Stan Karsten
Experienced R&D Investigator
Research Expertise
Publications
Automated Capillary-Based Vacuum Pulse-Assisted Instrument for Single-Cell Acquisition and Concurrent Detachment/Adhesion Assay, A-picK
SLAS Technology / Oct 01, 2021
Ma, D., Ma, Z., Kudo, L. C., & Karsten, S. L. (2021). Automated Capillary-Based Vacuum Pulse-Assisted Instrument for Single-Cell Acquisition and Concurrent Detachment/Adhesion Assay, A-picK. SLAS Technology, 26(5), 519–531. https://doi.org/10.1177/2472630320987219
Nanopin - A MEMS Based Sensor for the Analysis of Single Cell Mechanical Properties
2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS) / Jan 01, 2020
Kumemura, M., Kudo, L. C., Ma, Z., & Karsten, S. L. (2020, January). Nanopin - A MEMS Based Sensor for the Analysis of Single Cell Mechanical Properties. 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS). https://doi.org/10.1109/mems46641.2020.9056113
Developing a MEMS Device with Built-in Microfluidics for Biophysical Single Cell Characterization
Micromachines / Jun 01, 2018
Takayama, Y., Perret, G., Kumemura, M., Ataka, M., Meignan, S., Karsten, S., Fujita, H., Collard, D., Lagadec, C., & Tarhan, M. (2018). Developing a MEMS Device with Built-in Microfluidics for Biophysical Single Cell Characterization. Micromachines, 9(6), 275. https://doi.org/10.3390/mi9060275
Microfluidic Tissue Mesodissection in Molecular Cancer Diagnostics
SLAS Technology / Aug 01, 2017
Surrette, C., Shoudy, D., Corwin, A., Gao, W., Zavodszky, M. I., Karsten, S. L., Miller, T., Gerdes, M. J., Wood, N., Nelson, J. R., & Puleo, C. M. (2017). Microfluidic Tissue Mesodissection in Molecular Cancer Diagnostics. SLAS Technology, 22(4), 425–430. https://doi.org/10.1177/2211068216680208
Microtubule density and landing rate as parameters to analyze tau protein in the MT-kinesin “gliding” assay
Sensors and Actuators B: Chemical / Jan 01, 2017
Subramaniyan Parimalam, S., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2017). Microtubule density and landing rate as parameters to analyze tau protein in the MT-kinesin “gliding” assay. Sensors and Actuators B: Chemical, 238, 954–961. https://doi.org/10.1016/j.snb.2016.07.082
Direct electrical and mechanical characterization of in situ generated DNA between the tips of silicon nanotweezers (SNT)
Lab on a Chip / Jan 01, 2016
Karsten, S. L., Kumemura, M., Jalabert, L., Lafitte, N., Kudo, L. C., Collard, D., & Fujita, H. (2016). Direct electrical and mechanical characterization of in situ generated DNA between the tips of silicon nanotweezers (SNT). Lab on a Chip, 16(11), 2099–2107. https://doi.org/10.1039/c6lc00309e
Nano systems and devices for applications in biology and nanotechnology
Solid-State Electronics / Jan 01, 2016
Perret, G., Ginet, P., Tarhan, M. C., Baccouche, A., Lacornerie, T., Kumemura, M., Jalabert, L., Cleri, F., Lartigau, E. F., Kim, B. J., Karsten, S. L., Fujita, H., Rondelez, Y., Fujii, T., & Collard, D. (2016). Nano systems and devices for applications in biology and nanotechnology. Solid-State Electronics, 115, 66–73. https://doi.org/10.1016/j.sse.2015.08.019
On-chip microtubule gliding assay for parallel measurement of tau protein species
Lab on a Chip / Jan 01, 2016
Subramaniyan Parimalam, S., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2016). On-chip microtubule gliding assay for parallel measurement of tau protein species. Lab on a Chip, 16(9), 1691–1697. https://doi.org/10.1039/c5lc01486g
On-chip detection of wild 3R, 4R and mutant 4R tau through kinesin-microtubule binding
2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS) / Jan 01, 2015
