Work with Brad E Hoffman | NotedSource
University of South Florida
https://cv.notedsource.io/me/47RX8W4J
Brad E Hoffman
University of South Florida
Research Expertise
Immunology
Gene Therapy
Immunotherapy
Regulatory T cells (Tregs)
Immune Tolerance
Legacy Map
Full ViewPublications
Immunopathology of secondary‐progressive
multiple sclerosis
Annals of Neurology
2001
Hepatic Gene Transfer as a Means of
Tolerance Induction to Transgene Products
Current Gene Therapy
2009
Oral delivery of bioencapsulated
coagulation factor IX prevents inhibitor
formation and fatal anaphylaxis in
hemophilia B mice
Proceedings of the National Academy of
Sciences
2010
High-efficiency Transduction and
Correction of Murine Hemophilia B Using
AAV2 Vectors Devoid of Multiple
Surface-exposed Tyrosines
Molecular Therapy
2010
Superior In vivo Transduction of Human
Hepatocytes Using Engineered AAV3 Capsid
Molecular Therapy
2016
Plasmacytoid and conventional dendritic
cells cooperate in crosspriming AAV
capsid-specific CD8+ T cells
Blood
2017
Nonredundant Roles of IL-10 and TGF-β in
Suppression of Immune Responses to Hepatic
AAV-Factor IX Gene Transfer
Molecular Therapy
2011
Effective gene therapy for haemophilic
mice with pathogenic factor
IX
antibodies
EMBO Molecular Medicine
2013
Impact of the Underlying Mutation and the
Route of Vector Administration on Immune
Responses to Factor IX in Gene Therapy for
Hemophilia B
Molecular Therapy
2009
Improved Induction of Immune Tolerance to
Factor IX by Hepatic AAV-8 Gene Transfer
Human Gene Therapy
2009
Gene Therapy-Induced Antigen-Specific
Tregs Inhibit Neuro-inflammation and
Reverse Disease in a Mouse Model of
Multiple Sclerosis
Molecular Therapy
2018
Liver induced transgene tolerance with AAV
vectors
Cellular Immunology
2019
Type I IFN Sensing by cDCs and CD4+ T Cell
Help Are Both Requisite for Cross-Priming
of AAV Capsid-Specific CD8+ T Cells
Molecular Therapy
2020
The Balance between CD8+ T Cell-Mediated
Clearance of AAV-Encoded Antigen in the
Liver and Tolerance Is Dependent on the
Vector Dose
Molecular Therapy
2017
Plant-based oral tolerance to hemophilia
therapy employs a complex immune
regulatory response including LAP+CD4+ T
cells
Blood
2015
Ex vivo expanded autologous polyclonal
regulatory T cells suppress inhibitor
formation in hemophilia
Molecular Therapy - Methods &
Clinical Development
2014
Tolerance Induction to Cytoplasmic
β-Galactosidase by Hepatic AAV Gene
Transfer — Implications for Antigen
Presentation and Immunotoxicity
PLoS ONE
2009
Potential for cellular stress response to
hepatic factor VIII expression from AAV
vector
Molecular Therapy - Methods &
Clinical Development
2016
Prophylactic immune tolerance induced by
changing the ratio of antigen‐specific
effector to regulatory T cells
Journal of Thrombosis and
Haemostasis
2009
Low cost delivery of proteins
bioencapsulated in plant cells to human
non-immune or immune modulatory cells
Biomaterials
2016
Muscle as a Target for Supplementary
Factor IX Gene Transfer
Human Gene Therapy
2007
Regulatory T cells and TLR9 activation
shape antibody formation to a secreted
transgene product in AAV muscle gene
transfer
Cellular Immunology
2019
Prevention and Reversal of Antibody
Responses Against Factor IX in Gene
Therapy for Hemophilia B
Frontiers in Microbiology
2011
Presence of Oligoclonal T Cells in
Cerebrospinal Fluid of a Child with
Multiphasic Disseminated Encephalomyelitis
following Hepatitis A Virus Infection
Clinical Diagnostic Laboratory
Immunology
2001
Enhanced Transduction of Human
Hematopoietic Stem Cells by AAV6 Vectors:
Implications in Gene Therapy and Genome
Editing
Molecular Therapy - Nucleic Acids
2020
AAV3-miRNA vectors for growth suppression
of human hepatocellular carcinoma cells in
vitro and human liver tumors in a murine
xenograft model in vivo
Gene Therapy
2020
Apoptosis of infiltrating T cells in the
central nervous system of mice infected
with Theiler's murine encephalomyelitis
virus
Virology
2003
Covert Warfare Against the Immune System:
Decoy Capsids, Stealth Genomes, and
Suppressors
Molecular Therapy
2013
Alpha-1 Antitrypsin-Deficient Macrophages
Have Increased Matriptase-Mediated
Proteolytic Activity
American Journal of Respiratory Cell
and Molecular Biology
2017
Improved Adeno-associated Viral Gene
Transfer to Murine Glioma
Journal of Genetic Syndromes & Gene
