Trupti Trivedi, Ph.D.

Ph.D. with over 22 years translational research experience

Research Expertise

Cancer
Bone
Diabetes
Vitamin D deficiency
Skeletal muscle

Legacy Map

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Publications

Excess TGF-β mediates muscle weakness associated with bone metastases in mice
Nature Medicine
2015
Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis
Bone
2010
Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling
Bone Research
2017
Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways
Journal of Bone and Mineral Research
2014
The Role of TGFβ in Bone-Muscle Crosstalk
Current Osteoporosis Reports
2017
The Role of TGF-β in Bone Metastases
Biomolecules
2021
The vitamin D receptor is involved in the regulation of human breast cancer cell growth via a ligand-independent function in cytoplasm
Oncotarget
2017
Systemic effects of abnormal bone resorption on muscle, metabolism, and cognition
Bone
2022
Aging‐associated skeletal muscle defects in HER2/Neu transgenic mammary tumour model
JCSM Rapid Communications
2020
Translational Strategies to Target Metastatic Bone Disease
Cells
2022
Low-Magnitude Mechanical Signals Combined with Zoledronic Acid Reduce Musculoskeletal Weakness and Adiposity in Estrogen-Deprived Mice
Unknown Venue
2023
#49. Complete estrogen-deprived athymic nude mice are susceptible to changes in metabolism and musculoskeletal function mediated by a high-fat diet
Journal of Bone Oncology
2024
Zoledronic acid improves bone quality and muscle function in a high bone turnover state
Unknown Venue
2023
#5. Activating RET mutations in medullary thyroid cancer cells promotes osteoblastic bone metastasis by inhibiting osteoclastogenesis and stimulating osteoblast activity
Journal of Bone Oncology
2024
Bone-derived excess TGF-ß release is associated with cognitive dysfunction due to oxidation of RyR, Ca2+ leak and mitochondrial dysfunction
Journal of Bone Oncology
2024
Impact of a Long-Term High Fat Diet on Bone Microarchitecture and Muscle Structure in Adult Male and Female Normal Mice
Proceedings of IMPRS
2019
Impact of excess TGFβ on bone and muscle in condition of diet-induced obesity in mice with Camurati-Engelmann Disease
Proceedings of IMPRS
2018
Apoptosis Induction by Targeting Interferon Gamma Receptor 2 (IFNgammaR2) in Prostate Cancer: Ligand (IFNgamma)-Independent Novel Function of IFNgammaR2 as a Bax Inhibitor
Unknown Venue
2013
The vitamin D receptor promotes human breast cancer cell growth via a ligand independent pathway
Bone
2011

Education

University of Sydney

Cancer and bone / November, 2014

Sydney, New South Wales, Australia

Links & Social Media

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