Sandrina Heleno

Researcher at Polytechnic Institute of Bragança and head of the Food&Biotech Research Group

Bragança

Research Expertise

Food safety
Food microbiology
Bio-based extracts (antimicrobials, antioxidants, biostimulants)
Wines and vines
Stabilization of natural agents

About

I graduated in Biotechnological Engineering in 2008, obtained my master´s degree in Biotechnology in 2010 and my PhD in Sciences (Chemistry) in 2014. In 2015 I was awarded an FCT postdoc grant (2015-2018) and in 2018 I was awarded a Junior research contract through the Scientific Employment Stimulus (CEECIND/03040/2017) and I am currently an Assistant researcher at the Mountain Research Centre (CIMO) and Associated Laboratory SusTEC. During my career I´ve been acquiring important skills in the field of food science and technology by exploiting natural matrices. Thinking ahead, from the in vitro results, in my PhD I performed the chemical synthesis of human metabolites to characterize their behavior after metabolization. My research targets are the identification, separation and recovery of functional molecules, as well as their implementation as ingredients and bioactives in food, with an ultimate goal to extract high added-value molecules and reuse them in the food chain (from agriculture to the consumer). Being an integrated member of CIMO/ SusTEC, I´ve been exploiting the agrifood sector, mainly in implementing greener processes, and optimizing ideal conditions of stability for industry application. I´ve been participating in national and international financed research projects, being the PI of 4 financed projects composed of a multidisciplinary consortium with several renowned enterprises and research centers. My research activity resulted in the publication of more than 100 papers in indexed journals, 9 book chapters, 7 patents, related with the development of natural preservatives and functional foods including 1 patent related with the development of hipocholesterolemic extracts; and participated in more than 100 conferences having an h-index of 37. One of the international patents was transferred to the industry, leaded to the creation of a spin-of dedicated to the exploitation of the developed technology, a natural preservative. I am also na Associate Editor of the Frontiers in Nutrition Journal (IF=6.59) and guest editor of several special issues in indexed journals. I am also editor of a book entitled: Natural Secondary Metabolites - From Nature, Through Science, to Industry, from Springer Nature. I was a member of the team that awarded the first place of the European Social Innovation prize (50.000 Euros) and with three National prizes (2 BornFromKnowledge,1 CA Crédito agrícola (10.000 Euros). I am in the list of the 2% most cited researchers in the food area in a study perform by the Stanford University. I organized scientific events and currently supervise Pos-doctoral (2 ongoing), PhD students (12 ongoing), master (3). I have been also invited to evaluate international projects and also Pod-doctoral grant programs. All my research is in straight collaboration with enterprises, promoting the technology transfer from university to companies. I am also Principal Researcher of the collaborative laboratory Aquavalor and also member of the PanBalkan alliance in representation of Portugal. Recently I am head of the research group Food&Biotech inserted in CIMO/SusTEC. My research are relies on: functional foods, biofungicides, vines and wines technologies and natural antimicrobials.