Subramaniyan, S. P., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2015, January). On-chip detection of wild 3R, 4R and mutant 4R tau through kinesin-microtubule binding. 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS). https://doi.org/10.1109/memsys.2015.7050988
Point-of-care (POC) devices by means of advanced MEMS
Talanta / Dec 01, 2015
Karsten, S. L., Tarhan, M. C., Kudo, L. C., Collard, D., & Fujita, H. (2015). Point-of-care (POC) devices by means of advanced MEMS. Talanta, 145, 55–59. https://doi.org/10.1016/j.talanta.2015.04.032
Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay
2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS) / Jan 01, 2014
Subramaniyan, S. P., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2014, January). Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay. 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS). https://doi.org/10.1109/memsys.2014.6765639
Intestinal tumor suppression in ApcMin/+ mice by prostaglandin
D2 receptor PTGDR
Cancer Medicine / Apr 12, 2014
Tippin, B. L., Kwong, A. M., Inadomi, M. J., Lee, O. J., Park, J. M., Materi, A. M., Buslon, V. S., Lin, A. M., Kudo, L. C., Karsten, S. L., French, S. W., Narumiya, S., Urade, Y., Salido, E., & Lin, H. J. (2014). Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor <scp>PTGDR</scp>. Cancer Medicine, 3(4), 1041–1051. Portico. https://doi.org/10.1002/cam4.251
Biosensing MAPs as “roadblocks”: kinesin-based functional analysis of tau protein isoforms and mutants using suspended microtubules (sMTs)
Lab on a Chip / Jan 01, 2013
Tarhan, M. C., Orazov, Y., Yokokawa, R., Karsten, S. L., & Fujita, H. (2013). Biosensing MAPs as “roadblocks”: kinesin-based functional analysis of tau protein isoforms and mutants using suspended microtubules (sMTs). Lab on a Chip, 13(16), 3217. https://doi.org/10.1039/c3lc50151e
Motor protein based tau protein detection device
2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII) / Jun 01, 2013
Orazov, Y., Tarhan, M. C., Yokokawa, R., Karsten, S. L., & Fujita, H. (2013, June). Motor protein based tau protein detection device. 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII). https://doi.org/10.1109/transducers.2013.6627301
Nano bioresearch approach by microtechnology
Drug Discovery Today / Jun 01, 2013
Collard, D., Kim, S. H., Osaki, T., Kumemura, M., Kim, B., Fourmy, D., Fujii, T., Takeuchi, S., Karsten, S. L., & Fujita, H. (2013). Nano bioresearch approach by microtechnology. Drug Discovery Today, 18(11–12), 552–559. https://doi.org/10.1016/j.drudis.2013.02.002
Suspended microtubules demonstrate high sensitivity and low experimental variability in kinesin bead assay
The Analyst / Jan 01, 2013
Tarhan, M. C., Orazov, Y., Yokokawa, R., Karsten, S. L., & Fujita, H. (2013). Suspended microtubules demonstrate high sensitivity and low experimental variability in kinesin bead assay. The Analyst, 138(6), 1653. https://doi.org/10.1039/c3an36545j
Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance
Molecular Neurodegeneration / Feb 07, 2012
Ren, G., Ma, Z., Hui, M., Kudo, L. C., Hui, K.-S., & Karsten, S. L. (2012). Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance. Molecular Neurodegeneration, 7(S1). https://doi.org/10.1186/1750-1326-7-s1-s5
Application of a new microcantilever biosensor resonating at the air–liquid interface for direct insulin detection and continuous monitoring of enzymatic reactions
Lab on a Chip / Jan 01, 2012
Park, J., Karsten, S. L., Nishida, S., Kawakatsu, H., & Fujita, H. (2012). Application of a new microcantilever biosensor resonating at the air–liquid interface for direct insulin detection and continuous monitoring of enzymatic reactions. Lab on a Chip, 12(20), 4115. https://doi.org/10.1039/c2lc40232g
