Xinyuan Lei
Ph.D. level scientist with hands-on experience in immunology-oncology
Research Expertise
About
Publications
Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription
Cancer Research / Mar 15, 2019
Fan, S., Tian, T., Chen, W., Lv, X., Lei, X., Zhang, H., Sun, S., Cai, L., Pan, G., He, L., Ou, Z., Lin, X., Wang, X., Perez, M. F., Tu, Z., Ferrone, S., Tannous, B. A., & Li, J. (2019). Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription. Cancer Research, 79(6), 1069–1084. https://doi.org/10.1158/0008-5472.can-18-2505
Long Noncoding RNA MPRL Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via Disruption of Pre-miRNA Processing
Clinical Cancer Research / Jun 14, 2019
Tian, T., Lv, X., Pan, G., Lu, Y., Chen, W., He, W., Lei, X., Zhang, H., Liu, M., Sun, S., Ou, Z., Lin, X., Cai, L., He, L., Tu, Z., Wang, X., Tannous, B. A., Ferrone, S., Li, J., & Fan, S. (2019). Long Noncoding RNA MPRL Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via Disruption of Pre-miRNA Processing. Clinical Cancer Research, 25(12), 3673–3688. https://doi.org/10.1158/1078-0432.ccr-18-2739
Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation
Theranostics / Jan 01, 2019
Chen, W., Wang, P., Lu, Y., Jin, T., Lei, X., Liu, M., Zhuang, P., Liao, J., Lin, Z., Li, B., Peng, Y., Pan, G., Lv, X., Zhang, H., Ou, Z., Xie, S., Lin, X., Sun, S., Ferrone, S., … Fan, S. (2019). Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation. Theranostics, 9(20), 5739–5754. https://doi.org/10.7150/thno.37556
Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma
Biomedicine & Pharmacotherapy / Apr 01, 2019
Lu, Y., Li, Y., Wang, Z., Xie, S., Wang, Q., Lei, X., Ruan, Y., & Li, J. (2019). Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma. Biomedicine & Pharmacotherapy, 112, 108608. https://doi.org/10.1016/j.biopha.2019.108608
A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3–Specific CAR T Cells in Solid Tumors
Clinical Cancer Research / Apr 02, 2021
Lei, X., Ou, Z., Yang, Z., Zhong, J., Zhu, Y., Tian, J., Wu, J., Deng, H., Lin, X., Peng, Y., Li, B., He, L., Tu, Z., Chen, W., Li, Q., Liu, N., Zhang, H., Wang, Z., Fang, Z., … Fan, S. (2021). A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3–Specific CAR T Cells in Solid Tumors. Clinical Cancer Research, 27(13), 3757–3771. https://doi.org/10.1158/1078-0432.ccr-20-2487
LncRNA LTSCCAT promotes tongue squamous cell carcinoma metastasis via targeting the miR-103a-2-5p/SMYD3/TWIST1 axis
Cell Death & Disease / Feb 01, 2021
Liu, M., Liu, Q., Fan, S., Su, F., Jiang, C., Cai, G., Wang, Y., Liao, G., Lei, X., Chen, W., Bi, J., Cheng, W., Zhao, L., Ruan, Y., & Li, J. (2021). LncRNA LTSCCAT promotes tongue squamous cell carcinoma metastasis via targeting the miR-103a-2-5p/SMYD3/TWIST1 axis. Cell Death & Disease, 12(2). https://doi.org/10.1038/s41419-021-03415-2
Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation
Journal of Experimental Medicine / Feb 21, 2023
Qiu, Z., Khairallah, C., Chu, T. H., Imperato, J. N., Lei, X., Romanov, G., Atakilit, A., Puddington, L., & Sheridan, B. S. (2023). Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation. Journal of Experimental Medicine, 220(5). https://doi.org/10.1084/jem.20210923
Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression
Nature Communications / Jul 06, 2022
Lei, X., Lin, H., Wang, J., Ou, Z., Ruan, Y., Sadagopan, A., Chen, W., Xie, S., Chen, B., Li, Q., Wang, J., Lin, H., Zhu, X., Yuan, X., Tian, T., Lv, X., Fu, S., Zhu, X., Zhou, J., … Li, J. (2022). Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-31417-x
Identification of novel drug candidates for treating tongue squamous cell carcinoma using computational approaches
Feb 02, 2021
Li, Y., Chen, Z., Chen, L., & Li, W. (2021). Identification of novel drug candidates for treating tongue squamous cell carcinoma using computational approaches. https://doi.org/10.21203/rs.3.rs-177053/v1
1428-A Oral immunization withListeria-based cancer vaccines elicits protective gastrointestinal focused immunity in an orthotopic transplantation model of colorectal cancer
Regular Abstracts – Part 2 / Nov 01, 2023
Lei, X., Zhang, Y., Chuang, C., Chu, T., Garipcan, A., Qiu, Z., Li, X., Beyaz, S., & Sheridan, B. (2023). 1428-A Oral immunization withListeria-based cancer vaccines elicits protective gastrointestinal focused immunity in an orthotopic transplantation model of colorectal cancer. Regular Abstracts – Part 2, A1853–A1853. https://doi.org/10.1136/jitc-2023-sitc2023.1428-a
lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter
iScience / Feb 01, 2020
Fan, S., Tian, T., Lv, X., Lei, X., Yang, Z., Liu, M., Liang, F., Li, S., Lin, X., Lin, Z., Xie, S., Li, B., Chen, W., Pan, G., Lin, X., Ou, Z., Zhang, Y., Peng, Y., Xiao, L., … Li, J. (2020). lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter. IScience, 23(2), 100835. https://doi.org/10.1016/j.isci.2020.100835
Education
Stony Brook University
Ph.D. candidate, Microbiology and Immunology
Sun Yat-sen Memorial Hospital
Master of Medicine, Oral and Maxillofacial Surgery / June, 2019
Sun Yat-sen University
Bachelor of Medicine, Stomatology / June, 2016
Experience
Stony Brook University
Research Assistant/Teaching Assistant / August, 2019 — Present
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