Work with Leo R Fitzpatrick PhD | NotedSource
Please see my CV for details. I have 37 years of GI and
IBD Research experience. This includes both industry and
academic experience.
https://cv.notedsource.io/me/6VJE8NQR
Leo R Fitzpatrick PhD
GI Pharmacology and IBD Research Consultant
Greenwood , South Carolina, United States
of America
Research Expertise
Inflammatory Bowel Disease
Colitis
Arthritis
Surgery
Immunology
Immunology and Allergy
Gastroenterology
Physiology
Hepatology
Pharmacology
Pharmacology (medical)
Physiology (medical)
Biochemistry
Toxicology
Nutrition and Dietetics
Pediatrics, Perinatology and Child Health
Parasitology
Microbiology
Infectious Diseases
Virology
Molecular Medicine
Drug Discovery
Cellular and Molecular Neuroscience
Endocrinology
Endocrinology, Diabetes and Metabolism
Education
Dermatology
Molecular Biology
Cell Biology
Nephrology
Radiology, Nuclear Medicine and imaging
Biotechnology
Genetics
About
Please see my CV for details. I have 37 years
of GI and IBD Research experience. This
includes both industry and academic
experience.
Legacy Map
Full ViewPublications
Loss of the Tight Junction Protein ZO-1 in
Dextran Sulfate Sodium Induced Colitis
Journal of Surgical Research
2007
Deubiquitinating enzyme CYLD negatively
regulates the ubiquitin-dependent kinase
Tak1 and prevents abnormal T cell
responses
The Journal of Experimental
Medicine
2007
Suppression of Ulcerative Colitis in Mice
by Orally Available Inhibitors of
Sphingosine Kinase
Digestive Diseases and Sciences
2007
Therapeutic potential of flavonoids in
inflammatory bowel disease: A
comprehensive review
World Journal of Gastroenterology
2017
CAPE, an inhibitor of nuclear factor-kappa
B (NF-κB), attenuates bacterial
peptidoglycan polysaccharide (PG-PS)
induced colitis in rats
Gastroenterology
2001
CAPE, an inhibitor of nuclear factor-kappa
B (NF-κB), attenuates bacterial
peptidoglycan polysaccharide (PG-PS)
induced colitis in rats
Gastroenterology
2001
Efficacy of a novel sphingosine kinase
inhibitor in experimental Crohn’s disease
Inflammopharmacology
2010
MEP1A allele for meprin A metalloprotease
is a susceptibility gene for inflammatory
bowel disease
Mucosal Immunology
2009
OPC-compounds prevent oxidant-induced
carbonylation and depolymerization of the
F-actin cytoskeleton and intestinal
barrier hyperpermeability
Free Radical Biology and Medicine
2001
4SC-101, a novel immunosuppressive drug,
inhibits IL-17 and attenuates colitis in
two murine models of inflammatory bowel
disease†
Inflammatory Bowel Diseases
2010
Antiinflammatory effects of various drugs
on acetic acid induced colitis in the rat
Agents and Actions
1990
In vitro and in vivo effects of the
probiotic Escherichia coli strain M-17:
immunomodulation and attenuation of murine
colitis
British Journal of Nutrition
2008
Probiotics for the treatment ofClostridium difficileassociated disease
World Journal of Gastrointestinal
Pathophysiology
2013
Novel Pharmacological Approaches for
Inflammatory Bowel Disease: Targeting Key
Intracellular Pathways and the IL-23/IL-17
Axis
International Journal of
Inflammation
2012
Attenuation of arthritis in rodents by a
novel orally-available inhibitor of
sphingosine kinase
Inflammopharmacology
2010
NF-κB1 p105 Regulates T Cell Homeostasis
and Prevents Chronic Inflammation
The Journal of Immunology
2009
Effects of the Probiotic Formulation VSL#3
on Colitis in Weanling Rats
Journal of Pediatric Gastroenterology
and Nutrition
2007
Inhibition of IL-17 as a Pharmacological
Approach for IBD
International Reviews of
Immunology
2013
Dextran Sulfate Sodium-Induced Colitis Is
Associated with Enhanced Low Molecular
Mass Polypeptide 2 (LMP2) Expression and
Is Attenuated in LMP2 Knockout Mice
Digestive Diseases and Sciences
2006
Highly potent and selective gastrin
receptor antagonists based on CCK-4
Peptides 1992
1993
Effect of epidermal growth factor on
polyamine-synthesizing enzymes in rat
enterocytes
American Journal of
Physiology-Gastrointestinal and Liver
Physiology
1987
Bacillus Coagulans GBI-30 (BC30) improves
indices of Clostridium difficile-Induced
colitis in mice
Gut Pathogens
2011
A new potent and selective non-peptide
gastrin antagonist and brain
cholecystokinin receptor (CCK-B) ligand:
L-365,260
European Journal of Pharmacology
