Claudia Litterst

Established PhD research leader with a proven track record of developing innovative assays for the biotech industry

Walnut Creek, California, United States of America

Research Expertise

Cell Biology
Biochemistry
Molecular Biology
Analytical Chemistry
Genetics
Cellular and Molecular Neuroscience
Infectious Diseases
Oncology
Cancer Research
Drug Discovery
Molecular Medicine
Bioengineering

About

An established PhD research leader with 15 years of experience in the life sciences and diagnostics industries. Strong expertise in developing innovative PCR assays for oncology and infectious diseases diagnostics. Possessing post-doctoral training in cell-based assay development and high throughput screening for target identification and drug discovery. Academic background in signaling pathways that involve cancer, neurodegenerative and inflammatory diseases. Effective, productive management style to reach shared business goals and objectives. Well versed in the following areas: -Serving as a member of the extended research and development leadership team to support strategic planning initiatives. -Defining and executing experimental plans and protocols. Assuming responsibility for timely completion of activities. -Conducting in-depth analysis and interpretation of experimental data, generating comprehensive summaries, and supporting technical documents, including detailed protocols and reports and communicating progress to stakeholders. -Promoting innovation while adhering to internal and external guidelines and regulatory measures. -Working in a highly cross-functional, fast-paced environment to closely collaborate with business, scientific and medical affairs, legal, engineering, bioinformatics and other R&D teams. -Working with CROs. -Validation testing for hardware instrumentation, reagents and consumables for PCR and transfection. -Serving as subject matter expert for digital PCR.

Legacy Map

Full View

Publications

Functional Characterization of Multiple Transactivating Elements in β-Catenin, Some of Which Interact with the TATA-binding Proteinin Vitro
Journal of Biological Chemistry
1999
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
The EMBO Journal
2006
Multiplexed Target Detection Using DNA-Binding Dye Chemistry in Droplet Digital PCR
Analytical Chemistry
2013
Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets
Molecular Cell
2013
Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor
Journal of Biological Chemistry
2007
Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution
Nucleic Acids Research
2014
FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Aβ
Journal of Neurochemistry
2006
NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the α-Helical Region of the STAT5 Transactivation Domain
Journal of Biological Chemistry
2003
Structure of the NCoA-1/SRC-1 PAS-B Domain Bound to the LXXLL Motif of the STAT6 Transactivation Domain
Journal of Molecular Biology
2004
Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1
Journal of Biological Chemistry
2001
An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1
Journal of Biological Chemistry
2002
Cadherins Mediate Both the Association between PS1 and β-Catenin and the Effects of PS1 on β-Catenin Stability
Journal of Biological Chemistry
2005
Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors
Journal of Biological Chemistry
2009
Coactivators in Gene Regulation by STAT5
Vitamins & Hormones
2005
MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa
JAIDS Journal of Acquired Immune Deficiency Syndromes
2017
Very Low Abundance Single-Cell Transcript Quantification with 5-Plex ddPCRTM Assays
Methods in Molecular Biology
2018
Interaction of STAT6 with its co-activator SRC-1/NCoA-1 is regulated by dephosphorylation of the latter via PP2A
Nucleic Acids Research
2010
Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
Journal of Visualized Experiments
2010
Abstract 2301: Cross validation of NGS methylated targets using droplet digital PCR (ddPCR)
Cancer Research
2014
Abstract 5156: Multiplexed EGFR mutation detection with C797S and T790M allelic context using six-color digital PCR
Cancer Research
2022
Abstract P6-07-20: Allele-specific PCR assay for estrogen receptor (ESR1) mutation detection
Cancer Research
2017
Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
Journal of Visualized Experiments
2010
O3–03–02: PS1/γ–secretase regulate the EphB–induced Src signaling
Alzheimer's & Dementia
2006
P4-301 Presenilin-1/gamma secretase cleavage of ephrinb ligands and EPHB receptors
Neurobiology of Aging
2004
P3-330 γ-secretase processing of VE-cadherin regulates CBP-mediated transcription
Neurobiology of Aging
2004

Education

Goethe University Frankfurt

Ph.D., Biology / November, 2002

Frankfurt am Main

Albert Ludwig University of Freiburg

Master of Science, Biology / March, 1999

Freiburg

Experience

Roche

Research Leader and Principal Scientist II / June, 2015October, 2023

- Led the development of PCR-based assays for cancer, chronic liver and infectious disease biomarker and diagnostics. - Oversaw the early development of digital PCR reagents. - Led a team of non-PhD and PhD level scientists.

Bio-Rad Laboratories

Staff Scientist and Senior Scientist / 20082015

- Led the validation of new PCR reagents for the QX200 droplet digital PCR system. - Developed new applications for Bio-Rad reagents and instrumentation including mammalian cell transfection and PCR. - Published protocols for new applications in peer reviewed articles, technical reports and successfully filed patent applications.

Links & Social Media

Join Claudia on NotedSource!
Join Now

At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.

For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.

For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.

Expert Institutions
NotedSource has experts from Stanford University
Expert institutions using NotedSource include Oxfort University
Experts from McGill have used NotedSource to share their expertise
University of Chicago experts have used NotedSource
MIT researchers have used NotedSource
Proudly trusted by
Microsoft uses NotedSource for academic partnerships
Johnson & Johnson academic research projects on NotedSource
ProQuest (Clarivate) uses NotedSource as their industry academia platform
Slamom consulting engages academics for research collaboration on NotedSource
Omnicom and OMG find academics on notedsource
Unilever research project have used NotedSource to engage academic experts

Connect with researchers and scientists like Claudia Litterst on NotedSource to help your company with innovation, research, R&D, L&D, and more.