Cell Metabolism / Feb 01, 2012

Yuneva, M. O., Fan, T. W. M., Allen, T. D., Higashi, R. M., Ferraris, D. V., Tsukamoto, T., Matés, J. M., Alonso, F. J., Wang, C., Seo, Y., Chen, X., & Bishop, J. M. (2012). The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type. Cell Metabolism, 15(2), 157–170. https://doi.org/10.1016/j.cmet.2011.12.015

Proceedings of the National Academy of Sciences / Apr 08, 2008

Swarbrick, A., Roy, E., Allen, T., & Bishop, J. M. (2008). Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Proceedings of the National Academy of Sciences, 105(14), 5402–5407. https://doi.org/10.1073/pnas.0801505105

Cancer Research / Sep 13, 2011

Allen, T. D., Rodriguez, E. M., Jones, K. D., & Bishop, J. M. (2011). Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma. Cancer Research, 71(18), 6010–6018. https://doi.org/10.1158/0008-5472.can-11-0595

Oncotarget / May 13, 2014

Capaccione, K. M., Hong, X., Morgan, K. M., Liu, W., Bishop, M. J., Liu, L., Markert, E., Deen, M., Minerowicz, C., Bertino, J. R., Allen, T., & Pine, S. R. (2014). Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma. Oncotarget, 5(11), 3636–3650. https://doi.org/10.18632/oncotarget.1970

Cancer Research / Feb 01, 2006

Allen, T., van Tuyl, M., Iyengar, P., Jothy, S., Post, M., Tsao, M.-S., & Lobe, C. G. (2006). Grg1 Acts as a Lung-Specific Oncogene in a Transgenic Mouse Model. Cancer Research, 66(3), 1294–1301. https://doi.org/10.1158/0008-5472.can-05-1634

Cancer Biology & Therapy / Nov 02, 2014

Dong, F., Zhou, X., Li, C., Yan, S., Deng, X., Cao, Z., Li, L., Tang, B., Allen, T. D., & Liu, J. (2014). Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis. Cancer Biology & Therapy, 15(11), 1479–1488. https://doi.org/10.4161/15384047.2014.955728

Molecular and Cellular Biology / Aug 01, 1999

Wesley, C. S. (1999). Notch and Wingless Regulate Expression of Cuticle Patterning Genes. Molecular and Cellular Biology, 19(8), 5743–5758. https://doi.org/10.1128/mcb.19.8.5743

Cancer Research / Mar 14, 2011

Allen, T. D., Zhu, C. Q., Jones, K. D., Yanagawa, N., Tsao, M.-S., & Bishop, J. M. (2011). Interaction between MYC and MCL1 in the Genesis and Outcome of Non–Small-Cell Lung Cancer. Cancer Research, 71(6), 2212–2221. https://doi.org/10.1158/0008-5472.can-10-3590

Biochemical and Biophysical Research Communications / Jul 01, 2014

Dong, F., Guo, F., Li, L., Guo, L., Hou, Y., Hao, E., Yan, S., Allen, T. D., & Liu, J. (2014). Cadmium induces vascular permeability via activation of the p38 MAPK pathway. Biochemical and Biophysical Research Communications, 450(1), 447–452. https://doi.org/10.1016/j.bbrc.2014.05.140

Leukemia & Lymphoma / Jan 01, 2000

Allen, T. D., Zhlp, Y.-X., Hawley, T. S., & Hawley, R. G. (2000). TALE Homeoproteins as HOX11-Interacting Partners in T-cell Leukemia. Leukemia & Lymphoma, 39(3–4), 241–256. https://doi.org/10.3109/10428190009065824

Biochemical and Biophysical Research Communications / Aug 01, 2015

Liu, J., Li, Y., Dong, F., Li, L., Masuda, T., Allen, T. D., & Lobe, C. G. (2015). Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. Biochemical and Biophysical Research Communications, 463(4), 1230–1236. https://doi.org/10.1016/j.bbrc.2015.06.090

British Journal of Cancer / May 22, 2019

Sellers, K., Allen, T. D., Bousamra, M., Tan, J., Méndez-Lucas, A., Lin, W., Bah, N., Chernyavskaya, Y., MacRae, J. I., Higashi, R. M., Lane, A. N., Fan, T. W.-M., & Yuneva, M. O. (2019). Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes. British Journal of Cancer, 121(1), 51–64. https://doi.org/10.1038/s41416-019-0464-z

Experimental and Therapeutic Medicine / Sep 30, 2014

GUO, L., DONG, F., HOU, Y., CAI, W., ZHOU, X., HUANG, A.-L., YANG, M., ALLEN, T. D., & LIU, J. (2014). Dihydroartemisinin inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-activated protein kinase-independent pathway. Experimental and Therapeutic Medicine, 8(6), 1707–1712. https://doi.org/10.3892/etm.2014.1997

