Patricia SV, PhD
PhD Chemist with extensive writing experience and research interests in biology, chemistry, and envrionmental science
Research Expertise
Publications
A new genome-mining tool redefines the lasso peptide biosynthetic landscape
Nature Chemical Biology / Feb 28, 2017
Tietz, J. I., Schwalen, C. J., Patel, P. S., Maxson, T., Blair, P. M., Tai, H.-C., Zakai, U. I., & Mitchell, D. A. (2017). A new genome-mining tool redefines the lasso peptide biosynthetic landscape. Nature Chemical Biology, 13(5), 470–478. https://doi.org/10.1038/nchembio.2319
Structure, Bioactivity, and Resistance Mechanism of Streptomonomicin, an Unusual Lasso Peptide from an Understudied Halophilic Actinomycete
Chemistry & Biology / Feb 01, 2015
Metelev, M., Tietz, J. I., Melby, J. O., Blair, P. M., Zhu, L., Livnat, I., Severinov, K., & Mitchell, D. A. (2015). Structure, Bioactivity, and Resistance Mechanism of Streptomonomicin, an Unusual Lasso Peptide from an Understudied Halophilic Actinomycete. Chemistry & Biology, 22(2), 241–250. https://doi.org/10.1016/j.chembiol.2014.11.017
Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the Bacillus anthracis Membrane
ACS Infectious Diseases / Dec 23, 2015
Molohon, K. J., Saint-Vincent, P. M. B., Park, S., Doroghazi, J. R., Maxson, T., Hershfield, J. R., Flatt, K. M., Schroeder, N. E., Ha, T., & Mitchell, D. A. (2015). Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the Bacillus anthracis Membrane. ACS Infectious Diseases, 2(3), 207–220. https://doi.org/10.1021/acsinfecdis.5b00115
Structural and functional insight into an unexpectedly selective N -methyltransferase involved in plantazolicin biosynthesis
Proceedings of the National Academy of Sciences / Jul 22, 2013
Lee, J., Hao, Y., Blair, P. M., Melby, J. O., Agarwal, V., Burkhart, B. J., Nair, S. K., & Mitchell, D. A. (2013). Structural and functional insight into an unexpectedly selective N -methyltransferase involved in plantazolicin biosynthesis. Proceedings of the National Academy of Sciences, 110(32), 12954–12959. https://doi.org/10.1073/pnas.1306101110
Exploration of the Biosynthetic Potential of the Populus Microbiome
mSystems / Oct 30, 2018
Blair, P. M., Land, M. L., Piatek, M. J., Jacobson, D. A., Lu, T.-Y. S., Doktycz, M. J., & Pelletier, D. A. (2018). Exploration of the Biosynthetic Potential of the Populus Microbiome. MSystems, 3(5). https://doi.org/10.1128/msystems.00045-18
Beyond-the-Meter: Unaccounted Sources of Methane Emissions in the Natural Gas Distribution Sector
Environmental Science & Technology / Dec 06, 2019
Saint-Vincent, P. M. B., & Pekney, N. J. (2019). Beyond-the-Meter: Unaccounted Sources of Methane Emissions in the Natural Gas Distribution Sector. Environmental Science & Technology, 54(1), 39–49. https://doi.org/10.1021/acs.est.9b04657
An Analysis of Abandoned Oil Well Characteristics Affecting Methane Emissions Estimates in the Cherokee Platform in Eastern Oklahoma
Geophysical Research Letters / Nov 26, 2020
Saint‐Vincent, P. M. B., Reeder, M. D., Sams, J. I., & Pekney, N. J. (2020). An Analysis of Abandoned Oil Well Characteristics Affecting Methane Emissions Estimates in the Cherokee Platform in Eastern Oklahoma. Geophysical Research Letters, 47(23). Portico. https://doi.org/10.1029/2020gl089663
Identifying Abandoned Well Sites Using Database Records and Aeromagnetic Surveys
Environmental Science & Technology / May 18, 2020
Saint-Vincent, P. M. B., Sams, J. I., Hammack, R. W., Veloski, G. A., & Pekney, N. J. (2020). Identifying Abandoned Well Sites Using Database Records and Aeromagnetic Surveys. Environmental Science & Technology, 54(13), 8300–8309. https://doi.org/10.1021/acs.est.0c00044
Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases
ACS Chemical Biology / Nov 29, 2020
Harris, L. A., Saint-Vincent, P. M. B., Guo, X., Hudson, G. A., DiCaprio, A. J., Zhu, L., & Mitchell, D. A. (2020). Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases. ACS Chemical Biology, 15(12), 3167–3175. https://doi.org/10.1021/acschembio.0c00685
Synthesis of Plantazolicin Analogues Enables Dissection of Ligand Binding Interactions of a Highly Selective Methyltransferase
Organic Letters / Sep 24, 2013
Sharma, A., Saint-Vincent, P. M. B., & Mitchell, D. A. (2013). Synthesis of Plantazolicin Analogues Enables Dissection of Ligand Binding Interactions of a Highly Selective Methyltransferase. Organic Letters, 15(19), 5076–5079. https://doi.org/10.1021/ol402444a