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Publications

Bioactivity of phenolic acids: Metabolites versus parent compounds: A review
Food Chemistry
2015
Phenolic compounds: current industrial applications, limitations and future challenges
Food & Function
2021
Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities
Phytochemistry
2015
Cosmetics Preservation: A Review on Present Strategies
Molecules
2018
Tocopherols composition of Portuguese wild mushrooms with antioxidant capacity
Food Chemistry
2010
Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters
Food and Chemical Toxicology
2013
Fruiting body, spores and in vitro produced mycelium of Ganoderma lucidum from Northeast Portugal: A comparative study of the antioxidant potential of phenolic and polysaccharidic extracts
Food Research International
2012
Optimization of ultrasound-assisted extraction to obtain mycosterols from Agaricus bisporus L. by response surface methodology and comparison with conventional Soxhlet extraction
Food Chemistry
2016
Lamiaceae often used in Portuguese folk medicine as a source of powerful antioxidants: Vitamins and phenolics
LWT - Food Science and Technology
2010
Study and characterization of selected nutrients in wild mushrooms from Portugal by gas chromatography and high performance liquid chromatography
Microchemical Journal
2009
The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives
Food Research International
2015
Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines
Food and Chemical Toxicology
2010
The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits
Food and Chemical Toxicology
2017
A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L.) Pers. from Portugal and Serbia
Food Research International
2013
Systematic evaluation of the antioxidant potential of different parts of Foeniculum vulgare Mill. from Portugal
Food and Chemical Toxicology
2009
Physicochemical characterization and microbiology of wheat and rye flours
Food Chemistry
2019
Phenolic compounds characterization by LC-DAD- ESI/MSn and bioactive properties of Thymus algeriensis Boiss. & Reut. and Ephedra alata Decne
Food Research International
2019
Comparison of different bread types: Chemical and physical parameters
Food Chemistry
2020
Extraction of triterpenoids and phenolic compounds from Ganoderma lucidum: optimization study using the response surface methodology
Food & Function
2018
Functionalization of yogurts with Agaricus bisporus extracts encapsulated in spray-dried maltodextrin crosslinked with citric acid
Food Chemistry
2018
Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves
Industrial Crops and Products
2018
Anthocyanin Profile of Elderberry Juice: A Natural-Based Bioactive Colouring Ingredient with Potential Food Application
Molecules
2019
Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt)
Food Chemistry
2018
Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity
Microchemical Journal
2019
Calluna vulgaris (L.) Hull: chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
Food & Function
2019
The influence of electron beam radiation in the nutritional value, chemical composition and bioactivities of edible flowers of Bauhinia variegata L. var. candida alba Buch.-Ham from Brazil
Food Chemistry
2018
Profiling polyphenol composition by HPLC-DAD-ESI/MSn and the antibacterial activity of infusion preparations obtained from four medicinal plants
Food & Function
2018
Nutritional and bioactive oils from salmon (Salmo salar) side streams obtained by Soxhlet and optimized microwave-assisted extraction
Food Chemistry
2022
Chemical profile and bioactive properties of the essential oil isolated from Ammodaucus leucotrichus fruits growing in Sahara and its evaluation as a cosmeceutical ingredient
Industrial Crops and Products
2018
Mushroom-based cosmeceutical ingredients: Microencapsulation and in vitro release profile
Industrial Crops and Products
2018
Red pitaya (Hylocereus costaricensis) peel as a source of valuable molecules: Extraction optimization to recover natural colouring agents
Food Chemistry
2022
Microencapsulation of ergosterol and Agaricus bisporus L. extracts by complex coacervation using whey protein and chitosan: Optimization study using response surface methodology
LWT
2019
HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts ofZizyphus lotus(L.) Desf.
Food & Function
2019
A novel natural coating for food preservation: Effectiveness on microbial growth and physicochemical parameters
LWT
2019
Chemical and Bioactive Features of Amaranthus caudatus L. Flowers and Optimized Ultrasound-Assisted Extraction of Betalains
Foods
2021
Non-edible parts of Solanum stramoniifolium Jacq. – a new potent source of bioactive extracts rich in phenolic compounds for functional foods
Food & Function
2017
Promising Preserving Agents from Sage and Basil: A Case Study with Yogurts
Foods
2021
Sea bass (Dicentrarchus labrax) and sea bream (Sparus aurata) head oils recovered by microwave-assisted extraction: Nutritional quality and biological properties
Food and Bioproducts Processing
2022
