Wenting Zhao
Postdoctoral Research Scientist at Columbia University
Research Expertise
About
Publications
Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
Nature Cancer / Jan 11, 2021
Garofano, L., Migliozzi, S., Oh, Y. T., D’Angelo, F., Najac, R. D., Ko, A., Frangaj, B., Caruso, F. P., Yu, K., Yuan, J., Zhao, W., Di Stefano, A. L., Bielle, F., Jiang, T., Sims, P., Suvà, M. L., Tang, F., Su, X.-D., Ceccarelli, M., … Iavarone, A. (2021). Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities. Nature Cancer, 2(2), 141–156. https://doi.org/10.1038/s43018-020-00159-4
Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker
Genome Medicine / May 19, 2021
Chen, A. X., Gartrell, R. D., Zhao, J., Upadhyayula, P. S., Zhao, W., Yuan, J., Minns, H. E., Dovas, A., Bruce, J. N., Lasorella, A., Iavarone, A., Canoll, P., Sims, P. A., & Rabadan, R. (2021). Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker. Genome Medicine, 13(1). https://doi.org/10.1186/s13073-021-00906-x
Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq
Genome Medicine / May 11, 2021
Zhao, W., Dovas, A., Spinazzi, E. F., Levitin, H. M., Banu, M. A., Upadhyayula, P., Sudhakar, T., Marie, T., Otten, M. L., Sisti, M. B., Bruce, J. N., Canoll, P., & Sims, P. A. (2021). Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq. Genome Medicine, 13(1). https://doi.org/10.1186/s13073-021-00894-y
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
Nature Cancer / Nov 29, 2021
Arrieta, V. A., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K. B., Upadhyayula, P. S., Lee-Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2021). ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nature Cancer, 2(12), 1372–1386. https://doi.org/10.1038/s43018-021-00260-2
Quantitatively Predictable Control of Cellular Protein Levels through Proteasomal Degradation
ACS Synthetic Biology / Nov 07, 2017
Zhao, W., Pferdehirt, L., & Segatori, L. (2017). Quantitatively Predictable Control of Cellular Protein Levels through Proteasomal Degradation. ACS Synthetic Biology, 7(2), 540–552. https://doi.org/10.1021/acssynbio.7b00325
Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit
Nature Communications / Apr 08, 2014
Zhao, W., Bonem, M., McWhite, C., Silberg, J. J., & Segatori, L. (2014). Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit. Nature Communications, 5(1). https://doi.org/10.1038/ncomms4612
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial
The Lancet Oncology / Nov 01, 2022
Spinazzi, E. F., Argenziano, M. G., Upadhyayula, P. S., Banu, M. A., Neira, J. A., Higgins, D. M. O., Wu, P. B., Pereira, B., Mahajan, A., Humala, N., Al-Dalahmah, O., Zhao, W., Save, A. V., Gill, B. J. A., Boyett, D. M., Marie, T., Furnari, J. L., Sudhakar, T. D., Stopka, S. A., … Bruce, J. N. (2022). Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial. The Lancet Oncology, 23(11), 1409–1418. https://doi.org/10.1016/s1470-2045(22)00599-x
Input-dependent post-translational control of the reporter output enhances dynamic resolution of mammalian signaling systems
Methods in Enzymology / Jan 01, 2019
Jayanthi, B. E. K., Zhao, W., & Segatori, L. (2019). Input-dependent post-translational control of the reporter output enhances dynamic resolution of mammalian signaling systems. In Chemical and Synthetic Biology Approaches To Understand Cellular Functions – Part B (pp. 1–27). Elsevier. https://doi.org/10.1016/bs.mie.2019.02.013
Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity
Jun 19, 2019
Ding, H., Burgenske, D. M., Zhao, W., Subramaniam, P. S., Bakken, K. K., He, L., Alvarez, M. J., Laise, P., Paull, E. O., Spinazzi, E. F., Dovas, A., Marie, T., Upadhyayula, P., Cruz, F. D., Diolaiti, D., Kung, A., Bruce, J. N., Canoll, P., Sims, P. A., … Califano, A. (2019). Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity. https://doi.org/10.1101/675439
