Luca Tottone, Ph.D.

Oncology Scientist at the Sylvester Comprehensive Cancer Center (SCCC) - University of Miami

Research Expertise

Cancer Research
Oncology
Hematology
Molecular Biology
Biochemistry
Cell Biology
Immunology

About

PhD Scientist with 10+ years of hands-on research proficiency in the fields of small molecule drug discovery and preclinical biomarkers, conducting in vivo and in vitro translational studies in the field of cancer biology, with specific focus on hematology, blood malignancies, and therapeutics. <br> I have successfully authored several grant proposals (NJ Department of Health, American Society of Hematology, WES leukemia society), top-notch scientific papers (7 peer-reviewed scientific articles and counting), technical reports (international patent deposit for anti-leukemic small inhibitors), and presented my results to world-renowned experts during national and international meetings (Outstanding Abstract Award - Federation of American Societies for Experimental Biology among the others). In a nutshell:  Oncology scientist with proficiency in drug discovery, pre-clinical discovery, target validation, epigenetics.  Expert in in vivo/in vitro disease and mechanistic modeling, with focus on T-cell and myeloid leukemias therapeutics.  In vivo modeling of tumor generation, bone marrow transplants, PDXs, in vivo treatment, tissue sampling, necroscopy.  Gene editing expertise via viral and RNP gene transduction, RNAi, gene overexpression, gene silencing, CRISPR/Cas9.  Expertness in cell-based techniques, primary human samples isolation, cell culturing, aseptic techniques, drug testing.  NGS assays (RNA-Seq, scRNA-Seq, ChIP-Seq), RNA assays (qPCR), DNA assays (PCR, ChIP), Protein assays (IP, WB), Flow cytometry.  Critical thinker capable in managing complex scientific programs with excellent track record of scientific achievements.

Education

Sapienza University of Rome

PhD, Molecular Medicine

Rome

Sapienza University of Rome

Medical Biotechnology, Molecular Medicine

Rome

University of Teramo

Biotechnology

Teramo

Experience

Sylvester Comprehensive Cancer Center

Assistant Scientist / May, 2022Present

Rutgers University New Brunswick

Postdoctoral Fellowship / March, 2018Present

Istituto Pasteur-Fondazione Cenci Bolognetti

Postdoctoral Fellowship / November, 2017January, 2018

Istituto Italiano di Tecnologia Center for Life Nano Science

Postdoctoral Fellowship / February, 2017October, 2017

Links & Social Media

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