John Bilello Ph.D.
Principal and Consultant at Innovalyst ICAN
About
Publications
(132) Use of a depression biomarker panel to diagnose depression in chronic pain patients
The Journal of Pain / Apr 01, 2015
Tennant, F., Bilello, J., & Thurmond, L. (2015). (132) Use of a depression biomarker panel to diagnose depression in chronic pain patients. The Journal of Pain, 16(4), S9. https://doi.org/10.1016/j.jpain.2015.01.046
MDDScore
The Journal of Clinical Psychiatry / Feb 25, 2015
Bilello, J. A., Thurmond, L. M., Smith, K. M., Pi, B., Rubin, R., Wright, S. M., Taub, F., Henry, M. E., Shelton, R. C., & Papakostas, G. I. (2015). MDDScore: Confirmation of a Blood Test to Aid in the Diagnosis of Major Depressive Disorder. The Journal of Clinical Psychiatry, 76(02), e199–e206. https://doi.org/10.4088/jcp.14m09029
MDDScore and Biomarker Profiling in Patients Treated with Transcranial Magnetic Stimulation: Preliminary Data
Brain Stimulation / Sep 01, 2014
Bilello, J. A., Thurmond, L. M., Vaishnavi, S., & Kinback, K. M. (2014). MDDScore and Biomarker Profiling in Patients Treated with Transcranial Magnetic Stimulation: Preliminary Data. Brain Stimulation, 7(5), e17. https://doi.org/10.1016/j.brs.2014.07.002
The diagnosis of depression: current and emerging methods
Comprehensive Psychiatry / Jan 01, 2013
Smith, K. M., Renshaw, P. F., & Bilello, J. (2013). The diagnosis of depression: current and emerging methods. Comprehensive Psychiatry, 54(1), 1–6. https://doi.org/10.1016/j.comppsych.2012.06.006
Development of novel approaches to the evaluation of virucidal agents: separation of treated virions from test compounds
AIDS / Feb 01, 2001
Bilello, J., Belay, S., & Weislow, O. S. (2001). Development of novel approaches to the evaluation of virucidal agents: separation of treated virions from test compounds. AIDS, 15, S39. https://doi.org/10.1097/00002030-200102001-00056
The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic
Antimicrobial Agents and Chemotherapy / Apr 01, 2000
Snyder, S., D’Argenio, D. Z., Weislow, O., Bilello, J. A., & Drusano, G. L. (2000). The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic. Antimicrobial Agents and Chemotherapy, 44(4), 1051–1058. https://doi.org/10.1128/aac.44.4.1051-1058.2000
A 24-week open-label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir)
AIDS / May 01, 1996
Stein, D. S., Fish, D. G., Bilello, J. A., Preston, S. L., Martineau, G. L., & Drusano, G. L. (1996). A 24-week open-label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS, 10(5), 485–492. https://doi.org/10.1097/00002030-199605000-00006
Reduction Of The In Vitro Activity Of A77003, An Inhibitor Of Human Immunodeficiency Virus Protease, By Human Serum 1 Acid Glycoprotein
Journal of Infectious Diseases / Mar 01, 1995
Bilello, J. A., Bilello, P. A., Prichard, M., Robins, T., & Drusano, G. L. (1995). Reduction Of The In Vitro Activity Of A77003, An Inhibitor Of Human Immunodeficiency Virus Protease, By Human Serum 1 Acid Glycoprotein. Journal of Infectious Diseases, 171(3), 546–551. https://doi.org/10.1093/infdis/171.3.546
In vitro pharmacodynamic modeling of anti-retroviral agents and interferon
Antiviral Research / Apr 01, 1991
Bilello, J. A., Dudley, M. N., & Drusano, G. L. (1991). In vitro pharmacodynamic modeling of anti-retroviral agents and interferon. Antiviral Research, 15, 151. https://doi.org/10.1016/0166-3542(91)90290-8
