Dr. Jesse Butterfield
PhD engineer and former venture-backed founder with end-to-end experience in nanoparticle-based API-adjacent technologies process development and scale-up and coordinating external labs and manufacturers for regulated patient-facing products
About
Publications
Education
University of Colorado Boulder
Doctor of Philosophy / 2022
University of Colorado Boulder
M.S. / 2017
University of Washington
B.S. / 2013
Experience
Jesse Butterfield LLC
Founder, Contract Engineer, Musician / January, 2025 — December
Provide contract engineering support to early-stage technology ventures including mechanical design experimental planning and technical documentation for solar and hardware concepts. Bridge income with short-term gigs and paid musical performances while pursuing intensive personal projects in engineering music and writing. Drafted 4 patent apps on new tech.
HYPRSKN Inc.
Co-Founder, VP, Chief Technology Officer / January, 2021 — December, 2024
Co-founded company; owned RD roadmap manufacturing strategy and technical hiring (built mentored a 4-person lab). Invented and scaled photoresponsive biomaterials from benchtop to multi-liter production batches; improved yieldconsistency and lowered COGS. Standardized product and test batch characterization (DLS SEM viscometryrheology radiometry dosimetry colorimetry in-skin evaluations) and photoswitchingphotostability test methods. Implemented an early QMS backbone (SOP templates doc control training records) to support GMP readiness and tech transfer. Led DOE-driven process windows (synthesis dopant loading emulsification filtration formulation mixing sterilization) and authored clear technical reports for decisionshand-offs. Led strategic investor diligence: expedited two same-day patent filings to enable safe disclosure; delivered claim-to-capability mapping and technical demos. Vendor selectionprocurement; specs COAs and acceptance criteria with suppliers. Personally piloted longitudinal intradermal (self-use) evaluations of prototype materials under controlled photo-exposure; documented with standardized imaging and translated findings into DOE and SOP updates.
CHROMAPRAXIS LLC
Co-Founder, Chief Technology Officer / January, 2021 — December, 2022
Transitioned university research to startup-ready processes; built prototype workflows and experimental SOPs; prepared early IP disclosures. Ran initial opticalkinetics characterization and ex vivoin vivo evaluation planning.
University of Colorado Boulder
Research Assistant, Graduate Instructor / January, 2015 — December, 2022
Research (PhD MechEnanobiointerface): designed photoresponsive biomaterials (photochromic UV-absorbing in-skin colorimetric sensing); built UV-Vis Radiometry Dosimetry image-analysis workflows; led DOE studies; first-author publications + co-authored patents. Teaching (Instructor of Record DynamicsMCEN 2043): designed flippedhybrid sections rubricsproblem sets mentoring.
Boeing Commercial Airplanes
Mechanical Systems Engineer / January, 2013 — December, 2015
Supported 777X mechanicalhydraulics with configurationdocument control and cross-functional sign-offs for designmanufacturing changes. Coordinated suppliers; contributed to root-causecorrective actions and verification testing.
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