Javier O. Morales

Professor of drug delivery and pharmaceutical product development at University of Chile

Research Expertise

Pharmaceutics
Biotechnology
Pharmaceutical Science
Drug Discovery
Agronomy and Crop Science
Aquatic Science
Ecology
Ecology, Evolution, Behavior and Systematics
Pharmacology
Organic Chemistry
Physical and Theoretical Chemistry
Surfaces and Interfaces
Colloid and Surface Chemistry
Bioengineering
Biomedical Engineering
Development
Molecular Biology
Molecular Medicine
Clinical Biochemistry
Biochemistry
Pharmacology (medical)
Immunology
Infectious Diseases
Microbiology (medical)
Microbiology
Materials Chemistry
Inorganic Chemistry
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Spectroscopy
Electronic, Optical and Magnetic Materials

About

Javier O. Morales is a highly accomplished and experienced pharmaceutical professional with a strong academic background and extensive practical experience. He obtained his Bachelor of Science degree in Pharmacy in 2006 and the Pharmaceutical Chemist degree in 2008 from the University of Chile. He then went on to obtain his Ph.D. in Pharmaceutics from The University of Texas at Austin in 2012. Dr. Morales has since worked as an Assistant Professor and later as an Associate Professor at the University of Chile. He has also served as the Director of the Center of New Drugs for Hypertension (CENDHY), where he led a team of researchers in developing new and innovative pharmaceutical treatments for hypertension. Dr. Morales has a strong passion for research and has published numerous articles in international journals and has patented his developed technologies. His expertise in pharmaceuticals, nano and microstructured drug delivery systems, implants, and peptide drug discovery has made him a sought-after speaker at conferences and symposiums around the world. In addition to his academic and research achievements, Dr. Morales is also a dedicated mentor and has supervised and mentored several students in their research projects. He is known for his commitment to excellence and his ability to motivate and inspire others. Overall, Dr. Morales is a highly respected and accomplished pharmaceutical professional with a strong track record of success in academia. His contributions to the field of pharmaceutical sciences have made a significant impact, and he continues to be a leader in the industry.

Publications

Manufacture and characterization of mucoadhesive buccal films

European Journal of Pharmaceutics and Biopharmaceutics / Feb 01, 2011

Morales, J. O., & McConville, J. T. (2011). Manufacture and characterization of mucoadhesive buccal films. European Journal of Pharmaceutics and Biopharmaceutics, 77(2), 187–199. https://doi.org/10.1016/j.ejpb.2010.11.023

Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes

The AAPS Journal / Feb 13, 2017

Morales, J. O., Fathe, K. R., Brunaugh, A., Ferrati, S., Li, S., Montenegro-Nicolini, M., Mousavikhamene, Z., McConville, J. T., Prausnitz, M. R., & Smyth, H. D. C. (2017). Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes. The AAPS Journal, 19(3), 652–668. https://doi.org/10.1208/s12248-017-0054-z

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches

Theranostics / Jan 01, 2018

Bejarano, J., Navarro-Marquez, M., Morales-Zavala, F., Morales, J. O., Garcia-Carvajal, I., Araya-Fuentes, E., Flores, Y., Verdejo, H. E., Castro, P. F., Lavandero, S., & Kogan, M. J. (2018). Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches. Theranostics, 8(17), 4710–4732. https://doi.org/10.7150/thno.26284

Overview and Future Potential of Buccal Mucoadhesive Films as Drug Delivery Systems for Biologics

AAPS PharmSciTech / Apr 15, 2016

Montenegro-Nicolini, M., & Morales, J. O. (2016). Overview and Future Potential of Buccal Mucoadhesive Films as Drug Delivery Systems for Biologics. AAPS PharmSciTech, 18(1), 3–14. https://doi.org/10.1208/s12249-016-0525-z

Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films

European Journal of Pharmaceutical Sciences / Jan 01, 2017

Vuddanda, P. R., Montenegro-Nicolini, M., Morales, J. O., & Velaga, S. (2017). Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films. European Journal of Pharmaceutical Sciences, 96, 290–298. https://doi.org/10.1016/j.ejps.2016.09.011

Nanoparticles for the Treatment of Wounds

Current Pharmaceutical Design / Oct 07, 2015

Oyarzun-Ampuero, F., Vidal, A., Concha, M., Morales, J., Orellana, S., & Moreno-Villoslada, I. (2015). Nanoparticles for the Treatment of Wounds. Current Pharmaceutical Design, 21(29), 4329–4341. https://doi.org/10.2174/1381612821666150901104601

Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles

Current Opinion in Pharmacology / Oct 01, 2017

Morales, J. O., & Brayden, D. J. (2017). Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles. Current Opinion in Pharmacology, 36, 22–28. https://doi.org/10.1016/j.coph.2017.07.011

Novel strategies for the buccal delivery of macromolecules

Drug Development and Industrial Pharmacy / Mar 10, 2014

Morales, J. O., & McConville, J. T. (2014). Novel strategies for the buccal delivery of macromolecules. Drug Development and Industrial Pharmacy, 40(5), 579–590. https://doi.org/10.3109/03639045.2014.892960

Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery

Colloids and Surfaces B: Biointerfaces / Oct 01, 2014

Morales, J. O., Huang, S., Williams, R. O., & McConville, J. T. (2014). Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery. Colloids and Surfaces B: Biointerfaces, 122, 38–45. https://doi.org/10.1016/j.colsurfb.2014.05.025

Lipid nanoparticles for the topical delivery of retinoids and derivatives

Nanomedicine / Jan 01, 2015

Morales, J. O., Valdés, K., Morales, J., & Oyarzun-Ampuero, F. (2015). Lipid nanoparticles for the topical delivery of retinoids and derivatives. Nanomedicine, 10(2), 253–269. https://doi.org/10.2217/nnm.14.159

Inkjet Printing of Proteins: an Experimental Approach

The AAPS Journal / Oct 13, 2016

Montenegro-Nicolini, M., Miranda, V., & Morales, J. O. (2016). Inkjet Printing of Proteins: an Experimental Approach. The AAPS Journal, 19(1), 234–243. https://doi.org/10.1208/s12248-016-9997-8

Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins

Bioorganic & Medicinal Chemistry / May 01, 2008

Jullian, C., Morales-Montecinos, J., Zapata-Torres, G., Aguilera, B., Rodriguez, J., Arán, V., & Olea-Azar, C. (2008). Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins. Bioorganic & Medicinal Chemistry, 16(9), 5078–5084. https://doi.org/10.1016/j.bmc.2008.03.026

Surfactants: their critical role in enhancing drug delivery to the lungs

Therapeutic Delivery / May 01, 2011

Morales, J. O., Peters, J. I., & Williams, R. O. (2011). Surfactants: their critical role in enhancing drug delivery to the lungs. Therapeutic Delivery, 2(5), 623–641. https://doi.org/10.4155/tde.11.15

The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems

AAPS PharmSciTech / Jun 22, 2018

Montenegro-Nicolini, M., Reyes, P. E., Jara, M. O., Vuddanda, P. R., Neira-Carrillo, A., Butto, N., Velaga, S., & Morales, J. O. (2018). The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems. AAPS PharmSciTech, 19(8), 3376–3387. https://doi.org/10.1208/s12249-018-1105-1

Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films

European Journal of Pharmaceutical Sciences / Nov 01, 2017

Vuddanda, P. R., Montenegro-Nicolini, M., Morales, J. O., & Velaga, S. (2017). Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films. European Journal of Pharmaceutical Sciences, 109, 372–380. https://doi.org/10.1016/j.ejps.2017.08.019

