Susan Song, MD/PhD

Research Assistant Professor in Neuroscience at University of Pittsburgh

Pittsburgh, Pennsylvania, United States of America

Research Expertise

microglia
white matter
neurodegenerative disease
Cellular and Molecular Neuroscience
Neurology
Cell Biology
Neurology (clinical)
Cardiology and Cardiovascular Medicine
Immunology
Biomedical Engineering
Molecular Biology
Developmental Neuroscience
Pharmacology (medical)
Psychiatry and Mental health
Pharmacology
Physiology (medical)

About

Susan Song, MD/PhD, is a highly accomplished neuroscientist, with extensive education and experience in the field. She received her MD/PhD in Neurology and Neuroscience from Southern Medical University in 2015, where she conducted groundbreaking research on the molecular mechanisms of neurodegenerative diseases. Following this, she completed a post-doctoral fellowship in Neuroscience at the University of Pittsburgh, where she continued to excel in her research and received numerous awards and grants for her work. Dr. Song's expertise lies in studying the underlying causes and potential treatments for various neurological diseases, such as ischemic stroke, traumatic brain injury, glioblastoma, Alzheimer's disease, and multiple sclerosis. She has a deep understanding of the brain and nervous system, and is constantly seeking new ways to unravel the complexities of these diseases. Dr. Song has held several prestigious positions throughout her career, including her current position as Research Assistant Professor at the University of Pittsburgh. She has published numerous articles in top scientific journals and presented her research at international conferences. Her findings have contributed greatly to the field of neurology and have the potential to improve the lives of millions of people suffering from neurological disorders. Overall, Dr. Song is a highly respected and accomplished physician-scientist who is making significant contributions to the field of neurology. With her extensive education, diverse experience, and unwavering dedication to her patients, she is a true leader in the field and a valuable asset to the medical community.

Publications

Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke

Glia / Sep 19, 2017

Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., Stolz, D. B., St. Croix, C., Watkins, S. C., Chen, Y., He, P., Shull, G. E., & Sun, D. (2017). Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia, 66(1), 126–144. Portico. https://doi.org/10.1002/glia.23232

Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke

Progress in Neurobiology / Apr 01, 2021

Song, S., Huang, H., Guan, X., Fiesler, V., Bhuiyan, M. I. H., Liu, R., Jalali, S., Hasan, M. N., Tai, A. K., Chattopadhyay, A., Chaparala, S., Sun, M., Stolz, D. B., He, P., Agalliu, D., Sun, D., & Begum, G. (2021). Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke. Progress in Neurobiology, 199, 101963. https://doi.org/10.1016/j.pneurobio.2020.101963

Ion channels and transporters in microglial function in physiology and brain diseases

Neurochemistry International / Jan 01, 2021

Luo, L., Song, S., Ezenwukwa, C. C., Jalali, S., Sun, B., & Sun, D. (2021). Ion channels and transporters in microglial function in physiology and brain diseases. Neurochemistry International, 142, 104925. https://doi.org/10.1016/j.neuint.2020.104925

Roles of glial ion transporters in brain diseases

Glia / Aug 16, 2019

Song, S., Luo, L., Sun, B., & Sun, D. (2019). Roles of glial ion transporters in brain diseases. Glia, 68(3), 472–494. Portico. https://doi.org/10.1002/glia.23699

A Novel Na + -K + -Cl Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke

Stroke / Apr 01, 2019

Huang, H., Bhuiyan, M. I. H., Jiang, T., Song, S., Shankar, S., Taheri, T., Li, E., Schreppel, P., Hintersteininger, M., Yang, S.-S., Lin, S.-H., Molyneaux, B. J., Zhang, Z., Erker, T., & Sun, D. (2019). A Novel Na + -K + -Cl − Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke. Stroke, 50(4), 1021–1025. https://doi.org/10.1161/strokeaha.118.024287

Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery

Glia / Jul 25, 2018

Song, S., Wang, S., Pigott, V. M., Jiang, T., Foley, L. M., Mishra, A., Nayak, R., Zhu, W., Begum, G., Shi, Y., Carney, K. E., Hitchens, T. K., Shull, G. E., & Sun, D. (2018). Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery. Glia, 66(11), 2279–2298. Portico. https://doi.org/10.1002/glia.23456

Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

Journal of Neuroinflammation / Aug 28, 2021

Liu, Q., Bhuiyan, M. I. H., Liu, R., Song, S., Begum, G., Young, C. B., Foley, L. M., Chen, F., Hitchens, T. K., Cao, G., Chattopadhyay, A., He, L., & Sun, D. (2021). Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function. Journal of Neuroinflammation, 18(1). https://doi.org/10.1186/s12974-021-02234-8

The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases

Aging and disease / Jan 01, 2019

Huang, H., Song, S., Banerjee, S., Jiang, T., Zhang, J., Kahle, K. T., Sun, D., & Zhang, Z. (2019). The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging and Disease, 10(3), 626. https://doi.org/10.14336/ad.2018.0928

Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Communications Biology / Jan 11, 2022

