## Scientist Genomics I have my major, MSc, and PhD degrees in biology, human, and medical genetics. I have hands-on experience in a variety of molecular biology and genetic techniques and have worked on NGS library preparation, scRNA-seq, and data analysis. As shown in my resume (I can also send my CV if needed), in addition to genomic experiments, I have worked on other omic profiling such as epigenome (DNA methylation), proteomics, and transcriptomics in a variety of samples including human cells and animal tissues. With more than 20 years of work experience, I have worked in hospital, academic, and biotech settings and proactively had to take a strategic thinking and problem-solving approach. Thus, I am adaptable to changing directions and methods, and eager to work in a dynamic, fast-paced research and product development environment. I also have multiple experiences managing multicenter and international collaborations and managing multiple priorities in a cross-functional team. I personally give fundamental value to diversity and building new connections and collaborations, and learning from diverse team members. Continuous learning and teamwork are my core values. There are other examples of my attention to detail, optimizing and troubleshooting techniques and experiments in molecular biology, genomics, and NGS panel design. As an example of my resilience, in a collaboration between CZ Biohub and the Stanford Pediatrics Department, I had to pilot a split-seq and combinatorial barcoding NGS method for newborn lung samples from library preparation up to scRNA-seq analysis. With a strong background in genomics and biology and expertise in the wet lab and data analysis, I could be a valuable asset to the Product Development teams where they need someone to lead and advance genomics research and NGS technology development, outreach, and shaping the future of genomics research, especially in clinical genetics and medical genomics. As I pursue a multidisciplinary collaboration in my scientific rationale, particularly, I am eager to extend my dedication to commercialization and envision the genomics product for financial gain and bringing value to the market. In summary, I have expertise and am eager to continue to design, conduct, and optimize new biological and genomics experiments and elucidate underlying mechanisms. I have more than 20 years of direct work experience in clinical research, both within hospital settings and in functional genomics labs. These roles required me to perform a variety of monitoring tasks depending on the context. This included monitoring lab and patient data, as well as monitoring various types of data such as clinical, molecular, and omics data, including genomics and proteomics. I have experience in developing IVD tests such as NGS panels and Polygenic Risk Scores (PRS) for genetic diseases.

Mohsen Fathzadeh

Research Scientist, Genomics, Stanford University

Research Expertise

Genomic Medicine

Translational Genomics

Diabetes Prevention

Cardiometabolic Diseases

Single-Cell Genomics

Genetics

Genetics (clinical)

Molecular Biology

Endocrinology, Diabetes and Metabolism

Endocrinology

Hematology

Public Health, Environmental and Occupational Health

Cell Biology

Cardiology and Cardiovascular Medicine

Internal Medicine

Physiology (medical)

Pharmacology (medical)

About

Publications

A Form of the Metabolic Syndrome Associated with Mutations inDYRK1B

New England Journal of Medicine / May 15, 2014

Keramati, A. R., Fathzadeh, M., Go, G.-W., Singh, R., Choi, M., Faramarzi, S., Mane, S., Kasaei, M., Sarajzadeh-Fard, K., Hwa, J., Kidd, K. K., Babaee Bigi, M. A., Malekzadeh, R., Hosseinian, A., Babaei, M., Lifton, R. P., & Mani, A. (2014). A Form of the Metabolic Syndrome Associated with Mutations inDYRK1B. New England Journal of Medicine, 370(20), 1909–1919. https://doi.org/10.1056/nejmoa1301824

Rare NonconservativeLRP6Mutations Are Associated with Metabolic Syndrome

Human Mutation / Jun 18, 2013

Singh, R., Smith, E., Fathzadeh, M., Liu, W., Go, G.-W., Subrahmanyan, L., Faramarzi, S., McKenna, W., & Mani, A. (2013). Rare NonconservativeLRP6Mutations Are Associated with Metabolic Syndrome. Human Mutation, 34(9), 1221–1225. https://doi.org/10.1002/humu.22360

Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts

Molecular Biology Reports / Jun 27, 2007

Bazrgar, M., Karimi, M., Fathzadeh, M., Senemar, S., Peiravian, F., Shojaee, A., & Saadat, M. (2007). Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts. Molecular Biology Reports, 35(4), 495–499. https://doi.org/10.1007/s11033-007-9113-3

Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus

The American Journal of Human Genetics / Jun 01, 2016

Li, N., Subrahmanyan, L., Smith, E., Yu, X., Zaidi, S., Choi, M., Mane, S., Nelson-Williams, C., Behjati, M., Kazemi, M., Hashemi, M., Fathzadeh, M., Narayanan, A., Tian, L., Montazeri, F., Mani, M., Begleiter, M. L., Coon, B. G., Lynch, H. T., … Mani, A. (2016). Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. The American Journal of Human Genetics, 98(6), 1082–1091. https://doi.org/10.1016/j.ajhg.2016.03.022

