Leo R Fitzpatrick PhD

GI Pharmacology and IBD Research Consultant

Greenwood , South Carolina, United States of America

Research Expertise

Inflammatory Bowel Disease
Colitis
Arthritis
Surgery
Immunology
Immunology and Allergy
Gastroenterology
Physiology
Hepatology
Pharmacology
Pharmacology (medical)
Physiology (medical)
Biochemistry
Toxicology
Nutrition and Dietetics
Pediatrics, Perinatology and Child Health
Parasitology
Microbiology
Infectious Diseases
Virology
Molecular Medicine
Drug Discovery
Cellular and Molecular Neuroscience
Endocrinology
Endocrinology, Diabetes and Metabolism
Education
Dermatology
Molecular Biology
Cell Biology
Nephrology
Radiology, Nuclear Medicine and imaging
Biotechnology
Genetics

About

Please see my CV for details. I have 37 years of GI and IBD Research experience. This includes both industry and academic experience.

Publications

Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis

Journal of Surgical Research / Jun 01, 2007

Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L., Ruggiero, F., & Koltun, W. A. (2007). Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis. Journal of Surgical Research, 140(1), 12–19. https://doi.org/10.1016/j.jss.2006.07.050

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

The Journal of Experimental Medicine / Jun 04, 2007

Reiley, W. W., Jin, W., Lee, A. J., Wright, A., Wu, X., Tewalt, E. F., Leonard, T. O., Norbury, C. C., Fitzpatrick, L., Zhang, M., & Sun, S.-C. (2007). Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. The Journal of Experimental Medicine, 204(6), 1475–1485. https://doi.org/10.1084/jem.20062694

Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase

Digestive Diseases and Sciences / Dec 04, 2007

Maines, L. W., Fitzpatrick, L. R., French, K. J., Zhuang, Y., Xia, Z., Keller, S. N., Upson, J. J., & Smith, C. D. (2007). Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase. Digestive Diseases and Sciences, 53(4), 997–1012. https://doi.org/10.1007/s10620-007-0133-6

Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

World Journal of Gastroenterology / Jan 01, 2017

Salaritabar, A., Darvishi, B., Hadjiakhoondi, F., Manayi, A., Sureda, A., Nabavi, S. F., Fitzpatrick, L. R., Nabavi, S. M., & Bishayee, A. (2017). Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review. World Journal of Gastroenterology, 23(28), 5097. https://doi.org/10.3748/wjg.v23.i28.5097

CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats

Gastroenterology / Apr 01, 2001

FITZPATRICK, L., WANG, J., & LE, T. (2001). CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats. Gastroenterology, 120(5), A685–A685. https://doi.org/10.1016/s0016-5085(01)83409-0

CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats

Gastroenterology / Apr 01, 2001

Fitzpatrick, L. R., Wang, J., & Le, T. (2001). CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats. Gastroenterology, 120(5), A685. https://doi.org/10.1016/s0016-5085(08)83409-9

Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease

Inflammopharmacology / Feb 12, 2010

Maines, L. W., Fitzpatrick, L. R., Green, C. L., Zhuang, Y., & Smith, C. D. (2010). Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease. Inflammopharmacology, 18(2), 73–85. https://doi.org/10.1007/s10787-010-0032-x

MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease

Mucosal Immunology / May 01, 2009

Banerjee, S., Oneda, B., Yap, L. M., Jewell, D. P., Matters, G. L., Fitzpatrick, L. R., Seibold, F., Sterchi, E. E., Ahmad, T., Lottaz, D., & Bond, J. S. (2009). MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunology, 2(3), 220–231. https://doi.org/10.1038/mi.2009.3

OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability

Free Radical Biology and Medicine / Feb 01, 2001

Banan, A., Fitzpatrick, L., Zhang, Y., & Keshavarzian, A. (2001). OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability. Free Radical Biology and Medicine, 30(3), 287–298. https://doi.org/10.1016/s0891-5849(00)00471-8

4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease†

Inflammatory Bowel Diseases / Oct 01, 2010

Fitzpatrick, L. R., Deml, L., Hofmann, C., Small, J. S., Groeppel, M., Hamm, S., Lemstra, S., Leban, J., & Ammendola, A. (2010). 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease†. Inflammatory Bowel Diseases, 16(10), 1763–1777. https://doi.org/10.1002/ibd.21264

Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat

Agents and Actions / Jun 01, 1990

Fitzpatrick, L. R., Bostwick, J. S., Renzetti, M., Pendleton, R. G., & Decktor, D. L. (1990). Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. Agents and Actions, 30(3–4), 393–402. https://doi.org/10.1007/bf01966304

In vitro and in vivo effects of the probiotic Escherichia coli strain M-17: immunomodulation and attenuation of murine colitis

