Eshel Faraggi

Analytical Physicist

Research Expertise

Physics
Artificial Intelligence
Proteins
Cell Division
Ferromagnetism

About

Unique and passionate physicist with over 30 years experience in predicting the outcome of complex systems. Leading developer for a framework to predict the scaling of hysteresis, laser absorption by the retina, and the 3D structure of proteins. Responsible for implementing the bi-modal distribution of the protein dihedrals into protein structure prediction tools. Was among the first to introduce ML into 3D protein prediction. Over 15 years experience in ML and AI. A pioneer of this approach in bioinformatics.

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Publications

Improving protein fold recognition and template-based modeling by employing probabilistic-based matching between predicted one-dimensional structural properties of query and corresponding native properties of templates
Bioinformatics
2011
SPINE X: Improving protein secondary structure prediction by multistep learning coupled with prediction of solvent accessible surface area and backbone torsion angles
Journal of Computational Chemistry
2011
SPINE-D: Accurate Prediction of Short and Long Disordered Regions by a Single Neural-Network Based Method
Journal of Biomolecular Structure and Dynamics
2012
Predicting Continuous Local Structure and the Effect of Its Substitution for Secondary Structure in Fragment-Free Protein Structure Prediction
Structure
2009
Improving the prediction accuracy of residue solvent accessibility and real‐value backbone torsion angles of proteins by guided‐learning through a two‐layer neural network
Proteins: Structure, Function, and Bioinformatics
2008
BEST: Improved Prediction of B-Cell Epitopes from Antigen Sequences
PLoS ONE
2012
Real‐value prediction of backbone torsion angles
Proteins: Structure, Function, and Bioinformatics
2008
Direct prediction of profiles of sequences compatible with a protein structure by neural networks with fragment-based local and energy-based nonlocal profiles
Proteins: Structure, Function, and Bioinformatics
2014
Intrinsically Semi-disordered State and Its Role in Induced Folding and Protein Aggregation
Cell Biochemistry and Biophysics
2013
The GOR Method of Protein Secondary Structure Prediction and Its Application as a Protein Aggregation Prediction Tool
Methods in Molecular Biology
2016
Accurate single-sequence prediction of solvent accessible surface area using local and global features
Proteins: Structure, Function, and Bioinformatics
2014
DescribePROT: database of amino acid-level protein structure and function predictions
Nucleic Acids Research
2020
Predicting residue–residue contact maps by a two‐layer, integrated neural‐network method
Proteins: Structure, Function, and Bioinformatics
2009
Trends in template/fragment-free protein structure prediction
Theoretical Chemistry Accounts
2010
Magnetic energy loss in permalloy thin films and microstructures
Physical Review B
2005
Fluctuations of backbone torsion angles obtained from NMR‐determined structures and their prediction
Proteins: Structure, Function, and Bioinformatics
2010
Biophysical effects of pulsed lasers in the retina and other tissues containing strongly absorbing particles: shockwave and explosive bubble generation
Journal of Biomedical Optics
2005
A Global Machine Learning Based Scoring Function for Protein Structure Prediction
Biophysical Journal
2014
Stress confinement, shock wave formation, and laser-induced damage
SPIE Proceedings
2005
Methods for estimation of model accuracy in CASP12
Proteins: Structure, Function, and Bioinformatics
2017
Prediction of Protein Secondary Structure
Methods in Molecular Biology
2017
Comparing NMR and X-ray protein structure: Lindemann-like parameters and NMR disorder
Journal of Biomolecular Structure and Dynamics
2017
Prediction of One‐Dimensional Structural Properties Of Proteins by Integrated Neural Networks
Introduction to Protein Structure Prediction
2010
Intrinsic Disorder and Semi-disorder Prediction by SPINE-D
Methods in Molecular Biology
2016
Many-to-one binding by intrinsically disordered protein regions
Biocomputing 2020
2019
Fast and Accurate Accessible Surface Area Prediction Without a Sequence Profile
Methods in Molecular Biology
2016
GENN: A GEneral Neural Network for Learning Tabulated Data with Examples from Protein Structure Prediction
Methods in Molecular Biology
2014
Locally converging algorithms for determining the critical temperature in Ising systems
Physical Review B
2008