Song, S., Yu, L., Hasan, M. N., Paruchuri, S. S., Mullett, S. J., Sullivan, M. L. G., Fiesler, V. M., Young, C. B., Stolz, D. B., Wendell, S. G., & Sun, D. (2022). Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice. Communications Biology, 5(1). https://doi.org/10.1038/s42003-021-02984-4

WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats

Journal of Cerebral Blood Flow & Metabolism / Jan 01, 2016

Bhuiyan, M. I. H., Song, S., Yuan, H., Begum, G., Kofler, J., Kahle, K. T., Yang, S.-S., Lin, S.-H., Alper, S. L., Subramanya, A. R., & Sun, D. (2016). WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Journal of Cerebral Blood Flow & Metabolism, 37(8), 2780–2794. https://doi.org/10.1177/0271678x16675368

Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells

Theranostics / Jan 01, 2021

Hasan, M. N., Luo, L., Ding, D., Song, S., Bhuiyan, M. I. H., Liu, R., Foley, L. M., Guan, X., Kohanbash, G., Hitchens, T. K., Castro, M. G., Zhang, Z., & Sun, D. (2021). Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells. Theranostics, 11(3), 1295–1309. https://doi.org/10.7150/thno.50150

Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury

Journal of Neuroinflammation / Oct 05, 2022

Song, S., Hasan, M. N., Yu, L., Paruchuri, S. S., Bielanin, J. P., Metwally, S., Oft, H. C. M., Fischer, S. G., Fiesler, V. M., Sen, T., Gupta, R. K., Foley, L. M., Hitchens, T. K., Dixon, C. E., Cambi, F., Sen, N., & Sun, D. (2022). Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury. Journal of Neuroinflammation, 19(1). https://doi.org/10.1186/s12974-022-02608-6

Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation

Journal of Neural Engineering / Mar 19, 2021

Dubaniewicz, M., Eles, J. R., Lam, S., Song, S., Cambi, F., Sun, D., Wellman, S. M., & Kozai, T. D. Y. (2021). Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation. Journal of Neural Engineering, 18(4), 045001. https://doi.org/10.1088/1741-2552/abe8f1

Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke

International Journal of Molecular Sciences / Aug 27, 2023

Metwally, S. A. H., Paruchuri, S. S., Yu, L., Capuk, O., Pennock, N., Sun, D., & Song, S. (2023). Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke. International Journal of Molecular Sciences, 24(17), 13289. https://doi.org/10.3390/ijms241713289

Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells

Neural Regeneration Research / Jan 01, 2014

Jin, B., Jiang, X., Chang, H., Song, S., Chen, Z., Wang, Y., Yang, L., Du, M., Ke, Y., & Xu, R. (2014). Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells. Neural Regeneration Research, 9(5), 519. https://doi.org/10.4103/1673-5374.130079

Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1-BDNF signaling and microglia-oligodendrocyte crosstalk

Dec 11, 2023

Song, S., Oft, H., Metwally, S., Paruchuri, S., Bielanin, J., Fiesler, V., Sneiderman, C., Kohanbash, G., & Sun, D. (2023). Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1-BDNF signaling and microglia-oligodendrocyte crosstalk. https://doi.org/10.21203/rs.3.rs-3710892/v1

Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier

Frontiers in Cellular Neuroscience / Dec 01, 2023

Chen, Y., Lin, L., Bhuiyan, M. I. H., He, K., Jha, R., Song, S., Fiesler, V. M., Begum, G., Yin, Y., & Sun, D. (2023). Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1279385

Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas?

Journal of Neuro-Ophthalmology / Jul 05, 2023

Wei, Z., Taori, S., Song, S., Deng, H., Niranjan, A., & Lunsford, L. D. (2023). Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas? Journal of Neuro-Ophthalmology. https://doi.org/10.1097/wno.0000000000001914

Abstract P761: Reducing Reactive Astrocytes Improves Cognitive Function in a Mouse Model of Vascular Cognitive Impairment and Dementia

Stroke / Mar 01, 2021

Liu, Q., Bhuiyan, M. I., song, S., Begum, G., Liu, R., chen, fenghua, Cao, G., He, L., & Sun, D. (2021). Abstract P761: Reducing Reactive Astrocytes Improves Cognitive Function in a Mouse Model of Vascular Cognitive Impairment and Dementia. Stroke, 52(Suppl_1). https://doi.org/10.1161/str.52.suppl_1.p761

Microglia-oligodendrocyte interactions in post-injury brain repair

IBRO Reports / Sep 01, 2019

Sun, D. (2019). Microglia-oligodendrocyte interactions in post-injury brain repair. IBRO Reports, 6, S22. https://doi.org/10.1016/j.ibror.2019.07.056

Education

Southern Medical University

MD/PhD, Neurology, Neuroscience / June, 2015

Guangzhou

University of Pittsburgh

Post-doc, Neuroscience / December, 2019

Pittsburgh, Pennsylvania, United States of America

Experience

University of Pittsburgh

Research Assistant Professor / January, 2022Present

Research Instructor / January, 2020December, 2021

Postdoctoral Scholar / October, 2015December, 2019

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