Boris Leibovitch
Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia
Research Expertise
About
Publications
The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells
Cells / Mar 31, 2022
Dahiya, N. R., Leibovitch, B. A., Kadamb, R., Bansal, N., & Waxman, S. (2022). The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells. Cells, 11(7), 1179. https://doi.org/10.3390/cells11071179
Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells
Oncotarget / Aug 19, 2016
Kwon, Y.-J., Leibovitch, B. A., Bansal, N., Pereira, L., Chung, C.-Y., Ariztia, E. V., Zelent, A., Farias, E. F., & Waxman, S. (2016). Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells. Oncotarget, 8(51), 88421–88436. https://doi.org/10.18632/oncotarget.11381
Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer
Oncotarget / Jun 07, 2016
Bansal, N., Bosch, A., Leibovitch, B., Pereira, L., Cubedo, E., Yu, J., Pierzchalski, K., Jones, J. W., Fishel, M., Kane, M., Zelent, A., Waxman, S., & Farias, E. (2016). Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer. Oncotarget, 7(28), 43689–43702. https://doi.org/10.18632/oncotarget.9905
Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Molecular Cancer Therapeutics / Aug 01, 2015
Kwon, Y.-J., Petrie, K., Leibovitch, B. A., Zeng, L., Mezei, M., Howell, L., Gil, V., Christova, R., Bansal, N., Yang, S., Sharma, R., Ariztia, E. V., Frankum, J., Brough, R., Sbirkov, Y., Ashworth, A., Lord, C. J., Zelent, A., Farias, E., … Waxman, S. (2015). Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics, 14(8), 1824–1836. https://doi.org/10.1158/1535-7163.mct-14-0980-t
Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer
Oncotarget / Oct 09, 2015
Bansal, N., Petrie, K., Christova, R., Chung, C.-Y., Leibovitch, B. A., Howell, L., Gil, V., Sbirkov, Y., Lee, E., Wexler, J., Ariztia, E. V., Sharma, R., Zhu, J., Bernstein, E., Zhou, M.-M., Zelent, A., Farias, E., & Waxman, S. (2015). Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer. Oncotarget, 6(33), 34087–34105. https://doi.org/10.18632/oncotarget.6048
Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors
Developmental Biology / Jan 01, 2011
Marzan, C. V., Kupumbati, T. S., Bertran, S. P., Samuels, T., Leibovitch, B., Mira-y-Lopez, R., Ossowski, L., & Farias, E. F. (2011). Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors. Developmental Biology, 349(2), 125–136. https://doi.org/10.1016/j.ydbio.2010.10.018
Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells
Proceedings of the National Academy of Sciences / Jun 14, 2010
Farias, E. F., Petrie, K., Leibovitch, B., Murtagh, J., Chornet, M. B., Schenk, T., Zelent, A., & Waxman, S. (2010). Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells. Proceedings of the National Academy of Sciences, 107(26), 11811–11816. https://doi.org/10.1073/pnas.1006737107
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor
Blood / Mar 15, 2008
Marango, J., Shimoyama, M., Nishio, H., Meyer, J. A., Min, D.-J., Sirulnik, A., Martinez-Martinez, Y., Chesi, M., Bergsagel, P. L., Zhou, M.-M., Waxman, S., Leibovitch, B. A., Walsh, M. J., & Licht, J. D. (2008). The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood, 111(6), 3145–3154. https://doi.org/10.1182/blood-2007-06-092122
Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster
Cold Spring Harbor Symposia on Quantitative Biology / Jan 01, 2004
HAYNES, K. A., LEIBOVITCH, B. A., RANGWALA, S. H., CRAIG, C., & ELGIN, S. C. R. (2004). Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster. Cold Spring Harbor Symposia on Quantitative Biology, 69(0), 267–272. https://doi.org/10.1101/sqb.2004.69.267
Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery
Science / Jan 30, 2004
Pal-Bhadra, M., Leibovitch, B. A., Gandhi, S. G., Rao, M., Bhadra, U., Birchler, J. A., & Elgin, S. C. R. (2004). Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery. Science, 303(5658), 669–672. https://doi.org/10.1126/science.1092653
GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter
Molecular and Cellular Biology / Sep 01, 2002
Leibovitch, B. A., Lu, Q., Benjamin, L. R., Liu, Y., Gilmour, D. S., & Elgin, S. C. R. (2002). GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter. Molecular and Cellular Biology, 22(17), 6148–6157. https://doi.org/10.1128/mcb.22.17.6148-6157.2002
A heat-shock-activated cDNA encoding GAGA factor rescues some lethal mutations in the Drosophila melanogaster Trithorax-like gene
Genetical Research / Aug 01, 2001