Entropy, Fluctuations, and Disordered Proteins
Entropy
2019
Accurate Prediction of One-Dimensional Protein Structure Features Using SPINE-X
Methods in Molecular Biology
2016
Acoustical resonant absorption of pulsed laser radiation by a spherical absorber
Journal of Applied Physics
2007
Reoptimized UNRES Potential for Protein Model Quality Assessment
Genes
2018
The emergence of chaos in a laser irradiated spherical absorber
Chaos: An Interdisciplinary Journal of Nonlinear Science
2007
Simulation of hysteresis in magnetic nanoparticles with Nosé thermostating
Physical Review E
2003
Ab-initio calculations for shock wave and bubble production with Gaussian temporal laser pulses
SPIE Proceedings
2004
Computational Ways to Enhance Protein Inhibitor Design
Frontiers in Molecular Biosciences
2021
A Hybrid Levenberg–Marquardt Algorithm on a Recursive Neural Network for Scoring Protein Models
Methods in Molecular Biology
2020
Net widens for funding ofarXivpreprint server
Physics World
2010
Explicit solutions to phenomenological models of magnetization reversal of thin ferromagnetic films in the presence of a sawtooth magnetic field
Journal of Magnetism and Magnetic Materials
2006
Magnetic behavior of partially filled finite Ising surfaces
Physical Review B
2006
Response to pulsed radiation by a spherical solid absorber immersed in a transparent fluid
SPIE Proceedings
2005
Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A
Unknown Venue
2024
DescribePROT in 2023: more, higher-quality and experimental annotations and improved data download options
Nucleic Acids Research
2023
Prediction of Protein Aggregation Propensities using GOR Method
Biophysical Journal
2017
New Methods to Improve Protein Structure Prediction and Refinement
Biophysical Journal
2013
Preprint repository arXiv achieves milestone million uploads
Physics Today
2014
Chaos in the pressure generated by laser absorption by microparticles
SPIE Proceedings
2006
Rapid discrimination between deleterious and benign missense mutations in the CAGI 6 experiment
Human Genomics
2024
Prediction of Deleterious Single Amino Acid Polymorphisms with a Consensus Holdout Sampler
Current Genomics
2024
Prediction of Functional Effects of Protein Amino Acid Mutations
Lecture Notes in Computer Science
2023
There is only charge: Heisenberg-Coulomb based theory of the quarks, nucleons, and the nuclei
Unknown Venue
2022
Accessible Surface Area and the Prediction of the Phenotypes of Missense Mutations
Unknown Venue
2022
Prediction of Deleterious Protein Mutations
Biophysical Journal
2021
Entropy, Fluctuations, and Disordered Proteins. Linking between Sequence, Structure, and Disorder Information
Biophysical Journal
2020
Protein Secondary Structure Assignments and Their Usefulness for Dihedral Angle Prediction
Springer Series on Bio- and Neurosystems
2018
Combining Prediction of Protein Aggregation Propensities with Prediction of Other One-Dimensional Properties
Biophysical Journal
2018
2d. Beitragsmodell (arXiv)
Praxishandbuch Open Access
2017
(Invited) Photoinduced Charge Separation and Charge Transport in Carbon Nanostructure-Based Devices
ECS Meeting Abstracts
2013
Studies of dynamic processes in biomedicine by high-speed spectral optical coherence tomography
SPIE Proceedings
2007
Analyzing chaos in the pressure generated by laser absorption by microparticles
SPIE Proceedings
2007
Resonant absorption in nanometer gold spherical particles
SPIE Proceedings
2006
Synergistic effects of laser and adjuvant therapies for cancer: progress in the development of novel cancer treatment methods using combinations of photothermal, photochemical, immunotherapy, and chemotherapy
SPIE Proceedings
2005
Flux balance analysis of myocardial mitochondrial metabolic network
SPIE Proceedings
2005
APS Abstracts Submitted for Presentation at the 2003 APS Annual Meeting
Phytopathology®
2003
Prediction of Cavitating Flow Around Single Or Two-Component
CFD 2003: CFD Technology In Ship Hydrodynamics
2003
Erratum: Ferromagnetism in the Kondo-lattice model [Phys. Rev. B65,144419 (2002)]
Physical Review B
2002
Monte Carlo study on ferromagnetic phase transition of two-dimensional Ising model
Proceedings of the 2016 Joint International Information Technology, Mechanical and Electronic Engineering
2016

Education

Hebrew University of Jerusalem

BSc, Math/physics / May, 1996

Jerusalem

The University of Texas at Austin

PhD, Physics -- Magnetization and complex systems / May, 2003

Austin, Texas, United States of America

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