Lymphocyte transformation abnormalities in bovine immunodeficiency-like virus infected calves
Immunology Letters / Feb 01, 1991
Martin, S. J., O’Neill, T. P., Bilello, J. A., & Eiseman, J. L. (1991). Lymphocyte transformation abnormalities in bovine immunodeficiency-like virus infected calves. Immunology Letters, 27(2), 81–84. https://doi.org/10.1016/0165-2478(91)90132-t
Altered cellular functions in a PC-12 cell clone chronically infected with retrovirus
Biochemical and Biophysical Research Communications / Oct 01, 1986
Bilello, J. A., Hoffman, P. M., & Max, S. R. (1986). Altered cellular functions in a PC-12 cell clone chronically infected with retrovirus. Biochemical and Biophysical Research Communications, 140(2), 706–714. https://doi.org/10.1016/0006-291x(86)90789-8
Interferon-induced alterations in membrane functions and the growth of Daudi lymphoma and Friend leukemia cells
Bioscience Reports / Aug 01, 1982
Siegler, E., Schaefer, A., & Bilello, J. A. (1982). Interferon-induced alterations in membrane functions and the growth of Daudi lymphoma and Friend leukemia cells. Bioscience Reports, 2(8), 605–608. https://doi.org/10.1007/bf01314223
Biosynthesis, Modification and Processing of Viral Polyproteins
Protein Biosynthesis in Eukaryotes / Jan 01, 1982
Koch, G., Koch, F., Bilello, J. A., Hiller, E., Schârli, C., Warnecke, G., & Weber, C. (1982). Biosynthesis, Modification and Processing of Viral Polyproteins. In Protein Biosynthesis in Eukaryotes (pp. 275–309). Springer US. https://doi.org/10.1007/978-1-4684-4124-6_12
ALTERATIONS IN THE PROCESSING AND SHEDDING OF RETROVIRUS PROTEINS IN FRIEND ERYTHROLEUKEMIA CELLS
Biosynthesis, Modification, and Processing of Cellular and Viral Polyproteins / Jan 01, 1980
Bilello, J. A., Warnecke, G., Weber, C., & Koch, G. (1980). ALTERATIONS IN THE PROCESSING AND SHEDDING OF RETROVIRUS PROTEINS IN FRIEND ERYTHROLEUKEMIA CELLS. In Biosynthesis, Modification, and Processing of Cellular and Viral Polyproteins (pp. 185–201). Elsevier. https://doi.org/10.1016/b978-0-12-417560-0.50021-0
SFFV SPECIFIC GENE EXPRESSION IN INFECTED AND ERYTHROLEUKEMIA CELLS
Animal Virus Genetics / Jan 01, 1980
Frisby, D., Colletta, G., Pragnell, I., Ostertag, W., Bilello, J., Warnecke, G., & Koch, G. (1980). SFFV SPECIFIC GENE EXPRESSION IN INFECTED AND ERYTHROLEUKEMIA CELLS. In Animal Virus Genetics (pp. 411–423). Elsevier. https://doi.org/10.1016/b978-0-12-255850-4.50041-x
Growth of Murine Sarcoma Virus-Transformed Rat Kidney Cells in Nude Mice: Absence of Induction of Host Endogenous Viruses 2
JNCI: Journal of the National Cancer Institute / Jun 01, 1977
Bilello, J. A., Freedman, V. H., & Shin, S. (1977). Growth of Murine Sarcoma Virus-Transformed Rat Kidney Cells in Nude Mice: Absence of Induction of Host Endogenous Viruses 2. JNCI: Journal of the National Cancer Institute, 58(6), 1691–1694. https://doi.org/10.1093/jnci/58.6.1691
Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain
Postgraduate Medicine / Dec 17, 2016
Bilello, J. A., & Tennant, F. S. (2016). Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. Postgraduate Medicine, 129(1), 87–91. https://doi.org/10.1080/00325481.2017.1270155
Seeking an objective diagnosis of depression
Biomarkers in Medicine / Aug 01, 2016
Bilello, J. A. (2016). Seeking an objective diagnosis of depression. Biomarkers in Medicine, 10(8), 861–875. https://doi.org/10.2217/bmm-2016-0076
