Massimo Nardone

University of Guelph

Research Expertise

Sympathetic Nervous System
Blood Pressure Regulation
Cardiovascular physiology
Physiology
Endocrinology, Diabetes and Metabolism
Endocrine and Autonomic Systems

Publications

Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity

Journal of the American Heart Association / Feb 06, 2018

Nardone, M., Incognito, A. V., & Millar, P. J. (2018). Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity. Journal of the American Heart Association, 7(3). https://doi.org/10.1161/jaha.117.007971

Sympathetic neural modulation of arterial stiffness in humans

American Journal of Physiology-Heart and Circulatory Physiology / Dec 01, 2020

Nardone, M., Floras, J. S., & Millar, P. J. (2020). Sympathetic neural modulation of arterial stiffness in humans. American Journal of Physiology-Heart and Circulatory Physiology, 319(6), H1338–H1346. https://doi.org/10.1152/ajpheart.00734.2020

Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command

American Journal of Physiology-Heart and Circulatory Physiology / Jan 01, 2018

Doherty, C. J., Incognito, A. V., Notay, K., Burns, M. J., Slysz, J. T., Seed, J. D., Nardone, M., Burr, J. F., & Millar, P. J. (2018). Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command. American Journal of Physiology-Heart and Circulatory Physiology, 314(1), H3–H10. https://doi.org/10.1152/ajpheart.00494.2017

Sex Differences in Muscle Metaboreflex Activation after Static Handgrip Exercise

Medicine & Science in Sports & Exercise / Jul 23, 2021

LEE, J. B., NOTAY, K., SEED, J. D., NARDONE, M., OMAZIC, L. J., & MILLAR, P. J. (2021). Sex Differences in Muscle Metaboreflex Activation after Static Handgrip Exercise. Medicine & Science in Sports & Exercise, 53(12), 2596–2604. https://doi.org/10.1249/mss.0000000000002747

Noninvasive Microvascular Indices Reveal Peripheral Vascular Abnormalities in Patients With Suspected Coronary Microvascular Dysfunction

Canadian Journal of Cardiology / Aug 01, 2020

Nardone, M., Miner, S., McCarthy, M., Ardern, C. I., & Edgell, H. (2020). Noninvasive Microvascular Indices Reveal Peripheral Vascular Abnormalities in Patients With Suspected Coronary Microvascular Dysfunction. Canadian Journal of Cardiology, 36(8), 1289–1297. https://doi.org/10.1016/j.cjca.2019.12.003

Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction

Applied Physiology, Nutrition, and Metabolism / Jan 11, 2021

Nardone, M., Incognito, A. V., Teixeira, A. L., Cacoilo, J. A., Vianna, L. C., & Millar, P. J. (2021). Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction. Applied Physiology, Nutrition, and Metabolism, 1–7. https://doi.org/10.1139/apnm-2020-0721

Signal-averaged resting sympathetic transduction of blood pressure: is it time to account for prevailing muscle sympathetic burst frequency?

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Sep 01, 2021

Nardone, M., Incognito, A. V., Kathia, M. M., Omazic, L. J., Lee, J. B., Teixeira, A. L., Xie, S., Vianna, L. C., & Millar, P. J. (2021). Signal-averaged resting sympathetic transduction of blood pressure: is it time to account for prevailing muscle sympathetic burst frequency? American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 321(3), R484–R494. https://doi.org/10.1152/ajpregu.00131.2021

Within-breath sympathetic baroreflex sensitivity is modulated by lung volume but unaffected by acute intermittent hypercapnic hypoxia in men

American Journal of Physiology-Heart and Circulatory Physiology / Jul 01, 2020

Nardone, M., Teixeira, A. L., Incognito, A. V., Vermeulen, T. D., Shafer, B. M., Millar, P. J., & Foster, G. E. (2020). Within-breath sympathetic baroreflex sensitivity is modulated by lung volume but unaffected by acute intermittent hypercapnic hypoxia in men. American Journal of Physiology-Heart and Circulatory Physiology, 319(1), H213–H221. https://doi.org/10.1152/ajpheart.00296.2020

