Larissa Falcao
Senior Scientist & Manager, Viral Vaccines R&D
About
Education
Drexel University
Master of Science / 2014
Mumbai University
Bachelor of Pharmaceutical Sciences / 2010
Experience
Pfizer Inc. Viral Vaccines
Senior Scientist Manager / June, 2022 — December
Led DNA template production for mRNA for 5 viral projects (RSV, CMV, hMPV, PIV1, PIV3), evaluated plasmid vectors, and led preclinical evaluation of hMPV vaccine efficacy, including developing a neutralization assay. Mentored junior scientists, evaluated RSV monoclonal antibody resistant mutants, monitored clinical isolates, and authored technical reports and protocols.
Scientist / July, 2016 — June, 2022
Implemented an in-house de-novo gene synthesis platform and the robotic BioXPTM 3000 system for custom gene building and DNA template generation for mRNA vaccines. Generated DNA constructs for COVID-19 pseudorecombinant virus to test vaccine breadth. Led Influenza virus rescue project, developed VSV pseudo virus neutralization assay for saRNA, and optimized the HAI assay. Monitored RSV humoral immune responses and vaccine efficacy, supported cloning for modRNA constructs, and implemented Luminex multiplex PCR for RSV co-infections. Also supported CMV and VZV vaccine programs.
Pfizer Inc. BreakthroughIT
Scientist contractor Oncology / March, 2015 — May, 2016
Worked as a Scientist contractor in Oncology, focusing on research initiatives within BreakthroughIT.
Hemispherx Biopharma
Research Biochemist / September, 2014 — March, 2015
Served as a Research Biochemist, engaged in biochemical research activities.
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