A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients
Molecular Psychiatry / Dec 08, 2015
Fava, M., Johe, K., Ereshefsky, L., Gertsik, L. G., English, B. A., Bilello, J. A., Thurmond, L. M., Johnstone, J., Dickerson, B. C., Makris, N., Hoeppner, B. B., Flynn, M., Mischoulon, D., Kinrys, G., & Freeman, M. P. (2015). A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients. Molecular Psychiatry, 21(10), 1372–1380. https://doi.org/10.1038/mp.2015.178
Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a Pilot and Replication Study
Molecular Psychiatry / Dec 13, 2011
Papakostas, G. I., Shelton, R. C., Kinrys, G., Henry, M. E., Bakow, B. R., Lipkin, S. H., Pi, B., Thurmond, L., & Bilello, J. A. (2011). Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a Pilot and Replication Study. Molecular Psychiatry, 18(3), 332–339. https://doi.org/10.1038/mp.2011.166
Matrix metalloproteinases during and outside of migraine attacks without aura
Cephalalgia / Aug 01, 2009
Ashina, M., Tvedskov, J., Lipka, K., Bilello, J., Penkowa, M., & Olesen, J. (2009). Matrix metalloproteinases during and outside of migraine attacks without aura. Cephalalgia, 30(3), 303–310. https://doi.org/10.1111/j.1468-2982.2009.01954.x
Profiling serum biomarkers in patients with COPD: associations with clinical parameters
Thorax / Feb 27, 2007
Pinto-Plata, V., Toso, J., Lee, K., Park, D., Bilello, J., Mullerova, H., De Souza, M. M., Vessey, R., & Celli, B. (2007). Profiling serum biomarkers in patients with COPD: associations with clinical parameters. Thorax, 62(7), 595–601. https://doi.org/10.1136/thx.2006.064428
Use of Proteomic Patterns of Serum Biomarkers in Patients with Chronic Obstructive Pulmonary Disease: Correlation with Clinical Parameters
Proceedings of the American Thoracic Society / Aug 01, 2006
Pinto-Plata, V. (2006). Use of Proteomic Patterns of Serum Biomarkers in Patients with Chronic Obstructive Pulmonary Disease: Correlation with Clinical Parameters. Proceedings of the American Thoracic Society, 3(6), 465–466. https://doi.org/10.1513/pats.200603-030ms
The Agony and Ecstasy of “OMIC” Technologies in Drug Development
Current Molecular Medicine / Feb 01, 2005
Bilello, J. (2005). The Agony and Ecstasy of “OMIC” Technologies in Drug Development. Current Molecular Medicine, 5(1), 39–52. https://doi.org/10.2174/1566524053152898
In Vitro-In Vivo Model for Evaluating the Antiviral Activity of Amprenavir in Combination with Ritonavir Administered at 600 and 100 Milligrams, Respectively, Every 12 Hours
Antimicrobial Agents and Chemotherapy / Nov 01, 2003
Preston, S. L., Piliero, P. J., Bilello, J. A., Stein, D. S., Symonds, W. T., & Drusano, G. L. (2003). In Vitro-In Vivo Model for Evaluating the Antiviral Activity of Amprenavir in Combination with Ritonavir Administered at 600 and 100 Milligrams, Respectively, Every 12 Hours. Antimicrobial Agents and Chemotherapy, 47(11), 3393–3399. https://doi.org/10.1128/aac.47.11.3393-3399.2003
Pharmacodynamics of Abacavir in an In Vitro Hollow-Fiber Model System
Antimicrobial Agents and Chemotherapy / Feb 01, 2002
Drusano, G. L., Bilello, P. A., Symonds, W. T., Stein, D. S., McDowell, J., Bye, A., & Bilello, J. A. (2002). Pharmacodynamics of Abacavir in an In Vitro Hollow-Fiber Model System. Antimicrobial Agents and Chemotherapy, 46(2), 464–470. https://doi.org/10.1128/aac.46.2.464-470.2002
