Massimo Nardone
University of Guelph
Research Expertise
Publications
Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity
Journal of the American Heart Association / Feb 06, 2018
Nardone, M., Incognito, A. V., & Millar, P. J. (2018). Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity. Journal of the American Heart Association, 7(3). https://doi.org/10.1161/jaha.117.007971
Sympathetic neural modulation of arterial stiffness in humans
American Journal of Physiology-Heart and Circulatory Physiology / Dec 01, 2020
Nardone, M., Floras, J. S., & Millar, P. J. (2020). Sympathetic neural modulation of arterial stiffness in humans. American Journal of Physiology-Heart and Circulatory Physiology, 319(6), H1338–H1346. https://doi.org/10.1152/ajpheart.00734.2020
Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command
American Journal of Physiology-Heart and Circulatory Physiology / Jan 01, 2018
Doherty, C. J., Incognito, A. V., Notay, K., Burns, M. J., Slysz, J. T., Seed, J. D., Nardone, M., Burr, J. F., & Millar, P. J. (2018). Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command. American Journal of Physiology-Heart and Circulatory Physiology, 314(1), H3–H10. https://doi.org/10.1152/ajpheart.00494.2017
Sex Differences in Muscle Metaboreflex Activation after Static Handgrip Exercise
Medicine & Science in Sports & Exercise / Jul 23, 2021
LEE, J. B., NOTAY, K., SEED, J. D., NARDONE, M., OMAZIC, L. J., & MILLAR, P. J. (2021). Sex Differences in Muscle Metaboreflex Activation after Static Handgrip Exercise. Medicine & Science in Sports & Exercise, 53(12), 2596–2604. https://doi.org/10.1249/mss.0000000000002747
Noninvasive Microvascular Indices Reveal Peripheral Vascular Abnormalities in Patients With Suspected Coronary Microvascular Dysfunction
Canadian Journal of Cardiology / Aug 01, 2020
Nardone, M., Miner, S., McCarthy, M., Ardern, C. I., & Edgell, H. (2020). Noninvasive Microvascular Indices Reveal Peripheral Vascular Abnormalities in Patients With Suspected Coronary Microvascular Dysfunction. Canadian Journal of Cardiology, 36(8), 1289–1297. https://doi.org/10.1016/j.cjca.2019.12.003
Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction
Applied Physiology, Nutrition, and Metabolism / Jan 11, 2021
Nardone, M., Incognito, A. V., Teixeira, A. L., Cacoilo, J. A., Vianna, L. C., & Millar, P. J. (2021). Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction. Applied Physiology, Nutrition, and Metabolism, 1–7. https://doi.org/10.1139/apnm-2020-0721
Signal-averaged resting sympathetic transduction of blood pressure: is it time to account for prevailing muscle sympathetic burst frequency?
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Sep 01, 2021
Nardone, M., Incognito, A. V., Kathia, M. M., Omazic, L. J., Lee, J. B., Teixeira, A. L., Xie, S., Vianna, L. C., & Millar, P. J. (2021). Signal-averaged resting sympathetic transduction of blood pressure: is it time to account for prevailing muscle sympathetic burst frequency? American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 321(3), R484–R494. https://doi.org/10.1152/ajpregu.00131.2021
Within-breath sympathetic baroreflex sensitivity is modulated by lung volume but unaffected by acute intermittent hypercapnic hypoxia in men
American Journal of Physiology-Heart and Circulatory Physiology / Jul 01, 2020
Nardone, M., Teixeira, A. L., Incognito, A. V., Vermeulen, T. D., Shafer, B. M., Millar, P. J., & Foster, G. E. (2020). Within-breath sympathetic baroreflex sensitivity is modulated by lung volume but unaffected by acute intermittent hypercapnic hypoxia in men. American Journal of Physiology-Heart and Circulatory Physiology, 319(1), H213–H221. https://doi.org/10.1152/ajpheart.00296.2020
Blood pressure oscillations impact signal-averaged sympathetic transduction of blood pressure: implications for the association with resting sympathetic outflow
American Journal of Physiology-Heart and Circulatory Physiology / Oct 01, 2021