1989
Bacillus coagulans GBI-30, 6086 limits the
recurrence of Clostridium
difficile-Induced colitis following
vancomycin withdrawal in mice
Gut Pathogens
2012
IBD and Bile Acid Absorption: Focus on
Pre-clinical and Clinical Observations
Frontiers in Physiology
2020
Enhanced Intestinal Expression of the
Proteasome Subunit Low Molecular Mass
Polypeptide 2 in Patients with
Inflammatory Bowel Disease
Diseases of the Colon &
Rectum
2007
Effect of refeeding on polyamine
biosynthesis in isolated enterocytes
American Journal of
Physiology-Gastrointestinal and Liver
Physiology
1986
Experimental Osteoarthritis in Rats Is
Attenuated by ABC294640, a Selective
Inhibitor of Sphingosine Kinase-2
Pharmacology
2011
The Opioid Antagonist Naltrexone Improves
Murine Inflammatory Bowel Disease
Journal of Immunotoxicology
2008
Vidofludimus Inhibits Colonic
Interleukin-17 and Improves Hapten-Induced
Colitis in Rats by a Unique Dual Mode of
Action
Journal of Pharmacology and
Experimental Therapeutics
2012
A New Model of Chronic Hapten-induced
Colitis in Young Rats
Journal of Pediatric Gastroenterology
& Nutrition
2010
Relationship between ornithine
decarboxylase activity and gastric damage
American Journal of
Physiology-Gastrointestinal and Liver
Physiology
1987
The synthetic triterpenoid (CDDO-Im)
inhibits STAT3, as well as IL-17, and
improves DSS-induced colitis in mice
Inflammopharmacology
2014
Gliotoxin, an Inhibitor of Nuclear
Factor-Kappa B, Attenuates
Peptidoglycan-Polysaccharide-Induced
Colitis in Rats
Inflammatory Bowel Diseases
2002
Acidic Fibroblast Growth Factor
Accelerates the Healing of
Acetic-Acid-lnduced Gastric Ulcers in Rats
Digestion
1992
Development of high-affinity 5-HT3
receptor antagonists. 1. Initial
structure-activity relationship of novel
benzamides
Journal of Medicinal Chemistry
1992
Small-Molecule Drugs for the Treatment of
Inflammatory Bowel Disease
Comprehensive Medicinal Chemistry
III
2017
T2035 The Novel Probiotic Escherichia coli
Strain M-17 Uniquely Inhibits
Pro-Inflammatory Cytokine Secretion in
Macrophage and Colonic Epithelial Cell
Lines
Gastroenterology
2010
Potent 5‐hydroxytryptamine3
receptor antagonist activity of RG 12915
Drug Development Research
1993
The Effect of Fiber in the Postweaning
Diet on Nutritional and Intestinal
Morphological Indices in the Rat
Dietary Fiber
1986
Inflammation-induced functional
connectivity of melanin-concentrating
hormone and IL-10
Peptides
2014
Amiloride inhibits rat mucosal ornithine
decarboxylase activity and DNA synthesis
American Journal of
Physiology-Gastrointestinal and Liver
Physiology
1988
VPR-254: an inhibitor of ROR-gamma T with
potential utility for the treatment of
inflammatory bowel disease
Inflammopharmacology
2019
A Novel Mathematical Model for Determining
Faculty Workload
American Journal of Pharmaceutical
Education
2016
Skeletal muscle catabolism in
trinitrobenzene sulfonic acid–induced
murine colitis
Metabolism
2010
Indomethacin‐induced gastric antral damage
in hamsters: are neutrophils involved?
Alimentary Pharmacology &
Therapeutics
1999
Gastroprotective and ulcer healing profile
of the mast cell stabilizer quazolast in
rats
Agents and Actions
1991
Ror-gamma T inhibition as a
Pharmacological Approach for Inflammatory
Bowel Disease
Medical Research Archives
2015
Prostaglandin-Mediated Trophic Effects on
the Rat Duodenum: The Role of Polyamines
Experimental Biology and Medicine
1988
1232 Distinct cAMP signaling microdomains
differentially impact melanoma
Journal of Investigative
Dermatology
2018
Inhibition of IL-17 Release by the Novel
Anti-Inflammatory Drug Vidofludimus
Involves Attenuation of STAT3 and NF-kappa
B Signaling Pathways in Murine Splenocytes
and Hapten-Induced Colitis
Gastroenterology
2011
Peptic ulcers
Nursing Standard
1989
Effect of naproxen on the hamster gastric
antrum: ulceration, adaptation and
efficacy of anti‐ulcer drugs
Alimentary Pharmacology &
Therapeutics
1999
M1658 A Novel Immunosuppressive Drug
(4SC-101) Improves TNBS-Induced Colitis in
Mice
Gastroenterology
2009
The modulatory effects of plasma and
colonic milieu of patients with ulcerative
colitis on OPC antioxidant
The American Journal of
Gastroenterology
2001
Fos expression in the colonic myenteric
plexus induced by water avoidance stress
