Tshering Lama-Sherpa
Postdoctoral Fellow at UT Southwestern Medical Center with over 10 years of experience in cancer research.
Research Expertise
About
Publications
Adipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone
The American Journal of Pathology / Nov 01, 2016
Trotter, T. N., Gibson, J. T., Sherpa, T. L., Gowda, P. S., Peker, D., & Yang, Y. (2016). Adipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone. The American Journal of Pathology, 186(11), 3054–3063. https://doi.org/10.1016/j.ajpath.2016.07.012
Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages
Cancer Research / Jul 21, 2021
Hinshaw, D. C., Hanna, A., Lama-Sherpa, T., Metge, B., Kammerud, S. C., Benavides, G. A., Kumar, A., Alsheikh, H. A., Mota, M., Chen, D., Ballinger, S. W., Rathmell, J. C., Ponnazhagan, S., Darley-Usmar, V., Samant, R. S., & Shevde, L. A. (2021). Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages. Cancer Research, 81(21), 5425–5437. https://doi.org/10.1158/0008-5472.can-20-1723
An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks
Molecular Cancer Research / Feb 01, 2020
Lama-Sherpa, T. D., & Shevde, L. A. (2020). An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks. Molecular Cancer Research, 18(2), 185–193. https://doi.org/10.1158/1541-7786.mcr-19-0665
AKAP13 couples GPCR signaling to mTORC1 inhibition
PLOS Genetics / Oct 21, 2021
Zhang, S., Wang, H., Melick, C. H., Jeong, M.-H., Curukovic, A., Tiwary, S., Lama-Sherpa, T. D., Meng, D., Servage, K. A., James, N. G., & Jewell, J. L. (2021). AKAP13 couples GPCR signaling to mTORC1 inhibition. PLOS Genetics, 17(10), e1009832. https://doi.org/10.1371/journal.pgen.1009832
Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding
Cancer Letters / Oct 01, 2021
Alsheikh, H. A. M., Metge, B. J., Ha, C., Hinshaw, D. C., Mota, M. S. V., Kammerud, S. C., Lama-Sherpa, T., Sharafeldin, N., Wende, A. R., Samant, R. S., & Shevde, L. A. (2021). Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding. Cancer Letters, 517, 24–34. https://doi.org/10.1016/j.canlet.2021.05.022
Regulation of mTORC1 by the Rag GTPases
Biochemical Society Transactions / Mar 16, 2023
Lama-Sherpa, T. D., Jeong, M.-H., & Jewell, J. L. (2023). Regulation of mTORC1 by the Rag GTPases. Biochemical Society Transactions, 51(2), 655–664. https://doi.org/10.1042/bst20210038
SNAT7 regulates mTORC1 via macropinocytosis
Proceedings of the National Academy of Sciences / May 13, 2022
Meng, D., Yang, Q., Jeong, M.-H., Curukovic, A., Tiwary, S., Melick, C. H., Lama-Sherpa, T. D., Wang, H., Huerta-Rosario, M., Urquhart, G., Zacharias, L. G., Lewis, C., DeBerardinis, R. J., & Jewell, J. L. (2022). SNAT7 regulates mTORC1 via macropinocytosis. Proceedings of the National Academy of Sciences, 119(20). https://doi.org/10.1073/pnas.2123261119
Hedgehog signaling enables repair of ribosomal DNA double-strand breaks
Nucleic Acids Research / Sep 07, 2020
Lama-Sherpa, T. D., Lin, V. T. G., Metge, B. J., Weeks, S. E., Chen, D., Samant, R. S., & Shevde, L. A. (2020). Hedgehog signaling enables repair of ribosomal DNA double-strand breaks. Nucleic Acids Research, 48(18), 10342–10352. https://doi.org/10.1093/nar/gkaa733
Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape
Molecular Cancer Research / Sep 30, 2021
Lama-Sherpa, T. D., Das, S., Hinshaw, D. C., Kammerud, S. C., Song, P. N., Alsheikh, H. A., Sorace, A. G., Samant, R. S., & Shevde, L. A. (2021). Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape. Molecular Cancer Research, 20(1), 150–160. https://doi.org/10.1158/1541-7786.mcr-21-0257
Curcumin/cellulose micro crystals/chitosan films: Water absorption behavior and in vitro cytotoxicity
International Journal of Biological Macromolecules / Apr 01, 2015
Bajpai, S. K., Chand, N., Ahuja, S., & Roy, M. K. (2015). Curcumin/cellulose micro crystals/chitosan films: Water absorption behavior and in vitro cytotoxicity. International Journal of Biological Macromolecules, 75, 239–247. https://doi.org/10.1016/j.ijbiomac.2015.01.038
Abstract 115: Hedgehog signaling pathway promotes breast cancer adaptation to hypoxia
Cancer Research / Aug 15, 2020
Lama-Sherpa, T. D., Kammerud, S. C., & Shevde, L. A. (2020). Abstract 115: Hedgehog signaling pathway promotes breast cancer adaptation to hypoxia. Cancer Research, 80(16_Supplement), 115–115. https://doi.org/10.1158/1538-7445.am2020-115
Hedgehog Signaling in Carcinogenesis
Predictive Biomarkers in Oncology / Dec 07, 2018