Buccal Dosage Forms: General Considerations for Pediatric Patients

AAPS PharmSciTech / Jun 14, 2016

Montero-Padilla, S., Velaga, S., & Morales, J. O. (2016). Buccal Dosage Forms: General Considerations for Pediatric Patients. AAPS PharmSciTech, 18(2), 273–282. https://doi.org/10.1208/s12249-016-0567-2

Inkjet printing of small molecules, biologics, and nanoparticles

International Journal of Pharmaceutics / May 01, 2021

Chou, W.-H., Gamboa, A., & Morales, J. O. (2021). Inkjet printing of small molecules, biologics, and nanoparticles. International Journal of Pharmaceutics, 600, 120462. https://doi.org/10.1016/j.ijpharm.2021.120462

Protein-coated nanoparticles embedded in films as delivery platforms

Journal of Pharmacy and Pharmacology / Mar 29, 2013

Morales, J. O., Ross, A. C., & McConville, J. T. (2013). Protein-coated nanoparticles embedded in films as delivery platforms. Journal of Pharmacy and Pharmacology, 65(6), 827–838. https://doi.org/10.1111/jphp.12046

Magnesium-doped zinc oxide nanoparticles alter biofilm formation of Proteus mirabilis

Nanomedicine / Jun 01, 2019

Iribarnegaray, V., Navarro, N., Robino, L., Zunino, P., Morales, J., & Scavone, P. (2019). Magnesium-doped zinc oxide nanoparticles alter biofilm formation of Proteus mirabilis. Nanomedicine, 14(12), 1551–1564. https://doi.org/10.2217/nnm-2018-0420

Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer

Nanomedicine / Jan 01, 2016

Catalan-Figueroa, J., Palma-Florez, S., Alvarez, G., Fritz, H. F., Jara, M. O., & Morales, J. O. (2016). Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer. Nanomedicine, 11(2), 171–187. https://doi.org/10.2217/nnm.15.189

The Influence of Recrystallized Caffeine on Water-Swellable Polymethacrylate Mucoadhesive Buccal Films

AAPS PharmSciTech / Mar 02, 2013

Morales, J. O., Su, R., & McConville, J. T. (2013). The Influence of Recrystallized Caffeine on Water-Swellable Polymethacrylate Mucoadhesive Buccal Films. AAPS PharmSciTech, 14(2), 475–484. https://doi.org/10.1208/s12249-012-9891-3

Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety

Pharmaceutics / Mar 01, 2019

Sepúlveda-Rivas, S., Fritz, H., Valenzuela, C., Santiviago, C., & Morales, J. (2019). Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety. Pharmaceutics, 11(3), 103. https://doi.org/10.3390/pharmaceutics11030103

Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems

Vaccines / Oct 14, 2021

Trincado, V., Gala, R. P., & Morales, J. O. (2021). Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems. Vaccines, 9(10), 1177. https://doi.org/10.3390/vaccines9101177

Nanoparticles as Potential Novel Therapies for Urinary Tract Infections

Frontiers in Cellular and Infection Microbiology / Apr 19, 2021

Sánchez, S. V., Navarro, N., Catalán-Figueroa, J., & Morales, J. O. (2021). Nanoparticles as Potential Novel Therapies for Urinary Tract Infections. Frontiers in Cellular and Infection Microbiology, 11. https://doi.org/10.3389/fcimb.2021.656496

Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids

European Journal of Pharmaceutics and Biopharmaceutics / Nov 01, 2020

Gamboa, A., Schüßler, N., Soto-Bustamante, E., Romero-Hasler, P., Meinel, L., & Morales, J. O. (2020). Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids. European Journal of Pharmaceutics and Biopharmaceutics, 156, 203–218. https://doi.org/10.1016/j.ejpb.2020.09.007

Finding key nanoprecipitation variables for achieving uniform polymeric nanoparticles using neurofuzzy logic technology

Drug Delivery and Translational Research / Dec 29, 2017

Jara, M. O., Catalan-Figueroa, J., Landin, M., & Morales, J. O. (2017). Finding key nanoprecipitation variables for achieving uniform polymeric nanoparticles using neurofuzzy logic technology. Drug Delivery and Translational Research, 8(6), 1797–1806. https://doi.org/10.1007/s13346-017-0446-8