British Journal of Nutrition / Feb 18, 2008

Fitzpatrick, L. R., Small, J., Hoerr, R. A., Bostwick, E. F., Maines, L., & Koltun, W. A. (2008). In vitro and in vivo effects of the probiotic Escherichia coli strain M-17: immunomodulation and attenuation of murine colitis. British Journal of Nutrition, 100(03), 530–541. https://doi.org/10.1017/s0007114508930373

Probiotics for the treatment ofClostridium difficileassociated disease

World Journal of Gastrointestinal Pathophysiology / Jan 01, 2013

Fitzpatrick, L. R. (2013). Probiotics for the treatment ofClostridium difficileassociated disease. World Journal of Gastrointestinal Pathophysiology, 4(3), 47. https://doi.org/10.4291/wjgp.v4.i3.47

Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 Axis

International Journal of Inflammation / Jan 01, 2012

Fitzpatrick, L. R. (2012). Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 Axis. International Journal of Inflammation, 2012, 1–8. https://doi.org/10.1155/2012/389404

Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase

Inflammopharmacology / Oct 11, 2010

Fitzpatrick, L. R., Green, C., Frauenhoffer, E. E., French, K. J., Zhuang, Y., Maines, L. W., Upson, J. J., Paul, E., Donahue, H., Mosher, T. J., & Smith, C. D. (2010). Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology, 19(2), 75–87. https://doi.org/10.1007/s10787-010-0060-6

NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic Inflammation

The Journal of Immunology / Mar 01, 2009

Chang, M., Lee, A. J., Fitzpatrick, L., Zhang, M., & Sun, S.-C. (2009). NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic Inflammation. The Journal of Immunology, 182(5), 3131–3138. https://doi.org/10.4049/jimmunol.0803637

Effects of the Probiotic Formulation VSL#3 on Colitis in Weanling Rats

Journal of Pediatric Gastroenterology and Nutrition / May 01, 2007

Fitzpatrick, L. R., Hertzog, K. L., Quatse, A. L., Koltun, W. A., Small, J. S., & Vrana, K. (2007). Effects of the Probiotic Formulation VSL#3 on Colitis in Weanling Rats. Journal of Pediatric Gastroenterology and Nutrition, 44(5), 561–570. Portico. https://doi.org/10.1097/mpg.0b013e31803bda51

Inhibition of IL-17 as a Pharmacological Approach for IBD

International Reviews of Immunology / Jul 25, 2013

Fitzpatrick, L. R. (2013). Inhibition of IL-17 as a Pharmacological Approach for IBD. International Reviews of Immunology, 32(5–6), 544–555. https://doi.org/10.3109/08830185.2013.821118

Dextran Sulfate Sodium-Induced Colitis Is Associated with Enhanced Low Molecular Mass Polypeptide 2 (LMP2) Expression and Is Attenuated in LMP2 Knockout Mice

Digestive Diseases and Sciences / Jul 01, 2006

Fitzpatrick, L. R., Khare, V., Small, J. S., & Koltun, W. A. (2006). Dextran Sulfate Sodium-Induced Colitis Is Associated with Enhanced Low Molecular Mass Polypeptide 2 (LMP2) Expression and Is Attenuated in LMP2 Knockout Mice. Digestive Diseases and Sciences, 51(7), 1269–1276. https://doi.org/10.1007/s10620-006-8047-2

Highly potent and selective gastrin receptor antagonists based on CCK-4

Peptides 1992 / Jan 01, 1993

Ewing, W. R., Molino, B. F., Bolton, S. A., Manetta, V., Pendley, C., & Capilino, A. (1993). Highly potent and selective gastrin receptor antagonists based on CCK-4. In Peptides 1992 (pp. 619–620). Springer Netherlands. https://doi.org/10.1007/978-94-011-1470-7_280

Effect of epidermal growth factor on polyamine-synthesizing enzymes in rat enterocytes

American Journal of Physiology-Gastrointestinal and Liver Physiology / Feb 01, 1987

Fitzpatrick, L. R., Wang, P., & Johnson, L. R. (1987). Effect of epidermal growth factor on polyamine-synthesizing enzymes in rat enterocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 252(2), G209–G214. https://doi.org/10.1152/ajpgi.1987.252.2.g209

Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice

Gut Pathogens / Jan 01, 2011

Fitzpatrick, L. R., Small, J. S., Greene, W. H., Karpa, K. D., & Keller, D. (2011). Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice. Gut Pathogens, 3(1), 16. https://doi.org/10.1186/1757-4749-3-16

A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260

European Journal of Pharmacology / Mar 01, 1989

Lotti, V. J., & Chang, R. S. L. (1989). A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. European Journal of Pharmacology, 162(2), 273–280. https://doi.org/10.1016/0014-2999(89)90290-2

Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice

Gut Pathogens / Oct 01, 2012

Fitzpatrick, L. R., Small, J. S., Greene, W. H., Karpa, K. D., Farmer, S., & Keller, D. (2012). Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice. Gut Pathogens, 4(1). https://doi.org/10.1186/1757-4749-4-13