Genetic Counseling in Southern Iran: Consanguinity and Reason for Referral

Journal of Genetic Counseling / Jun 13, 2008

Fathzadeh, M., Babaie Bigi, M. A., Bazrgar, M., Yavarian, M., Tabatabaee, H. R., & Akrami, S. M. (2008). Genetic Counseling in Southern Iran: Consanguinity and Reason for Referral. Journal of Genetic Counseling, 17(5), 472–479. Portico. https://doi.org/10.1007/s10897-008-9163-2

FAM13A affects body fat distribution and adipocyte function

Nature Communications / Mar 19, 2020

Fathzadeh, M., Li, J., Rao, A., Cook, N., Chennamsetty, I., Seldin, M., Zhou, X., Sangwung, P., Gloudemans, M. J., Keller, M., Attie, A., Yang, J., Wabitsch, M., Carcamo-Orive, I., Tada, Y., Lusis, A. J., Shin, M. K., Molony, C. M., McLaughlin, T., … Knowles, J. W. (2020). FAM13A affects body fat distribution and adipocyte function. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-15291-z

Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice

Cell Reports / Oct 01, 2016

Chennamsetty, I., Coronado, M., Contrepois, K., Keller, M. P., Carcamo-Orive, I., Sandin, J., Fajardo, G., Whittle, A. J., Fathzadeh, M., Snyder, M., Reaven, G., Attie, A. D., Bernstein, D., Quertermous, T., & Knowles, J. W. (2016). Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice. Cell Reports, 17(2), 527–540. https://doi.org/10.1016/j.celrep.2016.09.005

Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice

Journal of Clinical Investigation / Feb 01, 2022

Bhat, N., Narayanan, A., Fathzadeh, M., Kahn, M., Zhang, D., Goedeke, L., Neogi, A., Cardone, R. L., Kibbey, R. G., Fernandez-Hernando, C., Ginsberg, H. N., Jain, D., Shulman, G. I., & Mani, A. (2022). Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal of Clinical Investigation, 132(3). https://doi.org/10.1172/jci153724

Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major

Haematologica / Feb 01, 2007

Bazrgar, M., Karimi, M., Peiravian, F., & Fathzadeh, M. (2007). Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major. Haematologica, 92(2), 256–257. https://doi.org/10.3324/haematol.10708

Exploration of the Processes of “Iranian Journal of Public Health” During 2016-2019

Iranian Journal of Public Health / Jun 10, 2020

FARHUD, D. D. (2020). Exploration of the Processes of “Iranian Journal of Public Health” During 2016-2019. Iranian Journal of Public Health. https://doi.org/10.18502/ijph.v49i2.3121

The Human Arylamine N-Acetyltransferase Type 2 Gene: Genomics and Cardiometabolic Risk

Arylamine N-acetyltransferases in Health and Disease / Apr 04, 2018

Fathzadeh, M., Hein, D. W., & Knowles, J. W. (2018). The Human Arylamine N-Acetyltransferase Type 2 Gene: Genomics and Cardiometabolic Risk. In Arylamine N-acetyltransferases in Health and Disease (pp. 43–67). WORLD SCIENTIFIC. https://doi.org/10.1142/9789813232013_0002

Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1

Cellular Signalling / Feb 01, 2022

Bhat, N., Narayanan, A., Fathzadeh, M., Shah, K., Dianatpour, M., Abou Ziki, M. D., & Mani, A. (2022). Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1. Cellular Signalling, 90, 110186. https://doi.org/10.1016/j.cellsig.2021.110186

History of the Evolution of Cardiovascular Risk Factors and the Predictive Value of Traditional Risk-Factor-Based Risk Assessment

Asymptomatic Atherosclerosis / Feb 08, 2010

Khera, A. (2010). History of the Evolution of Cardiovascular Risk Factors and the Predictive Value of Traditional Risk-Factor-Based Risk Assessment. In Asymptomatic Atherosclerosis (pp. 89–105). Humana Press. https://doi.org/10.1007/978-1-60327-179-0_7

Non-performing Loans

Banking in China / Jan 01, 2007

Cousin, V. (2007). Non-performing Loans. In Banking in China (pp. 81–95). Palgrave Macmillan UK. https://doi.org/10.1057/9780230595842_7

Frequency of cystathionine β-synthase 844INS68 polymorphism in Southern Iran

Molecular Biology Reports / Nov 29, 2007

Senemar, S., Doroudchi, M., Pezeshki, A. M., Bazrgar, M., Torab-Jahromi, A., & Ghaderi, A. (2007). Frequency of cystathionine β-synthase 844INS68 polymorphism in Southern Iran. Molecular Biology Reports, 36(2), 353–356. https://doi.org/10.1007/s11033-007-9186-z

