Thaddeus Allen

Professional who facilitates science, strategy and team building in biotech with a knack for deconstructing complexity to provide insight and direction.

San Francisco Bay Area, California, United States of America

Research Expertise

cancer

fibrosis

therapeutics

diagnostics

Cell Biology

Molecular Biology

Physiology

Oncology

Cancer Research

Pharmacology

Molecular Medicine

Hematology

Biochemistry

Virology

Pharmaceutical Science

Drug Discovery

Organic Chemistry

Complementary and alternative medicine

Analytical Chemistry

Plant Science

Biotechnology

Histology

Pharmacology (medical)

Bioengineering

Genetics

About

I am able to lead on various aspects of biotech including ideation and drug development, internal and CRO research, patent, partnership and KOL management, public relations and marketing and science writing projects.

Legacy Map

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Publications

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

Cell Metabolism

2012

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

Proceedings of the National Academy of Sciences

2008

Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma

Cancer Research

2011

Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma

Oncotarget

2014

Grg1 Acts as a Lung-Specific Oncogene in a Transgenic Mouse Model

Cancer Research

2006

Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis

Cancer Biology & Therapy

2014

Notch and Wingless Regulate Expression of Cuticle Patterning Genes

Molecular and Cellular Biology

1999

Interaction between MYC and MCL1 in the Genesis and Outcome of Non–Small-Cell Lung Cancer

Cancer Research

2011

Cadmium induces vascular permeability via activation of the p38 MAPK pathway

Biochemical and Biophysical Research Communications

2014

TALE Homeoproteins as HOX11-Interacting Partners in T-cell Leukemia

Leukemia & Lymphoma

2000

Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice

Biochemical and Biophysical Research Communications

2015

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

British Journal of Cancer

2019

Dihydroartemisinin inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-activated protein kinase-independent pathway

Experimental and Therapeutic Medicine

2014

GATA3-induced vWF upregulation in the lung adenocarcinoma vasculature

Oncotarget

2017

Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction

Experimental and Therapeutic Medicine

2015

The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin 1/Atg6-mediated lethal autophagy in polyploid cells

Experimental Cell Research

2020

Dihydroartemisinin ameliorates sepsis-induced hyperpermeability of glomerular endothelium via up-regulation of occludin expression

Biomedicine & Pharmacotherapy

2018

Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria

Circulation Research

2021

Pro-survival Bcl-2 Proteins are Modifiers of MYC-VX-680 Synthetic Lethality

Journal of Cellular Immunology

2020

Emerging Strategies to Attack Polyploid Cancer Cells

Journal of Cancer Immunology

2020

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Chemistry & Biodiversity

2024

Abstract LB_C10: An orally available small molecule inhibitor for synthetic lethal targeting of MYC expressing tumors

Molecular Cancer Therapeutics

2023

Abstract C098: Preclinical evaluation of eribulin in a veterinary clinical trial of metastatic spontaneous hemangiosarcoma in pet dogs

Molecular Cancer Therapeutics

2019

Abstract 5220: Reciprocal regulation of MYC and LKB1 modulates cell survival and differentiation in lung cancer

Cancer Research

2014

Abstract 1149: The role of the novel Notch1-Sox9 signaling axis in NSCLC progression and EMT

Cancer Research

2014

Abstract B17: Sox9 mediates Notch pathway-induced epithelial-mesenchymal transition (EMT) in lung adenocarcinoma.

Clinical Cancer Research

2014

Data from Interaction between <i>MYC</i> and <i>MCL1</i> in the Genesis and Outcome of Non–Small-Cell Lung Cancer

Unknown Venue

2023

Multiple negative elements contribute to repression of the HOX11 proto-oncogene

Oncogene

1998

Exploiting mechanism-informed phenotypic screening for development of next-generation antimitotic phytochemicals

Integrative Cancer Science and Therapeutics

2021

The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells

PLOS ONE

2023

2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization

European Journal of Medicinal Chemistry

2023

An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

Unknown Venue

2023

Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound

Unknown Venue

2023

In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis

Journal of Pharmaceutical and Biomedical Analysis

2023

Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B

Bioorganic & Medicinal Chemistry

2023

Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment

ACS Pharmacology & Translational Science

2023

The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy

Biomedicine & Pharmacotherapy

2022

A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata

Phytochemistry Letters

2021

A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

PLOS ONE

2021

The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects

Journal of Natural Products

2021

Notch1 activates angiogenic regulator Netrin4 in endothelial cells

Journal of Cellular and Molecular Medicine

2019

A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

Unknown Venue

2019

Purification, identification, and characterization of two benzophenanthridine alkaloids fromCorydalis longicalcaratarhizomes with anti-mitotic and polyploidy-inducing activities

Unknown Venue

2019

The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells

Unknown Venue

2019

Dihydroartemisinin up‐regulates VE‐cadherin expression in human renal glomerular endothelial cells

Journal of Cellular and Molecular Medicine

2017

Glomerular endothelial cell IQGAP2 and filtration barrier function

Kidney International

2016

CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma

Histopathology

2015

Postnatal Notch1 activation induces T-cell malignancy in conditional and inducible mouse models

International Journal of Oncology

2014

Cutaneously applied acyclovir acts systemically in the treatment of herpetic infection in the hairless mouse

Antiviral Research

1997

Education

University of Toronto

PhD, Department of Medical Biophysics - Molecular and Cellular Biology of Cancer / April, 2004

Toronto, Ontario, Canada

University of Toronto

MSc, Department of Medical Biophysics - Molecular and Cellular Biology of Cancer / October, 1998

Toronto, Ontario, Canada

BSc, Biology/Pharmacology Co-op Program / May, 1995

Hamilton, Ontario, Canada

Experience

The One Health Company

Scientific Writing Consultant / February, 2024 — Present

Science-based writing projects - The One Health Company offers next-generation sequencing screening of the canine cancer genome, coupled with matching targeted therapeutics.

Oncology Lead / August, 2018 — February, 2020

Product development, science consulting and writing projects related to PR, publications, legal and regulatory.

Tradewind BioScience, Inc.

CEO / January, 2018 — June, 2023

Startup that built an antibody for ovarian cancer treatment.

Anticancer Bioscience, Ltd.

VP Translational Biology and Business Development / August, 2018 — October, 2023

Hybrid position - responsible for both the mentoring of scientific teams researching small molecule drugs (MOA, PK, in vivo, etc.) and worked on strategic business development projects. Notably, the outward face of the company for partnering, vendor interactions and as a legal liaison.

Links & Social Media

LinkedIn Page

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