Julie Freed

Physician Scientist who focuses on translational cardiovascular research

Research Expertise

microvasculature
endothelial biology
translational science

Legacy Map

Full View

Publications

The Human Microcirculation
Circulation Research
2016
Ceramide Changes the Mediator of Flow-Induced Vasodilation From Nitric Oxide to Hydrogen Peroxide in the Human Microcirculation
Circulation Research
2014
Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation
Circulation Research
2016
Heart Failure With Preserved Ejection Fraction: A Comprehensive Review and Update of Diagnosis, Pathophysiology, Treatment, and Perioperative Implications
Journal of Cardiothoracic and Vascular Anesthesia
2021
Communication Is Key: Mechanisms of Intercellular Signaling in Vasodilation
Journal of Cardiovascular Pharmacology
2017
PGC-1α (Peroxisome Proliferator–Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure
Hypertension
2017
Detrimental effects of chemotherapy on human coronary microvascular function
American Journal of Physiology-Heart and Circulatory Physiology
2019
Gender Differences in Authorship in the Journal of Cardiothoracic and Vascular Anesthesia: A 28-Year Analysis of Publications Originating From the United States, 1990-2017
Journal of Cardiothoracic and Vascular Anesthesia
2019
Treatment of Vasoplegic Syndrome With Intravenous Hydroxocobalamin During Liver Transplantation
Journal of Cardiothoracic and Vascular Anesthesia
2017
Gender Composition and Trends of Journal of Cardiothoracic and Vascular Anesthesia Editorial Board Membership: A 33-Year Analysis, 1987-2019
Journal of Cardiothoracic and Vascular Anesthesia
2019
Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation
American Journal of Physiology-Heart and Circulatory Physiology
2017
Mitochondrial Reactive Oxygen Species and Vascular Function
Arteriosclerosis, Thrombosis, and Vascular Biology
2013
High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock
CHEST
2023
Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow‐Induced Dilation in the Human Microvasculature
Journal of the American Heart Association
2019
Hydroxocobalamin With or Without Methylene Blue May Improve Fluid Balance in Critically Ill Patients With Vasoplegic Syndrome After Cardiac Surgery: A Report of Two Cases
Journal of Cardiothoracic and Vascular Anesthesia
2018
Proteomic Analysis of Shear Stress-Mediated Protection from TNF-α in Endothelial Cells
Microcirculation
2010
Isolation of signal transduction complexes using biotin and crosslinking methodologies
PROTEOMICS
2007
Role of Adiponectin Receptor 1 in Promoting Nitric Oxide-Mediated Flow-Induced Dilation in the Human Microvasculature
Frontiers in Pharmacology
2022
High‐Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review
Nutrition in Clinical Practice
2019
Cardiac Physiology
Kaplan's Essentials of Cardiac Anesthesia
2018
Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers
Planta Medica
2017
Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis
Circulation Research
2024
S1P (Sphingosine-1-Phosphate)–Induced Vasodilation in Human Resistance Arterioles During Health and Disease
Hypertension
2022
Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease
Circulation Research
2024
A 50-year analysis of gender differences in United States authorship of original research articles in two major anesthesiology journals
Scientometrics
2019
Hydroxocobalamin for treatment of catecholamine-resistant vasoplegia during liver transplantation: A single-center series of 20 cases
International Journal of Surgery Case Reports
2022
Revealing the Role of Phosphatidylserine in Shear Stress–Mediated Protection in Endothelial Cells
Endothelium
2008
Moderate Aortic Valvular Insufficiency Invalidates Vortex Formation Time as an Index of Left Ventricular Filling Efficiency in Patients With Severe Degenerative Calcific Aortic Stenosis Undergoing Aortic Valve Replacement
Journal of Cardiothoracic and Vascular Anesthesia
2016
Healing the Broken Heart With Adrenomedullin
Circulation Research
2019
Advanced Age Attenuates Left Ventricular Filling Efficiency Quantified Using Vortex Formation Time: A Study of Octogenarians With Normal Left Ventricular Systolic Function Undergoing Coronary Artery Surgery
Journal of Cardiothoracic and Vascular Anesthesia
2018
Moderate, Short-Term, Local Hyperglycemia Attenuates Forearm Endothelium-Dependent Vasodilation After Transient Ischemia-Reperfusion in Human Volunteers
Journal of Cardiothoracic and Vascular Anesthesia
2017
Acute, Severe Pulmonary Arterial Hypertension During Off-Pump Coronary Artery Surgery: Is New Myocardial Ischemia, Cardiac Repositioning, or External Mitral Valve Compression the Culprit?
Journal of Cardiothoracic and Vascular Anesthesia
2016
Cobalt Blues: A New Complication of Hydroxocobalamin Therapy for Vasopressor-Resistant Vasoplegia in Patients Treated With Chronic Renal Replacement Therapy?
Journal of Cardiothoracic and Vascular Anesthesia
2019
You Are Only as Frail as Your Arteries: Prehabilitation of Elderly Surgical Patients
Current Anesthesiology Reports
2019
A Rare Cause of Intermittent Dyspnea, Occasional Palpitations, and Atypical Chest Discomfort
Journal of Cardiothoracic and Vascular Anesthesia
2018
An Unusual Finding in a Woman Undergoing Resection of a Large Anterior Mediastinal Mass
Journal of Cardiothoracic and Vascular Anesthesia
2018
A Rare Complication of Cardiopulmonary Resuscitation After Mitral Valve Replacement
Journal of Cardiothoracic and Vascular Anesthesia
2017
Is the peripheral microcirculation a window into the human coronary microvasculature?
Journal of Molecular and Cellular Cardiology
2024
Activation of Neutral Sphingomyelinase Contributes to Nitric Oxide‐Mediated Flow‐Induced Dilation in the Human Microvasculature
The FASEB Journal
2020
An Unexpected Finding During Repair of An Ascending Aortic Aneurysm
Journal of Cardiothoracic and Vascular Anesthesia
2018
Ying and Yang of Ceramide in the Vascular Endothelium
Arteriosclerosis, Thrombosis, and Vascular Biology
2024
Role of SIRT3 in Compensatory Flow-Induced Dilation Following High Pressure Stress in the Human Microcirculation
Physiology
2024
Blockade of endothelial Mas receptor restores the vasomotor response to phenylephrine in human resistance arterioles pretreated with captopril and exposed to propofol
BMC Anesthesiology
2022
Role of NOX2 in Ceramide‐Induced Human Microvascular Endothelial Dysfunction
