Daniel Milej, Ph.D.

Ph.D. in biomedical engineering

London, Ontario, Canada

Research Expertise

Biomedical Optics
NIRS
fNIRS
Diffuse Correlation Spectroscopy
CBF
Biotechnology
Biomedical Engineering
Atomic and Molecular Physics, and Optics
Biomaterials
Electronic, Optical and Magnetic Materials
Cardiology and Cardiovascular Medicine
Neurology (clinical)
Neurology
Radiology, Nuclear Medicine and imaging
Radiological and Ultrasound Technology
Critical Care and Intensive Care Medicine
Cognitive Neuroscience
Electrical and Electronic Engineering
Radiation
Anesthesiology and Pain Medicine
Pediatrics, Perinatology and Child Health
Behavioral Neuroscience
Biological Psychiatry
Psychiatry and Mental health
Neuropsychology and Physiological Psychology
Molecular Biology
Biochemistry
Endocrinology, Diabetes and Metabolism
Genetics
Health Informatics
Computer Science Applications
Software

About

Dr. Daniel Milej is a multidisciplinary researcher with experience in medical biophysics, electronics, biocybernetics, biomedical optics and engineering. He is highly knowledgeable and experienced in a range of research techniques. He is a Scientist at the Lawson Research Institute, leading the transition of multimodal optical imaging systems from a research setting to clinical use in an ICU and OR environment, working closely with teams of nurses, surgeons, doctors and respiratory therapists. Previously, he was a Postdoctoral Fellow and Research Associate working on developing noninvasive modalities for brain activity monitoring in the Department of Medical Biophysics at Western University. Before that, Dr. Milej worked as a Researcher at the Nalecz Institute of Biocybernetics and Biomedical Engineering. He obtained his Ph.D. in 2014 from the Polish Academy of Science, specializing in Biocybernetics and Biomedical Engineering. He received his MSc in Electronics/Optoelectronics from the Military University of Technology, Warsaw, Poland, in 2008.