IBD and Bile Acid Absorption: Focus on Pre-clinical and Clinical Observations

Frontiers in Physiology / Jun 12, 2020

Fitzpatrick, L. R., & Jenabzadeh, P. (2020). IBD and Bile Acid Absorption: Focus on Pre-clinical and Clinical Observations. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.00564

Enhanced Intestinal Expression of the Proteasome Subunit Low Molecular Mass Polypeptide 2 in Patients with Inflammatory Bowel Disease

Diseases of the Colon & Rectum / Mar 01, 2007

Fitzpatrick, L. R., Small, J. S., Poritz, L. S., McKenna, K. J., & Koltun, W. A. (2007). Enhanced Intestinal Expression of the Proteasome Subunit Low Molecular Mass Polypeptide 2 in Patients with Inflammatory Bowel Disease. Diseases of the Colon & Rectum, 50(3), 337–350. https://doi.org/10.1007/s10350-006-0796-7

Effect of refeeding on polyamine biosynthesis in isolated enterocytes

American Journal of Physiology-Gastrointestinal and Liver Physiology / May 01, 1986

Fitzpatrick, L. R., Wang, P., Eikenburg, B. E., Haddox, M. K., & Johnson, L. R. (1986). Effect of refeeding on polyamine biosynthesis in isolated enterocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 250(5), G709–G713. https://doi.org/10.1152/ajpgi.1986.250.5.g709

Experimental Osteoarthritis in Rats Is Attenuated by ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

Pharmacology / Jan 01, 2011

Fitzpatrick, L. R., Green, C., Maines, L. W., & Smith, C. D. (2011). Experimental Osteoarthritis in Rats Is Attenuated by ABC294640, a Selective Inhibitor of Sphingosine Kinase-2. Pharmacology, 87(3–4), 135–143. Portico. https://doi.org/10.1159/000323911

The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease

Journal of Immunotoxicology / Jan 01, 2008

Matters, G. L., Harms, J. F., McGovern, C., Fitzpatrick, L., Parikh, A., Nilo, N., & Smith, J. P. (2008). The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease. Journal of Immunotoxicology, 5(2), 179–187. https://doi.org/10.1080/15476910802131469

Vidofludimus Inhibits Colonic Interleukin-17 and Improves Hapten-Induced Colitis in Rats by a Unique Dual Mode of Action

Journal of Pharmacology and Experimental Therapeutics / Jun 12, 2012

Fitzpatrick, L. R., Small, J. S., Doblhofer, R., & Ammendola, A. (2012). Vidofludimus Inhibits Colonic Interleukin-17 and Improves Hapten-Induced Colitis in Rats by a Unique Dual Mode of Action. Journal of Pharmacology and Experimental Therapeutics, 342(3), 850–860. https://doi.org/10.1124/jpet.112.192203

A New Model of Chronic Hapten-induced Colitis in Young Rats

Journal of Pediatric Gastroenterology & Nutrition / Mar 01, 2010

Fitzpatrick, L. R., Meirelles, K., Small, J. S., Puleo, F. J., Koltun, W. A., & Cooney, R. N. (2010). A New Model of Chronic Hapten-induced Colitis in Young Rats. Journal of Pediatric Gastroenterology & Nutrition, 50(3), 240–250. https://doi.org/10.1097/mpg.0b013e3181cb8f4a

Relationship between ornithine decarboxylase activity and gastric damage

American Journal of Physiology-Gastrointestinal and Liver Physiology / Dec 01, 1987

Thirumalai, C. H., Tseng, C. C., Tabata, K., Fitzpatrick, L. R., & Johnson, L. R. (1987). Relationship between ornithine decarboxylase activity and gastric damage. American Journal of Physiology-Gastrointestinal and Liver Physiology, 253(1), G1–G6. https://doi.org/10.1152/ajpgi.1987.253.1.g1

The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice

Inflammopharmacology / Apr 09, 2014

Fitzpatrick, L. R., Stonesifer, E., Small, J. S., & Liby, K. T. (2014). The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice. Inflammopharmacology, 22(6), 341–349. https://doi.org/10.1007/s10787-014-0203-2

Gliotoxin, an Inhibitor of Nuclear Factor-Kappa B, Attenuates Peptidoglycan-Polysaccharide-Induced Colitis in Rats

Inflammatory Bowel Diseases / May 01, 2002

Fitzpatrick, L. R., Wang, J., & Le, T. (2002). Gliotoxin, an Inhibitor of Nuclear Factor-Kappa B, Attenuates Peptidoglycan-Polysaccharide-Induced Colitis in Rats. Inflammatory Bowel Diseases, 8(3), 159–167. https://doi.org/10.1097/00054725-200205000-00001