Lin, V. T. G., Lama-Sherpa, T. D., & Shevde, L. A. (2018). Hedgehog Signaling in Carcinogenesis. In Predictive Biomarkers in Oncology (pp. 297–304). Springer International Publishing. https://doi.org/10.1007/978-3-319-95228-4_24
The Role of Adipocyte Lineage Cells in Myeloma Growth and Dissemination in Bone
Blood / Dec 03, 2015
Trotter, T. N., Lama-Sherpa, T. D., Peker, D., Javed, A., Suva, L. J., & Yang, Y. (2015). The Role of Adipocyte Lineage Cells in Myeloma Growth and Dissemination in Bone. Blood, 126(23), 1797–1797. https://doi.org/10.1182/blood.v126.23.1797.1797
Abstract 2103: Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophages
Cancer Research / Jun 15, 2022
Hinshaw, D. C., Hanna, A., Lama-Sherpa, T., Metge, B., Kammerud, S. C., Benavides, G. A., Kumar, A., Alsheikh, H. A., Mota, M., Chen, D., Ballinger, S., Rathmell, J. C., Ponnazhagan, S., Darley-Usmar, V., Samant, R. S., & Shevde, L. A. (2022). Abstract 2103: Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophages. Cancer Research, 82(12_Supplement), 2103–2103. https://doi.org/10.1158/1538-7445.am2022-2103
Hedgehog signaling induced metabolic reprogramming is essential for M2 polarization of macrophages in breast cancer
The Journal of Immunology / May 01, 2020
Hinshaw, D. C., Hanna, A., Sherpa, T., Samant, R., & Shevde, L. (2020). Hedgehog signaling induced metabolic reprogramming is essential for M2 polarization of macrophages in breast cancer. The Journal of Immunology, 204(1_Supplement), 164.16-164.16. https://doi.org/10.4049/jimmunol.204.supp.164.16
Abstract P3-01-25: Hedgehog signaling-mediated adaptation to hypoxic microenvironment promotes osteoclastogenesis in advanced breast cancer
Cancer Research / Feb 15, 2020
Lama-Sherpa, T. D., Das, S., Hanna, A., Kammerud, S., & Shevde, L. A. (2020). Abstract P3-01-25: Hedgehog signaling-mediated adaptation to hypoxic microenvironment promotes osteoclastogenesis in advanced breast cancer. Cancer Research, 80(4_Supplement), P3-01-25-P3-01–25. https://doi.org/10.1158/1538-7445.sabcs19-p3-01-25
Abstract 3740: Ionizing radiation-induced transcriptomic changes in triple-negative breast cancer cells reveal putative mechanisms of treatment resistance
Cancer Research / Jul 01, 2019
Lin, V. T., Lama-Sherpa, T. D., Samant, R. S., & Shevde, L. A. (2019). Abstract 3740: Ionizing radiation-induced transcriptomic changes in triple-negative breast cancer cells reveal putative mechanisms of treatment resistance. Cancer Research, 79(13_Supplement), 3740–3740. https://doi.org/10.1158/1538-7445.am2019-3740
1H NMR spectral analysis as a new aspect to evaluate the stability of some edible oils
Annals of Agricultural Sciences / Dec 01, 2014
Almoselhy, R. I. M., Allam, M. H., El-Kalyoubi, M. H., & El-Sharkawy, A. A. (2014). 1H NMR spectral analysis as a new aspect to evaluate the stability of some edible oils. Annals of Agricultural Sciences, 59(2), 201–206. https://doi.org/10.1016/j.aoas.2014.11.006
Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells
PLoS ONE / Jan 23, 2014
Desai, V. D., Hsia, H. C., & Schwarzbauer, J. E. (2014). Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLoS ONE, 9(1), e86865. https://doi.org/10.1371/journal.pone.0086865
Ubiquitin-Dependent Protein Degradation
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering / Jan 01, 2013
Hegde, A. N. (2013). Ubiquitin-Dependent Protein Degradation. In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier. https://doi.org/10.1016/b978-0-12-409547-2.02826-2
Amyloid Formation and Polymerization-dependent Inactivation of the Yeast Prion Protein, Ure2p
GBM Annual Spring meeting Mosbach 2005 / Apr 01, 2005
Steven, A. (2005). Amyloid Formation and Polymerization-dependent Inactivation of the Yeast Prion Protein, Ure2p. GBM Annual Spring Meeting Mosbach 2005, 2005(Spring). https://doi.org/10.1240/sav_gbm_2005_m_001086
Education
Mississippi University for Women
Bachelor of Science in Biology, Science and Mathematics / May, 2014
University of Alabama at Birmingham
Ph.D., Molecular biology, Genetics, Biochemistry, Cancer Biology / December, 2020
Mississippi University for Women
Bachelor of Science in Biology, Science and Mathematics / May, 2014
Experience
University of Texas Southwestern Medical Center
Postdoctoral Researcher / February, 2021 — Present
Join Tesh on NotedSource!
Join Now
At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.
For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.
For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.
Expert Institutions
Proudly trusted by
