Samiksha Wasnik
Scientist Immunology and Regenerative Medicine
Research Expertise
About
Publications
Phylogeography of mtDNA haplogroup R7 in the Indian peninsula
BMC Evolutionary Biology / Aug 04, 2008
Chaubey, G., Karmin, M., Metspalu, E., Metspalu, M., Selvi-Rani, D., Singh, V. K., Parik, J., Solnik, A., Naidu, B. P., Kumar, A., Adarsh, N., Mallick, C. B., Trivedi, B., Prakash, S., Reddy, R., Shukla, P., Bhagat, S., Verma, S., Vasnik, S., … Villems, R. (2008). Phylogeography of mtDNA haplogroup R7 in the Indian peninsula. BMC Evolutionary Biology, 8(1). https://doi.org/10.1186/1471-2148-8-227
Evaluation of nano-biphasic calcium phosphate ceramics for bone tissue engineering applications: In vitro and preliminary in vivo studies
Journal of Biomaterials Applications / Jan 27, 2012
Reddy, S., Wasnik, S., Guha, A., Kumar, J. M., Sinha, A., & Singh, S. (2012). Evaluation of nano-biphasic calcium phosphate ceramics for bone tissue engineering applications: In vitro and preliminary in vivo studies. Journal of Biomaterials Applications, 27(5), 565–575. https://doi.org/10.1177/0885328211415132
1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites
JCI Insight / Sep 06, 2018
Wasnik, S., Rundle, C. H., Baylink, D. J., Yazdi, M. S., Carreon, E. E., Xu, Y., Qin, X., Lau, K.-H. W., & Tang, X. (2018). 1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites. JCI Insight, 3(17). https://doi.org/10.1172/jci.insight.98773
Ex vivoexpansion of haematopoietic stem/progenitor cells from human umbilical cord blood on acellular scaffolds prepared from MS-5 stromal cell line
Journal of Tissue Engineering and Regenerative Medicine / Apr 17, 2012
Tiwari, A., Tursky, M. L., Mushahary, D., Wasnik, S., Collier, F. M., Suma, K., Kirkland, M. A., & Pande, G. (2012). Ex vivoexpansion of haematopoietic stem/progenitor cells from human umbilical cord blood on acellular scaffolds prepared from MS-5 stromal cell line: Haematopoietic progenitor cell expansion on acellular matrices. Journal of Tissue Engineering and Regenerative Medicine, 7(11), 871–883. https://doi.org/10.1002/term.1479
Osteohematopoietic Stem Cell Niches in Bone Marrow
International Review of Cell and Molecular Biology Volume 298 / Jan 01, 2012
Wasnik, S., Tiwari, A., Kirkland, M. A., & Pande, G. (2012). Osteohematopoietic Stem Cell Niches in Bone Marrow. In International Review of Cell and Molecular Biology (pp. 95–133). Elsevier. https://doi.org/10.1016/b978-0-12-394309-5.00003-1
Dopamine Transporter (DAT1) VNTR Polymorphism and Alcoholism in Two Culturally Different Populations of South India
The American Journal on Addictions / May 16, 2012
Bhaskar, L. V. K. S., Thangaraj, K., Wasnik, S., Singh, L., & Raghavendra Rao, V. (2012). Dopamine Transporter (DAT1) VNTR Polymorphism and Alcoholism in Two Culturally Different Populations of South India. The American Journal on Addictions, 21(4), 343–347. Portico. https://doi.org/10.1111/j.1521-0391.2012.00244.x
Vitamin D as a Potential Therapy for Multiple Sclerosis: Where Are We?
