Leo R Fitzpatrick PhD
GI Pharmacology and IBD Research Consultant
Research Expertise
About
Publications
Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis
Journal of Surgical Research / Jun 01, 2007
Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L., Ruggiero, F., & Koltun, W. A. (2007). Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis. Journal of Surgical Research, 140(1), 12–19. https://doi.org/10.1016/j.jss.2006.07.050
Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses
The Journal of Experimental Medicine / Jun 04, 2007
Reiley, W. W., Jin, W., Lee, A. J., Wright, A., Wu, X., Tewalt, E. F., Leonard, T. O., Norbury, C. C., Fitzpatrick, L., Zhang, M., & Sun, S.-C. (2007). Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. The Journal of Experimental Medicine, 204(6), 1475–1485. https://doi.org/10.1084/jem.20062694
Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase
Digestive Diseases and Sciences / Dec 04, 2007
Maines, L. W., Fitzpatrick, L. R., French, K. J., Zhuang, Y., Xia, Z., Keller, S. N., Upson, J. J., & Smith, C. D. (2007). Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase. Digestive Diseases and Sciences, 53(4), 997–1012. https://doi.org/10.1007/s10620-007-0133-6
Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review
World Journal of Gastroenterology / Jan 01, 2017
Salaritabar, A., Darvishi, B., Hadjiakhoondi, F., Manayi, A., Sureda, A., Nabavi, S. F., Fitzpatrick, L. R., Nabavi, S. M., & Bishayee, A. (2017). Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review. World Journal of Gastroenterology, 23(28), 5097. https://doi.org/10.3748/wjg.v23.i28.5097
CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats
Gastroenterology / Apr 01, 2001
FITZPATRICK, L., WANG, J., & LE, T. (2001). CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats. Gastroenterology, 120(5), A685–A685. https://doi.org/10.1016/s0016-5085(01)83409-0
CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats
Gastroenterology / Apr 01, 2001
Fitzpatrick, L. R., Wang, J., & Le, T. (2001). CAPE, an inhibitor of nuclear factor-kappa B (NF-κB), attenuates bacterial peptidoglycan polysaccharide (PG-PS) induced colitis in rats. Gastroenterology, 120(5), A685. https://doi.org/10.1016/s0016-5085(08)83409-9
Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease
Inflammopharmacology / Feb 12, 2010
Maines, L. W., Fitzpatrick, L. R., Green, C. L., Zhuang, Y., & Smith, C. D. (2010). Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease. Inflammopharmacology, 18(2), 73–85. https://doi.org/10.1007/s10787-010-0032-x
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
Mucosal Immunology / May 01, 2009
Banerjee, S., Oneda, B., Yap, L. M., Jewell, D. P., Matters, G. L., Fitzpatrick, L. R., Seibold, F., Sterchi, E. E., Ahmad, T., Lottaz, D., & Bond, J. S. (2009). MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunology, 2(3), 220–231. https://doi.org/10.1038/mi.2009.3
OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability
Free Radical Biology and Medicine / Feb 01, 2001
Banan, A., Fitzpatrick, L., Zhang, Y., & Keshavarzian, A. (2001). OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability. Free Radical Biology and Medicine, 30(3), 287–298. https://doi.org/10.1016/s0891-5849(00)00471-8
4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease†
Inflammatory Bowel Diseases / Oct 01, 2010
Fitzpatrick, L. R., Deml, L., Hofmann, C., Small, J. S., Groeppel, M., Hamm, S., Lemstra, S., Leban, J., & Ammendola, A. (2010). 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease†. Inflammatory Bowel Diseases, 16(10), 1763–1777. https://doi.org/10.1002/ibd.21264
Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat
Agents and Actions / Jun 01, 1990
Fitzpatrick, L. R., Bostwick, J. S., Renzetti, M., Pendleton, R. G., & Decktor, D. L. (1990). Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. Agents and Actions, 30(3–4), 393–402. https://doi.org/10.1007/bf01966304
In vitro and in vivo effects of the probiotic Escherichia coli strain M-17: immunomodulation and attenuation of murine colitis
British Journal of Nutrition / Feb 18, 2008