Nardone, M., Katerberg, C., Incognito, A. V., Teixeira, A. L., Vianna, L. C., & Millar, P. J. (2021). Blood pressure oscillations impact signal-averaged sympathetic transduction of blood pressure: implications for the association with resting sympathetic outflow. American Journal of Physiology-Heart and Circulatory Physiology, 321(4), H798–H806. https://doi.org/10.1152/ajpheart.00422.2021
Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia
Medicine & Science in Sports & Exercise / Jun 02, 2021
SHAFER, B. M., INCOGNITO, A. V., VERMEULEN, T. D., NARDONE, M., TEIXEIRA, A. L., BENBARUJ, J., MILLAR, P. J., & FOSTER, G. E. (2021). Muscle Metaboreflex Control of Sympathetic Activity Is Preserved after Acute Intermittent Hypercapnic Hypoxia. Medicine & Science in Sports & Exercise, 53(11), 2233–2244. https://doi.org/10.1249/mss.0000000000002716
Assessing functional sympatholysis during rhythmic handgrip exercise using Doppler ultrasound and near-infrared spectroscopy: sex differences and test-retest reliability
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Nov 01, 2022
Teixeira, A. L., Garland, M., Lee, J. B., Nardone, M., & Millar, P. J. (2022). Assessing functional sympatholysis during rhythmic handgrip exercise using Doppler ultrasound and near-infrared spectroscopy: sex differences and test-retest reliability. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 323(5), R810–R821. https://doi.org/10.1152/ajpregu.00123.2022
Reply to Fadel et al.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Feb 01, 2022
Nardone, M., Vianna, L. C., & Millar, P. J. (2022). Reply to Fadel et al. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 322(2), R123–R125. https://doi.org/10.1152/ajpregu.00265.2021
Muscle sympathetic single-unit responses during rhythmic handgrip exercise and isocapnic hypoxia in males: the role of sympathoexcitation magnitude
Journal of Neurophysiology / Jul 01, 2021
Incognito, A. V., Teixeira, A. L., Shafer, B. M., Nardone, M., Vermeulen, T. D., Foster, G. E., & Millar, P. J. (2021). Muscle sympathetic single-unit responses during rhythmic handgrip exercise and isocapnic hypoxia in males: the role of sympathoexcitation magnitude. Journal of Neurophysiology, 126(1), 170–180. https://doi.org/10.1152/jn.00678.2020
Characterization of the Human Coronary Microvascular Response to Multiple Hyperaemic Agents
CJC Open / Feb 01, 2021
Nardone, M., McCarthy, M., Ardern, C. I., Edgell, H., Toleva, O., Nield, L. E., & Miner, S. E. S. (2021). Characterization of the Human Coronary Microvascular Response to Multiple Hyperaemic Agents. CJC Open, 3(2), 133–141. https://doi.org/10.1016/j.cjco.2020.09.017
Standard exercise stress testing attenuates peripheral microvascular function in patients with suspected coronary microvascular dysfunction
BMC Sports Science, Medicine and Rehabilitation / Feb 27, 2021
Nardone, M., Miner, S., McCarthy, M., & Edgell, H. (2021). Standard exercise stress testing attenuates peripheral microvascular function in patients with suspected coronary microvascular dysfunction. BMC Sports Science, Medicine and Rehabilitation, 13(1). https://doi.org/10.1186/s13102-021-00246-8
Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS)
Journal of Applied Physiology / Apr 01, 2020
Nardone, M., Guzman, J., Harvey, P. J., Floras, J. S., & Edgell, H. (2020). Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS). Journal of Applied Physiology, 128(4), 907–913. https://doi.org/10.1152/japplphysiol.00040.2020
Attenuated Sympathetic Blood Pressure Transduction in Patients With Treated Heart Failure With Reduced Ejection Fraction
Hypertension / Dec 01, 2022
Nardone, M., Notarius, C. F., Badrov, M. B., Millar, P. J., & Floras, J. S. (2022). Attenuated Sympathetic Blood Pressure Transduction in Patients With Treated Heart Failure With Reduced Ejection Fraction. Hypertension, 79(12), 2764–2773. https://doi.org/10.1161/hypertensionaha.122.19850
Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation
The Journal of Physiology / Jun 09, 2022
