Samiksha Wasnik

Scientist Immunology and Regenerative Medicine

Research Expertise

Immunology
Stem cell research
Biomedical science
Regenerative medicine
Ecology, Evolution, Behavior and Systematics
Biomedical Engineering
Biomaterials
Clinical Psychology
Psychiatry and Mental health
Computer Science Applications
Spectroscopy
Inorganic Chemistry
Physical and Theoretical Chemistry
Organic Chemistry
Catalysis
Molecular Biology
Immunology and Allergy
Infectious Diseases
Biochemistry
Genetics
Biotechnology
Cell Biology
Oncology
Cancer Research
Neurology (clinical)
Dermatology
Internal Medicine
Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Physiology
Clinical Biochemistry

About

Self-motivated research scientist with 10+ years of extensive experience in immunology, regenerative medicine, stem cell biology, T-cell bioengineering, mechanism of action study, in vitro/ in vivo assays, knowledge of sample collection, in-vivo model development for cancer, acute organ injury, bone fracture, sepsis, multiple sclerosis, IBD. ➢ Ability to work independently and within a team, leveraging experience in innovative lab technologies, resulting in a federal grant of $430,000 from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. ➢ Team leader, able to manage project priorities, mentored students, technicians, and post-docs. Responsible for writing and timely submissions for IACUC, IRB protocols, NIH/DOD/CIRM and institutional grant proposals. ➢ Completed projects on developing novel immune or cell therapies, resulting in +10 high-impact publications and one international patent.

Legacy Map

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Publications

Phylogeography of mtDNA haplogroup R7 in the Indian peninsula
BMC Evolutionary Biology
2008
Evaluation of nano-biphasic calcium phosphate ceramics for bone tissue engineering applications: In vitro and preliminary in vivo studies
Journal of Biomaterials Applications
2012
1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites
JCI Insight
2018
Ex vivoexpansion of haematopoietic stem/progenitor cells from human umbilical cord blood on acellular scaffolds prepared from MS-5 stromal cell line
Journal of Tissue Engineering and Regenerative Medicine
2012
Osteohematopoietic Stem Cell Niches in Bone Marrow
International Review of Cell and Molecular Biology Volume 298
2012
Dopamine Transporter (DAT1) VNTR Polymorphism and Alcoholism in Two Culturally Different Populations of South India
The American Journal on Addictions
2012
Vitamin D as a Potential Therapy for Multiple Sclerosis: Where Are We?
International Journal of Molecular Sciences
2020
In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis
The Journal of Immunology
2019
Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis
BMC Infectious Diseases
2019
Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90 + skeletal stem cells in fracture sites
Science Advances
2019
Dendritic cells, engineered to overexpress 25‐hydroxyvitamin D 1α‐hydroxylase and pulsed with a myelin antigen, provide myelin‐specific suppression of ongoing experimental allergic encephalomyelitis
The FASEB Journal
2017
Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation
American Journal of Physiology-Cell Physiology
2022
Effect of aging on stem cells
World Journal of Experimental Medicine
2017
Ex vivo isolation, expansion and bioengineering of CCR7+CD95-/or CD62L+CD45RA+ tumor infiltrating lymphocytes from acute myeloid leukemia patients’ bone marrow
Neoplasia
2021
Therapeutic Targeting of Mitochondrial Plasticity and Redox Control to Overcome Cancer Chemoresistance
Antioxidants & Redox Signaling
2023
Combination therapy of insulin‐like growth factor I and BTP ‐2 markedly improves lipopolysaccharide‐induced liver injury in mice
The FASEB Journal
2022
Premarket review and postmarket regulation of combination drug products
Combination Drug Delivery Approach as an Effective Therapy for Various Diseases
2022
Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche
Hematopoiesis
2023
FBP1-Altered Carbohydrate Metabolism Reduces Leukemic Viability through Activating P53 and Modulating the Mitochondrial Quality Control System In Vitro
International Journal of Molecular Sciences
2022
Title-Inflammatory Signaling Pathways in Allergic and Infection-Associated Lung Diseases
Allergies
2022
Targeting TKI-Activated NFKB2-MIF/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability
Biomedicines
2022
Inflammation- and Gut-Homing Macrophages, Engineered to De Novo Overexpress Active Vitamin D, Promoted the Regenerative Function of Intestinal Stem Cells
International Journal of Molecular Sciences
2021
The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury
International Journal of Molecular Sciences
2021
A novel vitamin D gene therapy for acute myeloid leukemia
Translational Oncology
2020
IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury
International Journal of Molecular Sciences
2020
Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model
Bone Reports
2020
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Journal of Visualized Experiments
2020
Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules
International Journal of Molecular Sciences
2019
An Overview of Polymeric Nanoparticles as Potential Cancer Therapeutics
Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics
2019
Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice
Immunology
2018
HSC Niche
Biology and Engineering of Stem Cell Niches
2017
Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
Journal of Visualized Experiments
2017
EnhancedEx VivoExpansion of Human Hematopoietic Progenitors on Native and Spin Coated Acellular Matrices Prepared from Bone Marrow Stromal Cells
Stem Cells International
2016
Recent trends in bone fracture therapeutics and management
Dentistry and Medical Research
2016
Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations
Neurological Sciences
2009

Education

Deakin University

Ph.D., Life sciences / May, 2014

Geelong, Victoria, Australia

MS, Biotechnology / May, 2005

Bilaspur

Experience

Loma Linda University

Research Specialist and Assistant Professor -Research / August, 2014Present

Loma Linda University

Post Doctoral researcher / August, 20142018

Regenerative medicine research

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