Fitzpatrick, L. R., Small, J., Hoerr, R. A., Bostwick, E. F., Maines, L., & Koltun, W. A. (2008). In vitro and in vivo effects of the probiotic Escherichia coli strain M-17: immunomodulation and attenuation of murine colitis. British Journal of Nutrition, 100(03), 530–541. https://doi.org/10.1017/s0007114508930373
Probiotics for the treatment ofClostridium difficileassociated disease
World Journal of Gastrointestinal Pathophysiology / Jan 01, 2013
Fitzpatrick, L. R. (2013). Probiotics for the treatment ofClostridium difficileassociated disease. World Journal of Gastrointestinal Pathophysiology, 4(3), 47. https://doi.org/10.4291/wjgp.v4.i3.47
Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 Axis
International Journal of Inflammation / Jan 01, 2012
Fitzpatrick, L. R. (2012). Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 Axis. International Journal of Inflammation, 2012, 1–8. https://doi.org/10.1155/2012/389404
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase
Inflammopharmacology / Oct 11, 2010
Fitzpatrick, L. R., Green, C., Frauenhoffer, E. E., French, K. J., Zhuang, Y., Maines, L. W., Upson, J. J., Paul, E., Donahue, H., Mosher, T. J., & Smith, C. D. (2010). Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology, 19(2), 75–87. https://doi.org/10.1007/s10787-010-0060-6
NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic Inflammation
The Journal of Immunology / Mar 01, 2009
Chang, M., Lee, A. J., Fitzpatrick, L., Zhang, M., & Sun, S.-C. (2009). NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic Inflammation. The Journal of Immunology, 182(5), 3131–3138. https://doi.org/10.4049/jimmunol.0803637
Effects of the Probiotic Formulation VSL#3 on Colitis in Weanling Rats
Journal of Pediatric Gastroenterology and Nutrition / May 01, 2007
Fitzpatrick, L. R., Hertzog, K. L., Quatse, A. L., Koltun, W. A., Small, J. S., & Vrana, K. (2007). Effects of the Probiotic Formulation VSL#3 on Colitis in Weanling Rats. Journal of Pediatric Gastroenterology and Nutrition, 44(5), 561–570. Portico. https://doi.org/10.1097/mpg.0b013e31803bda51
Inhibition of IL-17 as a Pharmacological Approach for IBD
International Reviews of Immunology / Jul 25, 2013
Fitzpatrick, L. R. (2013). Inhibition of IL-17 as a Pharmacological Approach for IBD. International Reviews of Immunology, 32(5–6), 544–555. https://doi.org/10.3109/08830185.2013.821118
Dextran Sulfate Sodium-Induced Colitis Is Associated with Enhanced Low Molecular Mass Polypeptide 2 (LMP2) Expression and Is Attenuated in LMP2 Knockout Mice
Digestive Diseases and Sciences / Jul 01, 2006
Fitzpatrick, L. R., Khare, V., Small, J. S., & Koltun, W. A. (2006). Dextran Sulfate Sodium-Induced Colitis Is Associated with Enhanced Low Molecular Mass Polypeptide 2 (LMP2) Expression and Is Attenuated in LMP2 Knockout Mice. Digestive Diseases and Sciences, 51(7), 1269–1276. https://doi.org/10.1007/s10620-006-8047-2
Highly potent and selective gastrin receptor antagonists based on CCK-4
Peptides 1992 / Jan 01, 1993
Ewing, W. R., Molino, B. F., Bolton, S. A., Manetta, V., Pendley, C., & Capilino, A. (1993). Highly potent and selective gastrin receptor antagonists based on CCK-4. In Peptides 1992 (pp. 619–620). Springer Netherlands. https://doi.org/10.1007/978-94-011-1470-7_280
Effect of epidermal growth factor on polyamine-synthesizing enzymes in rat enterocytes
American Journal of Physiology-Gastrointestinal and Liver Physiology / Feb 01, 1987
Fitzpatrick, L. R., Wang, P., & Johnson, L. R. (1987). Effect of epidermal growth factor on polyamine-synthesizing enzymes in rat enterocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 252(2), G209–G214. https://doi.org/10.1152/ajpgi.1987.252.2.g209
Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice
Gut Pathogens / Jan 01, 2011
Fitzpatrick, L. R., Small, J. S., Greene, W. H., Karpa, K. D., & Keller, D. (2011). Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice. Gut Pathogens, 3(1), 16. https://doi.org/10.1186/1757-4749-3-16
A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260
European Journal of Pharmacology / Mar 01, 1989
Lotti, V. J., & Chang, R. S. L. (1989). A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. European Journal of Pharmacology, 162(2), 273–280. https://doi.org/10.1016/0014-2999(89)90290-2
Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice
Gut Pathogens / Oct 01, 2012
