Felipe Oyarzun-Ampuero

Professor at Universidad of Chile with wide interest in encapsulation at nano, micro and macroscale

Research Expertise

Pharmaceutical Science
Food Science
Biotechnology
Pharmacology
Drug Discovery
Cell Biology
Biochemistry
Clinical Biochemistry
Molecular Biology
Physiology
Development
Bioengineering
Biomedical Engineering
Analytical Chemistry
Biomaterials
Polymers and Plastics
Materials Chemistry
Organic Chemistry
Environmental Chemistry
Molecular Medicine
Physical and Theoretical Chemistry
Medical–Surgical Nursing
Dermatology
Surgery
Surfaces, Coatings and Films
Process Chemistry and Technology
Inorganic Chemistry
Computer Science Applications
Catalysis
Spectroscopy
Pharmacology (medical)
Endocrinology, Diabetes and Metabolism
Internal Medicine
Electrochemistry
Condensed Matter Physics
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

About

Felipe Oyarzún Ampuero graduated as a Pharmaceutical Chemist in the Austral University of Chile (2004). He obtained a “Diploma of Advanced Studies” (year 2007) and the degree of “Doctor in Research and Development of Medicines” (year 2011) at the University of Santiago de Compostela (Spain). Later he developed postdoctoral studies (2011-2013) at the Polymer Laboratory of the Universidad Austral de Chile. To carry out these studies he has received scholarships from MINEDUC (undergraduate) and CONICYT (postgraduate). In 2013 he joined to the University of Chile as an academic with a project on “Insertion of Advanced Human Capital in the Academy”. He is currently the Director of the Department of Pharmaceutical Sciences and Technology. In the teaching field he teaches to undergraduate and graduate students (Master's and Doctorate). He has been a researcher responsible for projects related to basic science (1 Fondecyt startup, 3 Fondecyt Regular, 2 Fondecyt postdoctoral) and several technological and/or applied science projects (Fondequip, Fondef and Corfo, among others). He has also been principal investigator in projects of different kinds (Fondap, Fondef, Fondequip, Anillo, Fondecyt regular, among others). The laboratory directed by Dr. Oyarzún has the necessary equipment to characterize liquid and solid formulations of different sizes (from nanometers to millimeters), their stability and the release profile of the active molecule contained. His main lines of research are: Encapsulation of active molecules (drugs and nutrients) in nano- and microsystems mediated by non-covalent interactions. Study of chemical interactions for the formation of nano and microsystems. Development of new materials for the pharmaceutical and food industries. Dr. Oyarzún has published more than 50 ISI publications, almost all of them from the first quartile. Below are the patents in which he appears as an inventor: **Accepted patents:** Application for USA: A new and green methodology to create polymeric nanocarriers containig hydrophilic low molecular-weight drugs and providing a very high drug loading and a very high prolonged release” (US/16/888,438). Felipe Oyarzún, Gabriela Villamizar, Ignacio Moreno, Elton Molina (**GRANTED**). Application for Spain: Nanocapsules with a polimeric Shell (ES2385995B2). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED AND LICENSED**). Application for USA:Nanocapsules with a polimeric Shell (US 9415019, B2). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED**). Application for Europe: Nanocapsules with a polymeric Shell (EP2664324(B1). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED**). Application for Chile: Biomaterial que comprende quitosano y al menos un glicosaminoglicano” (PCT/CL2012/000023). Miguel Concha Murray, Ignacio Moreno Villoslada, Sandra Lorena Orellana Donoso, Felipe Oyarzun Ampuero, María Alejandra Vidal Villa, Annesi Gisela Giacaman Fonseca, María Francisca Pavicic Rojas, Carlos Morales Hernandez, Marcos Ruminot Bascur, Sandra Pamela Jofre Rivas (**GRANTED**). **Application patents:** M.P. Ocaranza, J.E. Jalil, J.O. Morales, F. Oyarzun-Ampuero, E. Soto-Bustamante, F. Gonzalez-Nilo. Composición farmacéutica que comprende un péptido o una combinación de péptidos agonistas de los receptores Mas, AT1 y AT2. Chilean Patent Application PCT/CL2023/050084. PCT Application: Compositions (PCT/IB2022/051550). Verónica Palma, Daniela Carrillo, Fernando Valenzuela, Felipe Oyarzún, María Gabriela Villamizar (**LICENCED**). PCT Application: Nanoparticle of chitosan and cyclodextrin containing encapsulated interferon and pharmaceutical compositions that contain it" (PCT/IB2019/052510). Rodrigo Naves, Luis González Felipe Oyarzún. PCT Application: Método para obtener nanoestructuras con carotenoides y nanoestructuras obtenidas (PCT/CL2017/0550046). Felipe Oyarzún, Javier Morales, Matías Silva, Mariela Inostroza, Andrew Quest, Marcelo Kogan, Simón Guerrero, Ignacio Moreno, Carlos Alarcón, Mario Flores, César Torres (**LICENCED**). PCT Application: Curcumin-Loaded nanoemulsions, method of manufacture, and method of preventive treatment using the same (PCT) (15/856,786). Felipe Oyarzún, Andrew Quest, Simón Guerrero, Marcelo Kogan, Pamela Contreras, Víctor Díaz, Pablo Lara, Areli Cárdenas, Lisette Leyton, Andrea Vivanco, Víctor Miranda. Application for Chile: Microdieta para especies marinas de cultivo, incluyendo peces en etapas de desarrollo, la que una vez deshidratada y reconstituida toma una forma alargada similar a un alimento vivo, y método de preparación (201603279). Felipe Andrés Oyarzún Ampuero, Ignacio Moreno-Villoslada, Mariela Inostroza Riquelme. Application for Brazil: Nanocapsules with a polymeric Shell (PI98213). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes. Application for China: Nanocapsules with a polymeric Shell (CN103596558). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes.

