Massimo Nardone
University of Guelph
Research Expertise
Publications
Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity
Journal of the American Heart Association / Feb 06, 2018
Nardone, M., Incognito, A. V., & Millar, P. J. (2018). Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity. Journal of the American Heart Association, 7(3). https://doi.org/10.1161/jaha.117.007971
Sympathetic neural modulation of arterial stiffness in humans
American Journal of Physiology-Heart and Circulatory Physiology / Dec 01, 2020
Nardone, M., Floras, J. S., & Millar, P. J. (2020). Sympathetic neural modulation of arterial stiffness in humans. American Journal of Physiology-Heart and Circulatory Physiology, 319(6), H1338–H1346. https://doi.org/10.1152/ajpheart.00734.2020
Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command
American Journal of Physiology-Heart and Circulatory Physiology / Jan 01, 2018
Doherty, C. J., Incognito, A. V., Notay, K., Burns, M. J., Slysz, J. T., Seed, J. D., Nardone, M., Burr, J. F., & Millar, P. J. (2018). Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command. American Journal of Physiology-Heart and Circulatory Physiology, 314(1), H3–H10. https://doi.org/10.1152/ajpheart.00494.2017
Sex Differences in Muscle Metaboreflex Activation after Static Handgrip Exercise
Medicine & Science in Sports & Exercise / Jul 23, 2021
LEE, J. B., NOTAY, K., SEED, J. D., NARDONE, M., OMAZIC, L. J., & MILLAR, P. J. (2021). Sex Differences in Muscle Metaboreflex Activation after Static Handgrip Exercise. Medicine & Science in Sports & Exercise, 53(12), 2596–2604. https://doi.org/10.1249/mss.0000000000002747
Noninvasive Microvascular Indices Reveal Peripheral Vascular Abnormalities in Patients With Suspected Coronary Microvascular Dysfunction
Canadian Journal of Cardiology / Aug 01, 2020
Nardone, M., Miner, S., McCarthy, M., Ardern, C. I., & Edgell, H. (2020). Noninvasive Microvascular Indices Reveal Peripheral Vascular Abnormalities in Patients With Suspected Coronary Microvascular Dysfunction. Canadian Journal of Cardiology, 36(8), 1289–1297. https://doi.org/10.1016/j.cjca.2019.12.003
Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction
Applied Physiology, Nutrition, and Metabolism / Jan 11, 2021
Nardone, M., Incognito, A. V., Teixeira, A. L., Cacoilo, J. A., Vianna, L. C., & Millar, P. J. (2021). Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction. Applied Physiology, Nutrition, and Metabolism, 1–7. https://doi.org/10.1139/apnm-2020-0721
Signal-averaged resting sympathetic transduction of blood pressure: is it time to account for prevailing muscle sympathetic burst frequency?
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Sep 01, 2021
Nardone, M., Incognito, A. V., Kathia, M. M., Omazic, L. J., Lee, J. B., Teixeira, A. L., Xie, S., Vianna, L. C., & Millar, P. J. (2021). Signal-averaged resting sympathetic transduction of blood pressure: is it time to account for prevailing muscle sympathetic burst frequency? American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 321(3), R484–R494. https://doi.org/10.1152/ajpregu.00131.2021
Within-breath sympathetic baroreflex sensitivity is modulated by lung volume but unaffected by acute intermittent hypercapnic hypoxia in men
American Journal of Physiology-Heart and Circulatory Physiology / Jul 01, 2020
Nardone, M., Teixeira, A. L., Incognito, A. V., Vermeulen, T. D., Shafer, B. M., Millar, P. J., & Foster, G. E. (2020). Within-breath sympathetic baroreflex sensitivity is modulated by lung volume but unaffected by acute intermittent hypercapnic hypoxia in men. American Journal of Physiology-Heart and Circulatory Physiology, 319(1), H213–H221. https://doi.org/10.1152/ajpheart.00296.2020
Blood pressure oscillations impact signal-averaged sympathetic transduction of blood pressure: implications for the association with resting sympathetic outflow