Flavonoids in Microheterogeneous Media, Relationship between Their Relative Location and Their Reactivity towards Singlet Oxygen

PLOS ONE / Jun 22, 2015

Günther, G., Berríos, E., Pizarro, N., Valdés, K., Montero, G., Arriagada, F., & Morales, J. (2015). Flavonoids in Microheterogeneous Media, Relationship between Their Relative Location and Their Reactivity towards Singlet Oxygen. PLOS ONE, 10(6), e0129749. https://doi.org/10.1371/journal.pone.0129749

A design of experiments to optimize a new manufacturing process for high activity protein-containing submicron particles

Drug Development and Industrial Pharmacy / Jan 08, 2013

Morales, J. O., Joks, G. M., Lamprecht, A., Ross, A. C., & McConville, J. T. (2013). A design of experiments to optimize a new manufacturing process for high activity protein-containing submicron particles. Drug Development and Industrial Pharmacy, 39(11), 1793–1801. https://doi.org/10.3109/03639045.2012.737332

Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs

Pharmaceutics / Nov 30, 2020

Chou, W.-H., Galaz, A., Jara, M. O., Gamboa, A., & Morales, J. O. (2020). Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs. Pharmaceutics, 12(12), 1168. https://doi.org/10.3390/pharmaceutics12121168

Orally disintegrating tablets and orally disintegrating mini tablets – novel dosage forms for pediatric use

Pharmaceutical Development and Technology / Jun 19, 2019

Comoglu, T., & Dilek Ozyilmaz, E. (2019). Orally disintegrating tablets and orally disintegrating mini tablets – novel dosage forms for pediatric use. Pharmaceutical Development and Technology, 24(7), 902–914. https://doi.org/10.1080/10837450.2019.1615090

A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages

European Journal of Pharmaceutical Sciences / Dec 01, 2018

Catalan-Figueroa, J., Boisset, C. B., Jara, M. O., Flores, M. E., Moreno-Villoslada, I., Fiedler, J. L., & Morales, J. O. (2018). A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages. European Journal of Pharmaceutical Sciences, 125, 215–222. https://doi.org/10.1016/j.ejps.2018.10.002

Preparation of a novel lipid-core micelle using a low-energy emulsification method

Drug Delivery and Translational Research / Apr 16, 2018

Fritz, H. F., Ortiz, A. C., Velaga, S. P., & Morales, J. O. (2018). Preparation of a novel lipid-core micelle using a low-energy emulsification method. Drug Delivery and Translational Research, 8(6), 1807–1814. https://doi.org/10.1007/s13346-018-0521-9

Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer

Current Pharmaceutical Design / Oct 07, 2015

Oyarzun-Ampuero, F., Guerrero, A., Hassan-Lopez, N., Morales, J., Bollo, S., Corvalan, A., Quest, A., & Kogan, M. (2015). Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer. Current Pharmaceutical Design, 21(29), 4145–4154. https://doi.org/10.2174/1381612821666150901095538

Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia

Molecular Pharmaceutics / Oct 12, 2020

Catalan-Figueroa, J., García, M. A., Contreras, P., Boisset, C. B., Gonzalez, P. M., Fiedler, J. L., Pérez, M. F., & Morales, J. O. (2020). Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia. Molecular Pharmaceutics, 18(2), 743–750. https://doi.org/10.1021/acs.molpharmaceut.0c00623

Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis

Antibiotics / Dec 11, 2020

Greatti, V. R., Oda, F., Sorrechia, R., Kapp, B. R., Seraphim, C. M., Weckwerth, A. C. V. B., Chorilli, M., Silva, P. B. D., Eloy, J. O., Kogan, M. J., Morales, J. O., & Pietro, R. C. L. R. (2020). Poly-ε-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis. Antibiotics, 9(12), 894. https://doi.org/10.3390/antibiotics9120894

Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases

Current Pharmaceutical Design / Oct 07, 2015

Morales, J., Sepulveda-Rivas, S., Oyarzun-Ampuero, F., Lavandero, S., & Kogan, M. (2015). Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases. Current Pharmaceutical Design, 21(29), 4276–4284. https://doi.org/10.2174/1381612821666150901103556

Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles – An update

International Journal of Pharmaceutics / Apr 01, 2023

Nair, V. V., Cabrera, P., Ramírez-Lecaros, C., Jara, M. O., Brayden, D. J., & Morales, J. O. (2023). Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles – An update. International Journal of Pharmaceutics, 636, 122789. https://doi.org/10.1016/j.ijpharm.2023.122789

Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy

Pharmaceutics / Jun 01, 2021

Sepúlveda-Rivas, S., Leal, M. S., Pedrozo, Z., Kogan, M. J., Ocaranza, M. P., & Morales, J. O. (2021). Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy. Pharmaceutics, 13(6), 822. https://doi.org/10.3390/pharmaceutics13060822

Nanomedicines for Brain Drug Delivery

Neuromethods / Jan 01, 2021

Nanomedicines for Brain Drug Delivery. (2021). In J. O. Morales & P. J. Gaillard (Eds.), Neuromethods. Springer US. https://doi.org/10.1007/978-1-0716-0838-8

Inhibition of cancer metabolism: a patent landscape

Pharmaceutical Patent Analyst / Jul 01, 2019

Katt, W. P., & Cerione, R. A. (2019). Inhibition of cancer metabolism: a patent landscape. Pharmaceutical Patent Analyst, 8(4), 117–138. https://doi.org/10.4155/ppa-2019-0012

Surface-Modified Nanoparticles to Improve Drug Delivery

Dekker Encyclopedia of Nanoscience and Nanotechnology, Third Edition / Oct 21, 2014

Oyarzun-Ampuero, F., Kogan, M. J., Neira-Carrillo, A., & Morales, J. O. (2014). Surface-Modified Nanoparticles to Improve Drug Delivery. In Dekker Encyclopedia of Nanoscience and Nanotechnology, Third Edition (pp. 1–7). Taylor & Francis. https://doi.org/10.1081/e-enn3-120051984

Selected abstracts from Excipient Fest 2017

Drug Development and Industrial Pharmacy / Dec 25, 2017

Selected abstracts from Excipient Fest 2017. (2017). Drug Development and Industrial Pharmacy, 44(5), 868–871. https://doi.org/10.1080/03639045.2017.1410331

Drug Delivery Systems: Oral Mucosal

Encyclopedia of Biomedical Polymers and Polymeric Biomaterials / Dec 04, 2015

Morales, J. O. (2015). Drug Delivery Systems: Oral Mucosal. In Encyclopedia of Biomedical Polymers and Polymeric Biomaterials (pp. 2894–2913). Taylor & Francis. https://doi.org/10.1081/e-ebpp-120050069

Book Review

Drug Development and Industrial Pharmacy / Jan 31, 2014

Morales, J. O. (2014). Book Review. Drug Development and Industrial Pharmacy, 41(4), 529–529. https://doi.org/10.3109/03639045.2014.884131

Structuration in the Interface of Direct and Reversed Micelles of Sucrose Esters, Studied by Fluorescent Techniques

PLOS ONE / Apr 23, 2015

Sandoval, C., Ortega, A., Sanchez, S. A., Morales, J., & Gunther, G. (2015). Structuration in the Interface of Direct and Reversed Micelles of Sucrose Esters, Studied by Fluorescent Techniques. PLOS ONE, 10(4), e0123669. https://doi.org/10.1371/journal.pone.0123669

Book Review

Drug Development and Industrial Pharmacy / Mar 07, 2014

Felton, L. A. (2014). Book Review. Drug Development and Industrial Pharmacy, 40(8), 1132–1132. https://doi.org/10.3109/03639045.2014.895376