Fitzpatrick, L. R., Small, J. S., Greene, W. H., Karpa, K. D., Farmer, S., & Keller, D. (2012). Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice. Gut Pathogens, 4(1). https://doi.org/10.1186/1757-4749-4-13
IBD and Bile Acid Absorption: Focus on Pre-clinical and Clinical Observations
Frontiers in Physiology / Jun 12, 2020
Fitzpatrick, L. R., & Jenabzadeh, P. (2020). IBD and Bile Acid Absorption: Focus on Pre-clinical and Clinical Observations. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.00564
Enhanced Intestinal Expression of the Proteasome Subunit Low Molecular Mass Polypeptide 2 in Patients with Inflammatory Bowel Disease
Diseases of the Colon & Rectum / Mar 01, 2007
Fitzpatrick, L. R., Small, J. S., Poritz, L. S., McKenna, K. J., & Koltun, W. A. (2007). Enhanced Intestinal Expression of the Proteasome Subunit Low Molecular Mass Polypeptide 2 in Patients with Inflammatory Bowel Disease. Diseases of the Colon & Rectum, 50(3), 337–350. https://doi.org/10.1007/s10350-006-0796-7
Effect of refeeding on polyamine biosynthesis in isolated enterocytes
American Journal of Physiology-Gastrointestinal and Liver Physiology / May 01, 1986
Fitzpatrick, L. R., Wang, P., Eikenburg, B. E., Haddox, M. K., & Johnson, L. R. (1986). Effect of refeeding on polyamine biosynthesis in isolated enterocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 250(5), G709–G713. https://doi.org/10.1152/ajpgi.1986.250.5.g709
Experimental Osteoarthritis in Rats Is Attenuated by ABC294640, a Selective Inhibitor of Sphingosine Kinase-2
Pharmacology / Jan 01, 2011
Fitzpatrick, L. R., Green, C., Maines, L. W., & Smith, C. D. (2011). Experimental Osteoarthritis in Rats Is Attenuated by ABC294640, a Selective Inhibitor of Sphingosine Kinase-2. Pharmacology, 87(3–4), 135–143. Portico. https://doi.org/10.1159/000323911
The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease
Journal of Immunotoxicology / Jan 01, 2008
Matters, G. L., Harms, J. F., McGovern, C., Fitzpatrick, L., Parikh, A., Nilo, N., & Smith, J. P. (2008). The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease. Journal of Immunotoxicology, 5(2), 179–187. https://doi.org/10.1080/15476910802131469
Vidofludimus Inhibits Colonic Interleukin-17 and Improves Hapten-Induced Colitis in Rats by a Unique Dual Mode of Action
Journal of Pharmacology and Experimental Therapeutics / Jun 12, 2012
Fitzpatrick, L. R., Small, J. S., Doblhofer, R., & Ammendola, A. (2012). Vidofludimus Inhibits Colonic Interleukin-17 and Improves Hapten-Induced Colitis in Rats by a Unique Dual Mode of Action. Journal of Pharmacology and Experimental Therapeutics, 342(3), 850–860. https://doi.org/10.1124/jpet.112.192203
A New Model of Chronic Hapten-induced Colitis in Young Rats
Journal of Pediatric Gastroenterology & Nutrition / Mar 01, 2010
Fitzpatrick, L. R., Meirelles, K., Small, J. S., Puleo, F. J., Koltun, W. A., & Cooney, R. N. (2010). A New Model of Chronic Hapten-induced Colitis in Young Rats. Journal of Pediatric Gastroenterology & Nutrition, 50(3), 240–250. https://doi.org/10.1097/mpg.0b013e3181cb8f4a
Relationship between ornithine decarboxylase activity and gastric damage
American Journal of Physiology-Gastrointestinal and Liver Physiology / Dec 01, 1987
Thirumalai, C. H., Tseng, C. C., Tabata, K., Fitzpatrick, L. R., & Johnson, L. R. (1987). Relationship between ornithine decarboxylase activity and gastric damage. American Journal of Physiology-Gastrointestinal and Liver Physiology, 253(1), G1–G6. https://doi.org/10.1152/ajpgi.1987.253.1.g1
The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice
Inflammopharmacology / Apr 09, 2014
Fitzpatrick, L. R., Stonesifer, E., Small, J. S., & Liby, K. T. (2014). The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice. Inflammopharmacology, 22(6), 341–349. https://doi.org/10.1007/s10787-014-0203-2
Gliotoxin, an Inhibitor of Nuclear Factor-Kappa B, Attenuates Peptidoglycan-Polysaccharide-Induced Colitis in Rats
Inflammatory Bowel Diseases / May 01, 2002
Fitzpatrick, L. R., Wang, J., & Le, T. (2002). Gliotoxin, an Inhibitor of Nuclear Factor-Kappa B, Attenuates Peptidoglycan-Polysaccharide-Induced Colitis in Rats. Inflammatory Bowel Diseases, 8(3), 159–167. https://doi.org/10.1097/00054725-200205000-00001