Dyrk1b is a key Regulatory Kinase Integrating Fgf, Shh and mTORC1 signaling in Skeletal Muscle Development and Homeostasis

Apr 23, 2020

Bhat, N., Narayanan, A., Fathzadeh, M., Srivastava, A., & Mani, A. (2020). Dyrk1b is a key Regulatory Kinase Integrating Fgf, Shh and mTORC1 signaling in Skeletal Muscle Development and Homeostasis. https://doi.org/10.1101/2020.04.22.055947

DYRK1B modifies insulin action in liver and skeletal muscle and predispose to atherosclerosis

Atherosclerosis / Jul 01, 2015

Fathzadeh, M., Keramati, A. R., Tavakkoly Bazzaz, J., Yarovinsky, T., Sarajzadeh, K., Amini, M., Noorafshan, A., Mehrabani, D., Dianatpour, M., Omrani, G. H. R., Bigi, M. A. B., Kasaei, M., Poustchi, H., Lifton, R., Malekzadeh, R., & Mani, A. (2015). DYRK1B modifies insulin action in liver and skeletal muscle and predispose to atherosclerosis. Atherosclerosis, 241(1), e23. https://doi.org/10.1016/j.atherosclerosis.2015.04.093

Whole Exome Analysis of Early Onset Alzheimer's Disease

Apr 01, 2013

Pericak-Vance, M. A. (2013). Whole Exome Analysis of Early Onset Alzheimer’s Disease. Defense Technical Information Center. https://doi.org/10.21236/ada602412

Abstract 554: The Association Of Multiple Variants In The TNXB Gene With Vascular Aneurysms And Dissections

Arteriosclerosis, Thrombosis, and Vascular Biology / May 01, 2022

Neogi, A., Towne, M., Dykas, D., Parsa, N., Attar, A., FATHZADEH, M., Bale, A., & Mani, A. (2022). Abstract 554: The Association Of Multiple Variants In The TNXB Gene With Vascular Aneurysms And Dissections. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(Suppl_1). https://doi.org/10.1161/atvb.42.suppl_1.554

SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease

Gene / Sep 01, 2018

Nasiri, M., Rauf, M., Kamfiroozie, H., Zibaeenezhad, M. J., & Jamali, Z. (2018). SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease. Gene, 672, 16–20. https://doi.org/10.1016/j.gene.2018.05.117

1736-P: Insulin Resistance and Mitochondrial Dysfunction Mediated by Nat1 Deficiency

Diabetes / Jun 01, 2020

SANGWUNG, P., FATHZADEH, M., & KNOWLES, J. (2020). 1736-P: Insulin Resistance and Mitochondrial Dysfunction Mediated by Nat1 Deficiency. Diabetes, 69(Supplement_1). https://doi.org/10.2337/db20-1736-p

Arylamine N-Acetyltransferases in Health and Disease

Sep 19, 2017

Laurieri, N., & Sim, E. (2017). Arylamine N-Acetyltransferases in Health and Disease: From Pharmacogenetics to Drug Discovery and Diagnostics. WORLD SCIENTIFIC. https://doi.org/10.1142/10763

Abstract 20140: Minibrain Relate Kinase / Dyrk1B Links Skeletal Muscle Glycolytic Metabolism with Insulin Resistance and Causes Metabolic Syndrome

Circulation / Nov 25, 2014

Fathzadeh, M., Keramati, A. R., Go, G., Singh, R., Sarajzadeh, K., Tavakkoly-Bazzaz, J., Noorafshan, A., Kasaei, M., Amini, M., Omrani, G. H. R., Babaee Bigi, M. A., Babaei, M., Hosseinian, A., Malekzadeh, R., Lifton, R., & Mani, A. (2014). Abstract 20140: Minibrain Relate Kinase / Dyrk1B Links Skeletal Muscle Glycolytic Metabolism with Insulin Resistance and Causes Metabolic Syndrome. Circulation, 130(suppl_2). https://doi.org/10.1161/circ.130.suppl_2.20140

The Metabolic Syndrome and DYRK1B

New England Journal of Medicine / Aug 21, 2014

The Metabolic Syndrome and DYRK1B. (2014). New England Journal of Medicine, 371(8), 784–786. https://doi.org/10.1056/nejmc1408235

Dyrk1b Displaces Fkbp12 from mTORC2, Causes its Activation and Triggers De Novo Lipogenesis: Implications for the Treatment of Diet-Induced Fatty Liver Disease

