Moshe Baruch, Ph.D

Biotech Scientist with Over a Decade of Experience in Synthetic Biology and Microbiology Projects

Research Expertise

Microbiology
Molecular Biology
Biomedical Engineering
Immunology
Virology
Parasitology
Genetics
Microbiology (medical)
Infectious Diseases
Biomaterials
Mechanics of Materials
Bioengineering
Ceramics and Composites
Biophysics

About

**MOSHE PROFESSIONAL SUMMARY:** * **Expertise in Molecular and Biochemistry:** Seasoned Scientist with strong biotech industry experience, specializing in fermentation, strain development, protein engineering, and synthesis. Proficient in cell culture management, Next Generation Sequencing (NGS), CRISPR gene editing, quantitative PCR (qPCR), and advanced analytical techniques including HPLC and flow cytometry. * **Biotech Industry and Leadership:** Demonstrated leadership in guiding cross-functional R&D and pre-clinical teams towards achieving project milestones. Experienced in innovation, project management, assay development, compiling Standard Operating Procedures (SOPs), ensuring compliance with Good Laboratory Practices (GLP), and familiarity with cGMP quality systems. * **Analytical and Programming Skills:** Strong analytical skills with a proven track record of using Python and MATLAB for data analysis, supported by a solid foundation in Linux and SQL. Competent in Microsoft Office Suite. * **Communication and Soft Skills:** Excellent time management, attention to detail, critical thinking, and strong communication skills, coupled with emotional intelligence, enhancing team collaboration and project success. * **Research Excellence:** Secured a non-diluted NIH SBIR grant and an EMBO fellowship. Published 11 articles in prestigious journals, including Cell and ACS Synthetic Biology. Contributed to 2 patents, showcasing a significant contribution to scientific knowledge and innovation.

Legacy Map

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Publications

An Extracellular Bacterial Pathogen Modulates Host Metabolism to Regulate Its Own Sensing and Proliferation
Cell
2014
PEDOT:PSS-based Multilayer Bacterial-Composite Films for Bioelectronics
Scientific Reports
2018
An elusive electron shuttle from a facultative anaerobe
eLife
2019
Transcriptional regulation of the sil locus by the SilCR signalling peptide and its implications on group A streptococcus virulence
Molecular Microbiology
2007
Modifying Cytochrome c Maturation Can Increase the Bioelectronic Performance of Engineered Escherichia coli
ACS Synthetic Biology
2019
Functional Analysis of the Quorum-Sensing Streptococcal Invasion Locus (sil)
PLoS Pathogens
2009
Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus
Frontiers in Cellular and Infection Microbiology
2014
A portable bioelectronic sensing system (BESSY) for environmental deployment incorporating differential microbial sensing in miniaturized reactors
PLOS ONE
2017
Electronic control of redox reactions inside Escherichia coli using a genetic module
PLOS ONE
2021
Precise electronic control of redox reactions inside Escherichia coli using a genetic module
Unknown Venue
2020
Host–Pathogen Relationship in Skin and Soft Tissue Infections Caused by Group AstreptococcusandStaphylococcus aureus
Bacterial Virulence
2010
Hydrogel-encapsulation to enhance bacterial diagnosis of colon inflammation
Biomaterials
2023
Group A streptococcus and host metabolism: virulence influences and potential treatments
Future Microbiology
2014
Author response: An elusive electron shuttle from a facultative anaerobe
Unknown Venue
2019
(Invited) Customizing Proteins and Microbes for Biological Fuel Cells
ECS Meeting Abstracts
2016

Education

Hebrew University of Jerusalem

Doctorate Degree (Ph.D.)

Jerusalem

Hebrew University of Jerusalem

Master of Science (MSc)

Jerusalem

Hebrew University of Jerusalem

bachelor's degree (B.A.Sc.)

Jerusalem

Experience

Pana Bio inc

Senior Scientist / October, 2021November, 2023

• Led the growth of a biotech startup from conception to a $3 million entity. • Built and managed a team comprising 11 employees and consultants. • Directed comprehensive pre-clinical studies to demonstrate feasibility and efficacy, aligning with expectations for pre-IND FDA meetings. • Led the application of Biochemistry and high-throughput molecular biology techniques to engineer probiotic bacterial strains that secrete anti-inflammatory human cytokines in a controlled manner, advancing therapeutic solutions. • Designed an NGS-based biomarker assay to improve the selection process for clinical trial participants, anticipating FDA requirements for the IND meeting. • Built and managed a diverse R&D team of scientists, a biomedical engineer, associate researchers, and a lab manager, fostering a culture of innovation and inclusivity.

Baylor College of Medicine

Scientist / September, 2020October, 2021

• Engineered optogenetic tools and developed Genetically Encoded Voltage Indicators (GEVIs) for neuron behavior modulation and in-vivo monitoring, using an integrated approach spanning synthetic biology to neuroscience. • Expertly managed cell cultures, specializing in human and rodent cell lines, ensuring optimal conditions and results for experimental setups. • Utilized Adeno-Associated Virus (AAV) methods for targeted neuronal manipulation. • Managed and updated SOPs and protocols, ensuring research quality and compliance. • Mastered advanced microscopy systems, such as automated confocal and Two-photon excitation, including proficiency with the NIS-Elements software (Nikon). • Mentored and trained team members, promoting professional growth and consistency in lab practices.

Rice University

Post-doc / July, 2018September, 2020

• Developed biocomputational circuits and bacterial sensors with synthetic biology, Biochemistry, and molecular biology techniques for biomarker detection in environmental samples. • Collaborated with multidisciplinary teams and played a pivotal role in multi-million-dollar projects, funded by the Office of Naval Research (ONR) and Defense Advanced Research Projects Agency (DARPA). • Developed and optimized a mini-bioreactor system capable of running 200 bioreactors for high-throughput screening of genetically engineered probiotic strains and their media, targeting desired attributes. • Spearheaded the optimization of state-of-the-art multiplex microfluidic systems. • Mastered analytical tools and methods, including Flow Cytometry, GC-MS, Microfluidics, and Python-based data analysis.

Lawrence Berkeley National Laboratory

Post-doc / August, 2014July, 2018

• Designed bacterial strains using synthetic biology, microbiology, and protein engineering to interface with electronic circuits, produce signals for biosensors, or convert substrates into biofuels. • Collaborated with material scientists and electronic engineers and biochemists to pioneer devices designed to interface engineered bacteria with electronic circuits, targeting biofuel generation and IoT biosensor advancements. • Optimized conditions for effective biofuel production in Automated Environmental Bioreactors for Controlled Cultivation, ranging in size from 5 mL to 10,000 mL. • Acquired a diverse skill set encompassing clean room operations, bioreactor usage, metabolic simulations, analytical techniques, such as HPLC/FPLC, protein engineering, and 3D printing for device development.

University of California, Berkeley

Post-Doc / 20152016

• Collaborated with electronic engineers on the innovative design of an autonomous bioelectronic sensing system aimed at advancing environmental biosensing for the Office of Naval Research (ONR). • Played a pivotal role in a multi-disciplinary, multi-million-dollar project funded by the ONR, ensuring timely milestone achievements and streamlined progress. • Led a dedicated team comprising two graduate students specializing in electronic engineering and synthetic biology.

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