Acidic Fibroblast Growth Factor Accelerates the Healing of Acetic-Acid-lnduced Gastric Ulcers in Rats
Digestion / Jan 01, 1992
Fitzpatrick, L. R., Jakubowska, A., Martin, G. E., Davis, M., Jaye, M. C., & Dionne, C. A. (1992). Acidic Fibroblast Growth Factor Accelerates the Healing of Acetic-Acid-lnduced Gastric Ulcers in Rats. Digestion, 53(1–2), 17–27. Portico. https://doi.org/10.1159/000200967
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides
Journal of Medicinal Chemistry / Mar 01, 1992
Youssefyeh, R. D., Campbell, H. F., Klein, S., Airey, J. E., Darkes, P., Powers, M., Schnapper, M., Neuenschwander, K., & Fitzpatrick, L. R. (1992). Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. Journal of Medicinal Chemistry, 35(5), 895–903. https://doi.org/10.1021/jm00083a014
Small-Molecule Drugs for the Treatment of Inflammatory Bowel Disease
Comprehensive Medicinal Chemistry III / Jan 01, 2017
Fitzpatrick, L. R., & Woldemariam, T. (2017). Small-Molecule Drugs for the Treatment of Inflammatory Bowel Disease. In Comprehensive Medicinal Chemistry III (pp. 495–510). Elsevier. https://doi.org/10.1016/b978-0-12-409547-2.12404-7
T2035 The Novel Probiotic Escherichia coli Strain M-17 Uniquely Inhibits Pro-Inflammatory Cytokine Secretion in Macrophage and Colonic Epithelial Cell Lines
Gastroenterology / May 01, 2010
Fitzpatrick, L. R., Small, J. S., Bostwick, E. F., & Hoerr, R. A. (2010). T2035 The Novel Probiotic Escherichia coli Strain M-17 Uniquely Inhibits Pro-Inflammatory Cytokine Secretion in Macrophage and Colonic Epithelial Cell Lines. Gastroenterology, 138(5), S-618. https://doi.org/10.1016/s0016-5085(10)62848-x
Potent 5‐hydroxytryptamine3 receptor antagonist activity of RG 12915
Drug Development Research / Jan 01, 1993
Martin, G. E., Chase, B. J., Davis, M. A., & Pendley, C. E. (1993). Potent 5‐hydroxytryptamine3 receptor antagonist activity of RG 12915. Drug Development Research, 28(1), 38–46. Portico. https://doi.org/10.1002/ddr.430280105
The Effect of Fiber in the Postweaning Diet on Nutritional and Intestinal Morphological Indices in the Rat
Dietary Fiber / Jan 01, 1986
Cassidy, M. M., Fitzpatrick, L. R., & Vahouny, G. V. (1986). The Effect of Fiber in the Postweaning Diet on Nutritional and Intestinal Morphological Indices in the Rat. In Dietary Fiber (pp. 229–251). Springer US. https://doi.org/10.1007/978-1-4613-2111-8_15
Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10
Peptides / May 01, 2014
Ziogas, D. C., Karagiannis, A. K. A., Geiger, B. M., Gras-Miralles, B., Najarian, R., Reizes, O., Fitzpatrick, L. R., & Kokkotou, E. (2014). Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10. Peptides, 55, 58–64. https://doi.org/10.1016/j.peptides.2014.02.005
Amiloride inhibits rat mucosal ornithine decarboxylase activity and DNA synthesis
American Journal of Physiology-Gastrointestinal and Liver Physiology / Mar 01, 1988
Ulrich-Baker, M. G., Wang, P., Fitzpatrick, L., & Johnson, L. R. (1988). Amiloride inhibits rat mucosal ornithine decarboxylase activity and DNA synthesis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 254(3), G408–G415. https://doi.org/10.1152/ajpgi.1988.254.3.g408
VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease
Inflammopharmacology / Sep 23, 2019
Fitzpatrick, L. R., Small, J., O’Connell, R., Talbott, G., Alton, G., & Zapf, J. (2019). VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease. Inflammopharmacology, 28(2), 499–511. https://doi.org/10.1007/s10787-019-00643-z
A Novel Mathematical Model for Determining Faculty Workload
American Journal of Pharmaceutical Education / Nov 01, 2016
Fitzpatrick, L. R., Millette-Snodgrass, C., & Atef, E. (2016). A Novel Mathematical Model for Determining Faculty Workload. American Journal of Pharmaceutical Education, 80(9), 152. https://doi.org/10.5688/ajpe809152
Skeletal muscle catabolism in trinitrobenzene sulfonic acid–induced murine colitis
Metabolism / Nov 01, 2010
Puleo, F., Meirelles, K., Navaratnarajah, M., Fitzpatrick, L., Shumate, M. L., Cooney, R. N., & Lang, C. H. (2010). Skeletal muscle catabolism in trinitrobenzene sulfonic acid–induced murine colitis. Metabolism, 59(11), 1680–1690. https://doi.org/10.1016/j.metabol.2010.03.021
Indomethacin‐induced gastric antral damage in hamsters: are neutrophils involved?