Publications

Chitosan–hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma
International Journal of Pharmaceutics
2009
Conventional spray-drying and future trends for the microencapsulation of fish oil
Trends in Food Science & Technology
2016
Nanoparticles for the Treatment of Wounds
Current Pharmaceutical Design
2015
Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery
European Journal of Pharmaceutical Sciences
2013
Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin
Antioxidants
2018
Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis
Nanoscale
2018
A new drug nanocarrier consisting of polyarginine and hyaluronic acid
European Journal of Pharmaceutics and Biopharmaceutics
2011
Lipid nanoparticles for the topical delivery of retinoids and derivatives
Nanomedicine
2015
Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases
Food Chemistry
2018
Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy
Journal of Controlled Release
2021
Design, development and evaluation of nanoemulsion containing avocado peel extract with anticancer potential: A novel biological active ingredient to enrich food
Food Hydrocolloids
2021
A Simple Mathematical Model for Wound Closure Evaluation
Journal of the American College of Clinical Wound Specialists
2015
Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules
Nanocomposite Particles for Bio-Applications
2011
Surface-Modified Nanoparticles to Improve Drug Delivery
Dekker Encyclopedia of Nanoscience and Nanotechnology, Third Edition
2014
Effect of the incorporation of liposomes loaded with rutin on the transport properties of edible film produced with hydroxypropyl methylcellulose: An in vitro release study
LWT
2024
Correction to: Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue
Diabetology & Metabolic Syndrome
2020
Colloidal nanomedicines with prolonged release of chloroquine based on interactions with aromatic polymers after mixing two liquids: from in silico simulation of nanoparticle formation to efficient in-bench scale up
Journal of Molecular Liquids
2024
Thermosensitive Chitosan Hydrogels: A Potential Strategy for Prolonged Iron Dextran Parenteral Supplementation
Polymers
2023
Thermosensitive Chitosan Hydrogels as a Vehicle for Iron Dextran as a Potential Strategy for Parenteral Nutrient Supplementation
Unknown Venue
2023
The Critical Role of Aromatic-Aromatic Drug-Polymer Interactions to Provide Nanomedicines Containing Chloroquine: A Simple Proposal to Provide High Encapsulation, High Stability, and Prolonged Drug Release
Unknown Venue
2020
Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue.
Unknown Venue
2020
The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules Effectively Reduces Helicobacter pylori Growth, Bacterial Biofilm Formation, Gastric Cell Adhesion and Internalization
Antioxidants
2023
Development of biodegradable and vermicompostable films based on alginate and waste eggshells
Food Hydrocolloids
2023
Efficacy of stem cell secretome loaded in hyaluronate sponge for topical treatment of psoriasis
Bioengineering & Translational Medicine
2023
Encapsulation of house fly larvae (Musca domestica) meal by ionic gelation as a strategy to develop a novel nutritive food ingredient with improved aroma and appearance
LWT
2022
Influence of the particle size of encapsulated chia oil on the oil release and bioaccessibility during in vitro gastrointestinal digestion
Food & Function
2022
MWCNT‐Organoimido Polyoxomolybdate Hybrid Material: Analytical Applications for Amperometric Sensing of Hydrogen Peroxide
Electroanalysis
2021
The key role of the drug self-aggregation ability to obtain optimal nanocarriers based on aromatic-aromatic drug-polymer interactions
European Journal of Pharmaceutics and Biopharmaceutics
2021
A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo
International Journal of Molecular Sciences
2021
House fly (Musca domestica) larvae meal as an ingredient with high nutritional value: Microencapsulation and improvement of organoleptic characteristics
Food Research International
2021
Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue
Diabetology & Metabolic Syndrome
2020
Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation
Marine Drugs
2020
Encapsulation of Iron Oxide Nanoparticles and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential
Journal of Nanoscience and Nanotechnology
2019
A New Methodology to Create Polymeric Nanocarriers Containing Hydrophilic Low Molecular-Weight Drugs: A Green Strategy Providing a Very High Drug Loading
