Dana Walsh, Ph.D.

Senior Microbiome Scientist at CosmosID

Research Expertise

microbiome
microbiology
gut health
infant microbiome
maternal microbiome
Microbiology (medical)
Infectious Diseases
Oncology
Cancer Research
Hepatology
Gastroenterology

About

Dana Walsh is a Senior Microbiome Scientist at CosmosID, a leading company in microbial genomics and bioinformatics. With a PhD in Toxicology and more than five years of experience in microbiome research, she manages the bioinformatics team and assists clients with design, analysis, and interpretation of multiomics data. She has a strong background in both wet bench and computational research, and has applied novel analysis methods to derive meaning from microbial taxonomic, functional, and metabolomic data. In her previous role at Rebiotix, she supported the development of microbiome-based live biotherapeutic drugs for various diseases. She also completed a postdoctoral fellowship at Mayo Clinic, where she investigated the role of the microbiome in cancers of the reproductive tract. She is passionate about exploring the microbiome dynamics and applications in the industrial sector, with a current emphasis on maternal and infant health.

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Publications

Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome)
Scientific Reports
2019
Distinguishing Human Peripheral Blood NK Cells from CD56dimCD16dimCD69+CD103+ Resident Nasal Mucosal Lavage Fluid Cells
Scientific Reports
2018
Alterations in airway microbiota in patients with PaO2/FiO2 ratio ≤ 300 after burn and inhalation injury
PLOS ONE
2017
Bridging preclinical and clinical gut microbiota research using the ex vivo SIFR® technology
Frontiers in Microbiology
2023
Development and Validation of a Novel Microbiome-Based Biomarker of Post-antibiotic Dysbiosis and Subsequent Restoration
Frontiers in Microbiology
2022
Porphyromonas somerae Invasion of Endometrial Cancer Cells
Frontiers in Microbiology
2021
1064. Treatment Success in Reducing Recurrent Clostridioides difficile Infection with Investigational Live Biotherapeutic RBX2660 Is Associated with Microbiota Restoration: Consistent Evidence from a Phase 3 Clinical Trial
Open Forum Infectious Diseases
2021
129. Antimicrobial Resistance Genes Were Reduced Following Administration of Investigational Microbiota-Based Live Biotherapeutic RBX2660 to Individuals with Recurrent Clostridioides difficile Infection
Open Forum Infectious Diseases
2021
Abstract A70: Metformin alters the gut microbiota of ovarian cancer patients treated with carboplatin/paclitaxel chemotherapy and enhances sensitivity in resistant tumors
Clinical Cancer Research
2018
LB5. A Long-Time Coming: Final 2-year Analysis of Efficacy, Durability, and Microbiome Changes in a Controlled Open-Label Trial of Investigational Microbiota-Based Drug RBX2660 for Recurrent Clostridioides difficile Infections
Open Forum Infectious Diseases
2019
30. Antimicrobial Resistance Genes Are Reduced Following Administration of Investigational Microbiota-based Therapeutic RBX7455 to Individuals with Recurrent clostrioides Difficile Infection
Open Forum Infectious Diseases
2020
29. Rapid Restoration of Bile Acid Compositions After Treatment with Investigational Microbiota-based Therapeutic RBX2660 for Recurrent clostrioides Difficile Infection
Open Forum Infectious Diseases
2020
Mo1931 FAILURE IS NOT FINAL: CLINICAL RESPONSE AND MICROBIOME RESTORATION BY INVESTIGATIONAL DRUG RBX2660 ARE NOT COMPROMISED FOLLOWING PREVIOUS NON-RESPONSE FOR PREVENTING CLOSTRIDIOIDES DIFFICILE RECURRENCE
Gastroenterology
2020
Abstract PR09: Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome): Putative role of Porphyromonas somerae in the disease
Cancer Research
2020
3296 Endometrial cancer microbiome biomarker for disease detection and microbial role in the disease
Journal of Clinical and Translational Science
2019
The probiotic Bacillus subtilis BS50 decreases gastrointestinal symptoms in healthy adults: a randomized, double-blind, placebo-controlled trial
Gut Microbes
2022

Education

University of North Carolina at Chapel Hill

Ph.D., Toxicology / May, 2016

Chapel Hill, North Carolina, United States of America

Concordia College - Minnesota

B.A., Biology / December, 2009

Moorhead, Minnesota, United States of America

Experience

CosmosID

Senior Microbiome Scientist / June, 2023Present

• Consult with clients to advise the best approach for their microbiome and metabolomics study design, sample collection and storage, sequencing and metabolomics methods, and bioinformatics and statistical analysis • Create custom analyses and reports helping clients understand their data • Manage and review scientific newsletters and blogs • Develop and test new methods for innovative data analysis • Promoted to senior microbiome scientist to lead custom project analysis and integration of new analysis methods and pipelines • Managed the bioinformatics team in sequencing production and project delivery

Microbiome Scientist / August, 2021June, 2023

• Identified the impact of microbiome-based therapeutics on subjects with Clostridioides difficile infection through analysis of micrbial community, functional, and metabolomics data • Established new methodologies for integration of complex microbial compositional, functional, and metabolomics data in the programming language R • Managed and developed relationships with microbiome analysis collaborators to drive high-quality and novel analysis methods and product development • Presented at least one oral talk per year at a national conference on the impact of biotherapeutics on the microbiome

NirvanaBiome

Microbiome Consultant / January, 2023Present

• Meet with customers (individuals and clinicians) to explain their gut microbiome test results • Provide a basic understanding of the gut microbiome and its importance in health along with individualized interpretation of results and recommendations of over-the-counter interventions that may help (such as the use of specific pre- and probiotics or dietary recommendations)

Rebiotix

Microbiome Analysis Scientist / June, 2019August, 2021

• Identified the impact of microbiome-based therapeutics on subjects with Clostridioides difficile infection through analysis of micrbial community, functional, and metabolomics data • Established new methodologies for integration of complex microbial compositional, functional, and metabolomics data in the programming language R • Managed and developed relationships with microbiome analysis collaborators to drive high-quality and novel analysis methods and product development • Presented at least one oral talk per year at a national conference on the impact of biotherapeutics on the microbiome

Mayo Clinic

Postdoctoral Research Fellow / October, 2016June, 2019

• Investigated the role of the vaginal and uterine microbiota in development and treatment of ovarian and endometrial cancer using human, mouse, and cell models • Determined the role of metformin in altering the gut microbiota during chemotherapy treatment for ovarian cancer in a patient-derived xenograft mouse model • Analyzed reproductive tract microbiota from patients with endometrial cancer to identify early vaginal biomarkers of disease using R • Developed an invasion assay to determine pathogenicity of specific members of the microbiota in endometrial and ovarian cancer. • Carried out complementary in vitro tissue culture work to determine the role of specific microbial products (bile acids and short-chain fatty acids) in killing of tumor cells.

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