Hollow‐Fiber Unit Evaluation of a New Human Immunodeficiency Virus Type 1 Protease Inhibitor, BMS‐232632, for Determination of the Linked Pharmacodynamic Variable
The Journal of Infectious Diseases / Apr 01, 2001
Drusano, G. L., Bilello, J. A., Preston, S. L., O’Mara, E., Kaul, S., Schnittman, S., & Echols, R. (2001). Hollow‐Fiber Unit Evaluation of a New Human Immunodeficiency Virus Type 1 Protease Inhibitor, BMS‐232632, for Determination of the Linked Pharmacodynamic Variable. The Journal of Infectious Diseases, 183(7), 1126–1129. https://doi.org/10.1086/319281
Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir
Antimicrobial Agents and Chemotherapy / Jun 01, 2000
Drusano, G. L., D’Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., Rogers, M., Prince, W., Bye, A., & Bilello, J. A. (2000). Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir. Antimicrobial Agents and Chemotherapy, 44(6), 1655–1659. https://doi.org/10.1128/aac.44.6.1655-1659.2000
The Safety and Efficacy of Granulocyte‐Macrophage Colony‐Stimulating Factor (Sargramostim) Added to Indinavir‐ or Ritonavir‐Based Antiretroviral Therapy: A Randomized Double‐Blind, Placebo‐Controlled Trial
The Journal of Infectious Diseases / Oct 01, 1999
Skowron, G., Stein, D., Drusano, G., Melbourne, K., Bilello, J., Mikolich, D., Rana, K., Agosti, J. M., Mongillo, A., Whitmore, J., & Gilbert, M. J. (1999). The Safety and Efficacy of Granulocyte‐Macrophage Colony‐Stimulating Factor (Sargramostim) Added to Indinavir‐ or Ritonavir‐Based Antiretroviral Therapy: A Randomized Double‐Blind, Placebo‐Controlled Trial. The Journal of Infectious Diseases, 180(4), 1064–1071. https://doi.org/10.1086/314981
Nucleoside Analog 1592U89 and Human Immunodeficiency Virus Protease Inhibitor 141W94 Are Synergistic In Vitro
Antimicrobial Agents and Chemotherapy / Sep 01, 1998
Drusano, G. L., D’Argenio, D. Z., Symonds, W., Bilello, P. A., McDowell, J., Sadler, B., Bye, A., & Bilello, J. A. (1998). Nucleoside Analog 1592U89 and Human Immunodeficiency Virus Protease Inhibitor 141W94 Are Synergistic In Vitro. Antimicrobial Agents and Chemotherapy, 42(9), 2153–2159. https://doi.org/10.1128/aac.42.9.2153
Phenotypic Variability of Lymphocyte Populations in Peripheral Blood and Lymph Nodes from HIV-Infected Individuals and the Impact of Antiretroviral Therapy
AIDS Research and Human Retroviruses / Mar 20, 1998
LANDAY, A. L., BETHEL, J., & SCHNITTMAN, S. (1998). Phenotypic Variability of Lymphocyte Populations in Peripheral Blood and Lymph Nodes from HIV-Infected Individuals and the Impact of Antiretroviral Therapy. AIDS Research and Human Retroviruses, 14(5), 445–451. https://doi.org/10.1089/aid.1998.14.445
Factors Influencing the Emergence of Resistance to Indinavir: Role of Virologic, Immunologic, and Pharmacologic Variables
Journal of Infectious Diseases / Aug 01, 1998
Drusano, G. L., Bilello, J. A., Stein, D. S., Nessly, M., Meibohm, A., Emini, E. A., Deutsch, P., Condra, J., Chodakewitz, J., & Holder, D. J. (1998). Factors Influencing the Emergence of Resistance to Indinavir: Role of Virologic, Immunologic, and Pharmacologic Variables. Journal of Infectious Diseases, 178(2), 360–367. https://doi.org/10.1086/515631
