Mai Mostafa

Biomedical Scientist

Research Expertise

Biochemistry
Molecular Biology
Immunology

About

Mai is a biomedical scientist with +15 years of expertise in in biochemistry, molecular biology & immunology. She has 4 years of experience in biomarker discovery for neurodegenerative diseases and immunoassay design, development and validation. She has strong leadership skills with project/team management expertise. My endeavor goal is to employ my skills/expertise with cross-functional team to move from basic research to translational research in drug discovery & development. Skills: \- Designing & troubleshooting research methodology and executing protocols to achieve the projects’ objectives\. \- Developing corrective and preventive plans and generating and executing the changes\. \- Excellent writing skills with an ability to design scientific protocols as evidenced by securing funds by the Michael J\. Fox Foundation and Partner Therapeutics for Parkinson’s disease research\. \- Excellent presentation skills as demonstrated by participating as a speaker in different scientific meetings/conferences\. Experience: \- Developing and validating screening assays \(qPCR array & MSD singleplex and multiplex assays\) to track the disease progression and therapeutic response in Parkinson’s disease patients treated with an immunomodulator drug \(Sargramostim\)\. \- Goal\-oriented scientist with \+15 years of expertise in the biological evaluation of nanoformulations\, stem cell research\, RNAi\, and immune cell\-disease interactions\, demonstrated by the fulfillment of \+12 projects related to human neurodegenerative\, infectious & cancer diseases\. \- Highly productive scientist and communication expert with an ability to work independently and within a team as evidenced by \+15 peer\-reviewed articles and 2 patents\. \- Proficient in many biochemistry & molecular biology techniques\. Techniques: cell culture \(BSL2/BSL3\)\, qPCR\, ddPCR\, PCR arrays\, western blot\, ELISA\, MSD assay\, flow cytometry\, electroporation\, transfection and animal studies\. \- Familiar with transcriptomics\, proteomics & bioinformatics as well as pathway enrichment analysis using different software \(IPA\, Cytoscape plugin ClueGo and StringApp\)\. Hobbies: Watching the historical movies and Broadway shows, biking & traveling with family.

Publications

The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats
Cancer Cell International
2011
Nanocarrier vaccines for SARS-CoV-2
Advanced Drug Delivery Reviews
2021
CD4+ effector T cells accelerate Alzheimer’s disease in mice
Journal of Neuroinflammation
2021
Synthesis, biological evaluation, and metabolic stability of phenazine derivatives as antibacterial agents
European Journal of Medicinal Chemistry
2018
A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention
Journal of Neuroimmune Pharmacology
2021
Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions
Frontiers in Immunology
2021
Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease
EBioMedicine
2021
Europium-Doped Cerium Oxide Nanoparticles for Microglial Amyloid Beta Clearance and Homeostasis
ACS Chemical Neuroscience
2022
Local renin-angiotensin system regulates the differentiation of mesenchymal stem cells into insulin-producing cells through angiotensin type 2 receptor
Biochimie
2017
Monocyte biomarkers define sargramostim treatment outcomes for Parkinson's disease
Clinical and Translational Medicine
2022
Development of an extended half-life GM-CSF fusion protein for Parkinson's disease
Journal of Controlled Release
2022
Multipolymer microsphere delivery of SARS-CoV-2 antigens
Acta Biomaterialia
2023
An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety, tolerability, and immune biomarkers from limited case numbers
Translational Neurodegeneration
2023
Neuroprotective mushrooms
NeuroImmune Pharmacology and Therapeutics
2024
Amyloid-β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice
Molecular Neurodegeneration
2023
Clinical biomarkers for Lewy body diseases
Cell & Bioscience
2023
Immune senescence in aged APP/PS1 mice
NeuroImmune Pharmacology and Therapeutics
2023
Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC
Non-Coding RNA
2022
Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions
Unknown Venue
2021
Preliminary preclinical study of Chol-DsiRNA polyplexes formed with PLL[30]-PEG[5K] for the RNAi-based therapy of breast cancer
Nanomedicine: Nanotechnology, Biology and Medicine
2021

Education

University of Nebraska Medical Center

PhD in Pharmaceutical Sciences, Pharmaceutical Sciences / March, 2022

Omaha

Ain Shams University

MSc in Pharmaceutical Sciences (Biochemistry), Biochemistry Department / May, 2012

Cairo

Ain Shams University

BSc in Pharmaceutical Sciences / May, 2006

Cairo

Experience

University of Nebraska Medical Center

Instructor / January, 2024March, 2024

Postdoc Research Associate / April, 2022December, 2023

Research Assistant / August, 2017March, 2022

Fulbright Scholar / September, 2016June, 2017

National Research Centre

Assistant researcher / June, 2007June, 2022

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