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Publications

Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink
Biomedical Optics Express
2014
Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol
Journal of Biomedical Optics
2014
Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol
Journal of Biomedical Optics
2014
Application of optical methods in the monitoring of traumatic brain injury: A review
Journal of Cerebral Blood Flow & Metabolism
2016
Wavelength-resolved measurements of fluorescence lifetime of indocyanine green
Journal of Biomedical Optics
2011
Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults
Neurophotonics
2018
In-vivo multilaboratory investigation of the optical properties of the human head
Biomedical Optics Express
2015
Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation
Journal of Biomedical Optics
2011
Single-session communication with a locked-in patient by functional near-infrared spectroscopy
Neurophotonics
2017
Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism
Neurophotonics
2020
Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: Validation against MRI
Journal of Cerebral Blood Flow & Metabolism
2019
Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigs
Biomedical Optics Express
2013
Characterizing dynamic cerebral vascular reactivity using a hybrid system combining time-resolved near-infrared and diffuse correlation spectroscopy
Biomedical Optics Express
2020
Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes
Biomedical Optics Express
2018
Optimization of the method for assessment of brain perfusion in humans using contrast-enhanced reflectometry: multidistance time-resolved measurements
Journal of Biomedical Optics
2015
Multiwavelength time-resolved detection of fluorescence during the inflow of indocyanine green into the adult’s brain
Journal of Biomedical Optics
2012
Optical monitoring of cerebral perfusion and metabolism in adults during cardiac surgery with cardiopulmonary bypass
Biomedical Optics Express
2020
Evaluation of hyperspectral NIRS for quantitative measurements of tissue oxygen saturation by comparison to time-resolved NIRS
Biomedical Optics Express
2019
Development of a stand-alone DCS system for monitoring absolute cerebral blood flow
Biomedical Optics Express
2019
Introduction to Multi-dimensional TCSPC
Springer Series in Chemical Physics
2015
Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study
Biomedical Optics Express
2014
Fluorescence-based method for assessment of blood-brain barrier disruption
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
2013
Incorporating early and late-arriving photons to improve the reconstruction of cerebral hemodynamic responses acquired by time-resolved near-infrared spectroscopy
Journal of Biomedical Optics
2021
Frequency analysis of oscillations in cerebral hemodynamics measured by time domain near infrared spectroscopy
Biomedical Optics Express
2019
Quantification of Cerebral Blood Flow in Adults by Dynamic Contrast-Enhanced NIRS: Validation against MRI
Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)
2018
Compressed sensing time-resolved spectrometer for quantification of light absorbers in turbid media
Biomedical Optics Express
2021
Shining Light on the Human Brain: An Optical BCI for Communicating with Patients with Brain Injuries
2020 IEEE International Conference on Systems, Man, and Cybernetics (SMC)
2020
Assessment by Multi‐Distance Hyperspectral NIRS of Changes in the Oxidation State of Cytochrome C Oxidase (oxCCO) to Carotid Artery Compressions
The FASEB Journal
2022
Self-Calibrated DCS for Monitoring Absolute Cerebral Blood Flow
Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)
2018
Validation of a Hyperspectral NIRS Method for Measuring Oxygen Saturation by Comparison to Time-Resolved NIRS
Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)
2018
Noninvasive Continuous Optical Monitoring of Absolute Cerebral Blood Flow in Adult Human Subjects
Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)
2018
Analysis of estimation of optical properties of sub superficial structures in multi layered tissue model using distribution function method
Computer Methods and Programs in Biomedicine
2020
An algorithm for assessment of inflow and washout of optical contrast agent to the brain by analysis of time-resolved diffuse reflectance and fluorescence signals
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
2013
Hybrid hsNIRS/DCS system for assessing cerebral blood flow and cytochrome c oxidase stability in preterm infants
Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
2022
NNeMo (Neonatal NeuroMonitor): a non-invasive brain monitor for continuous acquisition of cerebral blood flow and cytochrome c oxidase in the premature brain
Optical Tomography and Spectroscopy of Tissue XIV
2021
Cerebral perfusion and metabolic neuromonitoring during cardiopulmonary bypass
Optical Tomography and Spectroscopy of Tissue XIV
2021
Noninvasive Optical Monitoring of Cerebral Blood Flow, Critical Closing Pressure, and Arteriole Compliance in Adult Human Subjects
Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)
2018
Imaging of optically turbid medium with fluorescence inclusions by multichannel time-resolved measurements
Biomedical Optics
2008
Assessing extracerebral contamination in cerebral blood flow pulsatility measured by diffuse correlation spectroscopy
Optical Tomography and Spectroscopy of Tissue XV
2023
Sensitivity of a full-head coverage high-density time-resolved NIRS device to carotid compressions
Optical Tomography and Spectroscopy of Tissue XV
2023
Effects of blood pressure on brain metabolism during cardiopulmonary bypass
Clinical and Translational Neurophotonics 2023
2023
Assessing the Sensitivity of Multi-Distance Hyperspectral NIRS to Changes in the Oxidation State of Cytochrome C Oxidase in the Brain
Metabolites
2022
Assessing the relationship between the cerebral metabolic rate of oxygen and the oxidation state of cytochrome-c-oxidase
Neurophotonics
2022
Assessing cerebral blood flow, oxygenation and cytochrome c oxidase stability in preterm infants during the first 3 days after birth
Scientific Reports
2022
Assessing the sensitivity of multi-distance hsNIRS for measuring changes in oxCCO in the brain
Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
2022
Assessing the ability to monitor cerebral blood flow and oxygen consumption by combining time-resolved near-infrared and diffuse correlation spectroscopy
Optical Tomography and Spectroscopy of Tissue XIV