Predicting Clinical Progression or Death in Subjects with Early‐Stage Human Immunodeficiency Virus (HIV) Infection: A Comparative Analysis of Quantification of HIV RNA, Soluble Tumor Necrosis Factor Type II Receptors, Neopterin, and $\beta _{2}$ -Microglobulin
The Journal of Infectious Diseases / Nov 01, 1997
Stein, D. S., Lyles, R. H., Graham, N. M. H., Tassoni, C. J., Margolick, J. B., Phair, J. P., Rinaldo, C., Saah, R. D. A., & Bilello, J. (1997). Predicting Clinical Progression or Death in Subjects with Early‐Stage Human Immunodeficiency Virus (HIV) Infection: A Comparative Analysis of Quantification of HIV RNA, Soluble Tumor Necrosis Factor Type II Receptors, Neopterin, and $\beta _{2}$ -Microglobulin. The Journal of Infectious Diseases, 176(5), 1161–1167. https://doi.org/10.1086/514108
Soluble Tumor Necrosis Factor- Receptor Type II (sTNF RII) Correlates with Human Immunodeficiency Virus (HIV) RNA Copy Number in HIV-Infected Patients
Journal of Infectious Diseases / Feb 01, 1996
Bilello, J. A., Stellrecht, K., Drusano, G. L., & Stein, D. S. (1996). Soluble Tumor Necrosis Factor- Receptor Type II (sTNF RII) Correlates with Human Immunodeficiency Virus (HIV) RNA Copy Number in HIV-Infected Patients. Journal of Infectious Diseases, 173(2), 464–467. https://doi.org/10.1093/infdis/173.2.464
Antiretroviral Monotherapy in Early Stage Human Immunodeficiency Virus Disease Has No Detectable Effect on Virus Load in Peripheral Blood and Lymph Nodes
Journal of Infectious Diseases / Apr 01, 1996
Cohen, O. J., Pantaleo, G., Holodniy, M., Fox, C. H., Orenstein, J. M., Schnittman, S., Niu, M., Graziosi, C., Pavlakis, G. N., Lalezari, J., Bartlett, J. A., Steigbigel, R. T., Cohn, J., Novak, R., McMahon, D., Bilello, J., & Fauci, A. S. (1996). Antiretroviral Monotherapy in Early Stage Human Immunodeficiency Virus Disease Has No Detectable Effect on Virus Load in Peripheral Blood and Lymph Nodes. Journal of Infectious Diseases, 173(4), 849–856. https://doi.org/10.1093/infdis/173.4.849
Modeling combinations of antiretroviral agents in vitro with integration of pharmacokinetics: guidance in regimen choice for clinical trial evaluation
Antimicrobial Agents and Chemotherapy / May 01, 1996
Drusano, G. L., Prichard, M., Bilello, P. A., & Bilello, J. A. (1996). Modeling combinations of antiretroviral agents in vitro with integration of pharmacokinetics: guidance in regimen choice for clinical trial evaluation. Antimicrobial Agents and Chemotherapy, 40(5), 1143–1147. https://doi.org/10.1128/aac.40.5.1143
Relevance of Plasma Protein Binding to Antiviral Activity and Clinical Efficacy of Inhibitors of Human Immunodeficiency Virus Protease
Journal of Infectious Diseases / Jun 01, 1996
Bilello, J. A., & Drusano, G. L. (1996). Relevance of Plasma Protein Binding to Antiviral Activity and Clinical Efficacy of Inhibitors of Human Immunodeficiency Virus Protease. Journal of Infectious Diseases, 173(6), 1524–1525. https://doi.org/10.1093/infdis/173.6.1524
Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease
Antimicrobial Agents and Chemotherapy / Jun 01, 1996
Bilello, J. A., Bilello, P. A., Stellrecht, K., Leonard, J., Norbeck, D. W., Kempf, D. J., Robins, T., & Drusano, G. L. (1996). Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease. Antimicrobial Agents and Chemotherapy, 40(6), 1491–1497. https://doi.org/10.1128/aac.40.6.1491
Transmission in NFS/N mice of the heritable spongiform encephalopathy associated with the gray tremor mutation.