Oncotarget / Nov 30, 2017

Xu, Y., Pan, S., Liu, J., Dong, F., Cheng, Z., Zhang, J., Qi, R., Zang, Q., Zhang, C., Wang, X., Zhang, J., Wang, F., Allen, T. D., & Liu, J. (2017). GATA3-induced vWF upregulation in the lung adenocarcinoma vasculature. Oncotarget, 8(66), 110517–110529. https://doi.org/10.18632/oncotarget.22806

Experimental and Therapeutic Medicine / Sep 01, 2015

LI, Y., LI, L., DONG, F., GUO, L., HOU, Y., HU, H., YAN, S., ZHOU, X., LIAO, L., ALLEN, T. D., & LIU, J. (2015). Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction. Experimental and Therapeutic Medicine, 10(5), 1743–1749. https://doi.org/10.3892/etm.2015.2721

Experimental Cell Research / Sep 01, 2020

Zhang, J., Zhang, S., Shi, Q., Allen, T. D., You, F., & Yang, D. (2020). The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin 1/Atg6-mediated lethal autophagy in polyploid cells. Experimental Cell Research, 394(1), 112112. https://doi.org/10.1016/j.yexcr.2020.112112

Biomedicine & Pharmacotherapy / Mar 01, 2018

Cheng, Z., Qi, R., Li, L., Liu, Q., Zhang, W., Zhou, X., Xu, D., Allen, T. D., Pan, S., & Liu, J. (2018). Dihydroartemisinin ameliorates sepsis-induced hyperpermeability of glomerular endothelium via up-regulation of occludin expression. Biomedicine & Pharmacotherapy, 99, 313–318. https://doi.org/10.1016/j.biopha.2018.01.078

Circulation Research / Mar 05, 2021

Li, L., Liu, Q., Shang, T., Song, W., Xu, D., Allen, T. D., Wang, X., Jeong, J., Lobe, C. G., & Liu, J. (2021). Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria. Circulation Research, 128(5), 602–618. https://doi.org/10.1161/circresaha.120.316970

Journal of Cellular Immunology / Sep 23, 2020

Pro-survival Bcl-2 Proteins are Modifiers of MYC-VX-680 Synthetic Lethality. (2020). Journal of Cellular Immunology, 2(5). https://doi.org/10.33696/immunology.2.047

Journal of Cancer Immunology / Dec 31, 2020

Emerging Strategies to Attack Polyploid Cancer Cells. (2020). Journal of Cancer Immunology, 2(4). https://doi.org/10.33696/cancerimmunol.2.031

Chemistry & Biodiversity / Jan 10, 2024

Liang, Y., Li, Z., Zhang, J., Li, T., & Lv, C. (2024). Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects. Chemistry & Biodiversity, 21(2). Portico. https://doi.org/10.1002/cbdv.202301525

Molecular Cancer Therapeutics / Dec 01, 2023

Shi, Q., Zhang, T., Kalashova, J., Li, J., Yang, C., Li, H., Zhou, X., Long, Y., Abuliezi, Y. X., Lv, G., Yu, D., Zhang, S., Zhang, J., Allen, T. D., Liu, H., & Yang, D. (2023). Abstract LB_C10: An orally available small molecule inhibitor for synthetic lethal targeting of MYC expressing tumors. Molecular Cancer Therapeutics, 22(12_Supplement), LB_C10-LB_C10. https://doi.org/10.1158/1535-7163.targ-23-lb_c10

Molecular Cancer Therapeutics / Dec 01, 2019

Lopes, C. K., Post, G., Lambert, L., Lewis, B., Allen, T. D., Patel, A., & Littlefield, B. A. (2019). Abstract C098: Preclinical evaluation of eribulin in a veterinary clinical trial of metastatic spontaneous hemangiosarcoma in pet dogs. Molecular Cancer Therapeutics, 18(12_Supplement), C098–C098. https://doi.org/10.1158/1535-7163.targ-19-c098

Cancer Research / Oct 01, 2014

Cortez, M. A., Yang, C., Byers, L. A., Diao, L., Allen, T., Giri, U., Wang, J., Welsh, J., & Heymach, J. V. (2014). Abstract 5220: Reciprocal regulation of MYC and LKB1 modulates cell survival and differentiation in lung cancer. Cancer Research, 74(19_Supplement), 5220–5220. https://doi.org/10.1158/1538-7445.am2014-5220

