Tiffany Halvorsen
SynBio | Microbiology | Microbial Genomics
Research Expertise
About
Publications
Comparison of Kill Switch Toxins in Plant-Beneficial Pseudomonas fluorescens Reveals Drivers of Lethality, Stability, and Escape
ACS Synthetic Biology / Nov 08, 2022
Halvorsen, T. M., Ricci, D. P., Park, D. M., Jiao, Y., & Yung, M. C. (2022). Comparison of Kill Switch Toxins in Plant-Beneficial Pseudomonas fluorescens Reveals Drivers of Lethality, Stability, and Escape. ACS Synthetic Biology, 11(11), 3785–3796. https://doi.org/10.1021/acssynbio.2c00386
Escherichia coli EC93 deploys two plasmid-encoded class I contact-dependent growth inhibition systems for antagonistic bacterial interactions
Microbial Genomics / Mar 01, 2021
Wäneskog, M., Halvorsen, T., Filek, K., Xu, F., Hammarlöf, D. L., Hayes, C. S., Braaten, B. A., Low, D. A., Poole, S. J., & Koskiniemi, S. (2021). Escherichia coli EC93 deploys two plasmid-encoded class I contact-dependent growth inhibition systems for antagonistic bacterial interactions. Microbial Genomics, 7(3). https://doi.org/10.1099/mgen.0.000534
Leveraging microfluidic dielectrophoresis to distinguish compositional variations of lipopolysaccharide in E. coli
Frontiers in Bioengineering and Biotechnology / Feb 16, 2023
Wang, Q., Kim, H., Halvorsen, T. M., Chen, S., Hayes, C. S., & Buie, C. R. (2023). Leveraging microfluidic dielectrophoresis to distinguish compositional variations of lipopolysaccharide in E. coli. Frontiers in Bioengineering and Biotechnology, 11. https://doi.org/10.3389/fbioe.2023.991784
Electrogenetic signaling and information propagation for controlling microbial consortia via programmed lysis
Biotechnology and Bioengineering / Feb 09, 2023
VanArsdale, E., Navid, A., Chu, M. J., Halvorsen, T. M., Payne, G. F., Jiao, Y., Bentley, W. E., & Yung, M. C. (2023). Electrogenetic signaling and information propagation for controlling microbial consortia via programmed lysis. Biotechnology and Bioengineering, 120(5), 1366–1381. Portico. https://doi.org/10.1002/bit.28337
Lipidation of Class IV CdiA Effector Proteins Promotes Target Cell Recognition during Contact-Dependent Growth Inhibition
mBio / Oct 26, 2021
Halvorsen, T. M., Garza-Sánchez, F., Ruhe, Z. C., Bartelli, N. L., Chan, N. A., Nguyen, J. Y., Low, D. A., & Hayes, C. S. (2021). Lipidation of Class IV CdiA Effector Proteins Promotes Target Cell Recognition during Contact-Dependent Growth Inhibition. MBio, 12(5). https://doi.org/10.1128/mbio.02530-21
Education
Northern Arizona University
B.S., Biology / May, 2014
University of California, Santa Barbara
Ph.D., Molecular Biology & Biochemistry / December, 2020
Experience
Lawrence Livermore National Laboratory
Synthetic Biology Postdoctoral Researcher / February, 2021 — February, 2024
I designed and tested the stability of an array of kill switches for biocontainment of agricultural bacteria. My findings contributed to the rational design of stable yet effective containment systems in soil bacteria.
Lawrence Livermore National Laboratory
Staff Research Scientist — Synthetic Biology / February, 2024 — Present
I wrote a successful proposal to design a synthetic extremophile for bio manufacturing of sustainable plastics without the need for sterilization at any stage of the production process.
University of California, Santa Barbara
Graduate Student Researcher, Biomolecular Science & Engineering / September, 2014 — December, 2020
I studied the mechanism of (1) cell binding/adhesion by contact-dependent growth inhibition (CdiA) proteins and (2) how the ionophore toxins that they deliver into neighboring bacteria exploit native membrane proteins to enter the bilayer.
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