International Journal of Molecular Sciences / Apr 28, 2020
Wasnik, S., Sharma, I., Baylink, D. J., & Tang, X. (2020). Vitamin D as a Potential Therapy for Multiple Sclerosis: Where Are We? International Journal of Molecular Sciences, 21(9), 3102. https://doi.org/10.3390/ijms21093102
In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis
The Journal of Immunology / Jun 15, 2019
Xu, Y., Cheng, Y., Baylink, D. J., Wasnik, S., Goel, G., Huang, M., Cao, H., Qin, X., Lau, K.-H. W., Chan, C., Koch, A., Pham, L. H., Zhang, J., Li, C.-H., Wang, X., Berumen, E. C., Smith, J., & Tang, X. (2019). In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis. The Journal of Immunology, 202(12), 3447–3457. https://doi.org/10.4049/jimmunol.1800018
Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis
BMC Infectious Diseases / Dec 01, 2019
Li, C.-H., Tang, X., Wasnik, S., Wang, X., Zhang, J., Xu, Y., Lau, K.-H. W., Nguyen, H. B., & Baylink, D. J. (2019). Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis. BMC Infectious Diseases, 19(1). https://doi.org/10.1186/s12879-019-4529-7
Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90 + skeletal stem cells in fracture sites
Science Advances / Jul 05, 2019
Wasnik, S., Lakhan, R., Baylink, D. J., Rundle, C. H., Xu, Y., Zhang, J., Qin, X., Lau, K.-H. W., Carreon, E. E., & Tang, X. (2019). Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90 + skeletal stem cells in fracture sites. Science Advances, 5(7). https://doi.org/10.1126/sciadv.aaw2108
Dendritic cells, engineered to overexpress 25‐hydroxyvitamin D 1α‐hydroxylase and pulsed with a myelin antigen, provide myelin‐specific suppression of ongoing experimental allergic encephalomyelitis
The FASEB Journal / Mar 31, 2017
Li, C., Zhang, J., Baylink, D. J., Wang, X., Goparaju, N. B., Xu, Y., Wasnik, S., Cheng, Y., Berumen, E. C., Qin, X., William Lau, K., & Tang, X. (2017). Dendritic cells, engineered to overexpress 25‐hydroxyvitamin D 1α‐hydroxylase and pulsed with a myelin antigen, provide myelin‐specific suppression of ongoing experimental allergic encephalomyelitis. The FASEB Journal, 31(7), 2996–3006. Portico. https://doi.org/10.1096/fj.201601243r
Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation
American Journal of Physiology-Cell Physiology / May 01, 2022
Ahmed, A. S. I., Sheng, M. H. C., Lau, K.-H. W., Wilson, S. M., Wongworawat, M. D., Tang, X., Ghahramanpouri, M., Nehme, A., Xu, Y., Abdipour, A., Zhang, X.-B., Wasnik, S., & Baylink, D. J. (2022). Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation. American Journal of Physiology-Cell Physiology, 322(5), C977–C990. https://doi.org/10.1152/ajpcell.00413.2021
Effect of aging on stem cells
World Journal of Experimental Medicine / Jan 01, 2017
Ahmed, A. S. I., Sheng, M. H., Wasnik, S., Baylink, D. J., & Lau, K.-H. W. (2017). Effect of aging on stem cells. World Journal of Experimental Medicine, 7(1), 1. https://doi.org/10.5493/wjem.v7.i1.1
Ex vivo isolation, expansion and bioengineering of CCR7+CD95-/or CD62L+CD45RA+ tumor infiltrating lymphocytes from acute myeloid leukemia patients’ bone marrow
Neoplasia / Dec 01, 2021
Cao, H., Kim, D. H., Howard, A., Moz, H., Wasnik, S., Baylink, D. J., Chen, C.-S., Reeves, M. E., Mirshahidi, S., Xiao, J., Francis, O., Marcucci, G., & Xu, Y. (2021). Ex vivo isolation, expansion and bioengineering of CCR7+CD95-/or CD62L+CD45RA+ tumor infiltrating lymphocytes from acute myeloid leukemia patients’ bone marrow. Neoplasia, 23(12), 1252–1260. https://doi.org/10.1016/j.neo.2021.11.003
Therapeutic Targeting of Mitochondrial Plasticity and Redox Control to Overcome Cancer Chemoresistance
Antioxidants & Redox Signaling / Sep 01, 2023
Mani, S., Ralph, S. J., Swargiary, G., Rani, M., Wasnik, S., Singh, S. P., & Devi, A. (2023). Therapeutic Targeting of Mitochondrial Plasticity and Redox Control to Overcome Cancer Chemoresistance. Antioxidants & Redox Signaling, 39(7–9), 591–619. https://doi.org/10.1089/ars.2023.0379
Combination therapy of insulin‐like growth
factor I and
BTP
‐2 markedly improves
lipopolysaccharide‐induced liver injury in
mice
The FASEB Journal / Jul 15, 2022