The FASEB Journal
2022
Investigation of the Dual Functional Role of Ceramide in the Human Microcirculation
The FASEB Journal
2021
Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry
British Journal of Anaesthesia
2021
Role of AMPK in Adiponectin‐Mediated Restoration of Nitric Oxide‐Dependent Flow Induced Dilation in the Human Microvasculature
The FASEB Journal
2020
Characteristics associated with Publication of Randomized Controlled Trials in the Journal of Cardiothoracic and Vascular Anesthesia: A 15-Year Analysis, 2004-2018
Journal of Cardiothoracic and Vascular Anesthesia
2020
Effects of Anti‐Cancer Therapy on Human Microvascular Function ‐ a Longitudinal Study
The FASEB Journal
2020
Short-Term Angiotensin Subtype 1 Receptor Blockade Does Not Alter the Circulatory Responses to Sympathetic Nervous System Modulation in Healthy Volunteers Before and During Sevoflurane Anesthesia: Results of a Pilot Study
Journal of Cardiothoracic and Vascular Anesthesia
2016
Inhibition of Neutral Sphingomyelinase Prevents High Pressure‐Induced Shift in the Mediator of Endothelium‐Dependent Dilation from NO to H2O2
The FASEB Journal
2013
Advances in cardiovascular pharmacotherapy. II. Ivabradine, an inhibitor of the hyperpolarization-activated cyclic nucleotide-gated channel
Journal of Cardiothoracic and Vascular Anesthesia
2025
Advances in Cardiovascular Pharmacotherapy. I. Cardiac Myosin Inhibitors
Journal of Cardiothoracic and Vascular Anesthesia
2025
Abstract 4143871: Effect of Continuous Estrogen on Peripheral Microvascular Function in Women of Trans Experience
Circulation
2024
Abstract 4141446: Sodium Glucose Co-transporter 2 (SGLT2) Inhibitors Promote Resiliency to High Pressure Stress in the Human Microvasculature
Circulation
2024
Abstract 4141873: Estrogen Activates Endothelial Neutral Sphingomyelinase in a Sex-Dependent Manner
Circulation
2024
Acetylcholine-Induced Dilation in Human Arterioles Requires Ceramide Formation
Arteriosclerosis, Thrombosis, and Vascular Biology
2024
Activation of Piezo-1 Prevents Human Microvascular Endothelial Dysfunction During Acute Inhibition of Ceramide Formation
Physiology
2024
Divergent Vasodilator Mechanisms to Endothelial-Dependent Agonists with Advancing Age
Physiology
2024
Sphingosine-1-Phosphate Promotes Resiliency to External Stress in the Human Microvasculature
Physiology
2024
Chronic Estrogen Treatment Promotes Human Microvascular Endothelial Dysfunction Through Sex-Specific Regulation of Ceramide Formation
Physiology
2024
High Intensity Interval Exercise Causes Acute Microvascular Dysfunction in Elderly Individuals with Low Cardiorespiratory Fitness - A Pilot Study
Physiology
2024
865 Toll-like Receptor 9 (TLR9) suppression restores endothelial function in the maternal placental microvasculature in preeclampsia
American Journal of Obstetrics and Gynecology
2024
Abstract 11818: The Beneficial Effects of Ceramide on Human Microvascular Endothelial Function is Dependent on S1P/S1PR1 Signaling Axis
Circulation
2023
Abstract 12494: Role of Ceramide in Estrogen-Induced Oxidative Stress in Endothelial Cells From Individuals Assigned Male at Birth
Circulation
2023
Elevated Estrogen Induces Senescence in Male Endothelial Cells Via Neutral Sphingomyelinase-Mediated Ceramide Formation
Physiology
2023
Abstract 549: Ceramide Signaling Potentiates Microvascular Endothelial Dysfunction In Patients With Coronary Artery Disease
Arteriosclerosis, Thrombosis, and Vascular Biology
2023
Abstract 12364: Exogenous Sphingosine-1-Phosphate Restores Nitric Oxide-Mediated Flow-Induced Dilation During Acute Inhibition of Ceramide Formation
Circulation
2022
Abstract 470: Sphingosine-1-Phosphate Signaling In The Human Microvascular Endothelium During Health And Disease
Arteriosclerosis, Thrombosis, and Vascular Biology
2022
Is Estrogen a Friend or Foe of the Human Microcirculation Throughout the Lifespan?
The FASEB Journal
2022
Catheter‐based system for the treatment of left ventricular assist device thrombosis
Artificial Organs
2022
Investigation of Sphingosine‐1‐Phosphate‐induced Vasodilation in the Human Microvasculature
The FASEB Journal
2021
Role of AMPK in Determining the Mediator of Flow Induced Dilation in the Human Microvasculature
The FASEB Journal
2021
Human Microvascular Reactivity In Vivo Using Incident Dark Field Videomicroscopy
The FASEB Journal
2021
Sphingosine‐1‐Phosphate Receptor 1 Mediated Vasodilation in Human Arterioles
The FASEB Journal
2020
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Journal of Visualized Experiments
2018
There is no way to sugar coat it, you are getting older
American Journal of Physiology-Heart and Circulatory Physiology
2018
An Unusual Cause of an Isolated Transient Ischemic Attack in an Otherwise Healthy Elderly Man
Journal of Cardiothoracic and Vascular Anesthesia
2018
Methylene Blue
Anesthesia & Analgesia
2016
word count
SpringerReference
A Rare Complication of Metastatic Osteosarcoma
Journal of Cardiothoracic and Vascular Anesthesia
2017
Abstract 12272: Sphingosine-1-phosphate Reverts the Mechanism of Flow Induced Dilation to Nitric Oxide in Diseased Human Arterioles
Circulation
2015
Promoting Resiliency to Stress in the Vascular Endothelium
Basic & Clinical Pharmacology & Toxicology
2025
Noninvasive assessment of human microvascular function in health and disease using incident dark-field microscopy
American Journal of Physiology-Heart and Circulatory Physiology
2024
Addressing the decline in graduate students’ mental well-being
American Journal of Physiology-Heart and Circulatory Physiology
2023
Necessary Role of Acute Ceramide Formation in The Human Microvascular Endothelium During Health and Disease
Unknown Venue
2023
Estrogen and the Vascular Endothelium: The Unanswered Questions
Endocrinology
2023
17β-Estradiol promotes sex-specific dysfunction in isolated human arterioles
American Journal of Physiology-Heart and Circulatory Physiology
2023
New developments in translational microcirculatory research
American Journal of Physiology-Heart and Circulatory Physiology
2022
Vascular endothelial adiponectin signaling across the life span
American Journal of Physiology-Heart and Circulatory Physiology
2022
Sweat the small stuff: The human microvasculature and heart disease
Microcirculation
2020
Crossing signals: bioactive lipids in the microvasculature
American Journal of Physiology-Heart and Circulatory Physiology
2020