Effect of Natural Preservatives on the Nutritional Profile, Chemical Composition, Bioactivity and Stability of a Nutraceutical Preparation of Aloe arborescens
Antioxidants
2020
Terpenes
Natural Secondary Metabolites
2023
Natural Secondary Metabolites
Unknown Venue
2023
Phenolic profile and effects of acetone fractions obtained from the inflorescences of Calluna vulgaris (L.) Hull on vaginal pathogenic and non-pathogenic bacteria
Food & Function
2019
Detailed phytochemical characterization and bioactive properties of Myrtus nivelii Batt & Trab
Food & Function
2017
Preservation of Chocolate Muffins with Lemon Balm, Oregano, and Rosemary Extracts
Foods
2021
Effects of the seasonal variation in the phytochemical composition and bioactivities of the wild halophyte Suaeda fruticosa
Food Bioscience
2022
Nutraceuticals and dietary supplements: balancing out the pros and cons
Food & Function
2024
Effects of the extraction techniques on the chemical composition and bioactive properties of lemon balm (Melissa officinalis L.) plants grown under different cropping and irrigation regimes
Food Research International
2023
Non-Alkaloid Nitrogen-Containing Compounds from Fungi
Natural Secondary Metabolites
2023
Betacyanins obtained from alternative novel sources as natural food colorant additives: incorporated in savory and sweet food products
Food & Function
2023
Optimization through Response Surface Methodology of Dynamic Maceration of Olive (Olea europaea L.) Leaves
The 2nd International Electronic Conference on Foods—“Future Foods and Food Technologies for a Sustainable World”
2022
Improving the physicochemical properties of a traditional Portuguese cake – “económicos” with chestnut flour
Food & Function
2022
Antimicrobial Activity of Aqueous Plant Extracts as Potential Natural Additives
The 1st International Electronic Conference on Food Science and Functional Foods
2020
Magnesium and manganese induced changes on chemical, nutritional, antioxidant and antimicrobial properties of the pansy and Viola edible flowers
Food Chemistry
2024
Recovery of anthocyanins from Eugenia spp. fruit peels: a comparison between heat- and ultrasound-assisted extraction
Sustainable Food Technology
2024
Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
Antibiotics
2024
Cistus, Acacia, and Lemon verbena Valorization through Response Surface Methodology: Optimization Studies and Potential Application in the Pharmaceutical and Nutraceutical Industries
Pharmaceuticals
2024
Lemna minor: Unlocking the Value of This Duckweed for the Food and Feed Industry
Foods
2024
The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases
Antibiotics
2024
The influence of magnesium and manganese cations on the chemical and bioactive properties of purple and green basil
Food & Function
2024
Plant extracts as biocontrol agents against Aspergillus carbonarius growth and ochratoxin A production in grapes
International Journal of Food Microbiology
2023
Powdered Foods: Structure, Processing, and Challenges: A Review
Applied Sciences
2023
Optimization and comparison of heat- and ultrasound-assisted extraction methods for anthocyanin recovery from Sicana odorifera fruit epicarp
Biomass Conversion and Biorefinery
2023
Polyphenol Composition by HPLC-DAD-(ESI-)MS/MS and Bioactivities of Extracts from Grape Agri-Food Wastes
Molecules
2023
Recovery of High Valuable Bioactive Molecules from Vaccinium myrtillus L. Bioresidues
Waste and Biomass Valorization
2023
Chemical Characterization, Bioactivity and Toxicity of European Flora Plant Extracts in Search for Potential Natural Origin Preservatives
Plants
2023
Chemical and Bioactive Screening of Green Polyphenol-Rich Extracts from Chestnut By-Products: An Approach to Guide the Sustainable Production of High-Added Value Ingredients
Foods
2023
Assessment of the Use of Common Juniper (Juniperus communis L.) Foliage following the Cascade Principle
Molecules
2023
Fig Leaves (Ficus carica L.): Source of Bioactive Ingredients for Industrial Valorization
Processes
2023
Chemical Characterization and Bioactive Properties of Wine Lees and Diatomaceous Earth towards the Valorization of Underexploited Residues as Potential Cosmeceuticals
Cosmetics
2023
Inflammation: What’s There and What’s New?
Applied Sciences
2023
Plant Extracts and SARS-CoV-2: Research and Applications
Life
2023
The generally recognized as safe (GRAS) microalgae Haematococcus pluvialis (wet) as a multifunctional additive for coloring and improving the organoleptic and functional properties of foods
Food & Function
2023
Fermented food/beverage and health: current perspectives
Rendiconti Lincei. Scienze Fisiche e Naturali
2022
Fertilization of Pot-Grown Cichorium spinosum L.: How It Can Affect Plant Growth, Chemical Profile, and Bioactivities of Edible Parts?
Horticulturae
2022
Food dyes and health: Literature quantitative research analysis
Measurement: Food
2022
Recovery of Citric Acid from Citrus Peels: Ultrasound-Assisted Extraction Optimized by Response Surface Methodology
Chemosensors
2022
Chemical composition and industrial applications of Maritime pine (Pinus pinaster Ait.) bark and other non-wood parts
Reviews in Environmental Science and Bio/Technology
