Joseph Druso

Research Expertise

Biomedical Sciences
Molecular Biology
Cell Biology
Oncology
Cancer Research
Physiology
Biochemistry
Biotechnology
Drug Discovery
Medical Laboratory Technology
Histology
Biomedical Engineering
Bioengineering
Computer Science Applications
Physiology (medical)
Pharmacology (medical)

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Publications

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells
Proceedings of the National Academy of Sciences
2011
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
Nature Communications
2017
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice
Proceedings of the National Academy of Sciences
2008
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis
Proceedings of the National Academy of Sciences
2019
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
Cell Reports
2019
Deletion of Cdc42 Enhances ADAM17-Mediated Vascular Endothelial Growth Factor Receptor 2 Shedding and Impairs Vascular Endothelial Cell Survival and Vasculogenesis
Molecular and Cellular Biology
2013
EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation
Proceedings of the National Academy of Sciences
2010
Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer
Trends in Cancer
2018
Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases
American Journal of Physiology-Cell Physiology
2020
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice
Protein & Cell
2012
Lung organoids: advances in generation and 3D-visualization
Histochemistry and Cell Biology
2021
Cdc42 functions as a regulatory node for tumour‐derived microvesicle biogenesis
Journal of Extracellular Vesicles
2021
The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis
Journal of Biological Chemistry
2020
An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland
Journal of Biological Chemistry
2016
Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer
Unknown Venue
2022
Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer
Nature Biomedical Engineering
2023
A Redox Proteome Screen in Lungs From Patients With Idiopathic Pulmonary Fibrosis Identifies Cathepsin B as a Target for Glutathione-Dependent Protein Oxidation That Is Associated With Dysregulated Airway Epithelial Cell Proteostasis
A29. EPITHELIUM: FIRST LINE OF DEFENSE
2023
Oxidative Processes in the Endoplasmic Reticulum Contribute to Enhanced Oxidation of Collagen 1 and Promote Aberrant Activation of Lung Fibroblasts
A66. DISSECTING THE MATRIX AND MESENCHYMAL CELLS IN FIBROSIS
2023
Increases in Glutathione Dependent Protein Oxidation Impair Airway Basal Cell Differentiation
A107. MECHANISMS OF FIBROSIS/FIBROBLAST BIOLOGY
2022
Increases in Glutathione-Dependent Oxidation of Collagen 1 Occur in Idiopathic Pulmonary Fibrosis and Are Associated with Fibroblast Activation
A60. PULMONARY FIBROSIS: ANIMAL AND CELL CULTURE MODELS
2022
Oxidative Inactivation of Cathepsin B is Associated with Dysregulated Airway Stem Cell Proteostasis and Repair
Free Radical Biology and Medicine
2022
Correction to: Lung organoids: advances in generation and 3D-visualization
Histochemistry and Cell Biology
2021
Liver-Type Glutaminase is an Essential and Druggable Metabolic Node in Defined Breast Cancer Subtypes
SSRN Electronic Journal
2018

Education

Cornell University

Ph.D., Molecular Medicine / January, 2017

Ithaca, New York, United States of America

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