Stan Karsten

Experienced R&D Investigator

Research Expertise

Medical Laboratory Technology

Computer Science Applications

Electrical and Electronic Engineering

Control and Systems Engineering

Mechanical Engineering

Instrumentation

Electronic, Optical and Magnetic Materials

Materials Chemistry

Metals and Alloys

Surfaces, Coatings and Films

Condensed Matter Physics

Biochemistry

Biomedical Engineering

Bioengineering

Analytical Chemistry

Oncology

Radiology, Nuclear Medicine and imaging

Cancer Research

Pharmacology

Drug Discovery

Environmental Chemistry

Electrochemistry

Spectroscopy

Molecular Biology

Neurology (clinical)

Cellular and Molecular Neuroscience

Genetics

Genetics (clinical)

Cell Biology

Molecular Medicine

Developmental Biology

Cognitive Neuroscience

Modeling and Simulation

Applied Mathematics

Statistics and Probability

Legacy Map

Publications

Automated Capillary-Based Vacuum Pulse-Assisted Instrument for Single-Cell Acquisition and Concurrent Detachment/Adhesion Assay, A-picK

SLAS Technology

Nanopin - A MEMS Based Sensor for the Analysis of Single Cell Mechanical Properties

2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS)

Developing a MEMS Device with Built-in Microfluidics for Biophysical Single Cell Characterization

Microfluidic Tissue Mesodissection in Molecular Cancer Diagnostics

SLAS Technology

Microtubule density and landing rate as parameters to analyze tau protein in the MT-kinesin “gliding” assay

Sensors and Actuators B: Chemical

Direct electrical and mechanical characterization of in situ generated DNA between the tips of silicon nanotweezers (SNT)

Nano systems and devices for applications in biology and nanotechnology

Solid-State Electronics

On-chip microtubule gliding assay for parallel measurement of tau protein species

On-chip detection of wild 3R, 4R and mutant 4R tau through kinesin-microtubule binding

2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

Point-of-care (POC) devices by means of advanced MEMS

Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay

2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS)

Intestinal tumor suppression in Apc^Min/+ mice by prostaglandin D₂ receptor PTGDR

Cancer Medicine

Biosensing MAPs as “roadblocks”: kinesin-based functional analysis of tau protein isoforms and mutants using suspended microtubules (sMTs)

Motor protein based tau protein detection device

2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII)

Nano bioresearch approach by microtechnology

Drug Discovery Today

Suspended microtubules demonstrate high sensitivity and low experimental variability in kinesin bead assay

Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance

Molecular Neurodegeneration

Application of a new microcantilever biosensor resonating at the air–liquid interface for direct insulin detection and continuous monitoring of enzymatic reactions

Novel Cell and Tissue Acquisition System (CTAS): Microdissection of Live and Frozen Brain Tissues

A Systems Level, Functional Genomics Analysis of Chronic Epilepsy

Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis

Molecular Neurodegeneration

Motor protein motion along microtubules for molecular detection

2011 16th International Solid-State Sensors, Actuators and Microsystems Conference

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAUP301L double-transgenic mice

Human Molecular Genetics

Use of peripheral blood transcriptome biomarkers for epilepsy prediction

Neuroscience Letters

Integrative gene–tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis

Human Molecular Genetics

Cell Lineage and Regional Identity of Cultured Spinal Cord Neural Stem Cells and Comparison to Brain-Derived Neural Stem Cells

Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy

Proceedings of the National Academy of Sciences

Gene Expression Analysis of Neural Cells and Tissues Using DNA Microarrays

Current Protocols in Neuroscience

Report on the Workshop “New Technologies in Stem Cell Research,” Society for Pediatric Research, San Francisco, California, April 29, 2006

Genetic Analysis of Anterior-Posterior Expression Gradients in the Developing Mammalian Forebrain

Cerebral Cortex

A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration

Degradation of Tau Protein by Puromycin-Sensitive Aminopeptidase in Vitro

FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains

Nature Neuroscience

Exercise Your Amyloid

Identification of a Hoxd10‐regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development

Journal of Neuroscience Research

Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters

Journal of Neuroscience Methods

Microarray Platforms: Introduction and Application to Neurobiology

International Review of Neurobiology

Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks

Developmental Biology

An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis

Nucleic Acids Research

Gene Expression Analysis Using cDNA Microarrays

Current Protocols in Neuroscience

Thresholding rules for recovering a sparse signal from microarray experiments

Mathematical Biosciences

Novel type of genetic rearrangement in the iduronate-2-sulfatase (IDS) gene involving deletion, duplications, and inversions

Identification of 9 novel IDS gene mutations in 19 unrelated Hunter syndrome (Mucopolysaccharidosis type II) patients

Mutational spectrum of the iduronate-2-sulfatase (IDS) gene in 36 unrelated Russian MPS II patients

The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17

Double-strand breaks may initiate the inversion mutation causing the Hunter syndrome

Human Molecular Genetics

Two Distinct Deletions in theIDSGene and the GeneW: A Novel Type of Mutation Associated with the Hunter Syndrome

Education

Uppsala University

PhD, Genetics and Pathology

Uppsala

Links & Social Media

NeuroInDx, Inc.

ORCID

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