American Journal of Physiology-Heart and Circulatory Physiology / Oct 01, 2021
Nardone, M., Katerberg, C., Incognito, A. V., Teixeira, A. L., Vianna, L. C., & Millar, P. J. (2021). Blood pressure oscillations impact signal-averaged sympathetic transduction of blood pressure: implications for the association with resting sympathetic outflow. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H798–H806. https://doi.org/10.1152/ajpheart.00422.2021
Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia
Medicine & Science in Sports & Exercise / Jun 02, 2021
SHAFER, B. M., INCOGNITO, A. V., VERMEULEN, T. D., NARDONE, M., TEIXEIRA, A. L., BENBARUJ, J., MILLAR, P. J., & FOSTER, G. E. (2021). Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia. Medicine & Science in Sports & Exercise, 53(11), 2233–2244. https://doi.org/10.1249/mss.0000000000002716
Assessing functional sympatholysis during rhythmic handgrip exercise using Doppler ultrasound and near-infrared spectroscopy: sex differences and test-retest reliability
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Nov 01, 2022
Teixeira, A. L., Garland, M., Lee, J. B., Nardone, M., & Millar, P. J. (2022). Assessing functional sympatholysis during rhythmic handgrip exercise using Doppler ultrasound and near-infrared spectroscopy: sex differences and test-retest reliability. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 323(5), R810–R821. https://doi.org/10.1152/ajpregu.00123.2022
Reply to Fadel et al.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Feb 01, 2022
Nardone, M., Vianna, L. C., & Millar, P. J. (2022). Reply to Fadel et al. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 322(2), R123–R125. https://doi.org/10.1152/ajpregu.00265.2021
Muscle sympathetic single-unit responses during rhythmic handgrip exercise and isocapnic hypoxia in males: the role of sympathoexcitation magnitude
Journal of Neurophysiology / Jul 01, 2021
Incognito, A. V., Teixeira, A. L., Shafer, B. M., Nardone, M., Vermeulen, T. D., Foster, G. E., & Millar, P. J. (2021). Muscle sympathetic single-unit responses during rhythmic handgrip exercise and isocapnic hypoxia in males: the role of sympathoexcitation magnitude. Journal of Neurophysiology, 126(1), 170–180. https://doi.org/10.1152/jn.00678.2020
Characterization of the Human Coronary Microvascular Response to Multiple Hyperaemic Agents
CJC Open / Feb 01, 2021
Nardone, M., McCarthy, M., Ardern, C. I., Edgell, H., Toleva, O., Nield, L. E., & Miner, S. E. S. (2021). Characterization of the Human Coronary Microvascular Response to Multiple Hyperaemic Agents. CJC Open, 3(2), 133–141. https://doi.org/10.1016/j.cjco.2020.09.017
Standard exercise stress testing attenuates peripheral microvascular function in patients with suspected coronary microvascular dysfunction
BMC Sports Science, Medicine and Rehabilitation / Feb 27, 2021
Nardone, M., Miner, S., McCarthy, M., & Edgell, H. (2021). Standard exercise stress testing attenuates peripheral microvascular function in patients with suspected coronary microvascular dysfunction. BMC Sports Science, Medicine and Rehabilitation, 13(1). https://doi.org/10.1186/s13102-021-00246-8
Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS)
Journal of Applied Physiology / Apr 01, 2020
Nardone, M., Guzman, J., Harvey, P. J., Floras, J. S., & Edgell, H. (2020). Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS). Journal of Applied Physiology, 128(4), 907–913. https://doi.org/10.1152/japplphysiol.00040.2020
Attenuated Sympathetic Blood Pressure Transduction in Patients With Treated Heart Failure With Reduced Ejection Fraction
Hypertension / Dec 01, 2022
Nardone, M., Notarius, C. F., Badrov, M. B., Millar, P. J., & Floras, J. S. (2022). Attenuated Sympathetic Blood Pressure Transduction in Patients With Treated Heart Failure With Reduced Ejection Fraction. Hypertension, 79(12), 2764–2773. https://doi.org/10.1161/hypertensionaha.122.19850
Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation
The Journal of Physiology / Jun 09, 2022
Shafer, B. M., Incognito, A. V., Vermeulen, T. D., Nardone, M., Teixeira, A. L., Klassen, S. A., Millar, P. J., & Foster, G. E. (2022). Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation. The Journal of Physiology, 600(13), 3127–3147. Portico. https://doi.org/10.1113/jp282933
Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females
Clinical Autonomic Research / May 27, 2023
O’Brien, M. W., Nardone, M., Foster, M., Coovadia, Y., Usselman, C. W., Taylor, C. E., Millar, P. J., & Kimmerly, D. S. (2023). Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females. Clinical Autonomic Research, 33(4), 529–532. https://doi.org/10.1007/s10286-023-00949-7
Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Jun 01, 2022
Teixeira, A. L., Nardone, M., Samora, M., Fernandes, I. A., Ramos, P. S., Sabino-Carvalho, J. L., Ricardo, D. R., Millar, P. J., & Vianna, L. C. (2022). Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 322(6), R501–R510. https://doi.org/10.1152/ajpregu.00291.2021
Renal vascular conductance is unrelated to leg vascular conductance or muscle sympathetic nerve activity at rest and during stress in humans
Journal of Applied Physiology / Jul 01, 2023
Teixeira, A. L., Lee, J. B., Nardone, M., Burr, J. F., & Millar, P. J. (2023). Renal vascular conductance is unrelated to leg vascular conductance or muscle sympathetic nerve activity at rest and during stress in humans. Journal of Applied Physiology, 135(1), 154–164. https://doi.org/10.1152/japplphysiol.00673.2022
CKD patients have augmented beat-to-beat BP variability that is not improved with 12 weeks of cycling exercise
Physiology / May 01, 2023
Sabino-Carvalho, J., Jeong, J., Sprick, J., Nardone, M., DaCosta, D., & Park, J. (2023). CKD patients have augmented beat-to-beat BP variability that is not improved with 12 weeks of cycling exercise. Physiology, 38(S1). https://doi.org/10.1152/physiol.2023.38.s1.5729394
Augmented sympathetic neurovascular transduction following acute exercise in normotensive adults
Physiology / May 01, 2023
Nardone, M., Pfundt, K., & Millar, P. (2023). Augmented sympathetic neurovascular transduction following acute exercise in normotensive adults. Physiology, 38(S1). https://doi.org/10.1152/physiol.2023.38.s1.5732355
Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin and muscle
Experimental Physiology / May 20, 2013
Fatouleh, R., & Macefield, V. G. (2013). Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin and muscle. Experimental Physiology, 98(9), 1327–1336. Portico. https://doi.org/10.1113/expphysiol.2013.072421
Cannabis Inhalation Acutely Reduces Muscle Sympathetic Nerve Activity in Humans
Circulation / Dec 20, 2022
Cheung, C. P., Nardone, M., Lee, J. B., Baker, R. E., Millar, P. J., & Burr, J. F. (2022). Cannabis Inhalation Acutely Reduces Muscle Sympathetic Nerve Activity in Humans. Circulation, 146(25), 1972–1974. https://doi.org/10.1161/circulationaha.122.062564
Abstract 13228: Cannabis Inhalation Reduces Muscle Sympathetic Nerve Activity in Humans
Circulation / Nov 08, 2022
Cheung, C. P., Nardone, M., Lee, J. B., Baker, R. E., Millar, P. J., & Burr, J. F. (2022). Abstract 13228: Cannabis Inhalation Reduces Muscle Sympathetic Nerve Activity in Humans. Circulation, 146(Suppl_1). https://doi.org/10.1161/circ.146.suppl_1.13228
Pressor Response To Blood-Flow Restriction Exercise: Influence Of Muscle Mass And Central Blood Volume Reduction
Medicine & Science in Sports & Exercise / Sep 01, 2022
Pignanelli, C., Thompson, K. M. A., Cohen, J. N., Cheung, C. P., Coates, A. M., Nardone, M., Millar, P. J., & Burr, J. F. (2022). Pressor Response To Blood-Flow Restriction Exercise: Influence Of Muscle Mass And Central Blood Volume Reduction. Medicine & Science in Sports & Exercise, 54(9S), 351–351. https://doi.org/10.1249/01.mss.0000879432.31339.a2