2021
Combining time-resolved near-infrared spectroscopy with regression analysis to improve the reconstruction of cerebral hemodynamic responses
Optical Tomography and Spectroscopy of Tissue XIV
2021
The Potential Role of fNIRS in Evaluating Levels of Consciousness
Frontiers in Human Neuroscience
2021
Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation
Brain Sciences
2020
Assessing Time-Resolved fNIRS for Brain-Computer Interface Applications of Mental Communication
Frontiers in Neuroscience
2020
Using fMRI to investigate the potential cause of inverse oxygenation reported in fNIRS studies of motor imagery
Neuroscience Letters
2020
Assessing extracerebral signal contamination in optical measurements of cerebral blood flow and oxygenation
Diffuse Optical Spectroscopy and Imaging VII
2019
Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy
Neurocritical Care
2018
Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility
Scientific Reports
2018
Coupling of Oxy- and Deoxyhemoglobin concentrations with EEG rhythms during motor task
Scientific Reports
2017
Investigating the effects of cerebrospinal fluid removal on cerebral blood flow and oxidative metabolism in infants with post-hemorrhagic ventricular dilatation
Pediatric Research
2017
Quantification of blood-brain barrier permeability by dynamic contrast-enhanced NIRS
Scientific Reports
2017
Can time-resolved NIRS provide the sensitivity to detect brain activity during motor imagery consistently?
Biomedical Optics Express
2017
Human skull translucency: post mortem studies
Biomedical Optics Express
2016
Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS
Biomedical Optics Express
2016
A time-resolved subtraction method for evaluating the optical properties of layered turbid media (Conference Presentation)
Optical Interactions with Tissue and Cells XXVII
2016
Assessing the feasibility of time-resolved fNIRS to detect brain activity during motor imagery
Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
2016
Time-resolved subtraction method for measuring optical properties of turbid media
Applied Optics
2016
Quantification of blood–brain barrier permeability by time-resolved NIRS
Biomedical Optics 2016
2016
Quantification of blood–brain barrier permeability by time-resolved NIRS
Biomedical Optics 2016
2016
Quantification of blood–brain barrier permeability by time-resolved NIRS
Biomedical Optics 2016
2016
Dynamic Mapping of the Human Brain by Time-Resolved NIRS Techniques
Springer Series in Chemical Physics
2015
Estimation of light detection efficiency for different light guides used in time-resolved near-infrared spectroscopy
Biocybernetics and Biomedical Engineering
2015
A Monte Carlo study of fluorescence generation probability in a two-layered tissue model
Physics in Medicine and Biology
2014
Assessment of ICG inflow to the brain by time-resolved measurements of diffuse reflectance at 16 source-detector separations
Biomedical Optics 2014
2014
Assessment of cerebral perfusion in post-traumatic brain injury patients with the use of ICG-bolus tracking method
NeuroImage
2014
Development of a Multidistance Continuous Wave Near-Infrared Spectroscopy Device with Frequency Coding
Biomedical Optics 2014
2014
Evaluation of ICG washout based on time-resolved monitoring of fluorescence in patients with severe cerebral perfusion abnormalities
Biomedical Optics 2014
2014
Multi-center study of the optical properties of the human head
Biomedical Optics 2014
2014
Time-resolved multi-channel optical system for assessment of brain oxygenation and perfusion by monitoring of diffuse reflectance and fluorescence
Opto-Electronics Review
2014
Performance assessment of time-domain optical brain imagers: a multi-laboratory study
SPIE Proceedings
2013
Assessment of brain perfusion disorders by ICG bolus tracking with time-resolved fluorescence monitoring
Biomedical Optics and 3-D Imaging
2012
Inter-Laboratory Comparison of Optical Properties Performed on Intralipid and India Ink
Biomedical Optics and 3-D Imaging
2012
Multi-wavelength time-resolved measurements of diffuse reflectance: phantom study with dynamic inflow of ICG
Biomedical Optics and 3-D Imaging
2012
Performance Assessment of Time-Domain Optical Brain Imagers: The nEUROPt Protocol
Biomedical Optics and 3-D Imaging
2012
Time-resolved detection of fluorescent light during inflow of ICG to the brain—a methodological study
Physics in Medicine and Biology
2012
Time-resolved imaging of fluorescent inclusions in optically turbid medium: a phantom study
Biomedical Optics and 3-D Imaging
2012
Brain Perfusion Assessment by Optical Contrast Tracking Using Time-Resolved Fluorescence Detection
IFMBE Proceedings
2011
Multiwavelength time-resolved measurement of diffuse reflectance for brain oxygenation assessment during hypoxic challenge test
Optics in the Life Sciences
2011
Advantages of fluorescence over diffuse reflectance measurements tested in phantom experiments with dynamic inflow of ICG
Opto-Electronics Review
2010
An Instrument for Monitoring Inflow and Washout of an Optical Contrast Agent into the Brain
Advances in Intelligent and Soft Computing
2010
Monte Carlo simulations of time-resolved fluorescence in two-layered model of human head
Biomedical Optics and 3-D Imaging
2010
Multi-wavelength time-resolved detection of fluorescence of indocyanine green circulating in the human head
Biomedical Optics and 3-D Imaging
2010
Time-resolved imaging of fluorescent inclusions in optically turbid medium — phantom study
Opto-Electronics Review
2010
Towards the Definition of Accurately Calibrated Liquid Phantoms for Photon Migration at NIR Wavelengths: a Multi-Laboratory Study
Biomedical Optics and 3-D Imaging
2010
Transcranial time-resolved measurements of fluorescence of an exogeneous dye circulating in human brain
Biomedical Optics and 3-D Imaging
2010

Education

Western University

Post-doctorate fellowship, Department of Medical Biophysics / June, 2019

London

Polish Academy of Science

PhD, Nalecz Institute of Biocybernetics and Biomedical Engineering / June, 2014

Warsaw

Military Univeristy of Technology

MSc, Department of Electronics / June, 2008

Warsaw

Experience

Lawson Research Institute

Research Associate / July, 2019July, 2025

Scientist / August, 2024Present

Western University

Postdoctoral fellow / September, 2014June, 2019

Assistant Professor / September, 2024Present

Polish Academy of Science

Researcher/PhD Student / June, 2008September, 2014

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