High-Throughput Characterization and Optimization of Polyamide Hydrolase Activity Using Open Port Sampling Interface Mass Spectrometry
Journal of the American Society for Mass Spectrometry / Jun 01, 2023
Cahill, J. F., Kertesz, V., Saint-Vincent, P., Valentino, H., Drufva, E., Thiele, N., & Michener, J. K. (2023). High-Throughput Characterization and Optimization of Polyamide Hydrolase Activity Using Open Port Sampling Interface Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 34(7), 1383–1391. https://doi.org/10.1021/jasms.3c00097
Validation of a metabolite–GWAS network for Populus trichocarpa family 1 UDP-glycosyltransferases
Frontiers in Plant Science / Jul 21, 2023
Saint-Vincent, P. M. B., Furches, A., Galanie, S., Teixeira Prates, E., Aldridge, J. L., Labbe, A., Zhao, N., Martin, M. Z., Ranjan, P., Jones, P., Kainer, D., Kalluri, U. C., Chen, J.-G., Muchero, W., Jacobson, D. A., & Tschaplinski, T. J. (2023). Validation of a metabolite–GWAS network for Populus trichocarpa family 1 UDP-glycosyltransferases. Frontiers in Plant Science, 14. https://doi.org/10.3389/fpls.2023.1210146
Fugitive Methane Emissions from Abandoned Oil and Gas Wells in Northeastern Oklahoma
Goldschmidt Abstracts / Jan 01, 2020
Reeder, M., Pekney, N., & Saint Vincent, P. (2020). Fugitive Methane Emissions from Abandoned Oil and Gas Wells in Northeastern Oklahoma. Goldschmidt Abstracts. https://doi.org/10.46427/gold2020.2180
A national estimate of U.S. underground natural gas storage incident emissions
Environmental Research Letters / Jul 22, 2022
Li, H. Z., Saint-Vincent, P. M. B., Mundia-Howe, M., & Pekney, N. J. (2022). A national estimate of U.S. underground natural gas storage incident emissions. Environmental Research Letters, 17(8), 084013. https://doi.org/10.1088/1748-9326/ac8069
Historic and modern approaches for discovery of abandoned wells for methane emissions mitigation in Oil Creek State Park, Pennsylvania
Journal of Environmental Management / Feb 01, 2021
Saint-Vincent, P. M. B., Sams, J. I., Reeder, M. D., Mundia-Howe, M., Veloski, G. A., & Pekney, N. J. (2021). Historic and modern approaches for discovery of abandoned wells for methane emissions mitigation in Oil Creek State Park, Pennsylvania. Journal of Environmental Management, 280, 111856. https://doi.org/10.1016/j.jenvman.2020.111856
Isolation, Characterization, and Pathogenicity of Two Pseudomonas syringae Pathovars from Populus trichocarpa Seeds
Microorganisms / Jul 28, 2020
Saint-Vincent, P. M., Ridout, M., Engle, N. L., Lawrence, T. J., Yeary, M. L., Tschaplinski, T. J., Newcombe, G., & Pelletier, D. A. (2020). Isolation, Characterization, and Pathogenicity of Two Pseudomonas syringae Pathovars from Populus trichocarpa Seeds. Microorganisms, 8(8), 1137. https://doi.org/10.3390/microorganisms8081137
Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products
Bioorganic & Medicinal Chemistry / Dec 01, 2016
Molloy, E. M., Tietz, J. I., Blair, P. M., & Mitchell, D. A. (2016). Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorganic & Medicinal Chemistry, 24(24), 6276–6290. https://doi.org/10.1016/j.bmc.2016.05.021
In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products
ACS Chemical Biology / Jun 01, 2016
Deane, C. D., Burkhart, B. J., Saint-Vincent, P. M. B., Tietz, J. I., Lin, A., & Mitchell, D. A. (2016). In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products. ACS Chemical Biology, 11(8), 2232–2243. https://doi.org/10.1021/acschembio.6b00369
Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin
ACS Chemical Biology / Jan 30, 2015
Hao, Y., Saint-Vincent, P. M. B., Sharma, A., Mitchell, D. A., & Nair, S. K. (2015). Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin. ACS Chemical Biology, 10(5), 1209–1216. https://doi.org/10.1021/cb501042a
Education
University of Illinois at Urbana-Champaign
PhD, Chemistry / November, 2016
Wheaton College
BS, Chemistry / May, 2011
Wheaton College
BA, Spanish / May, 2011
Experience
Oak Ridge National Laboratory
Bioanalytical Chemist / January, 2022 — July, 2023
Postdoctoral Scientist / January, 2017 — December, 2018
Science Journal Editors
Editor / November, 2020 — Present
Leidos
Research Scientist / May, 2020 — January, 2022
National Energy Technology Laboratory
ORISE Postdoctoral Fellow / January, 2019 — May, 2020
Links & Social Media
Join Patricia on NotedSource!
Join Now
At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.
For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.
For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.
Expert Institutions
Proudly trusted by