Education

Medical College of Wisconsin

Ph.D., Physiology / May, 2008

Milwaukee, Wisconsin, United States of America

Medical College of Wisconsin

M.D. / May, 2011

Milwaukee, Wisconsin, United States of America

Experience

Medical College of Wisconsin

Executive Vice Chair, Associate Professor / July, 2017Present

Join Dr. Freed on NotedSource!
Join Now

At NotedSource, we believe that professors, post-docs, scientists and other researchers have deep, untapped knowledge and expertise that can be leveraged to drive innovation within companies. NotedSource is committed to bridging the gap between academia and industry by providing a platform for collaboration with industry and networking with other researchers.

For industry, NotedSource identifies the right academic experts in 24 hours to help organizations build and grow. With a platform of thousands of knowledgeable PhDs, scientists, and industry experts, NotedSource makes connecting and collaborating easy.

For academic researchers such as professors, post-docs, and Ph.D.s, NotedSource provides tools to discover and connect to your colleagues with messaging and news feeds, in addition to the opportunity to be paid for your collaboration with vetted partners.

Expert Institutions
NotedSource has experts from Stanford University
Expert institutions using NotedSource include Oxfort University
Experts from McGill have used NotedSource to share their expertise
University of Chicago experts have used NotedSource
MIT researchers have used NotedSource
Proudly trusted by
Microsoft uses NotedSource for academic partnerships
Johnson & Johnson academic research projects on NotedSource
ProQuest (Clarivate) uses NotedSource as their industry academia platform
Slamom consulting engages academics for research collaboration on NotedSource
Omnicom and OMG find academics on notedsource
Unilever research project have used NotedSource to engage academic experts

Connect with researchers and scientists like Julie Freed on NotedSource to help your company with innovation, research, R&D, L&D, and more.