALIZED DRUG SCREENING

Neuro-Oncology / Nov 01, 2019

Zhao, W., Spinazzi, E., Dovas, A., Upadhyayula, P., Marie, T., Sisti, M., Bruce, J., Canoll, P. D., & Sims, P. (2019). COMP-12. SINGLE-CELL TRANSCRIPTOME PROFILING OF GBM TISSUE ACUTE SLICE CULTURES FOR PERSONALIZED DRUG SCREENING. Neuro-Oncology, 21(Supplement_6), vi63–vi63. https://doi.org/10.1093/neuonc/noz175.255

A yeast selection system for the detection of proteasomal activation

Protein Engineering, Design and Selection / Nov 01, 2018

Zhao, W., Bachhav, B., McWhite, C., & Segatori, L. (2018). A yeast selection system for the detection of proteasomal activation. Protein Engineering, Design and Selection, 31(11), 437–445. https://doi.org/10.1093/protein/gzz006

Education

Rice University

PhD, Chemical and Biomolecular Engineering / August, 2017

Houston

Zhejiang Library

BS, Chemical and bioengineering / June, 2010

Zhejiang

Experience

Columbia University

Postdoctoral Research Scientist / September, 2017Present

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