Blood pressure oscillations impact signal-averaged sympathetic transduction of blood pressure: implications for the association with resting sympathetic outflow

American Journal of Physiology-Heart and Circulatory Physiology / Oct 01, 2021

Nardone, M., Katerberg, C., Incognito, A. V., Teixeira, A. L., Vianna, L. C., & Millar, P. J. (2021). Blood pressure oscillations impact signal-averaged sympathetic transduction of blood pressure: implications for the association with resting sympathetic outflow. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H798–H806. https://doi.org/10.1152/ajpheart.00422.2021

Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia

Medicine & Science in Sports & Exercise / Jun 02, 2021

SHAFER, B. M., INCOGNITO, A. V., VERMEULEN, T. D., NARDONE, M., TEIXEIRA, A. L., BENBARUJ, J., MILLAR, P. J., & FOSTER, G. E. (2021). Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia. Medicine & Science in Sports & Exercise, 53(11), 2233–2244. https://doi.org/10.1249/mss.0000000000002716

Assessing functional sympatholysis during rhythmic handgrip exercise using Doppler ultrasound and near-infrared spectroscopy: sex differences and test-retest reliability

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Nov 01, 2022

Teixeira, A. L., Garland, M., Lee, J. B., Nardone, M., & Millar, P. J. (2022). Assessing functional sympatholysis during rhythmic handgrip exercise using Doppler ultrasound and near-infrared spectroscopy: sex differences and test-retest reliability. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 323(5), R810–R821. https://doi.org/10.1152/ajpregu.00123.2022

Reply to Fadel et al.

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Feb 01, 2022

Nardone, M., Vianna, L. C., & Millar, P. J. (2022). Reply to Fadel et al. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 322(2), R123–R125. https://doi.org/10.1152/ajpregu.00265.2021

Muscle sympathetic single-unit responses during rhythmic handgrip exercise and isocapnic hypoxia in males: the role of sympathoexcitation magnitude

Journal of Neurophysiology / Jul 01, 2021

Incognito, A. V., Teixeira, A. L., Shafer, B. M., Nardone, M., Vermeulen, T. D., Foster, G. E., & Millar, P. J. (2021). Muscle sympathetic single-unit responses during rhythmic handgrip exercise and isocapnic hypoxia in males: the role of sympathoexcitation magnitude. Journal of Neurophysiology, 126(1), 170–180. https://doi.org/10.1152/jn.00678.2020

Characterization of the Human Coronary Microvascular Response to Multiple Hyperaemic Agents

CJC Open / Feb 01, 2021

Nardone, M., McCarthy, M., Ardern, C. I., Edgell, H., Toleva, O., Nield, L. E., & Miner, S. E. S. (2021). Characterization of the Human Coronary Microvascular Response to Multiple Hyperaemic Agents. CJC Open, 3(2), 133–141. https://doi.org/10.1016/j.cjco.2020.09.017

Standard exercise stress testing attenuates peripheral microvascular function in patients with suspected coronary microvascular dysfunction

BMC Sports Science, Medicine and Rehabilitation / Feb 27, 2021

Nardone, M., Miner, S., McCarthy, M., & Edgell, H. (2021). Standard exercise stress testing attenuates peripheral microvascular function in patients with suspected coronary microvascular dysfunction. BMC Sports Science, Medicine and Rehabilitation, 13(1). https://doi.org/10.1186/s13102-021-00246-8

Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS)

Journal of Applied Physiology / Apr 01, 2020

Nardone, M., Guzman, J., Harvey, P. J., Floras, J. S., & Edgell, H. (2020). Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS). Journal of Applied Physiology, 128(4), 907–913. https://doi.org/10.1152/japplphysiol.00040.2020

Attenuated Sympathetic Blood Pressure Transduction in Patients With Treated Heart Failure With Reduced Ejection Fraction

Hypertension / Dec 01, 2022

Nardone, M., Notarius, C. F., Badrov, M. B., Millar, P. J., & Floras, J. S. (2022). Attenuated Sympathetic Blood Pressure Transduction in Patients With Treated Heart Failure With Reduced Ejection Fraction. Hypertension, 79(12), 2764–2773. https://doi.org/10.1161/hypertensionaha.122.19850

Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation

The Journal of Physiology / Jun 09, 2022

Shafer, B. M., Incognito, A. V., Vermeulen, T. D., Nardone, M., Teixeira, A. L., Klassen, S. A., Millar, P. J., & Foster, G. E. (2022). Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation. The Journal of Physiology, 600(13), 3127–3147. Portico. https://doi.org/10.1113/jp282933

Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females

Clinical Autonomic Research / May 27, 2023

O’Brien, M. W., Nardone, M., Foster, M., Coovadia, Y., Usselman, C. W., Taylor, C. E., Millar, P. J., & Kimmerly, D. S. (2023). Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females. Clinical Autonomic Research, 33(4), 529–532. https://doi.org/10.1007/s10286-023-00949-7

Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Jun 01, 2022

Teixeira, A. L., Nardone, M., Samora, M., Fernandes, I. A., Ramos, P. S., Sabino-Carvalho, J. L., Ricardo, D. R., Millar, P. J., & Vianna, L. C. (2022). Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 322(6), R501–R510. https://doi.org/10.1152/ajpregu.00291.2021

Renal vascular conductance is unrelated to leg vascular conductance or muscle sympathetic nerve activity at rest and during stress in humans

Journal of Applied Physiology / Jul 01, 2023

Teixeira, A. L., Lee, J. B., Nardone, M., Burr, J. F., & Millar, P. J. (2023). Renal vascular conductance is unrelated to leg vascular conductance or muscle sympathetic nerve activity at rest and during stress in humans. Journal of Applied Physiology, 135(1), 154–164. https://doi.org/10.1152/japplphysiol.00673.2022

CKD patients have augmented beat-to-beat BP variability that is not improved with 12 weeks of cycling exercise

Physiology / May 01, 2023

Sabino-Carvalho, J., Jeong, J., Sprick, J., Nardone, M., DaCosta, D., & Park, J. (2023). CKD patients have augmented beat-to-beat BP variability that is not improved with 12 weeks of cycling exercise. Physiology, 38(S1). https://doi.org/10.1152/physiol.2023.38.s1.5729394

Augmented sympathetic neurovascular transduction following acute exercise in normotensive adults

Physiology / May 01, 2023

Nardone, M., Pfundt, K., & Millar, P. (2023). Augmented sympathetic neurovascular transduction following acute exercise in normotensive adults. Physiology, 38(S1). https://doi.org/10.1152/physiol.2023.38.s1.5732355

Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin and muscle

Experimental Physiology / May 20, 2013

Fatouleh, R., & Macefield, V. G. (2013). Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin and muscle. Experimental Physiology, 98(9), 1327–1336. Portico. https://doi.org/10.1113/expphysiol.2013.072421

Cannabis Inhalation Acutely Reduces Muscle Sympathetic Nerve Activity in Humans

Circulation / Dec 20, 2022

Cheung, C. P., Nardone, M., Lee, J. B., Baker, R. E., Millar, P. J., & Burr, J. F. (2022). Cannabis Inhalation Acutely Reduces Muscle Sympathetic Nerve Activity in Humans. Circulation, 146(25), 1972–1974. https://doi.org/10.1161/circulationaha.122.062564

Abstract 13228: Cannabis Inhalation Reduces Muscle Sympathetic Nerve Activity in Humans

Circulation / Nov 08, 2022

Cheung, C. P., Nardone, M., Lee, J. B., Baker, R. E., Millar, P. J., & Burr, J. F. (2022). Abstract 13228: Cannabis Inhalation Reduces Muscle Sympathetic Nerve Activity in Humans. Circulation, 146(Suppl_1). https://doi.org/10.1161/circ.146.suppl_1.13228

Pressor Response To Blood-Flow Restriction Exercise: Influence Of Muscle Mass And Central Blood Volume Reduction