Cancer Research / Oct 01, 2014

Capaccione, K. M., Hong, X., Morgan, K. M., Allen, T. D., Miles, G. D., Markert, E. K., Bishop, J. M., & Pine, S. R. (2014). Abstract 1149: The role of the novel Notch1-Sox9 signaling axis in NSCLC progression and EMT. Cancer Research, 74(19_Supplement), 1149–1149. https://doi.org/10.1158/1538-7445.am2014-1149

Clinical Cancer Research / Jan 15, 2014

Capaccione, K., Hong, X., Morgan, K. M., Liu, W., Allen, T., Bishop, J. M., & Pine, S. R. (2014). Abstract B17: Sox9 mediates Notch pathway-induced epithelial-mesenchymal transition (EMT) in lung adenocarcinoma. Clinical Cancer Research, 20(2_Supplement), B17–B17. https://doi.org/10.1158/1078-0432.14aacriaslc-b17

Mar 30, 2023

Allen, T. D., Zhu, C. Q., Jones, K. D., Yanagawa, N., Tsao, M.-S., & Bishop, J. M. (2023). Data from Interaction between <i>MYC</i> and <i>MCL1</i> in the Genesis and Outcome of Non–Small-Cell Lung Cancer. https://doi.org/10.1158/0008-5472.c.6503157.v1

Oncogene / Oct 08, 1998

Brake, R. L., Kees, U. R., & Watt, P. M. (1998). Multiple negative elements contribute to repression of the HOX11 proto-oncogene. Oncogene, 17(14), 1787–1795. https://doi.org/10.1038/sj.onc.1202078

Integrative Cancer Science and Therapeutics / Jan 01, 2021

Choudhry, N., David Allen, T., Ahire, V., Zhang, J., & Yang, D. (2021). Exploiting mechanism-informed phenotypic screening for development of next-generation antimitotic phytochemicals. Integrative Cancer Science and Therapeutics, 8(1). https://doi.org/10.15761/icst.1000350

PLOS ONE / Oct 30, 2023

Kalashova, J., Yang, C., Li, H., Long, Y., Yu, D., Zhang, T., Liu, X., Choudhry, N., Shi, Q., & Allen, T. D. (2023). The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells. PLOS ONE, 18(10), e0293283. https://doi.org/10.1371/journal.pone.0293283

European Journal of Medicinal Chemistry / Jan 01, 2023

Lv, G., Shi, Q., Zhang, T., Li, J., Kalashova, J., Long, Y., Sun, Y., Li, C., Choudhry, N., Li, H., Yang, C., Zhou, X., Reddy, M. C., Anantoju, K. K., Jupelli, R., Zhang, S., Zhang, J., Allen, T., Liu, H., … Yang, D. (2023). 2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization. European Journal of Medicinal Chemistry, 245, 114904. https://doi.org/10.1016/j.ejmech.2022.114904

Jan 30, 2023

Li, J., Zhang, T., Shi, Q., Lv, G., Zhou, X., Choudhry, N., Kalashova, J., Yang, C., Li, H., Long, Y., Sakthivel, B., Nimishetti, N., Liu, H., Allen, T. D., Zhang, J., & Yang, D. (2023). An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment. https://doi.org/10.1101/2023.01.29.526078

Apr 05, 2023

Shi, Q., Liu, X., Kalashova, J., Yang, C., Li, H., Long, Y., Zhang, T., Zhang, S., Lv, G., Huang, J., Liu, H., Zhang, J., Allen, T. D., & Yang, D. (2023). Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound. https://doi.org/10.1101/2023.04.03.535438

Journal of Pharmaceutical and Biomedical Analysis / Aug 01, 2023

Li, J., Choudhry, N., Lv, G., Nimishetti, N., Reddy, M. C., Liu, H., Allen, T. D., Zhang, J., & Yang, D. (2023). In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis. Journal of Pharmaceutical and Biomedical Analysis, 232, 115415. https://doi.org/10.1016/j.jpba.2023.115415

Bioorganic & Medicinal Chemistry / Feb 01, 2023

Lv, G., Shi, Q., Zhang, T., Li, J., Long, Y., Zhang, W., Choudhry, N., Yang, K., Li, H., Kalashova, J., Yang, C., Zhou, X., Reddy, M. C., Anantoju, K. K., Zhang, S., Zhang, J., Allen, T. D., Liu, H., Nimishetti, N., & Yang, D. (2023). Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B. Bioorganic & Medicinal Chemistry, 80, 117173. https://doi.org/10.1016/j.bmc.2023.117173

