Jayasinghe started his academic career at Brunel University in the Department of Mechanical Engineering. At Brunel he obtained his B.Eng(Hon) and M.Eng degrees and subsequently joined the Department of Materials Sciences at Queen Mary, University of London, where he earned his PhD. In the duration of his PhD, his research findings were awarded two top medals (the De Montfort and the Leonardo Da Vinci) presented to him at the House of Parliament in March and December respectively. Following his PhD he completed a post-doc and was later awarded a five year Robert's Fellowship funded by RCUK. In the first year of his fellowship, Jayasinghe pioneered the ability to electrospray and electrospin living cells and whole organisms. These finding have received wide press coverage through learned society periodical, popular scientific press and television interviews. In 2006 Jayasinghe joined the Department of Mechanical Engineering at UCL. In 2009 he was awarded highest honour bestowed to a younger aerosol scientist (SMOLUCHOWSKI Award) by the Gesellschaft für Aerosolforschung (GAeF). In 2010 The Institute of Materials, Mining and Minerals awarded him with the prestigious Sir George Beilby FRS memorial medal and prize for his seminal contributions to healthcare materials. Jayasinghe has published over 170 scientific papers and is at present fine tuning the discovered platform technologies for their wider utility in basic biology laboratories to their evaluation in the clinic.