SSRN Electronic Journal / Jan 01, 2020

Bhat, N., Narayanan, A., Fathzadeh, M., Kahn, M., Goedeke, L., Neogi, A., Ginsberg, H. N., Jain, D., Shulman, G. I., & Mani, A. (2020). Dyrk1b Displaces Fkbp12 from mTORC2, Causes its Activation and Triggers De Novo Lipogenesis: Implications for the Treatment of Diet-Induced Fatty Liver Disease. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3680878

CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation

Nature Genetics / Jul 29, 2019

Esteghamat, F., Broughton, J. S., Smith, E., Cardone, R., Tyagi, T., Guerra, M., Szabó, A., Ugwu, N., Mani, M. V., Azari, B., Kayingo, G., Chung, S., Fathzadeh, M., Weiss, E., Bender, J., Mane, S., Lifton, R. P., Adeniran, A., Nathanson, M. H., … Mani, A. (2019). CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nature Genetics, 51(8), 1233–1243. https://doi.org/10.1038/s41588-019-0470-3

Dorothy Warburton (1936–2016)

The American Journal of Human Genetics / Oct 01, 2016

Hassold, T., Hook, E. B., & Jacobs, P. A. (2016). Dorothy Warburton (1936–2016). The American Journal of Human Genetics, 99(4), 1000. https://doi.org/10.1016/j.ajhg.2016.08.013

Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus

The American Journal of Human Genetics / Oct 01, 2016

Li, N., Subrahmanyan, L., Smith, E., Yu, X., Zaidi, S., Choi, M., Mane, S., Nelson-Williams, C., Behjati, M., Kazemi, M., Hashemi, M., Fathzadeh, M., Narayanan, A., Tian, L., Montazeri, F., Mani, M., Begleiter, M. L., Coon, B. G., Lynch, H. T., … Mani, A. (2016). Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. The American Journal of Human Genetics, 99(4), 1000. https://doi.org/10.1016/j.ajhg.2016.09.003

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Journal of Diabetes Research / Jan 01, 2015

Wang, S., Song, K., Srivastava, R., Fathzadeh, M., Li, N., & Mani, A. (2015). The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis. Journal of Diabetes Research, 2015, 1–10. https://doi.org/10.1155/2015/468627

Education

Tehran University of Medical Sciences

Medical Genetics / 2015

Tehran

Stanford University

PhD Fellowship, Genetics / 2021

Stanford, California, United States of America

Yale University

Postgraduate, Cardiovascular Genetics / 2015

New Haven, Connecticut, United States of America

Experience

Stanford U

Links & Social Media

Research Web Site

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Mohsen Fathzadeh

Research Scientist, Genomics, Stanford University

Research Expertise

About

Publications

A Form of the Metabolic Syndrome Associated with Mutations inDYRK1B

Rare NonconservativeLRP6Mutations Are Associated with Metabolic Syndrome

Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts

Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus

Genetic Counseling in Southern Iran: Consanguinity and Reason for Referral

FAM13A affects body fat distribution and adipocyte function

Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice

Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice

Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major

Exploration of the Processes of “Iranian Journal of Public Health” During 2016-2019

The Human Arylamine N-Acetyltransferase Type 2 Gene: Genomics and Cardiometabolic Risk

Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1

History of the Evolution of Cardiovascular Risk Factors and the Predictive Value of Traditional Risk-Factor-Based Risk Assessment

Non-performing Loans

Frequency of cystathionine β-synthase 844INS68 polymorphism in Southern Iran

Dyrk1b is a key Regulatory Kinase Integrating Fgf, Shh and mTORC1 signaling in Skeletal Muscle Development and Homeostasis

DYRK1B modifies insulin action in liver and skeletal muscle and predispose to atherosclerosis

Whole Exome Analysis of Early Onset Alzheimer's Disease

Abstract 554: The Association Of Multiple Variants In The TNXB Gene With Vascular Aneurysms And Dissections

SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease

1736-P: Insulin Resistance and Mitochondrial Dysfunction Mediated by Nat1 Deficiency

Arylamine N-Acetyltransferases in Health and Disease

Abstract 20140: Minibrain Relate Kinase / Dyrk1B Links Skeletal Muscle Glycolytic Metabolism with Insulin Resistance and Causes Metabolic Syndrome

The Metabolic Syndrome and DYRK1B

Dyrk1b Displaces Fkbp12 from mTORC2, Causes its Activation and Triggers De Novo Lipogenesis: Implications for the Treatment of Diet-Induced Fatty Liver Disease

CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation

Dorothy Warburton (1936–2016)

Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Education

Tehran University of Medical Sciences

Stanford University

Yale University

Experience

Stanford U

Links & Social Media

Research Web Site

Join Mohsen on NotedSource!

Join Now

Expert Institutions

Proudly trusted by