ACS Pharmacology & Translational Science / Jul 21, 2023

Li, J., Zhang, T., Shi, Q., Lv, G., Zhou, X., Choudhry, N., Kalashova, J., Yang, C., Li, H., Long, Y., Sakthivel, B., Nimishetti, N., Liu, H., Allen, T. D., Zhang, J., & Yang, D. (2023). Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment. ACS Pharmacology & Translational Science, 6(8), 1155–1163. https://doi.org/10.1021/acsptsci.3c00054

Biomedicine & Pharmacotherapy / Mar 01, 2022

Yan, Z., Shi, Q., Liu, X., Li, J., Ahire, V., Zhang, S., Zhang, J., Yang, D., & Allen, T. D. (2022). The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy. Biomedicine & Pharmacotherapy, 147, 112645. https://doi.org/10.1016/j.biopha.2022.112645

Phytochemistry Letters / Feb 01, 2021

Li, J., Yan, Z., Li, H., Shi, Q., Huang, L., Nimishetti, N., Allen, T. D., Yang, D., & Zhang, J. (2021). A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata. Phytochemistry Letters, 41, 180–185. https://doi.org/10.1016/j.phytol.2020.12.001

PLOS ONE / Mar 24, 2021

Zhang, J., Zhang, S., Shi, Q., Allen, T. D., You, F., & Yang, D. (2021). A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil. PLOS ONE, 16(3), e0248355. https://doi.org/10.1371/journal.pone.0248355

Journal of Natural Products / Aug 18, 2021

Li, J., Yan, Z., Li, H., Shi, Q., Ahire, V., Zhang, S., Nimishetti, N., Yang, D., Allen, T. D., & Zhang, J. (2021). The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects. Journal of Natural Products, 84(8), 2312–2320. https://doi.org/10.1021/acs.jnatprod.1c00429

Journal of Cellular and Molecular Medicine / Feb 19, 2019

Liu, Q., Allen, T. D., Song, W., Wada, Y., Lobe, C. G., & Liu, J. (2019). Notch1 activates angiogenic regulator Netrin4 in endothelial cells. Journal of Cellular and Molecular Medicine, 23(5), 3762–3766. Portico. https://doi.org/10.1111/jcmm.14240

Oct 10, 2019

Zhang, J., Zhang, S., Shi, Q., Allen, T. D., You, F., & Yang, D. (2019). A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil. https://doi.org/10.1101/801134

Oct 31, 2019

Li, J., Yan, Z., Li, H., Shi, Q., Huang, L., Allen, T. D., Yang, D., & Zhang, J. (2019). Purification, identification, and characterization of two benzophenanthridine alkaloids fromCorydalis longicalcaratarhizomes with anti-mitotic and polyploidy-inducing activities. https://doi.org/10.1101/821124

Jun 27, 2019

Zhang, J., Zhang, S., Wu, F., Shi, Q., Allen, T., You, F., & Yang, D. (2019). The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells. https://doi.org/10.1101/684266

Journal of Cellular and Molecular Medicine / Nov 29, 2017

Li, L., Chen, X., Dong, F., Liu, Q., Zhang, C., Xu, D., Allen, T. D., & Liu, J. (2017). Dihydroartemisinin up‐regulates <scp>VE</scp>‐cadherin expression in human renal glomerular endothelial cells. Journal of Cellular and Molecular Medicine, 22(3), 2028–2032. Portico. https://doi.org/10.1111/jcmm.13448

Kidney International / May 01, 2016

Dong, F., Li, L., Chen, X., Allen, T., & Liu, J. (2016). Glomerular endothelial cell IQGAP2 and filtration barrier function. Kidney International, 89(5), 1160–1161. https://doi.org/10.1016/j.kint.2015.09.006

Histopathology / Jan 15, 2015

Dong, F., Cheng, Y., Sun, Q., Lu, W., Zhang, G., Li, L., Allen, T. D., & Liu, J. (2015). <scp>CD</scp>109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma. Histopathology, 67(1), 133–135. Portico. https://doi.org/10.1111/his.12609

International Journal of Oncology / Aug 29, 2014

LIU, J., DONG, F., FUNG, I., CHEN, E., ALLEN, T. D., DEUTSCH, U., & LOBE, C. G. (2014). Postnatal Notch1 activation induces T-cell malignancy in conditional and inducible mouse models. International Journal of Oncology, 45(5), 1997–2004. https://doi.org/10.3892/ijo.2014.2626

Antiviral Research / Aug 01, 1997

Bolger, G. T., Allen, T., Garneau, M., Lapeyre, N., Liard, F., & Jaramillo, J. (1997). Cutaneously applied acyclovir acts systemically in the treatment of herpetic infection in the hairless mouse. Antiviral Research, 35(3), 157–165. https://doi.org/10.1016/s0166-3542(97)00024-7