Novel Cell and Tissue Acquisition System (CTAS): Microdissection of Live and Frozen Brain Tissues
PLoS ONE / Jul 24, 2012
Kudo, L. C., Vi, N., Ma, Z., Fields, T., Avliyakulov, N. K., Haykinson, M. J., Bragin, A., & Karsten, S. L. (2012). Novel Cell and Tissue Acquisition System (CTAS): Microdissection of Live and Frozen Brain Tissues. PLoS ONE, 7(7), e41564. https://doi.org/10.1371/journal.pone.0041564
A Systems Level, Functional Genomics Analysis of Chronic Epilepsy
PLoS ONE / Jun 14, 2011
Winden, K. D., Karsten, S. L., Bragin, A., Kudo, L. C., Gehman, L., Ruidera, J., Geschwind, D. H., & Engel, J. (2011). A Systems Level, Functional Genomics Analysis of Chronic Epilepsy. PLoS ONE, 6(6), e20763. https://doi.org/10.1371/journal.pone.0020763
Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis
Molecular Neurodegeneration / May 07, 2011
Ren, G., Ma, Z., Hui, M., Kudo, L. C., Hui, K.-S., & Karsten, S. L. (2011). Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis. Molecular Neurodegeneration, 6(1). https://doi.org/10.1186/1750-1326-6-29
Motor protein motion along microtubules for molecular detection
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference / Jun 01, 2011
Tarhan, M. C., Yokokawa, R., Qiu, H., Karsten, S. L., & Fujita, H. (2011, June). Motor protein motion along microtubules for molecular detection. 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference. https://doi.org/10.1109/transducers.2011.5969363
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAUP301L double-transgenic mice
Human Molecular Genetics / Feb 14, 2011
Kudo, L. C., Parfenova, L., Ren, G., Vi, N., Hui, M., Ma, Z., Lau, K., Gray, M., Bardag-Gorce, F., Wiedau-Pazos, M., Hui, K.-S., & Karsten, S. L. (2011). Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAUP301L double-transgenic mice. Human Molecular Genetics, 20(9), 1820–1833. https://doi.org/10.1093/hmg/ddr065
Use of peripheral blood transcriptome biomarkers for epilepsy prediction
Neuroscience Letters / Jun 01, 2011
Karsten, S. L., Kudo, L. C., & Bragin, A. J. (2011). Use of peripheral blood transcriptome biomarkers for epilepsy prediction. Neuroscience Letters, 497(3), 213–217. https://doi.org/10.1016/j.neulet.2011.03.019
Integrative gene–tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis
Human Molecular Genetics / Jun 08, 2010
Kudo, L. C., Parfenova, L., Vi, N., Lau, K., Pomakian, J., Valdmanis, P., Rouleau, G. A., Vinters, H. V., Wiedau-Pazos, M., & Karsten, S. L. (2010). Integrative gene–tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis. Human Molecular Genetics, 19(16), 3233–3253. https://doi.org/10.1093/hmg/ddq232
Cell Lineage and Regional Identity of Cultured Spinal Cord Neural Stem Cells and Comparison to Brain-Derived Neural Stem Cells
PLoS ONE / Jan 16, 2009
Kelly, T. K., Karsten, S. L., Geschwind, D. H., & Kornblum, H. I. (2009). Cell Lineage and Regional Identity of Cultured Spinal Cord Neural Stem Cells and Comparison to Brain-Derived Neural Stem Cells. PLoS ONE, 4(1), e4213. https://doi.org/10.1371/journal.pone.0004213
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy
Proceedings of the National Academy of Sciences / May 19, 2009
Ohmi, K., Kudo, L. C., Ryazantsev, S., Zhao, H.-Z., Karsten, S. L., & Neufeld, E. F. (2009). Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy. Proceedings of the National Academy of Sciences, 106(20), 8332–8337. https://doi.org/10.1073/pnas.0903223106
Gene Expression Analysis of Neural Cells and Tissues Using DNA Microarrays
Current Protocols in Neuroscience / Oct 01, 2008