Nehme, A., Ghahramanpouri, M., Ahmed, I., Golsorkhi, M., Thomas, N., Munoz, K., Abdipour, A., Tang, X., Wilson, S. M., Wasnik, S., & Baylink, D. J. (2022). Combination therapy of insulin‐like growth factor I and <scp>BTP</scp> ‐2 markedly improves lipopolysaccharide‐induced liver injury in mice. The FASEB Journal, 36(8). Portico. https://doi.org/10.1096/fj.202200227rr
Premarket review and postmarket regulation of combination drug products
Combination Drug Delivery Approach as an Effective Therapy for Various Diseases / Jan 01, 2022
Wasnik, S. (2022). Premarket review and postmarket regulation of combination drug products. In Combination Drug Delivery Approach as an Effective Therapy for Various Diseases (pp. 331–352). Elsevier. https://doi.org/10.1016/b978-0-323-85873-1.00002-2
Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche
Hematopoiesis / Nov 14, 2023
Wasnik, S., Chaturvedula, L. M., & Tripura, C. (2023). Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche. In Hematopoiesis (pp. 73–107). Apple Academic Press. https://doi.org/10.1201/9781003413059-4
FBP1-Altered Carbohydrate Metabolism Reduces Leukemic Viability through Activating P53 and Modulating the Mitochondrial Quality Control System In Vitro
International Journal of Molecular Sciences / Sep 27, 2022
Xu, Y., Tran, L., Tang, J., Nguyen, V., Sewell, E., Xiao, J., Hino, C., Wasnik, S., Francis-Boyle, O. L., Zhang, K. K., Xie, L., Zhong, J. F., Baylink, D. J., Chen, C.-S., Reeves, M. E., & Cao, H. (2022). FBP1-Altered Carbohydrate Metabolism Reduces Leukemic Viability through Activating P53 and Modulating the Mitochondrial Quality Control System In Vitro. International Journal of Molecular Sciences, 23(19), 11387. https://doi.org/10.3390/ijms231911387
Title-Inflammatory Signaling Pathways in Allergic and Infection-Associated Lung Diseases
Allergies / Jun 01, 2022
Upadhyay, M., Nehme, A., & Wasnik, S. (2022). Title-Inflammatory Signaling Pathways in Allergic and Infection-Associated Lung Diseases. Allergies, 2(2), 57–74. https://doi.org/10.3390/allergies2020006
Targeting TKI-Activated NFKB2-MIF/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability
Biomedicines / Apr 30, 2022
Cao, H., Tadros, V., Hiramoto, B., Leeper, K., Hino, C., Xiao, J., Pham, B., Kim, D. H., Reeves, M. E., Chen, C.-S., Zhong, J. F., Zhang, K. K., Xie, L., Wasnik, S., Baylink, D. J., & Xu, Y. (2022). Targeting TKI-Activated NFKB2-MIF/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability. Biomedicines, 10(5), 1038. https://doi.org/10.3390/biomedicines10051038
Inflammation- and Gut-Homing Macrophages, Engineered to De Novo Overexpress Active Vitamin D, Promoted the Regenerative Function of Intestinal Stem Cells
International Journal of Molecular Sciences / Sep 01, 2021
Xu, Y., Baylink, D. J., Cao, H., Xiao, J., Abdalla, M. I., Wasnik, S., & Tang, X. (2021). Inflammation- and Gut-Homing Macrophages, Engineered to De Novo Overexpress Active Vitamin D, Promoted the Regenerative Function of Intestinal Stem Cells. International Journal of Molecular Sciences, 22(17), 9516. https://doi.org/10.3390/ijms22179516
The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury
International Journal of Molecular Sciences / May 15, 2021
Munoz, K., Wasnik, S., Abdipour, A., Bi, H., Wilson, S. M., Tang, X., Ghahramanpouri, M., & Baylink, D. J. (2021). The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury. International Journal of Molecular Sciences, 22(10), 5244. https://doi.org/10.3390/ijms22105244
A novel vitamin D gene therapy for acute myeloid leukemia
Translational Oncology / Dec 01, 2020
Xu, Y., Payne, K., Pham, L. H. G., Eunwoo, P., Xiao, J., Chi, D., Lyu, J., Campion, R., Wasnik, S., Jeong, I. S., Tang, X., Baylink, D. J., Chen, C. S., Reeves, M., Akhtari, M., Mirshahidi, S., Marcucci, G., & Cao, H. (2020). A novel vitamin D gene therapy for acute myeloid leukemia. Translational Oncology, 13(12), 100869. https://doi.org/10.1016/j.tranon.2020.100869
IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury
International Journal of Molecular Sciences / Jun 08, 2020