2022
Food Additives from Fruit and Vegetable By-Products and Bio-Residues: A Comprehensive Review Focused on Sustainability
Sustainability
2022
Comparison between Different Extraction Methods in the Recovery of Bioactive Molecules from Melissa officinalis L. under Sustainable Cultivation: Chemical and Bioactive Characterization
The 2nd International Electronic Conference on Plant Sciences—10th Anniversary of Journal Plants
2022
Plant volatiles: Using Scented molecules as food additives
Trends in Food Science & Technology
2022
Arbutus unedo leaf extracts as potential dairy preservatives: case study on quark cheese
Food & Function
2022
Chemical and Bioactive Characterization of the Essential Oils Obtained from Three Mediterranean Plants
Molecules
2021
Novel Incorporation of Red-Stage Haematococcus pluvialis Wet Paste as a Colourant and Enhancer of the Organoleptic and Functional Properties of Filloas †
The 2nd International Electronic Conference on Foods—“Future Foods and Food Technologies for a Sustainable World”
2021
Food Metabolites as Tools for Authentication, Processing, and Nutritive Value Assessment
Foods
2021
Anthocyanins from Rubus fruticosus L. and Morus nigra L. Applied as Food Colorants: A Natural Alternative
Plants
2021
Differences in the phenolic composition and nutraceutical properties of freeze dried and oven-dried wild and domesticated samples of Sanguisorba minor Scop
LWT
2021
Valorisation of black mulberry and grape seeds: Chemical characterization and bioactive potential
Food Chemistry
2021
Stabilization of Bioactive Molecules Through the Spray-Drying Technique: Current Applications and Challenges
Methods and Protocols in Food Science
2021
Betacyanins from Gomphrena globosa L. flowers: Incorporation in cookies as natural colouring agents
Food Chemistry
2020
Potato peels as sources of functional compounds for the food industry: A review
Trends in Food Science & Technology
2020
An Upcoming Approach to Alzheimer's Disease: Ethnopharmacological Potential of Plant Bioactive Molecules
Current Medicinal Chemistry
2020
Bacterial Resistance: Antibiotics of Last Generation used in Clinical Practice and the Arise of Natural Products as New Therapeutic Alternatives
Current Pharmaceutical Design
2020
Promising Antioxidant and Antimicrobial Food Colourants from Lonicera caerulea L. var. Kamtschatica
Antioxidants
2019
Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago
Industrial Crops and Products
2017
Chemical, Nutritional, and Bioactive Potential of Mushrooms
Edible and Medicinal Mushrooms
2017
Development of dairy beverages functionalized with pure ergosterol and mycosterol extracts: an alternative to phytosterol-based beverages
Food & Function
2017
Determination of Antioxidant Compounds in Foodstuff
Food Safety
2016
Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties
Molecules
2016
Optimization of microwave-assisted extraction of ergosterol from Agaricus bisporus L. by-products using response surface methodology
Food and Bioproducts Processing
2016
Chemical composition, antioxidant activity and bioaccessibility studies in phenolic extracts of two Hericium wild edible species
LWT - Food Science and Technology
2015
Nutritional value, bioactive compounds and antioxidant properties of three edible mushrooms from Poland
Food Bioscience
2015
Nutritional value, bioactive compounds, antimicrobial activity and bioaccessibility studies with wild edible mushrooms
LWT - Food Science and Technology
2015
Coprinopsis atramentaria extract, its organic acids, and synthesized glucuronated and methylated derivatives as antibacterial and antifungal agents
Food Funct.
2014
Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives
Food Research International
2014
Phenolic, Polysaccharidic, and Lipidic Fractions of Mushrooms from Northeastern Portugal: Chemical Compounds with Antioxidant Properties
Journal of Agricultural and Food Chemistry
2012
Effects of trophism on nutritional and nutraceutical potential of wild edible mushrooms
Food Research International
2011
Targeted metabolites analysis in wild Boletus species
LWT - Food Science and Technology
2011
Toward the Antioxidant and Chemical Characterization of Mycorrhizal Mushrooms from Northeast Portugal
Journal of Food Science
2011

Education

University of Minho

PhD student / December, 2014

Braga

Instituto Politécnico de Bragança

Master in Biotechnology, Biology and Biotechnology / July, 2010

Bragança

Instituto Politécnico de Bragança

degree in Biotechnological engineering, Biology and Biotecnology / July, 2008

Bragança

Experience

Fundacao para a Ciencia e a Tecnologia

Pos-Doc Researcher / July, 2015June, 2016

Polytechnic University og Bragança

Junior Researcher / April, 2019March, 2022

Polytechnic University of Bragança

Assistant Researcher / April, 2022Present

Colaborative Laboratory AquaValor

Principal Researcher / January, 2020Present

PanBalkan alliance

Portuguese representative / September, 2019Present

Polytechnic University of Bragança

Head of the Food and Biotech Research Group / September, 2023Present

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