Acidic Fibroblast Growth Factor Accelerates the Healing of Acetic-Acid-lnduced Gastric Ulcers in Rats

Digestion / Jan 01, 1992

Fitzpatrick, L. R., Jakubowska, A., Martin, G. E., Davis, M., Jaye, M. C., & Dionne, C. A. (1992). Acidic Fibroblast Growth Factor Accelerates the Healing of Acetic-Acid-lnduced Gastric Ulcers in Rats. Digestion, 53(1–2), 17–27. Portico. https://doi.org/10.1159/000200967

Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides

Journal of Medicinal Chemistry / Mar 01, 1992

Youssefyeh, R. D., Campbell, H. F., Klein, S., Airey, J. E., Darkes, P., Powers, M., Schnapper, M., Neuenschwander, K., & Fitzpatrick, L. R. (1992). Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. Journal of Medicinal Chemistry, 35(5), 895–903. https://doi.org/10.1021/jm00083a014

Small-Molecule Drugs for the Treatment of Inflammatory Bowel Disease

Comprehensive Medicinal Chemistry III / Jan 01, 2017

Fitzpatrick, L. R., & Woldemariam, T. (2017). Small-Molecule Drugs for the Treatment of Inflammatory Bowel Disease. In Comprehensive Medicinal Chemistry III (pp. 495–510). Elsevier. https://doi.org/10.1016/b978-0-12-409547-2.12404-7

T2035 The Novel Probiotic Escherichia coli Strain M-17 Uniquely Inhibits Pro-Inflammatory Cytokine Secretion in Macrophage and Colonic Epithelial Cell Lines

Gastroenterology / May 01, 2010

Fitzpatrick, L. R., Small, J. S., Bostwick, E. F., & Hoerr, R. A. (2010). T2035 The Novel Probiotic Escherichia coli Strain M-17 Uniquely Inhibits Pro-Inflammatory Cytokine Secretion in Macrophage and Colonic Epithelial Cell Lines. Gastroenterology, 138(5), S-618. https://doi.org/10.1016/s0016-5085(10)62848-x

Potent 5‐hydroxytryptamine3 receptor antagonist activity of RG 12915

Drug Development Research / Jan 01, 1993

Martin, G. E., Chase, B. J., Davis, M. A., & Pendley, C. E. (1993). Potent 5‐hydroxytryptamine3 receptor antagonist activity of RG 12915. Drug Development Research, 28(1), 38–46. Portico. https://doi.org/10.1002/ddr.430280105

The Effect of Fiber in the Postweaning Diet on Nutritional and Intestinal Morphological Indices in the Rat

Dietary Fiber / Jan 01, 1986

Cassidy, M. M., Fitzpatrick, L. R., & Vahouny, G. V. (1986). The Effect of Fiber in the Postweaning Diet on Nutritional and Intestinal Morphological Indices in the Rat. In Dietary Fiber (pp. 229–251). Springer US. https://doi.org/10.1007/978-1-4613-2111-8_15

Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10

Peptides / May 01, 2014

Ziogas, D. C., Karagiannis, A. K. A., Geiger, B. M., Gras-Miralles, B., Najarian, R., Reizes, O., Fitzpatrick, L. R., & Kokkotou, E. (2014). Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10. Peptides, 55, 58–64. https://doi.org/10.1016/j.peptides.2014.02.005

Amiloride inhibits rat mucosal ornithine decarboxylase activity and DNA synthesis

American Journal of Physiology-Gastrointestinal and Liver Physiology / Mar 01, 1988

Ulrich-Baker, M. G., Wang, P., Fitzpatrick, L., & Johnson, L. R. (1988). Amiloride inhibits rat mucosal ornithine decarboxylase activity and DNA synthesis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 254(3), G408–G415. https://doi.org/10.1152/ajpgi.1988.254.3.g408

VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease

Inflammopharmacology / Sep 23, 2019

Fitzpatrick, L. R., Small, J., O’Connell, R., Talbott, G., Alton, G., & Zapf, J. (2019). VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease. Inflammopharmacology, 28(2), 499–511. https://doi.org/10.1007/s10787-019-00643-z

A Novel Mathematical Model for Determining Faculty Workload

American Journal of Pharmaceutical Education / Nov 01, 2016

Fitzpatrick, L. R., Millette-Snodgrass, C., & Atef, E. (2016). A Novel Mathematical Model for Determining Faculty Workload. American Journal of Pharmaceutical Education, 80(9), 152. https://doi.org/10.5688/ajpe809152

Skeletal muscle catabolism in trinitrobenzene sulfonic acid–induced murine colitis

Metabolism / Nov 01, 2010

Puleo, F., Meirelles, K., Navaratnarajah, M., Fitzpatrick, L., Shumate, M. L., Cooney, R. N., & Lang, C. H. (2010). Skeletal muscle catabolism in trinitrobenzene sulfonic acid–induced murine colitis. Metabolism, 59(11), 1680–1690. https://doi.org/10.1016/j.metabol.2010.03.021

Indomethacin‐induced gastric antral damage in hamsters: are neutrophils involved?

