Moshe Baruch, Ph.D
Biotech Scientist with Over a Decade of Experience in Synthetic Biology and Microbiology Projects
Research Expertise
About
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Education
Hebrew University of Jerusalem
Doctorate Degree (Ph.D.)
Hebrew University of Jerusalem
Master of Science (MSc)
Hebrew University of Jerusalem
bachelor's degree (B.A.Sc.)
Experience
Pana Bio inc
Senior Scientist / October, 2021 — November, 2023
• Led the growth of a biotech startup from conception to a $3 million entity. • Built and managed a team comprising 11 employees and consultants. • Directed comprehensive pre-clinical studies to demonstrate feasibility and efficacy, aligning with expectations for pre-IND FDA meetings. • Led the application of Biochemistry and high-throughput molecular biology techniques to engineer probiotic bacterial strains that secrete anti-inflammatory human cytokines in a controlled manner, advancing therapeutic solutions. • Designed an NGS-based biomarker assay to improve the selection process for clinical trial participants, anticipating FDA requirements for the IND meeting. • Built and managed a diverse R&D team of scientists, a biomedical engineer, associate researchers, and a lab manager, fostering a culture of innovation and inclusivity.
Baylor College of Medicine
Scientist / September, 2020 — October, 2021
• Engineered optogenetic tools and developed Genetically Encoded Voltage Indicators (GEVIs) for neuron behavior modulation and in-vivo monitoring, using an integrated approach spanning synthetic biology to neuroscience. • Expertly managed cell cultures, specializing in human and rodent cell lines, ensuring optimal conditions and results for experimental setups. • Utilized Adeno-Associated Virus (AAV) methods for targeted neuronal manipulation. • Managed and updated SOPs and protocols, ensuring research quality and compliance. • Mastered advanced microscopy systems, such as automated confocal and Two-photon excitation, including proficiency with the NIS-Elements software (Nikon). • Mentored and trained team members, promoting professional growth and consistency in lab practices.
Rice University
Post-doc / July, 2018 — September, 2020
• Developed biocomputational circuits and bacterial sensors with synthetic biology, Biochemistry, and molecular biology techniques for biomarker detection in environmental samples. • Collaborated with multidisciplinary teams and played a pivotal role in multi-million-dollar projects, funded by the Office of Naval Research (ONR) and Defense Advanced Research Projects Agency (DARPA). • Developed and optimized a mini-bioreactor system capable of running 200 bioreactors for high-throughput screening of genetically engineered probiotic strains and their media, targeting desired attributes. • Spearheaded the optimization of state-of-the-art multiplex microfluidic systems. • Mastered analytical tools and methods, including Flow Cytometry, GC-MS, Microfluidics, and Python-based data analysis.
Lawrence Berkeley National Laboratory
Post-doc / August, 2014 — July, 2018
• Designed bacterial strains using synthetic biology, microbiology, and protein engineering to interface with electronic circuits, produce signals for biosensors, or convert substrates into biofuels. • Collaborated with material scientists and electronic engineers and biochemists to pioneer devices designed to interface engineered bacteria with electronic circuits, targeting biofuel generation and IoT biosensor advancements. • Optimized conditions for effective biofuel production in Automated Environmental Bioreactors for Controlled Cultivation, ranging in size from 5 mL to 10,000 mL. • Acquired a diverse skill set encompassing clean room operations, bioreactor usage, metabolic simulations, analytical techniques, such as HPLC/FPLC, protein engineering, and 3D printing for device development.
University of California, Berkeley
Post-Doc / 2015 — 2016
• Collaborated with electronic engineers on the innovative design of an autonomous bioelectronic sensing system aimed at advancing environmental biosensing for the Office of Naval Research (ONR). • Played a pivotal role in a multi-disciplinary, multi-million-dollar project funded by the ONR, ensuring timely milestone achievements and streamlined progress. • Led a dedicated team comprising two graduate students specializing in electronic engineering and synthetic biology.
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