Jason Locasale

Scientist, metabolism and nutrition

Legacy Map

Publications

Quantitation of metabolic activity from isotope tracing data using automated methodology

Nature Metabolism

Separation of reproductive decline from lifespan extension during methionine restriction

Diet and Cancer Metabolism

Cold Spring Harbor Perspectives in Medicine

Quantification of metabolic activity from isotope tracing data using automated methodology

Histone butyrylation is a dietary link to epigenetics

Nature Metabolism

Delineating a Role for Methionine Metabolism in Colorectal Cancer

Cancer Research

Methionine availability influences essential H3K36me3 dynamics during cell differentiation

Lysine metabolism at the nexus of crotonylation and tumor immunity

Uncoupling of lifespan and reproductive tradeoffs by dietary methionine and one-carbon metabolism

Data from Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Data from Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Data from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Data from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Data from Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Supplementary Data from Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Supplementary Figure 1 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 1 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 2 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 2 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 3 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 3 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 4 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 4 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 5 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 5 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 6 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 6 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 7 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 7 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 8 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Figure 8 from SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Supplementary Table S1 from Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Supplementary Table S1 from Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Nucleotide metabolism is linked to cysteine availability

Journal of Biological Chemistry

Data from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Data from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Figure from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Figure from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Table from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Table from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Table from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Table from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Table from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Supplementary Table from Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Amino acid variability, tradeoffs and optimality in human diet

Nature Communications

Diet and Exercise in Cancer Metabolism

Cancer Discovery

Nucleotide metabolism is linked to cysteine availability

Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

MNK2 deficiency potentiates β-cell regeneration via translational regulation

Nature Chemical Biology

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Cancer Research

The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

Integrated Metabolic and Gene Expression Profiling Reveals New Therapeutic Modalities for Rapidly Proliferating Breast Cancers

Amino acid variability, tradeoffs and optimality in human diet

TGF-β signaling suppresses TCA cycle metabolism in renal cancer

¹³C tracer analysis identifies extensive recycling of endogenous CO₂in vivo

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Nature Communications

Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics

Nature Reviews Genetics

Integrated Metabolic Profiling and Gene Expression Analysis Reveals Therapeutic Modalities in Breast Cancer

The evolving metabolic landscape of chromatin biology and epigenetics

Nature Reviews Genetics

Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Cancer Discovery

Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney

Disease Models & Mechanisms

A spoonful of DHAP keeps mTORC1 running on sugars

Nature Metabolism

The Molecular Link from Diet to Cancer Cell Metabolism

Cooperative virus propagation in COVID-19 transmission

A reactive metabolite as an immune suppressant

Nature Immunology

NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism

Nature Metabolism

The Na⁺/K⁺ATPase Regulates Glycolysis and Modifies Immune Metabolism in Tumors

Metabolism in the tumor microenvironment: insights from single-cell analysis

Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life

The Journal of Immunology

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Nature Communications

Quantitative analysis of the physiological contributions of glucose to the TCA cycle

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Nature Reviews Cancer

Metabolic landscape of the tumor microenvironment at single cell resolution

Nature Communications

Nutrient availability shapes methionine metabolism in p16/ MTAP -deleted cells

Science Advances

SPHK1 Is a Novel Target of Metformin in Ovarian Cancer

Molecular Cancer Research

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Nature Communications

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8 ⁺ T cells

Science Immunology

Thermodynamic constraints on the regulation of metabolic fluxes

Journal of Biological Chemistry

Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases

Thermodynamic constraints on the regulation of metabolic fluxes

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

Nature Communications

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width

Nature Communications

Environmental factors shape methionine metabolism in p16/MTAP deleted cells

Methionine metabolism influences the genomic architecture of H3K4me3 with the link to gene expression encoded in peak width

Molecular features that predict the response to antimetabolite chemotherapies

Cancer & Metabolism

Metabolomics: A Primer

Trends in Biochemical Sciences

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Trends in Cancer

Metabolic pattern formation in the tumor microenvironment

Molecular Systems Biology

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product

Cell Metabolism

A toxin that fuels metabolism

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Nature Genetics

Metabolomics reveals intratumor heterogeneity – Implications for precision medicine

Methionine metabolism is essential for SIRT 1‐regulated mouse embryonic stem cell maintenance and embryonic development

The EMBO Journal

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Nature Neuroscience

RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity

Cell Chemical Biology

Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord

Current Biology

Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

Experimental Gerontology

The impact of cellular metabolism on chromatin dynamics and epigenetics

Nature Cell Biology

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

Nature Immunology

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

Cell Metabolism

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

Nature Cell Biology

A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect

Biophysical Journal

Metabolic interactions with cancer epigenetics

Molecular Aspects of Medicine

Understanding metabolism with flux analysis: From theory to application

Metabolic Engineering

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

A new layer of glycolysis

Nature Chemical Biology

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3

Genes & Development

Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Nature Cell Biology

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

Proceedings of the National Academy of Sciences

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

Cell Metabolism

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo

The Warburg Effect: How Does it Benefit Cancer Cells?

