Larissa Falcao

Senior Scientist & Manager, Viral Vaccines R&D

About

A scientist with over 7 years of experience designing, leading, and implementing a wide range of experiments to pre-clinically evaluate several viral vaccines.

Education

Drexel University

Master of Science / 2014

Mumbai University

Bachelor of Pharmaceutical Sciences / 2010

Experience

Pfizer Inc. Viral Vaccines

Senior Scientist Manager / June, 2022December

Led DNA template production for mRNA for 5 viral projects (RSV, CMV, hMPV, PIV1, PIV3), evaluated plasmid vectors, and led preclinical evaluation of hMPV vaccine efficacy, including developing a neutralization assay. Mentored junior scientists, evaluated RSV monoclonal antibody resistant mutants, monitored clinical isolates, and authored technical reports and protocols.

Scientist / July, 2016June, 2022

Implemented an in-house de-novo gene synthesis platform and the robotic BioXPTM 3000 system for custom gene building and DNA template generation for mRNA vaccines. Generated DNA constructs for COVID-19 pseudorecombinant virus to test vaccine breadth. Led Influenza virus rescue project, developed VSV pseudo virus neutralization assay for saRNA, and optimized the HAI assay. Monitored RSV humoral immune responses and vaccine efficacy, supported cloning for modRNA constructs, and implemented Luminex multiplex PCR for RSV co-infections. Also supported CMV and VZV vaccine programs.

Pfizer Inc. BreakthroughIT

Scientist contractor Oncology / March, 2015May, 2016

Worked as a Scientist contractor in Oncology, focusing on research initiatives within BreakthroughIT.

Hemispherx Biopharma

Research Biochemist / September, 2014March, 2015

Served as a Research Biochemist, engaged in biochemical research activities.

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