Therapy
2013
Optimal Immunofluorescent Staining for
Human Factor IX and Infiltrating T Cells
following Gene Therapy for Hemophilia B
Journal of Genetic Syndromes & Gene
Therapy
2013
Reprogramming Immune Response With
Capsid-Optimized AAV6 Vectors for
Immunotherapy of Cancer
Journal of Immunotherapy
2015
Gene Therapy for Hemophilia
Hematology/Oncology Clinics of North
America
2017
Induction of antigen-specific tolerance by
hepatic AAV immunotherapy regardless of
T cell epitope usage or mouse strain
background
Molecular Therapy - Methods &
Clinical Development
2023
Coaxing the liver into preventing
autoimmune disease in the brain
Journal of Clinical Investigation
2008
Gene Therapy Research at the Frontiers of
Viral Immunology
Frontiers in Microbiology
2012
AAV Vector-Based Gene Therapy, Progress
and Current Challenges
Safety and Efficacy of Gene-Based
Therapeutics for Inherited
Disorders
2017
In vivo applications and toxicities of
AAV-based gene therapies in rare diseases
Orphanet Journal of Rare Diseases
2025
Upregulation of CD8+ regulatory T cells
following liver-directed AAV gene therapy
Cellular Immunology
2024
Utilizing AI to drive AAV-based gene
delivery to the CNS
Cell and Gene Therapy Insights
2023
Liver cells transduced with AAV.MOG
increase the frequency of MOG-specific T
regulatory cells capable of reducing EAE
by adoptive transfer
The Journal of Immunology
2023
Use of immunosuppressants to treat
multiple sclerosis
Multiple Sclerosis Therapeutics
2011
Peer Review #2 of "Feature selection based
on differentially correlated gene pairs
reveals the mechanism of IFN-β therapy for
multiple sclerosis (v0.2)"
Unknown Venue
2020
521. AAV Immunotherapy Induces Functional
Antigen Specific Regulatory T-Cells to a
Neuroantigen: A Potential Treatment for MS
Molecular Therapy
2015
Multi-transgene AAV immunotherapy
re-establishes immune tolerance and
provides comprehensive protection in
animal model of MS
The Journal of Immunology
2022
Novel gene immunotherapy prevents
Aquaporin-4 (AQP4) mediated
neuroinflammation and demyelination in a
mouse model of multiple sclerosis
The Journal of Immunology
2022
Gene Therapy induced Tregs: A treatment
for relapsing-remitting MS in mice
The Journal of Immunology
2018
The mechanism of preventing EAE via gene
therapy
The Journal of Immunology
2018
TLR9-Activating CpG-B ODN but Not TLR7
Agonists Triggers Antibody Formation to
Factor IX in Muscle Gene Transfer
Human Gene Therapy Methods
2019
A dynamic approach for treating autoimmune
disease.
The Journal of Immunology
2017
Vector mediated in vivo induction
of antigen-specific regulatory T cells
abrogates clinical and histological signs
of EAE
The Journal of Immunology
2016
79. Vector Dose Delineates Between
Chronic, Non-Functional CD8+ T Cell
Response and Tolerance to the Transgene
Product Upon Liver Gene Transfer
Molecular Therapy
2016
AAV3 Capsid Is Superior for In Vivo Gene
Transfer to Human Hepatocytes Compared to
Serotypes 5 and 8 in a Mouse/Human
Chimeric Model
Blood
2015
221. The Utilization of Capsid-Optimized
Adeno-Associated Virus (AAV) Vectors for
Cancer Immunotherapy
Molecular Therapy
2015
786. Re-Establishing Immune Tolerance to
Neuroantigens by AAV Gene Therapy
Molecular Therapy
2014
190. Capsid Modified AAV2 Vectors Are
Capable of Generating Functional Cytotoxic
T Cells in a Prime-Boost Vaccine Protocol
Molecular Therapy
2013
668. Capsid Modified AAV2 Vectors Are
Capable of Generating Vaccine-Mediated
Protection
Molecular Therapy
2012
584. Optimization of rAAV for Anti-Glioma
Therapy
Molecular Therapy
2012
993. Systemic Expression of Transgene
Product Is Not Required for Induction of
Immune Tolerance by AAV2 Hepatic Gene
Transfer
Molecular Therapy
2009
A Prophylactic Protocol for the Prevention
of Inhibitor Formation in Gene Therapy for
Hemophilia B by Shifting the Balance from
An Effector to a Regulatory T Cell
Response
Blood
2008
1010. Tolerance Induction to Factor IX by
Gene Transfer in an Unfavorable Genetic
Background
Molecular Therapy
2008
Initial Identification of a Mouse Human
Factor IX-Specific CD8+ T-Cell Epitope.
Blood
2006
Identical T-cell receptor transcripts are
clonally expanded in the CNS of
TMEV-infected mice with early acute &
late chronic demyelinating disease
Journal of Neuroimmunology
1998
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