GRANOK, H., LEIBOVITCH, B. A., & ELGIN, S. C. R. (2001). A heat-shock-activated cDNA encoding GAGA factor rescues some lethal mutations in the Drosophila melanogaster Trithorax-like gene. Genetical Research, 78(1), 13–21. https://doi.org/10.1017/s0016672301005122
Chromatin organization and transcriptional control of gene expression in Drosophila
Gene / Aug 01, 2000
Farkas, G., Leibovitch, B. A., & Elgin, S. C. R. (2000). Chromatin organization and transcriptional control of gene expression in Drosophila. Gene, 253(2), 117–136. https://doi.org/10.1016/s0378-1119(00)00240-7
Chromatin: Ga-ga over GAGA factor
Current Biology / Mar 01, 1995
Granok, H., Leibovitch, B. A., Shaffer, C. D., & Elgin, S. C. R. (1995). Chromatin: Ga-ga over GAGA factor. Current Biology, 5(3), 238–241. https://doi.org/10.1016/s0960-9822(95)00048-0
Mutations That Affect Ion Channels Change the Sensitivity ofDrosophila Melanogasterto Volatile Anesthetics
Journal of Neurogenetics / Jan 01, 1995
Leibovitch, B. A., Campbell, D. B., Krishnan, K. S., & Nash, H. A. (1995). Mutations That Affect Ion Channels Change the Sensitivity ofDrosophila Melanogasterto Volatile Anesthetics. Journal of Neurogenetics, 10(1), 1–13. https://doi.org/10.3109/01677069509083455
Telomeres and P-element of Drosophila melanogaster contain sequences that replicate autonomously in Saccharomyces cerevisiae
Molecular and General Genetics MGG / Nov 01, 1984
Danilevskaya, O. N., Kurenova, E. V., Leibovitch, B. A., Shevelev, A. Ya., Bass, I. A., & Khesin, R. B. (1984). Telomeres and P-element of Drosophila melanogaster contain sequences that replicate autonomously in Saccharomyces cerevisiae. Molecular and General Genetics MGG, 197(2), 342–344. https://doi.org/10.1007/bf00330983
Increase in the number of histone genes in case of their deficiency in Drosophila melanogaster
Molecular and General Genetics MGG / Jul 01, 1980
Chernyshev, A. I., Bashkirov, V. N., Leibovitch, B. A., & Khesin, R. B. (1980). Increase in the number of histone genes in case of their deficiency in Drosophila melanogaster. Molecular and General Genetics MGG, 178(3), 663–668. https://doi.org/10.1007/bf00337876
Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the White gene position effect variegation in Drosophila melanogaster
Molecular and General Genetics MGG / Jan 01, 1978
Khesin, R. B., & Leibovitch, B. A. (1978). Influence of deficiency of the histone gene-containing 38B-40 region on X-chromosome template activity and the White gene position effect variegation in Drosophila melanogaster. Molecular and General Genetics MGG, 162(3), 323–328. https://doi.org/10.1007/bf00268858
Comparison of in vivo and in vitro RNA synthesis on polytene chromosomes of Drosophila
Chromosoma / Jan 01, 1976
Leibovitch, B. A., Belyaeva, E. S., Zhimulev, I. F., & Khesin, R. B. (1976). Comparison of in vivo and in vitro RNA synthesis on polytene chromosomes of Drosophila. Chromosoma, 54(4), 349–362. https://doi.org/10.1007/bf00292815
Synthesis of RNA by Escherichia coli RNA polymerase on the chromosomes of Drosophila melanogaster
Chromosoma / Jan 01, 1974
Khesin, R. B., & Leibovitch, B. A. (1974). Synthesis of RNA by Escherichia coli RNA polymerase on the chromosomes of Drosophila melanogaster. Chromosoma, 46(2), 161–172. https://doi.org/10.1007/bf00332514
Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1
Translational Oncology / Feb 01, 2022
Kadamb, R., Leibovitch, B. A., Farias, E. F., Dahiya, N., Suryawanshi, H., Bansal, N., & Waxman, S. (2022). Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1. Translational Oncology, 16, 101320. https://doi.org/10.1016/j.tranon.2021.101320
Education
Moscow Region State University
PhD, Molecular Biology / April, 1978
Moscow Region State University
MS, Genetics / July, 1972
Moscow Region State University
BS, Genetics / April, 1971
Experience
NYU Langone Medical Center
Associate Research Scientist / June, 2021 — September, 2022
Wet lab research and teaching Molecular and Cell Biology in MD program
Icahn School of Medicine at Mount Sinai
Assistant Professor / July, 2004 — June, 2021
Wet lab research and teaching Molecular and Cell Biology in MD program
Washington University in St. Louis
Post-doctoral Research Associate / June, 1994 — June, 2004
Wet lab research and teaching Molecular and Cell Biology in MS program
National Institutes of Health
Visiting Associate / April, 1992 — June, 1994
Wet lab research in Neurophysiology
University of Connecticut
Visiting Professor / January, 1992 — April, 1992
Wet lab research and teaching Molecular and Cell Biology in PhD program
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