Elee Shimshoni
Postdoctoral Associate at MIT working on complex human cell models for drug discovery
Research Expertise
About
Publications
Tumor macrophages are pivotal constructors of tumor collagenous matrix
Journal of Experimental Medicine / Oct 03, 2016
Afik, R., Zigmond, E., Vugman, M., Klepfish, M., Shimshoni, E., Pasmanik-Chor, M., Shenoy, A., Bassat, E., Halpern, Z., Geiger, T., Sagi, I., & Varol, C. (2016). Tumor macrophages are pivotal constructors of tumor collagenous matrix. Journal of Experimental Medicine, 213(11), 2315–2331. https://doi.org/10.1084/jem.20151193
ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation
Gut / Nov 21, 2014
Shimshoni, E., Yablecovitch, D., Baram, L., Dotan, I., & Sagi, I. (2014). ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation. Gut, 64(3), 367–372. https://doi.org/10.1136/gutjnl-2014-308048
Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cells
Oncogene / Nov 21, 2011
Shahar, O. D., Ram, E. V. S. R., Shimshoni, E., Hareli, S., Meshorer, E., & Goldberg, M. (2011). Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cells. Oncogene, 31(30), 3495–3504. https://doi.org/10.1038/onc.2011.516
Distinct extracellular–matrix remodeling events precede symptoms of inflammation
Matrix Biology / Feb 01, 2021
Shimshoni, E., Adir, I., Afik, R., Solomonov, I., Shenoy, A., Adler, M., Puricelli, L., Sabino, F., Savickas, S., Mouhadeb, O., Gluck, N., Fishman, S., Werner, L., Salame, T.-M., Shouval, D. S., Varol, C., auf dem Keller, U., Podestà, A., Geiger, T., … Sagi, I. (2021). Distinct extracellular–matrix remodeling events precede symptoms of inflammation. Matrix Biology, 96, 47–68. https://doi.org/10.1016/j.matbio.2020.11.001
Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In Vitro
PLoS ONE / Oct 23, 2013
Shahar, O. D., Gabizon, R., Feine, O., Alhadeff, R., Ganoth, A., Argaman, L., Shimshoni, E., Friedler, A., & Goldberg, M. (2013). Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In Vitro. PLoS ONE, 8(10), e78472. https://doi.org/10.1371/journal.pone.0078472
Sample Preparation of Extracellular Matrix of Murine Colons for Scanning Electron Microscopy
Methods in Molecular Biology / Jan 01, 2019
Shimshoni, E., & Sagi, I. (2019). Sample Preparation of Extracellular Matrix of Murine Colons for Scanning Electron Microscopy. In Collagen (pp. 129–133). Springer New York. https://doi.org/10.1007/978-1-4939-9095-5_9
Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy
International Journal of Molecular Sciences / Nov 02, 2020
van Rijn, J. M., Werner, L., Aydemir, Y., Spronck, J. M. A., Pode-Shakked, B., van Hoesel, M., Shimshoni, E., Polak-Charcon, S., Talmi, L., Eren, M., Weiss, B., H.J. Houwen, R., Barshack, I., Somech, R., Nieuwenhuis, E. E. S., Sagi, I., Raas-Rothschild, A., Middendorp, S., & Shouval, D. S. (2020). Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy. International Journal of Molecular Sciences, 21(21), 8200. https://doi.org/10.3390/ijms21218200
Epithelial-Stromal Interactions in Barrett’s Esophagus Modeled in Human Organ Chips
Gastro Hep Advances / Jan 01, 2023
Shimshoni, E., Merry, G. E., Milot, Z. D., Oh, C. Y., Horvath, V., Gould, R. A., Caruso, J. A., Chen-Tanyolac, C., Gascard, P., Sangwan, V., Bérubé, J., Bailey, S. D., Hall, S., Stachler, M. D., Ferri, L., Tlsty, T. D., & Ingber, D. E. (2023). Epithelial-Stromal Interactions in Barrett’s Esophagus Modeled in Human Organ Chips. Gastro Hep Advances, 2(5), 676–680. https://doi.org/10.1016/j.gastha.2023.03.009
Integrated Metabolomics and Proteomics of Symptomatic and Early Presymptomatic States of Colitis
Journal of Proteome Research / Mar 18, 2024
Shimshoni, E., Solomonov, I., Sagi, I., & Ghini, V. (2024). Integrated Metabolomics and Proteomics of Symptomatic and Early Presymptomatic States of Colitis. Journal of Proteome Research, 23(4), 1420–1432. https://doi.org/10.1021/acs.jproteome.3c00860
Education
Weizmann Institute of Science
Ph.D, Life Sciences / August, 2019
Weizmann Institute of Science
M.Sc., Life Sciences / February, 2014
Hebrew University of Jerusalem
B.Sc., Biology, Psychology / August, 2011
Experience
MIT
Postdoctoral Associate / November, 2022 — Present
• Developed 2D and 3D primary human cell-based disease models for studying obesity and atherosclerosis. • Trained and mentored research technicians and students on cell culture, molecular biology techniques and experimental design. • Collaborated with chemists and computational biologists to test novel therapeutics and targets using cell-based models.
Harvard University
Postdoctoral Fellow / August, 2019 — November, 2022
• Led a project aimed at studying the role of the stroma in the progression from Barrett’s Esophagus to Esophageal Cancer, as part of an international collaboration of clinical and academic partners. • Developed two distinct Esophagus Chip models using human primary cells, both containing a 3D stromal compartment: One of the normal esophagus and one of Barrett’s Esophagus. • Collaborated with Emulate, Inc. as a beta user of their new organ-on-a-chip design and provided feedback leading to improvements to the design that was eventually brought to the market. • Advised collaborators on techniques and subject matters within my domains of expertise, including inflammatory bowel disease, extracellular matrix, and organs-on-chips. • Summarized my work at the Ingber Lab in a first-author publication.
Weizmann Institute of Science
Graduate Student / November, 2011 — August, 2019
• Led a multi-collaborator multidisciplinary team to study and characterize changes in the extracellular matrix that predict colitis, spanning a wide range of analytical approaches. • Authored two first-author publications and a book chapter on extracellular matrix biology in colitis. • Contributed to three other publications in the lab by carrying out imaging, analyses, and writing. • Mentored collaborators and junior students in the lab on animal models, imaging, proteomics, and data analysis techniques, as well as on their English writing skills by reviewing theses and manuscripts.
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