Karsten, S. L., Kudo, L. C., & Geschwind, D. H. (2008). Gene Expression Analysis of Neural Cells and Tissues Using DNA Microarrays. Current Protocols in Neuroscience, 45(1). Portico. https://doi.org/10.1002/0471142301.ns0428s45
Report on the Workshop “New Technologies in Stem Cell Research,” Society for Pediatric Research, San Francisco, California, April 29, 2006
Stem Cells / Apr 01, 2007
Cheng, J. C., Horwitz, E. M., Karsten, S. L., Shoemaker, L., Kornblumc, H. I., Malik, P., & Sakamoto, K. M. (2007). Report on the Workshop “New Technologies in Stem Cell Research,” Society for Pediatric Research, San Francisco, California, April 29, 2006. Stem Cells, 25(4), 1070–1088. https://doi.org/10.1634/stemcells.2006-0397
Genetic Analysis of Anterior-Posterior Expression Gradients in the Developing Mammalian Forebrain
Cerebral Cortex / Dec 05, 2006
Kudo, L. C., Karsten, S. L., Chen, J., Levitt, P., & Geschwind, D. H. (2006). Genetic Analysis of Anterior-Posterior Expression Gradients in the Developing Mammalian Forebrain. Cerebral Cortex, 17(9), 2108–2122. https://doi.org/10.1093/cercor/bhl118
A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration
Neuron / Sep 01, 2006
Karsten, S. L., Sang, T.-K., Gehman, L. T., Chatterjee, S., Liu, J., Lawless, G. M., Sengupta, S., Berry, R. W., Pomakian, J., Oh, H. S., Schulz, C., Hui, K.-S., Wiedau-Pazos, M., Vinters, H. V., Binder, L. I., Geschwind, D. H., & Jackson, G. R. (2006). A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration. Neuron, 51(5), 549–560. https://doi.org/10.1016/j.neuron.2006.07.019
Degradation of Tau Protein by Puromycin-Sensitive Aminopeptidase in Vitro
Biochemistry / Nov 24, 2006
Sengupta, S., Horowitz, P. M., Karsten, S. L., Jackson, G. R., Geschwind, D. H., Fu, Y., Berry, R. W., & Binder, L. I. (2006). Degradation of Tau Protein by Puromycin-Sensitive Aminopeptidase in Vitro. Biochemistry, 45(50), 15111–15119. https://doi.org/10.1021/bi061830d
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
Nature Neuroscience / Feb 19, 2006
Lobo, M. K., Karsten, S. L., Gray, M., Geschwind, D. H., & Yang, X. W. (2006). FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nature Neuroscience, 9(3), 443–452. https://doi.org/10.1038/nn1654
Exercise Your Amyloid
Cell / Mar 01, 2005
Karsten, S. L., & Geschwind, D. H. (2005). Exercise Your Amyloid. Cell, 120(5), 572–574. https://doi.org/10.1016/j.cell.2005.02.027
Identification of a Hoxd10‐regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development
Journal of Neuroscience Research / Jan 06, 2004
Hedlund, E., Karsten, S. L., Kudo, L., Geschwind, D. H., & Carpenter, E. M. (2004). Identification of a Hoxd10‐regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. Journal of Neuroscience Research, 75(3), 307–319. Portico. https://doi.org/10.1002/jnr.10844
Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters
Journal of Neuroscience Methods / Feb 01, 2004
Bragin, A., Karsten, S. L., Almajano, J., Wilson, C. L., Geschwind, D. H., & Engel, J. (2004). Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters. Journal of Neuroscience Methods, 133(1–2), 49–55. https://doi.org/10.1016/j.jneumeth.2003.09.016
Microarray Platforms: Introduction and Application to Neurobiology
International Review of Neurobiology / Jan 01, 2004
Karsten, S. L., Kudo, L. C., & Geschwind, D. H. (2004). Microarray Platforms: Introduction and Application to Neurobiology. In DNA Arrays in Neurobiology (pp. 1–23). Elsevier. https://doi.org/10.1016/s0074-7742(04)60001-8
Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks
Developmental Biology / Sep 01, 2003