Alimentary Pharmacology & Therapeutics / Feb 01, 1999
Fitzpatrick, Sakurai, & Le. (1999). Indomethacin‐induced gastric antral damage in hamsters: are neutrophils involved? Alimentary Pharmacology & Therapeutics, 13(2), 195–202. Portico. https://doi.org/10.1046/j.1365-2036.1999.00444.x
Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats
Agents and Actions / Jul 01, 1991
Fitzpatrick, L. R., & Decktor, D. L. (1991). Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats. Agents and Actions, 33(3–4), 330–336. https://doi.org/10.1007/bf01986582
Ror-gamma T inhibition as a Pharmacological Approach for Inflammatory Bowel Disease
Medical Research Archives / Aug 17, 2015
Fitzpatrick, L. R. (2015). Ror-gamma T inhibition as a Pharmacological Approach for Inflammatory Bowel Disease. Medical Research Archives, 2(2). https://doi.org/10.18103/mra.v0i4.334
Prostaglandin-Mediated Trophic Effects on the Rat Duodenum: The Role of Polyamines
Experimental Biology and Medicine / Nov 01, 1988
Fitzpatrick, L. R., Gaginella, T. S., Haddox, M. K., & Johnson, L. R. (1988). Prostaglandin-Mediated Trophic Effects on the Rat Duodenum: The Role of Polyamines. Experimental Biology and Medicine, 189(2), 201–205. https://doi.org/10.3181/00379727-189-42798
1232 Distinct cAMP signaling microdomains differentially impact melanoma
Journal of Investigative Dermatology / May 01, 2018
Drozdz, M. M., Wang, J., & Zippin, J. H. (2018). 1232 Distinct cAMP signaling microdomains differentially impact melanoma. Journal of Investigative Dermatology, 138(5), S209. https://doi.org/10.1016/j.jid.2018.03.1247
Inhibition of IL-17 Release by the Novel Anti-Inflammatory Drug Vidofludimus Involves Attenuation of STAT3 and NF-kappa B Signaling Pathways in Murine Splenocytes and Hapten-Induced Colitis
Gastroenterology / May 01, 2011
Fitzpatrick, L. R., Small, J. S., & Ammendola, A. (2011). Inhibition of IL-17 Release by the Novel Anti-Inflammatory Drug Vidofludimus Involves Attenuation of STAT3 and NF-kappa B Signaling Pathways in Murine Splenocytes and Hapten-Induced Colitis. Gastroenterology, 140(5), S-837. https://doi.org/10.1016/s0016-5085(11)63470-7
Peptic ulcers
Nursing Standard / Jan 21, 1989
Peptic ulcers. (1989). Nursing Standard, 3(17), 16–16. https://doi.org/10.7748/ns.3.17.16.s43
Effect of naproxen on the hamster gastric antrum: ulceration, adaptation and efficacy of anti‐ulcer drugs
Alimentary Pharmacology & Therapeutics / Nov 01, 1999
Fitzpatrick, Sakurai, & Le. (1999). Effect of naproxen on the hamster gastric antrum: ulceration, adaptation and efficacy of anti‐ulcer drugs. Alimentary Pharmacology & Therapeutics, 13(11), 1553–1562. Portico. https://doi.org/10.1046/j.1365-2036.1999.00624.x
M1658 A Novel Immunosuppressive Drug (4SC-101) Improves TNBS-Induced Colitis in Mice
Gastroenterology / May 01, 2009
Fitzpatrick, L. R., Small, J. S., Zhang, G., & Jankowsky, R. (2009). M1658 A Novel Immunosuppressive Drug (4SC-101) Improves TNBS-Induced Colitis in Mice. Gastroenterology, 136(5), A-404. https://doi.org/10.1016/s0016-5085(09)61857-6
The modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on OPC antioxidant
The American Journal of Gastroenterology / Sep 01, 2001
FARHADI, A. (2001). The modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on OPC antioxidant. The American Journal of Gastroenterology, 96(9), S290. https://doi.org/10.1016/s0002-9270(01)03699-1
Fos expression in the colonic myenteric plexus induced by water avoidance stress in different rat strains
Gastroenterology / Apr 01, 2001