in different rat strains
Gastroenterology
2001
Protection by Acidified Maalox against
Indomethacin-Induced Gastric Antral
Ulceration in Hamsters
Digestion
1991
Tu1744 - Ex Vivo Effects of Ror-Gamma T
Inhibitors on Proinflammatory Cytokine
Secretion from Colonic Strips of Mice with
DSS-Induced Colitis
Gastroenterology
2018
A Novel ROR-Gamma T Inhibitor (VPR-254)
Attenuates Key Parameters of Innate Immune
Colitis in Mice
Gastroenterology
2017
Sa1834 Effects of Silymarin Fractions on
Pro-Inflammatory Cytokine Secretion from
Macrophage and Colonic Epithelial Cell
Lines
Gastroenterology
2016
90 Efficacy of a Novel Small Molecule
RORgt Inverse Agonist in Mouse DSS and
TNBS Models of Inflammatory Bowel Disease
Gastroenterology
2015
Sa2053 Bacillus Coagulans Bc30 Limits the
Recurrence of Clostridium diJicile-Induced
Colitis Following Vancomycin Withdrawal in
Mice
Gastroenterology
2012
Probiotic Treatment of Colitis in Animal
Models and People
Bioactive Foods in Promoting
Health
2010
M1651 Melanin-Concentrating Hormone
Receptor 1 Antagonists Attenuate
TNBS-Induced Colitis in Mice
Gastroenterology
2009
A comparison of sucralfate and bismuth
subsalicylate formulations in rabbit
esophageal models
Gastroenterology
1995
The Sphingosine Kinase 2 Inhibitor
Opaganib Protects Against Acute Kidney
Injury in Mice
International Journal of Nephrology and
Renovascular Disease
2022
Role of the δ-Opioid Receptor in 2 Murine
Models of Colitis
Comparative Medicine
2020
Evidence that the Ubiquitin Proteasome
System Plays a Prominent Role in
Inflammatory Bowel Disease: Possible
Pharmacological Approaches
Pharmacy & Pharmacology
International Journal
2016
Tu1617 The Synthetic Triterpenoid
(CDDO-IM) Inhibits STAT3, As Well As
IL-17, and Improves DSS-Induced Colitis in
Mice
Gastroenterology
2013
Bacillus Coagulans (Bc 30 ) Improves Some
Indices of Clostridium difficile -Induced
Colitis in Mice
Gastroenterology
2011
Characterization of the reactivation phase
of dextran sodium sulfate (DSS)-induced
colitis in rats
Gastroenterology
1998
Novel characterization and quantification
of bismuth binding to gastric mucosa
Gastroenterology
1995
Dietary Fiber, Bile Acids, and Intestinal
Morphology
Dietary Fiber in Health and
Disease
1982
Regulation of intestinal ornithine
decarboxylase (ODC) expression during
postnatal development by ODC antizyme in
rats
Gastroenterology
2000
RELT is overexpressed in human
inflammatory bowel disease and breast
cancer.
The Journal of Immunology
2023
Drug Discovery Approaches for Inflammatory
Bowel Disease
Biologics and Biosimilars
2022
In Vitro and Ex Vivo Effects of Silymarin
Derivatives on Proinflammatory Cytokine
Secretion Using a Murine Colonic Strip
Model
Planta Medica International Open
2018
Ex Vivo Effects of Silymarin Fractions on
Pro-Inflammatory Cytokine Secretion from
Colonic Strips of Mice with Dssinduced
Colitis
Gastroenterology
2017
P012 Vidofludimus inhibits IL-17 and
improves hapten-induced colitis in young
rats by a unique dual mode of action
Journal of Crohn's and Colitis
2012
Colitis Development in IL-10 Deficient
Mice Reveals a Direct Role of MCH in
Regulating IL-10 Expression by Monocytes
Gastroenterology
2011
Alterations in amino acid uptake and
transport in TNBS-induced colitis
Inflammatory Bowel Diseases
2008
Alterations in the IGF-I axis and
ubiquitin E3 ligases (atrogin-1, MuRF1) in
TNBS-induced colitis: A mechanism for loss
of muscle mass in IBD
Inflammatory Bowel Diseases
2008
S1743 Efficacy of a Sphingosine Kinase
Inhibitor in the Treatment of
2,4,6-Trinitrobenezenesulfonic Acid
(TNBS)-Induced Colitis in Rats
Gastroenterology
2008
The Devil Is in the Details: The
Pharmaceutical Industry’s Use of Gifts to
Physicians as Marketing Strategy
Journal of Surgical Research
2007
Efficacy of a Sphingosine Kinase Inhibitor
in the Treatment of
2,4,6-Trinitrobenezenesulfonic Acid
(TNBS)-Induced Colitis in Mice
Gastrointestinal Endoscopy
2007
A Role For Meprin‐ α In A Model Of
Inflammatory Bowel Disease
The FASEB Journal
2007
Education
PhD, Physiology
Post Doctoral Fellowship, GI Physiology
Experience
California NorthState University
Penn State College of Medicine
Otsuka Pharmaceutical
Procter and Gamble
Rhone Poulenc Rorer
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