Medicine & Science in Sports & Exercise / Sep 01, 2022

Pignanelli, C., Thompson, K. M. A., Cohen, J. N., Cheung, C. P., Coates, A. M., Nardone, M., Millar, P. J., & Burr, J. F. (2022). Pressor Response To Blood-Flow Restriction Exercise: Influence Of Muscle Mass And Central Blood Volume Reduction. Medicine & Science in Sports & Exercise, 54(9S), 351–351. https://doi.org/10.1249/01.mss.0000879432.31339.a2

Hypoxia‐induced sympathetic long‐term facilitation is mediated by a rightward shift in sympathetic action potential amplitude distribution and baroreflex resetting of action potential clusters

The FASEB Journal / May 01, 2022

Shafer, B., Incognito, A., Vermeulen, T., Nardone, M., Teixeira, A., Klassen, S., Millar, P., & Foster, G. (2022). Hypoxia‐induced sympathetic long‐term facilitation is mediated by a rightward shift in sympathetic action potential amplitude distribution and baroreflex resetting of action potential clusters. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r2888

Intra and inter‐day reproducibility of the functional sympatholysis protocol during rhythmic handgrip exercise in healthy humans

The FASEB Journal / May 01, 2022

Teixeira, A. L., Garland, M., Lee, J. B., Nardone, M., & Millar, P. J. (2022). Intra and inter‐day reproducibility of the functional sympatholysis protocol during rhythmic handgrip exercise in healthy humans. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r4098

Sympathetic transduction of blood pressure during graded lower body negative pressure

The FASEB Journal / May 01, 2022

Nardone, M., Katerberg, C., Teixeira, A. L., & Millar, P. J. (2022). Sympathetic transduction of blood pressure during graded lower body negative pressure. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r3374

Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics

Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease / Jan 01, 2022

Millar, P. J., Nardone, M., & Floras, J. S. (2022). Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics. Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, 369–390. https://doi.org/10.1016/b978-0-323-91391-1.00024-8

Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults

Journal of Neurophysiology / Sep 01, 2020

Incognito, A. V., Nardone, M., Teixeira, A. L., Lee, J. B., Kathia, M. M., & Millar, P. J. (2020). Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults. Journal of Neurophysiology, 124(3), 682–690. https://doi.org/10.1152/jn.00305.2020

Case Studies in Physiology: Sympathetic neural discharge patterns in a healthy young male during end-expiratory breath hold-induced sinus pause

Journal of Applied Physiology / Aug 01, 2020

Vermeulen, T. D., Shafer, B. M., Incognito, A. V., Nardone, M., Teixeira, A. L., Millar, P. J., Shoemaker, J. K., & Foster, G. E. (2020). Case Studies in Physiology: Sympathetic neural discharge patterns in a healthy young male during end-expiratory breath hold-induced sinus pause. Journal of Applied Physiology, 129(2), 230–237. https://doi.org/10.1152/japplphysiol.00307.2020

Stretching our understanding of baroreflex control in humans: evidence of a positive feedback pulmonary baroreflex

The Journal of Physiology / Mar 28, 2020

Nardone, M., & Teixeira, A. L. (2020). Stretching our understanding of baroreflex control in humans: evidence of a positive feedback pulmonary baroreflex. The Journal of Physiology, 598(8), 1435–1436. Portico. https://doi.org/10.1113/jp279662

Comparison of Non‐Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction

The FASEB Journal / Apr 01, 2019

Nardone, M., Miner, S., McCarthy, M., & Edgell, H. (2019). Comparison of Non‐Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction. The FASEB Journal, 33(S1). Portico. https://doi.org/10.1096/fasebj.2019.33.1_supplement.689.1

Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans

Journal of Applied Physiology / Nov 01, 2016

Notay, K., Seed, J. D., Incognito, A. V., Doherty, C. J., Nardone, M., Burns, M. J., & Millar, P. J. (2016). Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans. Journal of Applied Physiology, 121(5), 1065–1073. https://doi.org/10.1152/japplphysiol.00736.2016

Education

York University

MSc, Physiology / 2019

Toronto, Ontario, Canada

University of Guelph

Ph.D, Physiology / 2023 (anticipated)

Guelph, Ontario, Canada
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