Trends in Biochemical Sciences

Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice

Annals of the New York Academy of Sciences

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

Correction to: ‘The Warburg Effect: How Does it Benefit Cancer Cells?’

Trends in Biochemical Sciences

Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism

Nature Communications

One‐carbon metabolism and epigenetics: understanding the specificity

Annals of the New York Academy of Sciences

Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape

Cell Metabolism

A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data

Computational Biology and Chemistry

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Seminars in Cancer Biology

Dysregulated metabolism contributes to oncogenesis

Seminars in Cancer Biology

The rate of glycolysis quantitatively mediates specific histone acetylation sites

Cancer & Metabolism

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

Cell Metabolism

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

Molecular & Cellular Proteomics

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment

Extraction parameters for metabolomics from cultured cells

Analytical Biochemistry

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet*

Molecular & Cellular Proteomics

A roadmap for interpreting 13 C metabolite labeling patterns from cells

Current Opinion in Biotechnology

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

Cancer Research

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Journal of Clinical Investigation

Evaluating Bioactive Food Components in Obesity and Cancer Prevention

Critical Reviews in Food Science and Nutrition

Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells

Characterization of the Usage of the Serine Metabolic Network in Human Cancer

Estimating Relative Changes of Metabolic Fluxes

PLoS Computational Biology

Heterogeneity of glycolysis in cancers and therapeutic opportunities

Biochemical Pharmacology

A Fundamental Trade-off in Covalent Switching and Its Circumvention by Enzyme Bifunctionality in Glucose Homeostasis

Journal of Biological Chemistry

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Proceedings of the National Academy of Sciences

Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide

Molecular Cancer Research

A metabolic signature of colon cancer initiating cells

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Journal of Visualized Experiments

Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology

Analytical Chemistry

Erratum: Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis

Cell Death & Disease

Correction for Sun et al., Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Proceedings of the National Academy of Sciences

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis

Cell Death & Disease

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Epigenetics and cancer metabolism

Serine, glycine and one-carbon units: cancer metabolism in full circle

Nature Reviews Cancer

Computational approaches for understanding energy metabolism

WIREs Systems Biology and Medicine

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

Nature Biotechnology

Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

Nature Structural & Molecular Biology

The consequences of enhanced cell-autonomous glucose metabolism

Trends in Endocrinology & Metabolism

Metabolomics of Human Cerebrospinal Fluid Identifies Signatures of Malignant Glioma

Molecular & Cellular Proteomics

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Maximizing the Efficacy of Angiogenesis Inhibitors

Journal of Clinical Oncology

Interactions between epigenetics and metabolism in cancers

Frontiers in Oncology

Metabolic rewiring drives resistance to targeted cancer therapy

Molecular Systems Biology

Cancer Cell Metabolism

Insulin-like Growth Factors and Cancer

Human pluripotent stem cells decouple respiration from energy production

The EMBO Journal

IL-6 and Ovarian Cancer—Letter

Clinical Cancer Research

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

PHGDH amplification and altered glucose metabolism in human melanoma

Pigment Cell & Melanoma Research

Genetic selection for enhanced serine metabolism in cancer development

Metabolic Flux and the Regulation of Mammalian Cell Growth

Cell Metabolism

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Nature Genetics

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

Science Signaling

Metabolic Pathway Alterations that Support Cell Proliferation

Cold Spring Harbor Symposia on Quantitative Biology

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases

Proceedings of the National Academy of Sciences

Altered metabolism in cancer

Rewiring of glycolysis in cancer cell metabolism

Cancer's insatiable appetite

Nature Biotechnology

Signatures of Protein-DNA Recognition in Free DNA Binding Sites

Journal of Molecular Biology

Maximum Entropy Reconstructions of Dynamic Signaling Networks from Quantitative Proteomics Data

Three-state kinetic mechanism for scaffold-mediated signal transduction

Physical Review E

Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins

PLoS Computational Biology

Allovalency revisited: An analysis of multisite phosphorylation and substrate rebinding

The Journal of Chemical Physics

Signal duration and the time scale dependence of signal integration in biochemical pathways

BMC Systems Biology

Scaffold proteins confer diverse regulatory properties to protein kinase cascades

Proceedings of the National Academy of Sciences

The Stimulatory Potency of T Cell Antigens Is Influenced by the Formation of the Immunological Synapse

Computational Investigations into the Origins of Short-Term Biochemical Memory in T cell Activation

Education

Massachusetts Institute of Technology

PHD

Cambridge, Massachusetts, United States of America

Rutgers University New Brunswick

BA

New Brunswick, New Jersey, United States of America

Experience

Duke University School of Medicine

Associate Professor / August, 2015 — March, 2024

Cornell University

Assistant Professor / 2012 — July, 2015

Harvard Medical School

Postdoc / 2008 — 2011

Links & Social Media

Link

ORCID

Join Jason on NotedSource!

Join Now

At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.

For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.

For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.

Expert Institutions

Proudly trusted by

Connect with researchers and scientists like Jason Locasale on NotedSource to help your company with innovation, research, R&D, L&D, and more.