Mohsen Fathzadeh

Research Scientist, Genomics, Stanford University

Research Expertise

Genomic Medicine
Translational Genomics
Diabetes Prevention
Cardiometabolic Diseases
Single-Cell Genomics
Genetics
Genetics (clinical)
Molecular Biology
Endocrinology, Diabetes and Metabolism
Endocrinology
Hematology
Public Health, Environmental and Occupational Health
Cell Biology
Cardiology and Cardiovascular Medicine
Internal Medicine
Physiology (medical)
Pharmacology (medical)

About

## Scientist Genomics I have my major, MSc, and PhD degrees in biology, human, and medical genetics. I have hands-on experience in a variety of molecular biology and genetic techniques and have worked on NGS library preparation, scRNA-seq, and data analysis. As shown in my resume (I can also send my CV if needed), in addition to genomic experiments, I have worked on other omic profiling such as epigenome (DNA methylation), proteomics, and transcriptomics in a variety of samples including human cells and animal tissues. With more than 20 years of work experience, I have worked in hospital, academic, and biotech settings and proactively had to take a strategic thinking and problem-solving approach. Thus, I am adaptable to changing directions and methods, and eager to work in a dynamic, fast-paced research and product development environment. I also have multiple experiences managing multicenter and international collaborations and managing multiple priorities in a cross-functional team. I personally give fundamental value to diversity and building new connections and collaborations, and learning from diverse team members. Continuous learning and teamwork are my core values. There are other examples of my attention to detail, optimizing and troubleshooting techniques and experiments in molecular biology, genomics, and NGS panel design. As an example of my resilience, in a collaboration between CZ Biohub and the Stanford Pediatrics Department, I had to pilot a split-seq and combinatorial barcoding NGS method for newborn lung samples from library preparation up to scRNA-seq analysis. With a strong background in genomics and biology and expertise in the wet lab and data analysis, I could be a valuable asset to the Product Development teams where they need someone to lead and advance genomics research and NGS technology development, outreach, and shaping the future of genomics research, especially in clinical genetics and medical genomics. As I pursue a multidisciplinary collaboration in my scientific rationale, particularly, I am eager to extend my dedication to commercialization and envision the genomics product for financial gain and bringing value to the market. In summary, I have expertise and am eager to continue to design, conduct, and optimize new biological and genomics experiments and elucidate underlying mechanisms. I have more than 20 years of direct work experience in clinical research, both within hospital settings and in functional genomics labs. These roles required me to perform a variety of monitoring tasks depending on the context. This included monitoring lab and patient data, as well as monitoring various types of data such as clinical, molecular, and omics data, including genomics and proteomics. I have experience in developing IVD tests such as NGS panels and Polygenic Risk Scores (PRS) for genetic diseases.

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Publications

A Form of the Metabolic Syndrome Associated with Mutations inDYRK1B
New England Journal of Medicine
2014
Rare NonconservativeLRP6Mutations Are Associated with Metabolic Syndrome
Human Mutation
2013
Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts
Molecular Biology Reports
2007
Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus
The American Journal of Human Genetics
2016
Genetic Counseling in Southern Iran: Consanguinity and Reason for Referral
Journal of Genetic Counseling
2008
FAM13A affects body fat distribution and adipocyte function
Nature Communications
2020
Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice
Cell Reports
2016
Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice
Journal of Clinical Investigation
2022
Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major
Haematologica
2007
Exploration of the Processes of “Iranian Journal of Public Health” During 2016-2019
Iranian Journal of Public Health
2020
The Human Arylamine N-Acetyltransferase Type 2 Gene: Genomics and Cardiometabolic Risk
Arylamine N-acetyltransferases in Health and Disease
2018
Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1
Cellular Signalling
2022
History of the Evolution of Cardiovascular Risk Factors and the Predictive Value of Traditional Risk-Factor-Based Risk Assessment
Asymptomatic Atherosclerosis
2010
Non-performing Loans
Banking in China
2007
Frequency of cystathionine β-synthase 844INS68 polymorphism in Southern Iran
Molecular Biology Reports
2007
Dyrk1b is a key Regulatory Kinase Integrating Fgf, Shh and mTORC1 signaling in Skeletal Muscle Development and Homeostasis
Unknown Venue
2020
DYRK1B modifies insulin action in liver and skeletal muscle and predispose to atherosclerosis
Atherosclerosis
2015
Whole Exome Analysis of Early Onset Alzheimer's Disease
Unknown Venue
2013
Abstract 554: The Association Of Multiple Variants In The TNXB Gene With Vascular Aneurysms And Dissections
Arteriosclerosis, Thrombosis, and Vascular Biology
2022
SIRT1 gene polymorphisms associated with decreased risk of atherosclerotic coronary artery disease
Gene
2018
1736-P: Insulin Resistance and Mitochondrial Dysfunction Mediated by Nat1 Deficiency
Diabetes
2020
Arylamine N-Acetyltransferases in Health and Disease
Unknown Venue
2017
Abstract 20140: Minibrain Relate Kinase / Dyrk1B Links Skeletal Muscle Glycolytic Metabolism with Insulin Resistance and Causes Metabolic Syndrome
Circulation
2014
The Metabolic Syndrome and DYRK1B
New England Journal of Medicine
2014
Dyrk1b Displaces Fkbp12 from mTORC2, Causes its Activation and Triggers De Novo Lipogenesis: Implications for the Treatment of Diet-Induced Fatty Liver Disease
SSRN Electronic Journal
2020
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation
Nature Genetics
2019
Dorothy Warburton (1936–2016)
The American Journal of Human Genetics
2016
Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus
The American Journal of Human Genetics
2016
The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis
Journal of Diabetes Research
2015

Education

Tehran University of Medical Sciences

Medical Genetics / 2015

Tehran

Stanford University

PhD Fellowship, Genetics / 2021

Stanford, California, United States of America

Yale University

Postgraduate, Cardiovascular Genetics / 2015

New Haven, Connecticut, United States of America

Experience

Stanford U

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