Brendan Monogue, Ph.D.

PhD Research Associate in Immunology and Microbiology

Denver, Colorado, United States of America

Research Expertise

Neurodegeneration

Neuroimmunity

Innate Immunity

Immunology

Virology

Flow Cytometry

Multiomics

B-cells

Murine Models

Infectious Disease

Fluorescent Microscopy

Scientific writing

Grant writing

About

I am an experienced researcher with expertise in the fields of immunology, virology, and neuroscience. After developing a background in biochemistry during my undergraduate studies, I pursued my Ph.D. at the University of Colorado Anschutz. My thesis work, focusing on the role of the Parkinson's protein (alpha-synuclein) on immune responses in the central nervous system, helped me develop my skills in assay design, murine modeling, and data analysis. I am particularly skilled at fluorescent microscopy and disease modeling. My work not only resulted in my thesis publication in the journal *Brain,* but also resulted in the successful funding of an R01 grant for our lab. Following this, I developed my molecular biology skills during a brief postdoctoral position in Bonn, Germany. My work in Bonn included pathway analysis and multi-omics analysis. More recently, I have joined the lab of Dr. Roberta Pelanda at the Univeristy of Colorado, studying the origins of autoimmunity and disruptions in central tolerance. I have mentored several students, succesfully applied for grants, and published several peer-reviewed papers.

Publications

Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions

mBio / Apr 28, 2020

Chatterjee, A., Willett, J. L. E., Nguyen, U. T., Monogue, B., Palmer, K. L., Dunny, G. M., & Duerkop, B. A. (2020). Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions. MBio, 11(2). https://doi.org/10.1128/mbio.03120-19

Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue

Brain / Jul 18, 2022

Monogue, B., Chen, Y., Sparks, H., Behbehani, R., Chai, A., Rajic, A. J., Massey, A., Kleinschmidt-Demasters, B. K., Vermeren, M., Kunath, T., & Beckham, J. D. (2022). Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue. Brain, 145(10), 3622–3636. https://doi.org/10.1093/brain/awac192

Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication

Viruses / Oct 18, 2020

Sparks, H., Monogue, B., Akiyama, B., Kieft, J., & Beckham, J. D. (2020). Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. Viruses, 12(10), 1177. https://doi.org/10.3390/v12101177

A functional role for alpha-synuclein in neuroimmune responses

Journal of Neuroimmunology / Mar 01, 2023

Heiden, D. L., Monogue, B., Ali, M. D. H., & Beckham, J. D. (2023). A functional role for alpha-synuclein in neuroimmune responses. Journal of Neuroimmunology, 376, 578047. https://doi.org/10.1016/j.jneuroim.2023.578047

Alpha-synuclein supports interferon stimulated gene expression in neurons

Apr 27, 2020

Massey, A. R., Monogue, B., Chen, Y., Lesteberg, K., Johnson, M. E., Bergkvist, L., Steiner, J. A., Ma, J., Mahalingam, R., Kleinschmidt-Demasters, B. K., Escobar Galvis, M. L., Brundin, P., Kunath, T., & Beckham, J. D. (2020). Alpha-synuclein supports interferon stimulated gene expression in neurons. https://doi.org/10.1101/2020.04.25.061762

Bystander CD8+ T cells are Important Antiviral Effectors in the Brain

The Journal of Immunology / May 01, 2023

Berger, J., Monogue, B., Heiden, D., Klarquist, J., Beckham, J. D., & Berg, L. J. (2023). Bystander CD8+ T cells are Important Antiviral Effectors in the Brain. The Journal of Immunology, 210(1_Supplement), 59.14-59.14. https://doi.org/10.4049/jimmunol.210.supp.59.14

A unique gammadelta T cell population in the brain during viral infection

The Journal of Immunology / May 01, 2022

Berger, J., Monogue, B., Beckham, J. D., & Berg, L. (2022). A unique gammadelta T cell population in the brain during viral infection. The Journal of Immunology, 208(1_Supplement), 182.12-182.12. https://doi.org/10.4049/jimmunol.208.supp.182.12

Education

University of Denver

BS, Biochemistry / June, 2017

Denver, Colorado, United States of America

University of Colorado Anschutz Medical Campus

Ph.D., Microbiology / January, 2023

Aurora, Colorado, United States of America

Experience

University of Colorado Anschutz Medical Campus

Pre-Doctoral Research Assistant / September, 2017 — January, 2023

Led a research project in the lab of Dr. David Beckham studying the role of alpha-synuclein protein in regulating neuroimmune responses

DZNE Bonn

Postdoctoral Researcher / February, 2023 — August, 2024

Postdoctoral Researcher project studying the role of the mTOR pathway in microglial function

University of Coloraod Anschutz

Research Associate / September, 2024 — Present

Post-doctoral research associate studying the impact of chemokine pathways in regulating central B-cell tolerance and autoimmunity

Links & Social Media

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