Alimentary Pharmacology & Therapeutics / Feb 01, 1999

Fitzpatrick, Sakurai, & Le. (1999). Indomethacin‐induced gastric antral damage in hamsters: are neutrophils involved? Alimentary Pharmacology & Therapeutics, 13(2), 195–202. Portico. https://doi.org/10.1046/j.1365-2036.1999.00444.x

Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats

Agents and Actions / Jul 01, 1991

Fitzpatrick, L. R., & Decktor, D. L. (1991). Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats. Agents and Actions, 33(3–4), 330–336. https://doi.org/10.1007/bf01986582

Ror-gamma T inhibition as a Pharmacological Approach for Inflammatory Bowel Disease

Medical Research Archives / Aug 17, 2015

Fitzpatrick, L. R. (2015). Ror-gamma T inhibition as a Pharmacological Approach for Inflammatory Bowel Disease. Medical Research Archives, 2(2). https://doi.org/10.18103/mra.v0i4.334

Prostaglandin-Mediated Trophic Effects on the Rat Duodenum: The Role of Polyamines

Experimental Biology and Medicine / Nov 01, 1988

Fitzpatrick, L. R., Gaginella, T. S., Haddox, M. K., & Johnson, L. R. (1988). Prostaglandin-Mediated Trophic Effects on the Rat Duodenum: The Role of Polyamines. Experimental Biology and Medicine, 189(2), 201–205. https://doi.org/10.3181/00379727-189-42798

1232 Distinct cAMP signaling microdomains differentially impact melanoma

Journal of Investigative Dermatology / May 01, 2018

Drozdz, M. M., Wang, J., & Zippin, J. H. (2018). 1232 Distinct cAMP signaling microdomains differentially impact melanoma. Journal of Investigative Dermatology, 138(5), S209. https://doi.org/10.1016/j.jid.2018.03.1247

Inhibition of IL-17 Release by the Novel Anti-Inflammatory Drug Vidofludimus Involves Attenuation of STAT3 and NF-kappa B Signaling Pathways in Murine Splenocytes and Hapten-Induced Colitis

Gastroenterology / May 01, 2011

Fitzpatrick, L. R., Small, J. S., & Ammendola, A. (2011). Inhibition of IL-17 Release by the Novel Anti-Inflammatory Drug Vidofludimus Involves Attenuation of STAT3 and NF-kappa B Signaling Pathways in Murine Splenocytes and Hapten-Induced Colitis. Gastroenterology, 140(5), S-837. https://doi.org/10.1016/s0016-5085(11)63470-7

Peptic ulcers

Nursing Standard / Jan 21, 1989

Peptic ulcers. (1989). Nursing Standard, 3(17), 16–16. https://doi.org/10.7748/ns.3.17.16.s43

Effect of naproxen on the hamster gastric antrum: ulceration, adaptation and efficacy of anti‐ulcer drugs

Alimentary Pharmacology & Therapeutics / Nov 01, 1999

Fitzpatrick, Sakurai, & Le. (1999). Effect of naproxen on the hamster gastric antrum: ulceration, adaptation and efficacy of anti‐ulcer drugs. Alimentary Pharmacology & Therapeutics, 13(11), 1553–1562. Portico. https://doi.org/10.1046/j.1365-2036.1999.00624.x

M1658 A Novel Immunosuppressive Drug (4SC-101) Improves TNBS-Induced Colitis in Mice

Gastroenterology / May 01, 2009

Fitzpatrick, L. R., Small, J. S., Zhang, G., & Jankowsky, R. (2009). M1658 A Novel Immunosuppressive Drug (4SC-101) Improves TNBS-Induced Colitis in Mice. Gastroenterology, 136(5), A-404. https://doi.org/10.1016/s0016-5085(09)61857-6

The modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on OPC antioxidant

The American Journal of Gastroenterology / Sep 01, 2001

FARHADI, A. (2001). The modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on OPC antioxidant. The American Journal of Gastroenterology, 96(9), S290. https://doi.org/10.1016/s0002-9270(01)03699-1

Fos expression in the colonic myenteric plexus induced by water avoidance stress in different rat strains

Gastroenterology / Apr 01, 2001

MIAMPAMBA, M., MILLION, M., & TACHE, Y. (2001). Fos expression in the colonic myenteric plexus induced by water avoidance stress in different rat strains. Gastroenterology, 120(5), A715–A715. https://doi.org/10.1016/s0016-5085(01)83560-5

Protection by Acidified Maalox against Indomethacin-Induced Gastric Antral Ulceration in Hamsters

