Boris Leibovitch

Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia

New York, New York, United States of America

Research Expertise

Cancer Research

Cell Biology

Developmental Biology

Molecular Biology

Hematology

Immunology

Biochemistry

Genetics

Oncology

About

I am experienced molecular and cell biologist with deep genetics background who worked many years in USA and Russia on the bench and as teacher. Both types of work had demanded extremely broad knowledge and understanding of developments in the fields. Participation in grant writing, editorial/reviewer work for scientific journals and consulting colleagues on these subjects added a lot to my broad experience as the scientist.

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Publications

The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells

Cells

2022

Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells

Oncotarget

2016

Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer

Oncotarget

2016

Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

Molecular Cancer Therapeutics

2015

Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer

Oncotarget

2015

Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors

Developmental Biology

2011

Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells

Proceedings of the National Academy of Sciences

2010

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

Blood

2008

Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster

Cold Spring Harbor Symposia on Quantitative Biology

2004

Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery

Science

2004

GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter

Molecular and Cellular Biology

2002

A heat-shock-activated cDNA encoding GAGA factor rescues some lethal mutations in the Drosophila melanogaster Trithorax-like gene

Genetical Research

2001

Chromatin organization and transcriptional control of gene expression in Drosophila

Gene

2000

Chromatin: Ga-ga over GAGA factor

Current Biology

1995

Mutations That Affect Ion Channels Change the Sensitivity ofDrosophila Melanogasterto Volatile Anesthetics

Journal of Neurogenetics

1995

Telomeres and P-element of Drosophila melanogaster contain sequences that replicate autonomously in Saccharomyces cerevisiae

Molecular and General Genetics MGG

1984

Increase in the number of histone genes in case of their deficiency in Drosophila melanogaster

Molecular and General Genetics MGG

1980

Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the White gene position effect variegation in Drosophila melanogaster

Molecular and General Genetics MGG

1978

Comparison of in vivo and in vitro RNA synthesis on polytene chromosomes of Drosophila

Chromosoma

1976

Synthesis of RNA by Escherichia coli RNA polymerase on the chromosomes of Drosophila melanogaster

Chromosoma

1974

Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

Translational Oncology

2022

Education

Moscow Region State University

PhD, Molecular Biology / April, 1978

Moscow

Moscow Region State University

MS, Genetics / July, 1972

Moscow

Moscow Region State University

BS, Genetics / April, 1971

Moscow

Experience

NYU Langone Medical Center

Associate Research Scientist / June, 2021 — September, 2022

Wet lab research and teaching Molecular and Cell Biology in MD program

Icahn School of Medicine at Mount Sinai

Assistant Professor / July, 2004 — June, 2021

Wet lab research and teaching Molecular and Cell Biology in MD program

Washington University in St. Louis

Post-doctoral Research Associate / June, 1994 — June, 2004

Wet lab research and teaching Molecular and Cell Biology in MS program

National Institutes of Health

Visiting Associate / April, 1992 — June, 1994

Wet lab research in Neurophysiology

University of Connecticut

Visiting Professor / January, 1992 — April, 1992

Wet lab research and teaching Molecular and Cell Biology in PhD program

Links & Social Media

ORCID

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