Elee Shimshoni
Postdoctoral Associate at MIT working on complex human cell models for drug discovery
Research Expertise
About
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Education
Weizmann Institute of Science
Ph.D, Life Sciences / August, 2019
Weizmann Institute of Science
M.Sc., Life Sciences / February, 2014
Hebrew University of Jerusalem
B.Sc., Biology, Psychology / August, 2011
Experience
MIT
Postdoctoral Associate / November, 2022 — Present
• Developed 2D and 3D primary human cell-based disease models for studying obesity and atherosclerosis. • Trained and mentored research technicians and students on cell culture, molecular biology techniques and experimental design. • Collaborated with chemists and computational biologists to test novel therapeutics and targets using cell-based models.
Harvard University
Postdoctoral Fellow / August, 2019 — November, 2022
• Led a project aimed at studying the role of the stroma in the progression from Barrett’s Esophagus to Esophageal Cancer, as part of an international collaboration of clinical and academic partners. • Developed two distinct Esophagus Chip models using human primary cells, both containing a 3D stromal compartment: One of the normal esophagus and one of Barrett’s Esophagus. • Collaborated with Emulate, Inc. as a beta user of their new organ-on-a-chip design and provided feedback leading to improvements to the design that was eventually brought to the market. • Advised collaborators on techniques and subject matters within my domains of expertise, including inflammatory bowel disease, extracellular matrix, and organs-on-chips. • Summarized my work at the Ingber Lab in a first-author publication.
Weizmann Institute of Science
Graduate Student / November, 2011 — August, 2019
• Led a multi-collaborator multidisciplinary team to study and characterize changes in the extracellular matrix that predict colitis, spanning a wide range of analytical approaches. • Authored two first-author publications and a book chapter on extracellular matrix biology in colitis. • Contributed to three other publications in the lab by carrying out imaging, analyses, and writing. • Mentored collaborators and junior students in the lab on animal models, imaging, proteomics, and data analysis techniques, as well as on their English writing skills by reviewing theses and manuscripts.
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