Shafer, B. M., Incognito, A. V., Vermeulen, T. D., Nardone, M., Teixeira, A. L., Klassen, S. A., Millar, P. J., & Foster, G. E. (2022). Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation. The Journal of Physiology, 600(13), 3127–3147. Portico. https://doi.org/10.1113/jp282933
Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females
Clinical Autonomic Research / May 27, 2023
O’Brien, M. W., Nardone, M., Foster, M., Coovadia, Y., Usselman, C. W., Taylor, C. E., Millar, P. J., & Kimmerly, D. S. (2023). Higher sympathetic transduction is independently associated with greater very short-term diastolic blood pressure variability in young healthy males and females. Clinical Autonomic Research, 33(4), 529–532. https://doi.org/10.1007/s10286-023-00949-7
Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology / Jun 01, 2022
Teixeira, A. L., Nardone, M., Samora, M., Fernandes, I. A., Ramos, P. S., Sabino-Carvalho, J. L., Ricardo, D. R., Millar, P. J., & Vianna, L. C. (2022). Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 322(6), R501–R510. https://doi.org/10.1152/ajpregu.00291.2021
Renal vascular conductance is unrelated to leg vascular conductance or muscle sympathetic nerve activity at rest and during stress in humans
Journal of Applied Physiology / Jul 01, 2023
Teixeira, A. L., Lee, J. B., Nardone, M., Burr, J. F., & Millar, P. J. (2023). Renal vascular conductance is unrelated to leg vascular conductance or muscle sympathetic nerve activity at rest and during stress in humans. Journal of Applied Physiology, 135(1), 154–164. https://doi.org/10.1152/japplphysiol.00673.2022
CKD patients have augmented beat-to-beat BP variability that is not improved with 12 weeks of cycling exercise
Physiology / May 01, 2023
Sabino-Carvalho, J., Jeong, J., Sprick, J., Nardone, M., DaCosta, D., & Park, J. (2023). CKD patients have augmented beat-to-beat BP variability that is not improved with 12 weeks of cycling exercise. Physiology, 38(S1). https://doi.org/10.1152/physiol.2023.38.s1.5729394
Augmented sympathetic neurovascular transduction following acute exercise in normotensive adults
Physiology / May 01, 2023
Nardone, M., Pfundt, K., & Millar, P. (2023). Augmented sympathetic neurovascular transduction following acute exercise in normotensive adults. Physiology, 38(S1). https://doi.org/10.1152/physiol.2023.38.s1.5732355
Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin and muscle
Experimental Physiology / May 20, 2013
Fatouleh, R., & Macefield, V. G. (2013). Cardiorespiratory coupling of sympathetic outflow in humans: a comparison of respiratory and cardiac modulation of sympathetic nerve activity to skin and muscle. Experimental Physiology, 98(9), 1327–1336. Portico. https://doi.org/10.1113/expphysiol.2013.072421
Cannabis Inhalation Acutely Reduces Muscle Sympathetic Nerve Activity in Humans
Circulation / Dec 20, 2022
Cheung, C. P., Nardone, M., Lee, J. B., Baker, R. E., Millar, P. J., & Burr, J. F. (2022). Cannabis Inhalation Acutely Reduces Muscle Sympathetic Nerve Activity in Humans. Circulation, 146(25), 1972–1974. https://doi.org/10.1161/circulationaha.122.062564
Abstract 13228: Cannabis Inhalation Reduces Muscle Sympathetic Nerve Activity in Humans
Circulation / Nov 08, 2022
Cheung, C. P., Nardone, M., Lee, J. B., Baker, R. E., Millar, P. J., & Burr, J. F. (2022). Abstract 13228: Cannabis Inhalation Reduces Muscle Sympathetic Nerve Activity in Humans. Circulation, 146(Suppl_1). https://doi.org/10.1161/circ.146.suppl_1.13228
Pressor Response To Blood-Flow Restriction Exercise: Influence Of Muscle Mass And Central Blood Volume Reduction
Medicine & Science in Sports & Exercise / Sep 01, 2022
Pignanelli, C., Thompson, K. M. A., Cohen, J. N., Cheung, C. P., Coates, A. M., Nardone, M., Millar, P. J., & Burr, J. F. (2022). Pressor Response To Blood-Flow Restriction Exercise: Influence Of Muscle Mass And Central Blood Volume Reduction. Medicine & Science in Sports & Exercise, 54(9S), 351–351. https://doi.org/10.1249/01.mss.0000879432.31339.a2
Hypoxia‐induced sympathetic long‐term facilitation is mediated by a rightward shift in sympathetic action potential amplitude distribution and baroreflex resetting of action potential clusters