Hypoxia‐induced sympathetic long‐term facilitation is mediated by a rightward shift in sympathetic action potential amplitude distribution and baroreflex resetting of action potential clusters
The FASEB Journal / May 01, 2022
Shafer, B., Incognito, A., Vermeulen, T., Nardone, M., Teixeira, A., Klassen, S., Millar, P., & Foster, G. (2022). Hypoxia‐induced sympathetic long‐term facilitation is mediated by a rightward shift in sympathetic action potential amplitude distribution and baroreflex resetting of action potential clusters. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r2888
Intra and inter‐day reproducibility of the functional sympatholysis protocol during rhythmic handgrip exercise in healthy humans
The FASEB Journal / May 01, 2022
Teixeira, A. L., Garland, M., Lee, J. B., Nardone, M., & Millar, P. J. (2022). Intra and inter‐day reproducibility of the functional sympatholysis protocol during rhythmic handgrip exercise in healthy humans. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r4098
Sympathetic transduction of blood pressure during graded lower body negative pressure
The FASEB Journal / May 01, 2022
Nardone, M., Katerberg, C., Teixeira, A. L., & Millar, P. J. (2022). Sympathetic transduction of blood pressure during graded lower body negative pressure. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r3374
Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics
Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease / Jan 01, 2022
Millar, P. J., Nardone, M., & Floras, J. S. (2022). Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics. Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, 369–390. https://doi.org/10.1016/b978-0-323-91391-1.00024-8
Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults
Journal of Neurophysiology / Sep 01, 2020
Incognito, A. V., Nardone, M., Teixeira, A. L., Lee, J. B., Kathia, M. M., & Millar, P. J. (2020). Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults. Journal of Neurophysiology, 124(3), 682–690. https://doi.org/10.1152/jn.00305.2020
Case Studies in Physiology: Sympathetic neural discharge patterns in a healthy young male during end-expiratory breath hold-induced sinus pause
Journal of Applied Physiology / Aug 01, 2020
Vermeulen, T. D., Shafer, B. M., Incognito, A. V., Nardone, M., Teixeira, A. L., Millar, P. J., Shoemaker, J. K., & Foster, G. E. (2020). Case Studies in Physiology: Sympathetic neural discharge patterns in a healthy young male during end-expiratory breath hold-induced sinus pause. Journal of Applied Physiology, 129(2), 230–237. https://doi.org/10.1152/japplphysiol.00307.2020
Stretching our understanding of baroreflex control in humans: evidence of a positive feedback pulmonary baroreflex
The Journal of Physiology / Mar 28, 2020
Nardone, M., & Teixeira, A. L. (2020). Stretching our understanding of baroreflex control in humans: evidence of a positive feedback pulmonary baroreflex. The Journal of Physiology, 598(8), 1435–1436. Portico. https://doi.org/10.1113/jp279662
Comparison of Non‐Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction
The FASEB Journal / Apr 01, 2019
Nardone, M., Miner, S., McCarthy, M., & Edgell, H. (2019). Comparison of Non‐Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction. The FASEB Journal, 33(S1). Portico. https://doi.org/10.1096/fasebj.2019.33.1_supplement.689.1
Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans
Journal of Applied Physiology / Nov 01, 2016
Notay, K., Seed, J. D., Incognito, A. V., Doherty, C. J., Nardone, M., Burns, M. J., & Millar, P. J. (2016). Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans. Journal of Applied Physiology, 121(5), 1065–1073. https://doi.org/10.1152/japplphysiol.00736.2016
Education
York University
MSc, Physiology / 2019
University of Guelph
Ph.D, Physiology / 2023 (anticipated)
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