MIAMPAMBA, M., MILLION, M., & TACHE, Y. (2001). Fos expression in the colonic myenteric plexus induced by water avoidance stress in different rat strains. Gastroenterology, 120(5), A715–A715. https://doi.org/10.1016/s0016-5085(01)83560-5
Protection by Acidified Maalox against Indomethacin-Induced Gastric Antral Ulceration in Hamsters
Digestion / Jan 01, 1991
Fitzpatrick, L. R. (1991). Protection by Acidified Maalox against Indomethacin-Induced Gastric Antral Ulceration in Hamsters. Digestion, 50(1), 1–6. Portico. https://doi.org/10.1159/000200733
Tu1744 - Ex Vivo Effects of Ror-Gamma T Inhibitors on Proinflammatory Cytokine Secretion from Colonic Strips of Mice with DSS-Induced Colitis
Gastroenterology / May 01, 2018
Fitzpatrick, L. R., Talbott, G., Buhr, C. A., Alton, G., & Zapf, J. (2018). Tu1744 - Ex Vivo Effects of Ror-Gamma T Inhibitors on Proinflammatory Cytokine Secretion from Colonic Strips of Mice with DSS-Induced Colitis. Gastroenterology, 154(6), S-1007-S-1008. https://doi.org/10.1016/s0016-5085(18)33370-5
A Novel ROR-Gamma T Inhibitor (VPR-254) Attenuates Key Parameters of Innate Immune Colitis in Mice
Gastroenterology / Apr 01, 2017
Fitzpatrick, L. R., O’Connell, R., Talbott, G., Bendele, P., Alton, G., & Zapf, J. (2017). A Novel ROR-Gamma T Inhibitor (VPR-254) Attenuates Key Parameters of Innate Immune Colitis in Mice. Gastroenterology, 152(5), S30–S31. https://doi.org/10.1016/s0016-5085(17)30468-7
Sa1834 Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Macrophage and Colonic Epithelial Cell Lines
Gastroenterology / Apr 01, 2016
Fitzpatrick, L. R., Talbott, G., & Woldemariam, T. (2016). Sa1834 Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Macrophage and Colonic Epithelial Cell Lines. Gastroenterology, 150(4), S376–S377. https://doi.org/10.1016/s0016-5085(16)31323-3
90 Efficacy of a Novel Small Molecule RORgt Inverse Agonist in Mouse DSS and TNBS Models of Inflammatory Bowel Disease
Gastroenterology / Apr 01, 2015
Fitzpatrick, L. R., Zapf, J., Flood, E. M., Ravula, S. B., Lingardo, L. K., Small, J., Tucci, F., Buhr, C. A., & Alton, G. (2015). 90 Efficacy of a Novel Small Molecule RORgt Inverse Agonist in Mouse DSS and TNBS Models of Inflammatory Bowel Disease. Gastroenterology, 148(4), S-26. https://doi.org/10.1016/s0016-5085(15)30090-1
Sa2053 Bacillus Coagulans Bc30 Limits the Recurrence of Clostridium diJicile-Induced Colitis Following Vancomycin Withdrawal in Mice
Gastroenterology / May 01, 2012
Fitzpatrick, L. R., Small, J. S., Greene, W., Karpa, K., & Keller, D. (2012). Sa2053 Bacillus Coagulans Bc30 Limits the Recurrence of Clostridium diJicile-Induced Colitis Following Vancomycin Withdrawal in Mice. Gastroenterology, 142(5), S-390. https://doi.org/10.1016/s0016-5085(12)61479-6
Probiotic Treatment of Colitis in Animal Models and People
Bioactive Foods in Promoting Health / Jan 01, 2010
Fitzpatrick, L. R., & Karpa, K. D. (2010). Probiotic Treatment of Colitis in Animal Models and People. In Bioactive Foods in Promoting Health (pp. 571–587). Elsevier. https://doi.org/10.1016/b978-0-12-374938-3.00034-7
M1651 Melanin-Concentrating Hormone Receptor 1 Antagonists Attenuate TNBS-Induced Colitis in Mice
Gastroenterology / May 01, 2009
Fitzpatrick, L. R., Small, J. S., & Zhang, G. (2009). M1651 Melanin-Concentrating Hormone Receptor 1 Antagonists Attenuate TNBS-Induced Colitis in Mice. Gastroenterology, 136(5), A-403. https://doi.org/10.1016/s0016-5085(09)61850-3
A comparison of sucralfate and bismuth subsalicylate formulations in rabbit esophageal models
Gastroenterology / Apr 01, 1995
A comparison of sucralfate and bismuth subsalicylate formulations in rabbit esophageal models. (1995). Gastroenterology, 108(4), A94. https://doi.org/10.1016/0016-5085(95)23040-8
