Jinyu Shan

Revolutionizing Bacterial Diagnosis with Phage Technology | Expert in Lyme and Tick-Borne Disease Molecular Diagnostics | Skilled in Scientific Writing and Team Collaboration | Supported by BBSRC ICURe

Research Expertise

phage therapy
molecular diagnostics
clinical microbiology

About

Dr. Jinyu Shan stands as a pivotal figure in molecular microbiology, seamlessly integrating an illustrious academic career with significant contributions to industry innovation. Fluent in English and Mandarin Chinese, and proficient in Cantonese, Dr. Shan leverages his linguistic capabilities to foster international collaborations and effectively communicate complex scientific concepts. Holding advanced degrees from renowned institutions like Shandong University, Nankai University, and the University of Warwick, Dr. Shan's extensive educational background lays the foundation for his groundbreaking work in both academia and biotechnology. His efforts are particularly notable in the fields of phage therapy and molecular diagnostics for bacterial infections such as Lyme and tick-borne diseases, where he combines research excellence with practical application and citizen sciences to address pressing public health needs. At the University of Leicester and Phelix Research & Development, Dr. Shan has led pioneering research in phage-based diagnostics and therapies and directed the development and commercialization (IP licencing) of innovative diagnostic kits, adhering to strict ISO standards. His leadership roles at Youseq Ltd, Marker Diagnostics Ltd and Rosalind Franklin Laboratory have further showcased his expertise in developing biomarkers and managing laboratory operations to meet ISO15189 standards. Dr. Shan's scholarly output includes influential publications on novel diagnostic methods and active engagement in public health through citizen science projects and popular science articles, establishing him as a leader in his field. He is a sought-after speaker at international microbiology and infectious disease conferences, reflecting his commitment to scientific education and mentoring. Dr. Shan is actively involved with professional societies and has served as a judge for the LymeX Diagnostics Prize Competition, highlighting his dedication to advancing Lyme disease diagnostics. His interdisciplinary approach exemplifies his commitment to improving public health through innovative biomedical research. Recently, Dr. Shan's work has gained additional acclaim as he joined the BBSRC ICURe Programme, aimed at commercializing his phage-based Lyme diagnostic technologies. This recognition underscores the impact and commercial potential of his research, bridging the gap between laboratory discoveries and clinical application, thus advancing patient care globally. This achievement marks a significant milestone in Dr. Shan's career, emphasizing his influence as a driving force in the evolution of infectious disease diagnostics.

Legacy Map

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Publications

Transcription of a ‘photosynthetic’ T4‐type phage during infection of a marine cyanobacterium
Environmental Microbiology
2006
Diverse Temperate Bacteriophage Carriage in Clostridium difficile 027 Strains
PLoS ONE
2012
Bacteriophages are more virulent to bacteria with human cells than they are in bacterial culture; insights from HT-29 cells
Scientific Reports
2018
Temperature dependent bacteriophages of a tropical bacterial pathogen
Frontiers in Microbiology
2014
Prophage Carriage and Diversity within Clinically Relevant Strains of Clostridium difficile
Applied and Environmental Microbiology
2012
Light-dependent adsorption of photosynthetic cyanophages to Synechococcus  sp. WH7803
FEMS Microbiology Letters
2010
Infection by the ‘photosynthetic’ phage S-PM2 induces increased synthesis of phycoerythrin in Synechococcus sp. WH7803
FEMS Microbiology Letters
2008
Isolation and characterization of a novel podovirus which infects burkholderia pseudomallei
Virology Journal
2011
Temperature-dependent virus lifecycle choices may reveal and predict facets of the biology of opportunistic pathogenic bacteria
Scientific Reports
2018
A flavonoid compound fromChrysosplenium nudicauleinhibits growth and induces apoptosis of the human stomach cancer cell line SGC-7901
Pharmaceutical Biology
2015
Targeting Multicopy Prophage Genes for the Increased Detection of Borrelia burgdorferi Sensu Lato (s.l.), the Causative Agents of Lyme Disease, in Blood
Frontiers in Microbiology
2021
Diversity, Dynamics and Therapeutic Application of Clostridioides difficile Bacteriophages
Viruses
2022
The study of Mössbauer effect in EuBa2Cu3O7-y
Hyperfine Interactions
1992
The structurome of a Clostridium difficile phage and the remarkable accurate prediction of its novel phage receptor-binding protein
Unknown Venue
2021
Receptor-binding protein of Clostridium difficile phage CDHS-1
Unknown Venue
2022
PHAGE Impact and the Impact of Phages
PHAGE
2023
Macrophage inflammatory protein‐2 and vascular endothelial growth factor regulate corneal neovascularization induced by infection with Pseudomonas aeruginosa in mice
Immunology & Cell Biology
2002
Use of Specific Borrelia Phages as a New Strategy for Improved Diagnostic Tests
Methods in Molecular Biology
2024
Overcoming the Challenges of Lyme Disease Diagnosis: The Role of Phage-based Testing
Unknown Venue
2023
Combining citizen science and molecular diagnostic methods to investigate the prevalence of Borrelia burgdorferi s.l. and Borrelia miyamotoi in tick pools across Great Britain
Frontiers in Microbiology
2023
Activity of a Bacteriophage Cocktail to Control Salmonella Growth Ex Vivo in Avian, Porcine, and Human Epithelial Cell Cultures
PHAGE
2023
Overcoming the Challenges of Lyme Disease Diagnosis: The Role of Phage-based Testing
Medical Research Archives
2023
Targeting multicopy prophage genes for the differential diagnosis of Lyme disease
Unknown Venue
2020
Construction of human MASP-2-CCP1/2SP, CCP2SP, SP plasmid DNA nanolipoplexes and the effects on tuberculosis in BCG-infected mice
Microbial Pathogenesis
2017
Preparation of RNA from Bacteria Infected with Bacteriophages: A Case Study from the Marine Unicellular Synechococcus sp. WH7803 Infected by Phage S-PM2
Methods in Molecular Biology
2009

Education

University of Warwick

PhD, Biological Sciences / December, 2017

Coventry

Nankai University

MSc, Microbiology / July, 2000

Tianjin

Shandong University

BSc, Microbiology / July, 1997

Jinan

Experience

University of Leicester

Research Fellow/Chief Scientific Officer / January, 2015Present

Research Associate / April, 2008April, 2014

Youseq Ltd

Product Technical Manager / July, 2023December, 2023

Marker Diagnostics UK Ltd

Chief Scientist / November, 2022July, 2023

Rosaland Franklin Laboratory

Associate Principle Scientist / January, 2022April, 2022

Cignpost Diagnostics

Deputy Lab Manager / August, 2021January, 2022

Office for National Statistics

Community Advisor / November, 2020May, 2021

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