Digestion / Jan 01, 1991

Fitzpatrick, L. R. (1991). Protection by Acidified Maalox against Indomethacin-Induced Gastric Antral Ulceration in Hamsters. Digestion, 50(1), 1–6. Portico. https://doi.org/10.1159/000200733

Tu1744 - Ex Vivo Effects of Ror-Gamma T Inhibitors on Proinflammatory Cytokine Secretion from Colonic Strips of Mice with DSS-Induced Colitis

Gastroenterology / May 01, 2018

Fitzpatrick, L. R., Talbott, G., Buhr, C. A., Alton, G., & Zapf, J. (2018). Tu1744 - Ex Vivo Effects of Ror-Gamma T Inhibitors on Proinflammatory Cytokine Secretion from Colonic Strips of Mice with DSS-Induced Colitis. Gastroenterology, 154(6), S-1007-S-1008. https://doi.org/10.1016/s0016-5085(18)33370-5

A Novel ROR-Gamma T Inhibitor (VPR-254) Attenuates Key Parameters of Innate Immune Colitis in Mice

Gastroenterology / Apr 01, 2017

Fitzpatrick, L. R., O’Connell, R., Talbott, G., Bendele, P., Alton, G., & Zapf, J. (2017). A Novel ROR-Gamma T Inhibitor (VPR-254) Attenuates Key Parameters of Innate Immune Colitis in Mice. Gastroenterology, 152(5), S30–S31. https://doi.org/10.1016/s0016-5085(17)30468-7

Sa1834 Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Macrophage and Colonic Epithelial Cell Lines

Gastroenterology / Apr 01, 2016

Fitzpatrick, L. R., Talbott, G., & Woldemariam, T. (2016). Sa1834 Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Macrophage and Colonic Epithelial Cell Lines. Gastroenterology, 150(4), S376–S377. https://doi.org/10.1016/s0016-5085(16)31323-3

90 Efficacy of a Novel Small Molecule RORgt Inverse Agonist in Mouse DSS and TNBS Models of Inflammatory Bowel Disease

Gastroenterology / Apr 01, 2015

Fitzpatrick, L. R., Zapf, J., Flood, E. M., Ravula, S. B., Lingardo, L. K., Small, J., Tucci, F., Buhr, C. A., & Alton, G. (2015). 90 Efficacy of a Novel Small Molecule RORgt Inverse Agonist in Mouse DSS and TNBS Models of Inflammatory Bowel Disease. Gastroenterology, 148(4), S-26. https://doi.org/10.1016/s0016-5085(15)30090-1

Sa2053 Bacillus Coagulans Bc30 Limits the Recurrence of Clostridium diJicile-Induced Colitis Following Vancomycin Withdrawal in Mice

Gastroenterology / May 01, 2012

Fitzpatrick, L. R., Small, J. S., Greene, W., Karpa, K., & Keller, D. (2012). Sa2053 Bacillus Coagulans Bc30 Limits the Recurrence of Clostridium diJicile-Induced Colitis Following Vancomycin Withdrawal in Mice. Gastroenterology, 142(5), S-390. https://doi.org/10.1016/s0016-5085(12)61479-6

Probiotic Treatment of Colitis in Animal Models and People

Bioactive Foods in Promoting Health / Jan 01, 2010

Fitzpatrick, L. R., & Karpa, K. D. (2010). Probiotic Treatment of Colitis in Animal Models and People. In Bioactive Foods in Promoting Health (pp. 571–587). Elsevier. https://doi.org/10.1016/b978-0-12-374938-3.00034-7

M1651 Melanin-Concentrating Hormone Receptor 1 Antagonists Attenuate TNBS-Induced Colitis in Mice

Gastroenterology / May 01, 2009

Fitzpatrick, L. R., Small, J. S., & Zhang, G. (2009). M1651 Melanin-Concentrating Hormone Receptor 1 Antagonists Attenuate TNBS-Induced Colitis in Mice. Gastroenterology, 136(5), A-403. https://doi.org/10.1016/s0016-5085(09)61850-3

A comparison of sucralfate and bismuth subsalicylate formulations in rabbit esophageal models

Gastroenterology / Apr 01, 1995

A comparison of sucralfate and bismuth subsalicylate formulations in rabbit esophageal models. (1995). Gastroenterology, 108(4), A94. https://doi.org/10.1016/0016-5085(95)23040-8

The Sphingosine Kinase 2 Inhibitor Opaganib Protects Against Acute Kidney Injury in Mice

International Journal of Nephrology and Renovascular Disease / Nov 01, 2022

Maines, L. W., Green, C. L., Keller, S. N., Fitzpatrick, L. R., & Smith, C. D. (2022). The Sphingosine Kinase 2 Inhibitor Opaganib Protects Against Acute Kidney Injury in Mice. International Journal of Nephrology and Renovascular Disease, Volume 15, 323–334. https://doi.org/10.2147/ijnrd.s386396