Hysteretic Genetic Circuit for Detection of Proteasomal Degradation in Mammalian Cells
ACS Synthetic Biology / Aug 15, 2019
Zeng, Y., Bhagyashree, B., Zhao, W., Nguyen, T., & Segatori, L. (2019). Hysteretic Genetic Circuit for Detection of Proteasomal Degradation in Mammalian Cells. ACS Synthetic Biology, 8(9), 2025–2035. https://doi.org/10.1021/acssynbio.9b00074
CTNI-25. PHASE IB CLINICAL TRIAL OF CHRONIC CONVECTION-ENHANCED DELIVERY OF TOPOTECAN FOR RECURRENT GLIOBLASTOMA
Neuro-Oncology / Nov 01, 2020
Bruce, J., Spinazzi, E., Lassman, A., Iwamoto, F., Welch, M., Banu, M., Argenziano, M., Upadhyayula, P., Agar, N. Y. R., Humala, N., Marie, T., Pereira, B., Sudhakar, T., Mahajan, A., Neira, J., Lignelli-Dipple, A., Grinband, J., Sims, P., D’Amico, R., & Canoll, P. (2020). CTNI-25. PHASE IB CLINICAL TRIAL OF CHRONIC CONVECTION-ENHANCED DELIVERY OF TOPOTECAN FOR RECURRENT GLIOBLASTOMA. Neuro-Oncology, 22(Supplement_2), ii47–ii48. https://doi.org/10.1093/neuonc/noaa215.192
TAMI-57. INDUCTION OF FERROPTOSIS PROMOTES IMMUNOGENIC CELL DEATH AND ACTIVATION OF THE IMMUNE MICROENVIRONMENT IN GLIOMA
Neuro-Oncology / Nov 02, 2021
Argenziano, M., Banu, M., Dovas, A., Zhao, W., Furnari, J., Higgins, D., Upadhyayula, P., Mahajan, A., Humala, N., Sims, P., Bruce, J. N., & Canoll, P. (2021). TAMI-57. INDUCTION OF FERROPTOSIS PROMOTES IMMUNOGENIC CELL DEATH AND ACTIVATION OF THE IMMUNE MICROENVIRONMENT IN GLIOMA. Neuro-Oncology, 23(Supplement_6), vi210–vi210. https://doi.org/10.1093/neuonc/noab196.839
A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma
Feb 23, 2023
Banu, M. A., Dovas, A., Argenziano, M. G., Zhao, W., Grajal, H. C., Higgins, D. M. O., Sperring, C. P., Pereira, B., Ye, L. F., Mahajan, A., Humala, N., Furnari, J. L., Upadhyayula, P. S., Zandkarimi, F., Nguyen, T. T. T., Wu, P. B., Hai, L., Karan, C., Razavilar, A., … Canoll, P. D. (2023). A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma. https://doi.org/10.1101/2023.02.22.529581
Consensus scHPF Identifies Cell Type-Specific Drug Responses in Glioma by Integrating Large-Scale scRNA-seq
Dec 07, 2023
Levitin, H. M., Zhao, W., Bruce, J. N., Canoll, P., & Sims, P. A. (2023). Consensus scHPF Identifies Cell Type-Specific Drug Responses in Glioma by Integrating Large-Scale scRNA-seq. https://doi.org/10.1101/2023.12.05.570193
Abstract 102: Microanatomy of Intracranial Human Thrombi by Single Nuclei Transcriptomics
Stroke / Feb 01, 2024
Spinazzi, E. F., Leifer, V. P., Argenziano, M. G., Zhao, W., Alexander, J. E., Mahajan, A., Furnari, J. L., Kotidis, C. P., Canoll, P. D., Sims, P. A., Mandigo, G. K., Connolly, E. S., & Lavine, S. D. (2024). Abstract 102: Microanatomy of Intracranial Human Thrombi by Single Nuclei Transcriptomics. Stroke, 55(Suppl_1). https://doi.org/10.1161/str.55.suppl_1.102
TMIC-24. FERROPTOSIS INDUCES IMMUNOGENIC CELL DEATH AND SYNERGIZES WITH CD47 BLOCKADE TO REPROGRAM THE GLIOMA MICROENVIRONMENT
Neuro-Oncology / Nov 01, 2023
Sperring, C., Argenziano, M., Banu, M., Dovas, A., Mela, A., Zhao, W., Furnari, J., Pereira, B., Ager, C., Yeary, M., Shapiro, B., Kotidis, C., Adeyuan, O., Higgins, D., Upadhyayula, P., Mahajan, A., Humala, N., Izar, B., Sims, P., … Canoll, P. (2023). TMIC-24. FERROPTOSIS INDUCES IMMUNOGENIC CELL DEATH AND SYNERGIZES WITH CD47 BLOCKADE TO REPROGRAM THE GLIOMA MICROENVIRONMENT. Neuro-Oncology, 25(Supplement_5), v283–v283. https://doi.org/10.1093/neuonc/noad179.1090
Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma
Sep 12, 2023
Cheng, Y. L., Banu, M. A., Zhao, W., Rosenfeld, S. S., Canoll, P., & Sims, P. A. (2023). Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma. https://doi.org/10.1101/2023.09.09.557001
A lymph node slice culture model to characterize T cell activation dynamics and anti-viral responses in human tissue
The Journal of Immunology / May 01, 2023
