Elee Shimshoni

Postdoctoral Associate at MIT working on complex human cell models for drug discovery

Research Expertise

extracellular matrix
3D cell culture
inflammation
tumor microenvironment
fibroblasts
Immunology
Immunology and Allergy
Gastroenterology
Cancer Research
Molecular Biology
Genetics
Physical and Theoretical Chemistry
Spectroscopy
Organic Chemistry
Computer Science Applications
Inorganic Chemistry
Catalysis
Biochemistry

About

Elee is a postdoctoral associate at the Department of Chemistry and CSAIL at MIT, working on developing complex cell models for drug discovery. Elee has been studying gastrointestinal diseases for the past 10 years, and is interested in stromal and especially extracellular matrix biology. Elee believes that in order to treat human disease, we must look to the microenvironment for therapeutic targets. Elee is also passionate about science communication and views it as an inseparable part of a scientist's role in society. Currently, she serves as the Scientific Director, and regularly writes for, the non-profit organization "Little, Big Science", which is one of Israel's most popular science communication platforms. Previously, Elee was a postdoc at the Wyss Institute at Harvard University, working on organs-on-chips models for Inflammation and Cancer. Elee received her PhD and my MSc from the Weizmann Institute of Science, where she studies the role of the extracellular matrix in inflammatory bowel disease. Prior to that, Elee received my BSc in Biology and Psychology from the Hebrew University of Jerusalem.

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Education

Weizmann Institute of Science

Ph.D, Life Sciences / August, 2019

Rehovot

Weizmann Institute of Science

M.Sc., Life Sciences / February, 2014

Rehovot

Hebrew University of Jerusalem

B.Sc., Biology, Psychology / August, 2011

Jerusalem

Experience

MIT

Postdoctoral Associate / November, 2022Present

• Developed 2D and 3D primary human cell-based disease models for studying obesity and atherosclerosis. • Trained and mentored research technicians and students on cell culture, molecular biology techniques and experimental design. • Collaborated with chemists and computational biologists to test novel therapeutics and targets using cell-based models.

Harvard University

Postdoctoral Fellow / August, 2019November, 2022

• Led a project aimed at studying the role of the stroma in the progression from Barrett’s Esophagus to Esophageal Cancer, as part of an international collaboration of clinical and academic partners. • Developed two distinct Esophagus Chip models using human primary cells, both containing a 3D stromal compartment: One of the normal esophagus and one of Barrett’s Esophagus. • Collaborated with Emulate, Inc. as a beta user of their new organ-on-a-chip design and provided feedback leading to improvements to the design that was eventually brought to the market. • Advised collaborators on techniques and subject matters within my domains of expertise, including inflammatory bowel disease, extracellular matrix, and organs-on-chips. • Summarized my work at the Ingber Lab in a first-author publication.

Weizmann Institute of Science

Graduate Student / November, 2011August, 2019

• Led a multi-collaborator multidisciplinary team to study and characterize changes in the extracellular matrix that predict colitis, spanning a wide range of analytical approaches. • Authored two first-author publications and a book chapter on extracellular matrix biology in colitis. • Contributed to three other publications in the lab by carrying out imaging, analyses, and writing. • Mentored collaborators and junior students in the lab on animal models, imaging, proteomics, and data analysis techniques, as well as on their English writing skills by reviewing theses and manuscripts.

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