The Sphingosine Kinase 2 Inhibitor Opaganib Protects Against Acute Kidney Injury in Mice
International Journal of Nephrology and Renovascular Disease / Nov 01, 2022
Maines, L. W., Green, C. L., Keller, S. N., Fitzpatrick, L. R., & Smith, C. D. (2022). The Sphingosine Kinase 2 Inhibitor Opaganib Protects Against Acute Kidney Injury in Mice. International Journal of Nephrology and Renovascular Disease, Volume 15, 323–334. https://doi.org/10.2147/ijnrd.s386396
Role of the δ-Opioid Receptor in 2 Murine Models of Colitis
Comparative Medicine / Feb 01, 2020
Bobo, T. R., Fitzpatrick, L. R., Whitcomb, T. L., Cooper, T. K., Raiciulescu, S., & Smith, J. P. (2020). Role of the δ-Opioid Receptor in 2 Murine Models of Colitis. Comparative Medicine, 70(1), 25–34. https://doi.org/10.30802/aalas-cm-19-000024
Evidence that the Ubiquitin Proteasome System Plays a Prominent Role in Inflammatory Bowel Disease: Possible Pharmacological Approaches
Pharmacy & Pharmacology International Journal / Feb 02, 2016
Fitzpatrick, L. R. (2016). Evidence that the Ubiquitin Proteasome System Plays a Prominent Role in Inflammatory Bowel Disease: Possible Pharmacological Approaches. Pharmacy & Pharmacology International Journal, 4(1). https://doi.org/10.15406/ppij.2016.04.00062
Tu1617 The Synthetic Triterpenoid (CDDO-IM) Inhibits STAT3, As Well As IL-17, and Improves DSS-Induced Colitis in Mice
Gastroenterology / May 01, 2013
Stonesifer, E., Fitzpatrick, L. R., Small, J., & Liby, K. T. (2013). Tu1617 The Synthetic Triterpenoid (CDDO-IM) Inhibits STAT3, As Well As IL-17, and Improves DSS-Induced Colitis in Mice. Gastroenterology, 144(5), S-807. https://doi.org/10.1016/s0016-5085(13)62986-8
Bacillus Coagulans (Bc 30 ) Improves Some Indices of Clostridium difficile -Induced Colitis in Mice
Gastroenterology / May 01, 2011
Fitzpatrick, L. R., Small, J. S., Greene, W., Karpa, K., & Keller, D. (2011). Bacillus Coagulans (Bc 30 ) Improves Some Indices of Clostridium difficile -Induced Colitis in Mice. Gastroenterology, 140(5), S-849. https://doi.org/10.1016/s0016-5085(11)63523-3
Characterization of the reactivation phase of dextran sodium sulfate (DSS)-induced colitis in rats
Gastroenterology / Apr 01, 1998
Fitzpatrick, L. R., Williams, J., & Le. Maryland, T. (1998). Characterization of the reactivation phase of dextran sodium sulfate (DSS)-induced colitis in rats. Gastroenterology, 114, A976. https://doi.org/10.1016/s0016-5085(98)83975-9
Novel characterization and quantification of bismuth binding to gastric mucosa
Gastroenterology / Apr 01, 1995
Novel characterization and quantification of bismuth binding to gastric mucosa. (1995). Gastroenterology, 108(4), A180. https://doi.org/10.1016/0016-5085(95)23381-4
Dietary Fiber, Bile Acids, and Intestinal Morphology
Dietary Fiber in Health and Disease / Jan 01, 1982
Cassidy, M. M., Lightfoot, F. G., & Vahouny, G. V. (1982). Dietary Fiber, Bile Acids, and Intestinal Morphology. In Dietary Fiber in Health and Disease (pp. 239–264). Springer US. https://doi.org/10.1007/978-1-4615-6850-6_22
Regulation of intestinal ornithine decarboxylase (ODC) expression during postnatal development by ODC antizyme in rats
Gastroenterology / Apr 01, 2000
Lin, C.-H., Tolia, V. K., & Vijesurier, R. M. (2000). Regulation of intestinal ornithine decarboxylase (ODC) expression during postnatal development by ODC antizyme in rats. Gastroenterology, 118(4), A292. https://doi.org/10.1016/s0016-5085(00)83253-9
RELT is overexpressed in human inflammatory bowel disease and breast cancer.