Karsten, S. L., Kudo, L. C., Jackson, R., Sabatti, C., Kornblum, H. I., & Geschwind, D. H. (2003). Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks. Developmental Biology, 261(1), 165–182. https://doi.org/10.1016/s0012-1606(03)00274-4
An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis
Nucleic Acids Research / Jan 15, 2002
Karsten, S. L. (2002). An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis. Nucleic Acids Research, 30(2), 4e–44. https://doi.org/10.1093/nar/30.2.e4
Gene Expression Analysis Using c DNA Microarrays
Current Protocols in Neuroscience / Jul 01, 2002
Karsten, S. L., & Geshwind, D. H. (2002). Gene Expression Analysis Using <scp>c</scp><scp>DNA</scp> Microarrays. Current Protocols in Neuroscience, 20(1). Portico. https://doi.org/10.1002/0471142301.ns0428s20
Thresholding rules for recovering a sparse signal from microarray experiments
Mathematical Biosciences / Mar 01, 2002
Sabatti, C., Karsten, S. L., & Geschwind, D. H. (2002). Thresholding rules for recovering a sparse signal from microarray experiments. Mathematical Biosciences, 176(1), 17–34. https://doi.org/10.1016/s0025-5564(01)00102-x
Novel type of genetic rearrangement in the iduronate-2-sulfatase (IDS) gene involving deletion, duplications, and inversions
Human Mutation / Dec 01, 1999
Karsten, S., Voskoboeva, E., Krasnopolskaja, X., & Bondeson, M.-L. (1999). Novel type of genetic rearrangement in the iduronate-2-sulfatase (IDS) gene involving deletion, duplications, and inversions. Human Mutation, 14(6), 471–476. https://doi.org/10.1002/(sici)1098-1004(199912)14:6<471::aid-humu5>3.0.co;2-5
Identification of 9 novel IDS gene mutations in 19 unrelated Hunter syndrome (Mucopolysaccharidosis type II) patients
Human Mutation / Jan 01, 1998
Karsten, S. L., Voskoboeva, E., Carlberg, B.-M., Kleijer, W. J., Tönnesen, T., Pettersson, U., & Bondeson, M.-L. (1998). Identification of 9 novel IDS gene mutations in 19 unrelated Hunter syndrome (Mucopolysaccharidosis type II) patients. Human Mutation, 12(6), 433–433. https://doi.org/10.1002/(sici)1098-1004(1998)12:6<433::aid-humu12>3.0.co;2-m
Mutational spectrum of the iduronate-2-sulfatase (IDS) gene in 36 unrelated Russian MPS II patients
Human Genetics / Dec 15, 1998
Karsten, S., Voskoboeva, E., Tishkanina, S., Pettersson, U., Krasnopolskaja, X., & Bondeson, M.-L. (1998). Mutational spectrum of the iduronate-2-sulfatase (IDS) gene in 36 unrelated Russian MPS II patients. Human Genetics, 103(6), 732–735. https://doi.org/10.1007/s004390050901
The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17
Human Genetics / Sep 01, 1998
Aronsson, F. C., Magnusson, P., Andersson, B., Karsten, S. L., Shibasaki, Y., Lendon, C. L., Goate, A. M., & Brookes, A. J. (1998). The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. Human Genetics, 103(3), 340–345. https://doi.org/10.1007/s004390050827
Double-strand breaks may initiate the inversion mutation causing the Hunter syndrome
Human Molecular Genetics / Apr 01, 1997
Lagerstedt, K. (1997). Double-strand breaks may initiate the inversion mutation causing the Hunter syndrome. Human Molecular Genetics, 6(4), 627–633. https://doi.org/10.1093/hmg/6.4.627
Two Distinct Deletions in theIDSGene and the GeneW: A Novel Type of Mutation Associated with the Hunter Syndrome
Genomics / Jul 01, 1997
Karsten, S. L., Lagerstedt, K., Carlberg, B.-M., Kleijer, W. J., Zaremba, J., Van Diggelen, O. P., Czartoryska, B., Pettersson, U., & Bondeson, M.-L. (1997). Two Distinct Deletions in theIDSGene and the GeneW: A Novel Type of Mutation Associated with the Hunter Syndrome. Genomics, 43(2), 123–129. https://doi.org/10.1006/geno.1997.4811
Education
Uppsala University
PhD, Genetics and Pathology
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