Molecular Pharmaceutics
2019
Ionic Nanocomplexes of Hyaluronic Acid and Polyarginine to Form Solid Materials: A Green Methodology to Obtain Sponges with Biomedical Potential
Nanomaterials
2019
Synthesis of tuneable amphiphilic-modified polyketone polymers, their complexes with 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin, and their role in the photooxidation of 1,3,5-triphenylformazan confined in polymeric nanoparticles
Polymer
2019
A simple and green methodology to assemble poly(4-vinylpyridine) and a sulfonated azo-dye for obtaining stable polymeric nanoparticles
Polymer
2018
Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy
Current Topics in Medicinal Chemistry
2018
Protection of astaxanthin from photodegradation by its inclusion in hierarchically assembled nano and microstructures with potential as food
Food Hydrocolloids
2018
Aerogels made of chitosan and chondroitin sulfate at high degree of neutralization: Biological properties toward wound healing
Journal of Biomedical Materials Research Part B: Applied Biomaterials
2018
Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential
Molecules
2018
Antibacterial activity against Staphylococcus aureus of chitosan/chondroitin sulfate nanocomplex aerogels alone and enriched with erythromycin and elephant garlic (Allium ampeloprasum L. var. ampeloprasum) extract
Pure and Applied Chemistry
2018
Chitosan/chondroitin sulfate aerogels with high polymeric electroneutralization degree: formation and mechanical properties
Pure and Applied Chemistry
2017
Totally Organic Redox-Active pH-Sensitive Nanoparticles Stabilized by Amphiphilic Aromatic Polyketones
The Journal of Physical Chemistry B
2018
Aerogels containing 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin with controlled state of aggregation
Dyes and Pigments
2017
Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy
Current Pharmaceutical Design
2016
Facile Formation of Redox‐Active Totally Organic Nanoparticles in Water by In Situ Reduction of Organic Precursors Stabilized through Aromatic–Aromatic Interactions by Aromatic Polyelectrolytes
Macromolecular Rapid Communications
2016
Photochromic Solid Materials Based on Poly(decylviologen) Complexed with Alginate and Poly(sodium 4-styrenesulfonate)
The Journal of Physical Chemistry B
2015
Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases
Current Pharmaceutical Design
2015
Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer
Current Pharmaceutical Design
2015
Association Efficiency of Three Ionic Forms of Oxytetracycline to Cationic and Anionic Oil-In-Water Nanoemulsions Analyzed by Diafiltration
Journal of Pharmaceutical Sciences
2015
Immobilization of rhodamine 6G in calcium alginate microcapsules based on aromatic–aromatic interactions with poly(sodium 4-styrenesulfonate)
Reactive and Functional Polymers
2014
Flow Chemistry to Control the Synthesis of Nano and Microparticles for Biomedical Applications
Current Topics in Medicinal Chemistry
2014
Therapeutic Potential of a Low-Cost Device for Wound Healing
American Journal of Therapeutics
2013
A Potential Nanomedicine Consisting of Heparin‐Loaded Polysaccharide Nanocarriers for the Treatment of Asthma
Macromolecular Bioscience
2011
Chitosan-coated lipid nanocarriers for therapeutic applications
Journal of Drug Delivery Science and Technology
2010
Binding of chlorpheniramine maleate to pharmacologically important alginic acid, carboxymethylcellulose, κ‐carageenan, and ι‐carrageenan as studied by diafiltration
Journal of Applied Polymer Science
2005
Comparison between the binding of chlorpheniramine maleate to poly(sodium 4-styrenesulfonate) and the binding to other polyelectrolytes
Polymer
2005
USE OF ULTRAFILTRATION ON THE EVALUATION AND QUANTIFICATION OF THE INTERACTIONS BETWEEN POLYMERS AND LOW MOLECULAR-WEIGHT MOLECULES IN AQUEOUS SOLUTIONS
Journal of the Chilean Chemical Society
2004

Education

Austral University of Chile

Postdoc, Faculty of Medicine / January, 2013

Valdivia

University of Santiago de Compostela

Ph.D., Department of Pharmacy / November, 2011

Santiago de Compostela

Austral University of Chile

Pharmacist, Department of Pharmacy / March, 2004

Valdivia

Experience

University of Chile

Director / January, 2021Present

Associate Professor / January, 2016Present

Assistant Professor / January, 2013January, 2016

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