The Journal of Immunology / May 01, 2023
Cusick, J. K., Moua, P., Wong, S., Chang, E., Chou, E., Shyu, Y., Abram, A., Alcaide, J., Talbott, G., Yanumula, A., Qureshi, V., Budhiraja, A., Cusick, G., Shi, Y., Atapattu, D., & Fitzpatrick, L. (2023). RELT is overexpressed in human inflammatory bowel disease and breast cancer. The Journal of Immunology, 210(1_Supplement), 70.14-70.14. https://doi.org/10.4049/jimmunol.210.supp.70.14
Drug Discovery Approaches for Inflammatory Bowel Disease
Biologics and Biosimilars / May 03, 2022
Fitzpatrick, L. R., & Mokrushin, E. (2022). Drug Discovery Approaches for Inflammatory Bowel Disease. In Biologics and Biosimilars (pp. 371–384). CRC Press. https://doi.org/10.1201/9780429485626-23
In Vitro and Ex Vivo Effects of Silymarin Derivatives on Proinflammatory Cytokine Secretion Using a Murine Colonic Strip Model
Planta Medica International Open / Apr 01, 2018
Fitzpatrick, L., Mokrushin, E., Talbott, G., & Woldermariam, T. (2018). In Vitro and Ex Vivo Effects of Silymarin Derivatives on Proinflammatory Cytokine Secretion Using a Murine Colonic Strip Model. Planta Medica International Open, 5(02), e55–e60. https://doi.org/10.1055/a-0733-3716
Ex Vivo Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Colonic Strips of Mice with Dssinduced Colitis
Gastroenterology / Apr 01, 2017
Fitzpatrick, L. R., Talbott, G., Mokrushin, E., & Woldemariam, T. (2017). Ex Vivo Effects of Silymarin Fractions on Pro-Inflammatory Cytokine Secretion from Colonic Strips of Mice with Dssinduced Colitis. Gastroenterology, 152(5), S571. https://doi.org/10.1016/s0016-5085(17)32067-x
P012 Vidofludimus inhibits IL-17 and improves hapten-induced colitis in young rats by a unique dual mode of action
Journal of Crohn's and Colitis / Feb 01, 2012
Fitzpatrick, L. R., Small, J. S., Doblhofer, R., Henning, S. W., & Ammendola, A. (2012). P012 Vidofludimus inhibits IL-17 and improves hapten-induced colitis in young rats by a unique dual mode of action. Journal of Crohn’s and Colitis, 6, S15–S16. https://doi.org/10.1016/s1873-9946(12)60033-6
Colitis Development in IL-10 Deficient Mice Reveals a Direct Role of MCH in Regulating IL-10 Expression by Monocytes
Gastroenterology / May 01, 2011
Ziogas, D., ElKhal, A., Najarian, R. M., Mustafa, S. N., Reizes, O., Fitzpatrick, L. R., & Kokkotou, E. (2011). Colitis Development in IL-10 Deficient Mice Reveals a Direct Role of MCH in Regulating IL-10 Expression by Monocytes. Gastroenterology, 140(5), S-518. https://doi.org/10.1016/s0016-5085(11)62150-1
Alterations in amino acid uptake and transport in TNBS-induced colitis
Inflammatory Bowel Diseases / Dec 01, 2008
Puleo, F., Meng, Q., Navaratnarajah, M., Fitzpatrick, L., Koltun, W., & Cooney, R. (2008). Alterations in amino acid uptake and transport in TNBS-induced colitis: P-0016. Inflammatory Bowel Diseases, 14, S15. https://doi.org/10.1097/00054725-200812003-00051
Alterations in the IGF-I axis and ubiquitin E3 ligases (atrogin-1, MuRF1) in TNBS-induced colitis: A mechanism for loss of muscle mass in IBD
Inflammatory Bowel Diseases / Jan 01, 2008
Cooney, R., Fitzpatrick, L., Meirelles, K., Puleo, F., Koltun, W., & Lang, C. (2008). Alterations in the IGF-I axis and ubiquitin E3 ligases (atrogin-1, MuRF1) in TNBS-induced colitis: A mechanism for loss of muscle mass in IBD: P-077. Inflammatory Bowel Diseases, 14, S32. https://doi.org/10.1097/00054725-200801001-00110
S1743 Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Rats
Gastroenterology / Apr 01, 2008
Maines, L. W., Fitzpatrick, L. R., Green, C., & Smith, C. D. (2008). S1743 Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Rats. Gastroenterology, 134(4), A-261. https://doi.org/10.1016/s0016-5085(08)61214-7
The Devil Is in the Details: The Pharmaceutical Industry’s Use of Gifts to Physicians as Marketing Strategy
Journal of Surgical Research / Jun 01, 2007
McFadden, D. W., Calvario, E., & Graves, C. (2007). The Devil Is in the Details: The Pharmaceutical Industry’s Use of Gifts to Physicians as Marketing Strategy. Journal of Surgical Research, 140(1), 1–5. https://doi.org/10.1016/j.jss.2006.10.010
Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Mice
Gastrointestinal Endoscopy / Apr 01, 2007
Maines, L. W., Fitzpatrick, L. R., Green, C. L., & Smith, C. D. (2007). Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Mice. Gastrointestinal Endoscopy, 65(5), AB263. https://doi.org/10.1016/j.gie.2007.03.621
A Role For Meprin‐ α In A Model Of Inflammatory Bowel Disease
The FASEB Journal / Apr 01, 2007
Banerjee, S., Fitzpatrick, L. R., Bradley, S. G., & Bond, J. S. (2007). A Role For Meprin‐ α In A Model Of Inflammatory Bowel Disease. The FASEB Journal, 21(5). Portico. https://doi.org/10.1096/fasebj.21.5.a278-d
Education
PhD, Physiology
Post Doctoral Fellowship, GI Physiology
Experience
California NorthState University
Penn State College of Medicine
Otsuka Pharmaceutical
Procter and Gamble
Rhone Poulenc Rorer
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