Wasnik, S., Tang, X., Bi, H., Abdipour, A., E. Carreon, E., Sutjiadi, B., Lyu, J., Zhang, J., Wilson, S., & Baylink, D. J. (2020). IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury. International Journal of Molecular Sciences, 21(11), 4095. https://doi.org/10.3390/ijms21114095
Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model
Bone Reports / Jun 01, 2020
Chen, W., Wasnik, S., Fu, Y., Aranda, L., Rundle, C. H., Lau, K.-H. W., Baylink, D. J., & Zhang, X. (2020). Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model. Bone Reports, 12, 100236. https://doi.org/10.1016/j.bonr.2019.100236
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Journal of Visualized Experiments / Jan 22, 2020
Bi, H., Wasnik, S., Baylink, D. J., Liu, C., & Tang, X. (2020). In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction. Journal of Visualized Experiments, 155. https://doi.org/10.3791/60585
Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules
International Journal of Molecular Sciences / Sep 28, 2019
Wasnik, S., Baylink, D. J., Leavenworth, J., Liu, C., Bi, H., & Tang, X. (2019). Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules. International Journal of Molecular Sciences, 20(19), 4829. https://doi.org/10.3390/ijms20194829
An Overview of Polymeric Nanoparticles as Potential Cancer Therapeutics
Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics / Jan 01, 2019
Agarwal, S., Dominic, A., & Wasnik, S. (2019). An Overview of Polymeric Nanoparticles as Potential Cancer Therapeutics. In Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics (pp. 21–34). Elsevier. https://doi.org/10.1016/b978-0-12-816963-6.00002-9
Deficient arginase
II expression without
alteration in arginase I expression
attenuated experimental autoimmune
encephalomyelitis in mice
Immunology / Apr 16, 2018
Choudry, M., Tang, X., Santorian, T., Wasnik, S., Xiao, J., Xing, W., Lau, K. W., Mohan, S., Baylink, D. J., & Qin, X. (2018). Deficient arginase <scp>II</scp> expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice. Immunology, 155(1), 85–98. Portico. https://doi.org/10.1111/imm.12926
HSC Niche
Biology and Engineering of Stem Cell Niches / Jan 01, 2017
Wasnik, S., Chen, W., Ahmed, A. S. I., Zhang, X.-B., Tang, X., & Baylink, D. J. (2017). HSC Niche. In Biology and Engineering of Stem Cell Niches (pp. 63–73). Elsevier. https://doi.org/10.1016/b978-0-12-802734-9.00005-6
Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
Journal of Visualized Experiments / Dec 20, 2017
Xu, Y., Wasnik, S., Baylink, D. J., Berumen, E. C., & Tang, X. (2017). Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein. Journal of Visualized Experiments, 130. https://doi.org/10.3791/56401
EnhancedEx VivoExpansion of Human Hematopoietic Progenitors on Native and Spin Coated Acellular Matrices Prepared from Bone Marrow Stromal Cells
Stem Cells International / Jan 01, 2016
Wasnik, S., Kantipudi, S., Kirkland, M. A., & Pande, G. (2016). EnhancedEx VivoExpansion of Human Hematopoietic Progenitors on Native and Spin Coated Acellular Matrices Prepared from Bone Marrow Stromal Cells. Stem Cells International, 2016, 1–13. https://doi.org/10.1155/2016/7231567
Recent trends in bone fracture therapeutics and management
Dentistry and Medical Research / Jan 01, 2016
Wasnik, S., & Goparaju, N. (2016). Recent trends in bone fracture therapeutics and management. Dentistry and Medical Research, 4(2), 31. https://doi.org/10.4103/2348-1471.184724
Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations
Neurological Sciences / Sep 25, 2009
Bhaskar, L. V. K. S., Thangaraj, K., Mulligan, C. J., Wasnik, S., Nandan, A., Sharma, V. K., Sharma, V., Reddy, A. G., Singh, L., & Rao, V. R. (2009). Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations. Neurological Sciences, 30(6), 487–493. https://doi.org/10.1007/s10072-009-0139-2
Education
Deakin University
Ph.D., Life sciences / May, 2014
MS, Biotechnology / May, 2005
Experience
Loma Linda University
Research Specialist and Assistant Professor -Research / August, 2014 — Present
Loma Linda University
Post Doctoral researcher / August, 2014 — 2018
Regenerative medicine research
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