Proceedings of the National Academy of Sciences / Jun 01, 1987
Hoffman, P. M., Rohwer, R. G., MacAuley, C., Bilello, J. A., Hartley, J. W., & Morse, H. C. (1987). Transmission in NFS/N mice of the heritable spongiform encephalopathy associated with the gray tremor mutation. Proceedings of the National Academy of Sciences, 84(11), 3866–3870. https://doi.org/10.1073/pnas.84.11.3866
Murine Sarcoma Virus Gene Expression: Transformants Which Express Viral Envelope Glycoprotein In The Absence Of The Major Internal Protein And Infectious Particles
Proceedings of the National Academy of Sciences / Aug 01, 1974
Bilello, J. A., Strand, M., & August, J. T. (1974). Murine Sarcoma Virus Gene Expression: Transformants Which Express Viral Envelope Glycoprotein In The Absence Of The Major Internal Protein And Infectious Particles. Proceedings of the National Academy of Sciences, 71(8), 3234–3238. https://doi.org/10.1073/pnas.71.8.3234
Education
Albert Einstein College of Medicine
Ph.D/Molecular Biology, Molecular Biology / June, 1977
Southern Illinois University Carbondale
MA/Microbiology, Microbiology / June, 1969
City College of New York
BS, Biology / January, 1966
Albert Einstein College of Medicine
Ph.D/Molecular Biology, Molecular Biology / June, 1977
Southern Illinois University Carbondale
MA/Microbiology, Microbiology / June, 1969
City College of New York
BS, Biology / January, 1966
Experience
Innovalyst ICAN
Principal / July, 2018 — Present
Principal / July, 2018 — Present
Atlantic Diagnostic Laboratory
Scientific Officer / January, 2017 — Present
Scientific Officer / January, 2017 — Present
Ridge Diagnostic Laboratories
President and Chief Scientific Officer / January, 2009 — December, 2016
President and Chief Scientific Officer / January, 2009 — December, 2016
Ridge Diagnostics
Founder/Chief Scientific Officer / January, 2006 — December, 2008
Founder/Chief Scientific Officer / January, 2006 — December, 2008
GlaxoSmithKline
Director Technology Development / October, 2002 — December, 2005
Senior Therapeutic Area Advisor for Antivirals / January, 2002 — October, 2002
Director Technology Development / October, 2002 — December, 2005
Senior Therapeutic Area Advisor for Antivirals / January, 2002 — October, 2002
Virco Lab
Director, Preclinical Research and Development / June, 2000 — June, 2002
Director, Preclinical Research and Development / June, 2000 — June, 2002
SRA Life Sciences
1998 — 2000
1998 — 2000
Albany Medical College
Associate Professor of Medicine / 1992 — 1998
Associate Professor of Medicine / 1992 — 1998
Baltimore VA Medical Center
Chief, Molecular Biology Laboratory / 1985 — 1992
Chief, Molecular Biology Laboratory / 1985 — 1992
University of Maryland Baltimore
Assistant Professor / 1983 — 1989
Assistant Professor / 1983 — 1989
Johns Hopkins Medicine
Instructor / 1981 — 1983
Instructor / 1981 — 1983
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