The FASEB Journal / May 01, 2022
Shafer, B., Incognito, A., Vermeulen, T., Nardone, M., Teixeira, A., Klassen, S., Millar, P., & Foster, G. (2022). Hypoxia‐induced sympathetic long‐term facilitation is mediated by a rightward shift in sympathetic action potential amplitude distribution and baroreflex resetting of action potential clusters. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r2888
Intra and inter‐day reproducibility of the functional sympatholysis protocol during rhythmic handgrip exercise in healthy humans
The FASEB Journal / May 01, 2022
Teixeira, A. L., Garland, M., Lee, J. B., Nardone, M., & Millar, P. J. (2022). Intra and inter‐day reproducibility of the functional sympatholysis protocol during rhythmic handgrip exercise in healthy humans. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r4098
Sympathetic transduction of blood pressure during graded lower body negative pressure
The FASEB Journal / May 01, 2022
Nardone, M., Katerberg, C., Teixeira, A. L., & Millar, P. J. (2022). Sympathetic transduction of blood pressure during graded lower body negative pressure. The FASEB Journal, 36(S1). Portico. https://doi.org/10.1096/fasebj.2022.36.s1.r3374
Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics
Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease / Jan 01, 2022
Millar, P. J., Nardone, M., & Floras, J. S. (2022). Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics. Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, 369–390. https://doi.org/10.1016/b978-0-323-91391-1.00024-8
Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults
Journal of Neurophysiology / Sep 01, 2020
Incognito, A. V., Nardone, M., Teixeira, A. L., Lee, J. B., Kathia, M. M., & Millar, P. J. (2020). Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults. Journal of Neurophysiology, 124(3), 682–690. https://doi.org/10.1152/jn.00305.2020
Case Studies in Physiology: Sympathetic neural discharge patterns in a healthy young male during end-expiratory breath hold-induced sinus pause
Journal of Applied Physiology / Aug 01, 2020
Vermeulen, T. D., Shafer, B. M., Incognito, A. V., Nardone, M., Teixeira, A. L., Millar, P. J., Shoemaker, J. K., & Foster, G. E. (2020). Case Studies in Physiology: Sympathetic neural discharge patterns in a healthy young male during end-expiratory breath hold-induced sinus pause. Journal of Applied Physiology, 129(2), 230–237. https://doi.org/10.1152/japplphysiol.00307.2020
Stretching our understanding of baroreflex control in humans: evidence of a positive feedback pulmonary baroreflex
The Journal of Physiology / Mar 28, 2020
Nardone, M., & Teixeira, A. L. (2020). Stretching our understanding of baroreflex control in humans: evidence of a positive feedback pulmonary baroreflex. The Journal of Physiology, 598(8), 1435–1436. Portico. https://doi.org/10.1113/jp279662
Comparison of Non‐Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction
The FASEB Journal / Apr 01, 2019
Nardone, M., Miner, S., McCarthy, M., & Edgell, H. (2019). Comparison of Non‐Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction. The FASEB Journal, 33(S1). Portico. https://doi.org/10.1096/fasebj.2019.33.1_supplement.689.1
Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans
Journal of Applied Physiology / Nov 01, 2016
Notay, K., Seed, J. D., Incognito, A. V., Doherty, C. J., Nardone, M., Burns, M. J., & Millar, P. J. (2016). Validity and reliability of measuring resting muscle sympathetic nerve activity using short sampling durations in healthy humans. Journal of Applied Physiology, 121(5), 1065–1073. https://doi.org/10.1152/japplphysiol.00736.2016
Education
York University
MSc, Physiology / 2019
University of Guelph
Ph.D, Physiology / 2023 (anticipated)
Join Massimo on NotedSource!
Join Now
At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.
For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.
For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.