Role of the δ-Opioid Receptor in 2 Murine Models of Colitis

Comparative Medicine / Feb 01, 2020

Bobo, T. R., Fitzpatrick, L. R., Whitcomb, T. L., Cooper, T. K., Raiciulescu, S., & Smith, J. P. (2020). Role of the δ-Opioid Receptor in 2 Murine Models of Colitis. Comparative Medicine, 70(1), 25–34. https://doi.org/10.30802/aalas-cm-19-000024

Evidence that the Ubiquitin Proteasome System Plays a Prominent Role in Inflammatory Bowel Disease: Possible Pharmacological Approaches

Pharmacy & Pharmacology International Journal / Feb 02, 2016

Fitzpatrick, L. R. (2016). Evidence that the Ubiquitin Proteasome System Plays a Prominent Role in Inflammatory Bowel Disease: Possible Pharmacological Approaches. Pharmacy & Pharmacology International Journal, 4(1). https://doi.org/10.15406/ppij.2016.04.00062

Tu1617 The Synthetic Triterpenoid (CDDO-IM) Inhibits STAT3, As Well As IL-17, and Improves DSS-Induced Colitis in Mice

Gastroenterology / May 01, 2013

Stonesifer, E., Fitzpatrick, L. R., Small, J., & Liby, K. T. (2013). Tu1617 The Synthetic Triterpenoid (CDDO-IM) Inhibits STAT3, As Well As IL-17, and Improves DSS-Induced Colitis in Mice. Gastroenterology, 144(5), S-807. https://doi.org/10.1016/s0016-5085(13)62986-8

Bacillus Coagulans (Bc 30 ) Improves Some Indices of Clostridium difficile -Induced Colitis in Mice

Gastroenterology / May 01, 2011

Fitzpatrick, L. R., Small, J. S., Greene, W., Karpa, K., & Keller, D. (2011). Bacillus Coagulans (Bc 30 ) Improves Some Indices of Clostridium difficile -Induced Colitis in Mice. Gastroenterology, 140(5), S-849. https://doi.org/10.1016/s0016-5085(11)63523-3

Characterization of the reactivation phase of dextran sodium sulfate (DSS)-induced colitis in rats

Gastroenterology / Apr 01, 1998

Fitzpatrick, L. R., Williams, J., & Le. Maryland, T. (1998). Characterization of the reactivation phase of dextran sodium sulfate (DSS)-induced colitis in rats. Gastroenterology, 114, A976. https://doi.org/10.1016/s0016-5085(98)83975-9

Novel characterization and quantification of bismuth binding to gastric mucosa

Gastroenterology / Apr 01, 1995

Novel characterization and quantification of bismuth binding to gastric mucosa. (1995). Gastroenterology, 108(4), A180. https://doi.org/10.1016/0016-5085(95)23381-4

Dietary Fiber, Bile Acids, and Intestinal Morphology

Dietary Fiber in Health and Disease / Jan 01, 1982

Cassidy, M. M., Lightfoot, F. G., & Vahouny, G. V. (1982). Dietary Fiber, Bile Acids, and Intestinal Morphology. In Dietary Fiber in Health and Disease (pp. 239–264). Springer US. https://doi.org/10.1007/978-1-4615-6850-6_22

Regulation of intestinal ornithine decarboxylase (ODC) expression during postnatal development by ODC antizyme in rats

Gastroenterology / Apr 01, 2000

Lin, C.-H., Tolia, V. K., & Vijesurier, R. M. (2000). Regulation of intestinal ornithine decarboxylase (ODC) expression during postnatal development by ODC antizyme in rats. Gastroenterology, 118(4), A292. https://doi.org/10.1016/s0016-5085(00)83253-9

RELT is overexpressed in human inflammatory bowel disease and breast cancer.

The Journal of Immunology / May 01, 2023

Cusick, J. K., Moua, P., Wong, S., Chang, E., Chou, E., Shyu, Y., Abram, A., Alcaide, J., Talbott, G., Yanumula, A., Qureshi, V., Budhiraja, A., Cusick, G., Shi, Y., Atapattu, D., & Fitzpatrick, L. (2023). RELT is overexpressed in human inflammatory bowel disease and breast cancer. The Journal of Immunology, 210(1_Supplement), 70.14-70.14. https://doi.org/10.4049/jimmunol.210.supp.70.14

Drug Discovery Approaches for Inflammatory Bowel Disease

Biologics and Biosimilars / May 03, 2022

Fitzpatrick, L. R., & Mokrushin, E. (2022). Drug Discovery Approaches for Inflammatory Bowel Disease. In Biologics and Biosimilars (pp. 371–384). CRC Press. https://doi.org/10.1201/9780429485626-23

In Vitro and Ex Vivo Effects of Silymarin Derivatives on Proinflammatory Cytokine Secretion Using a Murine Colonic Strip Model