The development of ink jet printing on textiles

Ink Jet Textile Printing / Jan 01, 2015

Cie, C. (2015). The development of ink jet printing on textiles. In Ink Jet Textile Printing (pp. 15–27). Elsevier. https://doi.org/10.1016/b978-0-85709-230-4.00002-9

Photothermal Activatable Mucoadhesive Fiber Mats for On-Demand Delivery of Insulin via Buccal and Corneal Mucosa

Photothermal Activatable Mucoadhesive Fiber Mats for On-Demand Delivery of Insulin via Buccal and Corneal Mucosa. (n.d.). American Chemical Society (ACS). https://doi.org/10.1021/acsabm.1c01161.s001

Los bienes humanos básicos en la doctrina de Tomás de Aquino

Intus-Legere Filosofía / Mar 01, 2007

Miranda Montecinos, A. (2007). Los bienes humanos básicos en la doctrina de Tomás de Aquino. Intus-Legere Filosofía, 1(1). https://doi.org/10.15691/0718-5448vol1iss1a29

Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin

Pharmaceutics / Jan 10, 2023

Gamboa-Arancibia, M. E., Caro, N., Gamboa, A., Morales, J. O., González Casanova, J. E., Rojas Gómez, D. M., & Miranda-Rojas, S. (2023). Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin. Pharmaceutics, 15(1), 232. https://doi.org/10.3390/pharmaceutics15010232

Experimental design and optimization of a novel dual-release drug delivery system with therapeutic potential against infection with Helicobacter pylori

Colloids and Surfaces B: Biointerfaces / May 01, 2022

Arrua, E. C., Sanchez, S. V., Trincado, V., Hidalgo, A., Quest, A. F. G., & Morales, J. O. (2022). Experimental design and optimization of a novel dual-release drug delivery system with therapeutic potential against infection with Helicobacter pylori. Colloids and Surfaces B: Biointerfaces, 213, 112403. https://doi.org/10.1016/j.colsurfb.2022.112403

Mechanical Particle-Size Reduction Techniques

Formulating Poorly Water Soluble Drugs / Jan 01, 2022

Morales, J. O., Watts, A. B., & McConville, J. T. (2022). Mechanical Particle-Size Reduction Techniques. In AAPS Advances in the Pharmaceutical Sciences Series (pp. 141–177). Springer International Publishing. https://doi.org/10.1007/978-3-030-88719-3_4

Development of a Nanostructured Lipid Carrier (NLC) by a Low-Energy Method, Comparison of Release Kinetics and Molecular Dynamics Simulation

Pharmaceutics / Apr 10, 2021

Ortiz, A. C., Yañez, O., Salas-Huenuleo, E., & Morales, J. O. (2021). Development of a Nanostructured Lipid Carrier (NLC) by a Low-Energy Method, Comparison of Release Kinetics and Molecular Dynamics Simulation. Pharmaceutics, 13(4), 531. https://doi.org/10.3390/pharmaceutics13040531

Aptamer-functionalized lipid-core micelles loaded with rhenium tricarbonyl complex

Polyhedron / Feb 01, 2021

Ortiz, A. C., Casas, I., Mella, P., Naranjo, O., Pizarro, N., Vega, A., Cerda-Opazo, P., García, L., Morales, J. O., & Cepeda-Plaza, M. (2021). Aptamer-functionalized lipid-core micelles loaded with rhenium tricarbonyl complex. Polyhedron, 195, 114963. https://doi.org/10.1016/j.poly.2020.114963

Dember photovoltaic effect as method for structural characterization of phospholipidic membranes

Journal of Molecular Liquids / Apr 01, 2021

Yablonskii, S. V., Bodnarchuk, V. V., Geivandov, A. R., Romero-Hasler, P., Soto-Bustamante, E. A., & Morales, J. O. (2021). Dember photovoltaic effect as method for structural characterization of phospholipidic membranes. Journal of Molecular Liquids, 328, 115409. https://doi.org/10.1016/j.molliq.2021.115409

Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery

Neuromethods / Nov 20, 2020

Catalan-Figueroa, J., & Morales, J. O. (2020). Safety and Nanotoxicity Aspects of Nanomedicines for Brain-Targeted Drug Delivery. In Nanomedicines for Brain Drug Delivery (pp. 255–277). Springer US. https://doi.org/10.1007/978-1-0716-0838-8_10

Screening of critical variables in fabricating polycaprolactone nanoparticles using Neuro Fuzzy Logic

International Journal of Pharmaceutics / May 01, 2021

Jara, M. O., Landin, M., & Morales, J. O. (2021). Screening of critical variables in fabricating polycaprolactone nanoparticles using Neuro Fuzzy Logic. International Journal of Pharmaceutics, 601, 120558. https://doi.org/10.1016/j.ijpharm.2021.120558

Buccal Delivery of Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles / Jan 01, 2020

Ortiz, A. C., & Morales, J. O. (2020). Buccal Delivery of Nanoparticles. In AAPS Advances in the Pharmaceutical Sciences Series (pp. 107–124). Springer International Publishing. https://doi.org/10.1007/978-3-030-35910-2_5

Light-induced release of the cardioprotective peptide angiotensin-(1–9) from thermosensitive liposomes with gold nanoclusters

Journal of Controlled Release / Dec 01, 2020

Bejarano, J., Rojas, A., Ramírez-Sagredo, A., Riveros, A. L., Morales-Zavala, F., Flores, Y., Riquelme, J. A., Guzman, F., Araya, E., Chiong, M., Ocaranza, M. P., Morales, J. O., Villamizar Sarmiento, M. G., Sanchez, G., Lavandero, S., & Kogan, M. J. (2020). Light-induced release of the cardioprotective peptide angiotensin-(1–9) from thermosensitive liposomes with gold nanoclusters. Journal of Controlled Release, 328, 859–872. https://doi.org/10.1016/j.jconrel.2020.11.002

Preface to advances in thin film technologies in drug delivery

International Journal of Pharmaceutics / Nov 01, 2019

Gala, R. P., Morales, J. O., & McConville, J. T. (2019). Preface to advances in thin film technologies in drug delivery. International Journal of Pharmaceutics, 571, 118687. https://doi.org/10.1016/j.ijpharm.2019.118687

Formulation and Delivery of Macromolecules

AAPS PharmSciTech / Dec 09, 2016

Morales, J. O. (2016). Formulation and Delivery of Macromolecules. AAPS PharmSciTech, 18(1), 1–2. https://doi.org/10.1208/s12249-016-0685-x

Mechanical Particle-Size Reduction Techniques

Formulating Poorly Water Soluble Drugs / Jan 01, 2016

Morales, J. O., Watts, A. B., & McConville, J. T. (2016). Mechanical Particle-Size Reduction Techniques. In AAPS Advances in the Pharmaceutical Sciences Series (pp. 165–213). Springer International Publishing. https://doi.org/10.1007/978-3-319-42609-9_4

Preface for buccal drug delivery theme issue

Drug Development and Industrial Pharmacy / Feb 27, 2014

Morales, J. O., & McConville, J. T. (2014). Preface for buccal drug delivery theme issue. Drug Development and Industrial Pharmacy, 40(5), 577–578. https://doi.org/10.3109/03639045.2014.892961

Education

BSc, Pharmacy / November, 2006

Santiago

University of Chile

Professional Degree, PharmD / January, 2008

Santiago

The University of Texas at Austin

Ph.D., Pharmaceutics / December, 2012

Austin, Texas, United States of America

Experience

University of Chile

Assistant Professor / January, 2013October, 2019

University of Chile

Associate Professor / November, 2019Present

Center of New Drugs for Hypertension (CENDHY)

Director / December, 2019December, 2023

http://www.cendhy.cl/

Links & Social Media

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