George, A., Davis-Porada, J., Weng, S., Zhao, W., Farber, D. L., & Sims, P. (2023). A lymph node slice culture model to characterize T cell activation dynamics and anti-viral responses in human tissue. The Journal of Immunology, 210(1_Supplement), 250.11-250.11. https://doi.org/10.4049/jimmunol.210.supp.250.11
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
WFNOS 2022 Abstract Book / Jan 01, 2022
Arrieta, V. A., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K. B., Upadhyayula, P., Lee-Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2022). ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. WFNOS 2022 Abstract Book. https://doi.org/10.14791/btrt.2022.10.f-2616
Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
Nature Cancer / Feb 11, 2022
Arrieta, V. A., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K. B., Upadhyayula, P. S., Lee-Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2022). Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nature Cancer, 3(3), 373–373. https://doi.org/10.1038/s43018-022-00343-8
TAMI-70. METABOLIC VULNERABILITY TO GPX4 INHIBITION AND FERROPTOSIS OF QUIESCENT ASTROCYTE-LIKE GLIOMA CELL POPULATIONS
Neuro-Oncology / Nov 02, 2021
Banu, M., Dovas, A., Argenziano, M., Zhao, W., Higgins, D., Upadhyayula, P., Mahajan, A., Humala, N., Nguyen, T., Zandkarimi, F., Siegelin, M. D., Brent, S., Sims, P., Bruce, J. N., & Canoll, P. (2021). TAMI-70. METABOLIC VULNERABILITY TO GPX4 INHIBITION AND FERROPTOSIS OF QUIESCENT ASTROCYTE-LIKE GLIOMA CELL POPULATIONS. Neuro-Oncology, 23(Supplement_6), vi212–vi213. https://doi.org/10.1093/neuonc/noab196.852
BIOM-31. ERK1/2 PHOSPHORYLATION PREDICTS SURVIVAL FOLLOWING ANTI-PD-1 IMMUNOTHERAPY IN RECURRENT GLIOBLASTOMA
Neuro-Oncology / Nov 02, 2021
Arrieta, V., Chen, A. X., Kane, J. R., Kang, S. J., Kassab, C., Dmello, C., Zhao, J., Burdett, K., Upadhyayula, P., Chang, C., Shilati, J., Jaishankar, D., Chen, L., Gould, A., Zhang, D., Yuan, J., Zhao, W., Ling, X., Burks, J. K., … Sonabend, A. M. (2021). BIOM-31. ERK1/2 PHOSPHORYLATION PREDICTS SURVIVAL FOLLOWING ANTI-PD-1 IMMUNOTHERAPY IN RECURRENT GLIOBLASTOMA. Neuro-Oncology, 23(Supplement_6), vi17–vi17. https://doi.org/10.1093/neuonc/noab196.062
MODL-09. FEASIBILITY OF ACUTE SLICE CULTURE-SINGLE CELL SEQUENCING DRUG SCREENING AS A TOOL TO SELECT THERAPY FOR CHILDREN WITH RELAPSED BRAIN TUMORS
Neuro-Oncology / Dec 01, 2020
Gampel, B., Szalontay, L., Zhao, W., Garvin, J., Sethi, C., Stark, E., Sims, P., Canoll, P., & Zacharoulis, S. (2020). MODL-09. FEASIBILITY OF ACUTE SLICE CULTURE-SINGLE CELL SEQUENCING DRUG SCREENING AS A TOOL TO SELECT THERAPY FOR CHILDREN WITH RELAPSED BRAIN TUMORS. Neuro-Oncology, 22(Supplement_3), iii412–iii413. https://doi.org/10.1093/neuonc/noaa222.584
COMP-12. SINGLE-CELL TRANSCRIPTOME PROFILING OF GBM TISSUE ACUTE SLICE CULTURES FOR PERSONALIZED DRUG SCREENING
Neuro-Oncology / Nov 01, 2019
Zhao, W., Spinazzi, E., Dovas, A., Upadhyayula, P., Marie, T., Sisti, M., Bruce, J., Canoll, P. D., & Sims, P. (2019). COMP-12. SINGLE-CELL TRANSCRIPTOME PROFILING OF GBM TISSUE ACUTE SLICE CULTURES FOR PERSONALIZED DRUG SCREENING. Neuro-Oncology, 21(Supplement_6), vi63–vi63. https://doi.org/10.1093/neuonc/noz175.255
A yeast selection system for the detection of proteasomal activation
Protein Engineering, Design and Selection / Nov 01, 2018
Zhao, W., Bachhav, B., McWhite, C., & Segatori, L. (2018). A yeast selection system for the detection of proteasomal activation. Protein Engineering, Design and Selection, 31(11), 437–445. https://doi.org/10.1093/protein/gzz006
Education
Rice University
PhD, Chemical and Biomolecular Engineering / August, 2017
Zhejiang Library
BS, Chemical and bioengineering / June, 2010
Experience
Columbia University
Postdoctoral Research Scientist / September, 2017 — Present
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