Planta Medica International Open / Apr 01, 2018

Fitzpatrick, L., Mokrushin, E., Talbott, G., & Woldermariam, T. (2018). In Vitro and Ex Vivo Effects of Silymarin Derivatives on Proinflammatory Cytokine Secretion Using a Murine Colonic Strip Model. Planta Medica International Open, 5(02), e55–e60. https://doi.org/10.1055/a-0733-3716

Ex Vivo Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Colonic Strips of Mice with Dssinduced Colitis

Gastroenterology / Apr 01, 2017

Fitzpatrick, L. R., Talbott, G., Mokrushin, E., & Woldemariam, T. (2017). Ex Vivo Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Colonic Strips of Mice with Dssinduced Colitis. Gastroenterology, 152(5), S571. https://doi.org/10.1016/s0016-5085(17)32067-x

P012 Vidofludimus inhibits IL-17 and improves hapten-induced colitis in young rats by a unique dual mode of action

Journal of Crohn's and Colitis / Feb 01, 2012

Fitzpatrick, L. R., Small, J. S., Doblhofer, R., Henning, S. W., & Ammendola, A. (2012). P012 Vidofludimus inhibits IL-17 and improves hapten-induced colitis in young rats by a unique dual mode of action. Journal of Crohn’s and Colitis, 6, S15–S16. https://doi.org/10.1016/s1873-9946(12)60033-6

Colitis Development in IL-10 Deficient Mice Reveals a Direct Role of MCH in Regulating IL-10 Expression by Monocytes

Gastroenterology / May 01, 2011

Ziogas, D., ElKhal, A., Najarian, R. M., Mustafa, S. N., Reizes, O., Fitzpatrick, L. R., & Kokkotou, E. (2011). Colitis Development in IL-10 Deficient Mice Reveals a Direct Role of MCH in Regulating IL-10 Expression by Monocytes. Gastroenterology, 140(5), S-518. https://doi.org/10.1016/s0016-5085(11)62150-1

Alterations in amino acid uptake and transport in TNBS-induced colitis

Inflammatory Bowel Diseases / Dec 01, 2008

Puleo, F., Meng, Q., Navaratnarajah, M., Fitzpatrick, L., Koltun, W., & Cooney, R. (2008). Alterations in amino acid uptake and transport in TNBS-induced colitis: P-0016. Inflammatory Bowel Diseases, 14, S15. https://doi.org/10.1097/00054725-200812003-00051

Alterations in the IGF-I axis and ubiquitin E3 ligases (atrogin-1, MuRF1) in TNBS-induced colitis: A mechanism for loss of muscle mass in IBD

Inflammatory Bowel Diseases / Jan 01, 2008

Cooney, R., Fitzpatrick, L., Meirelles, K., Puleo, F., Koltun, W., & Lang, C. (2008). Alterations in the IGF-I axis and ubiquitin E3 ligases (atrogin-1, MuRF1) in TNBS-induced colitis: A mechanism for loss of muscle mass in IBD: P-077. Inflammatory Bowel Diseases, 14, S32. https://doi.org/10.1097/00054725-200801001-00110

S1743 Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Rats

Gastroenterology / Apr 01, 2008

Maines, L. W., Fitzpatrick, L. R., Green, C., & Smith, C. D. (2008). S1743 Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Rats. Gastroenterology, 134(4), A-261. https://doi.org/10.1016/s0016-5085(08)61214-7

The Devil Is in the Details: The Pharmaceutical Industry’s Use of Gifts to Physicians as Marketing Strategy

Journal of Surgical Research / Jun 01, 2007

McFadden, D. W., Calvario, E., & Graves, C. (2007). The Devil Is in the Details: The Pharmaceutical Industry’s Use of Gifts to Physicians as Marketing Strategy. Journal of Surgical Research, 140(1), 1–5. https://doi.org/10.1016/j.jss.2006.10.010

Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Mice

Gastrointestinal Endoscopy / Apr 01, 2007

Maines, L. W., Fitzpatrick, L. R., Green, C. L., & Smith, C. D. (2007). Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Mice. Gastrointestinal Endoscopy, 65(5), AB263. https://doi.org/10.1016/j.gie.2007.03.621

A Role For Meprin‐ α In A Model Of Inflammatory Bowel Disease

The FASEB Journal / Apr 01, 2007

Banerjee, S., Fitzpatrick, L. R., Bradley, S. G., & Bond, J. S. (2007). A Role For Meprin‐ α In A Model Of Inflammatory Bowel Disease. The FASEB Journal, 21(5). Portico. https://doi.org/10.1096/fasebj.21.5.a278-d

Education

PhD, Physiology

Post Doctoral Fellowship, GI Physiology

Experience

California NorthState University

Penn State College of Medicine

Otsuka Pharmaceutical

Procter and Gamble

Rhone Poulenc Rorer

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