Nasim Jamali, PhD

Broad Institute of MIT and Harvard

Research Expertise

Microscopy
Image analysis
Angiogenesis
Vit D
Retinopathy of Prematurity
Physiology (medical)
Cardiology and Cardiovascular Medicine
Physiology
Cancer Research
Molecular Medicine
Media Technology
Cell Biology
Health Informatics
Molecular Biology
Genetics
Biotechnology
Endocrinology, Diabetes and Metabolism

About

I am a growth-mindset computational biologist with a diverse background in cell biology, microscopy, imaging data analysis, and morphological profiling. I have experience with bringing an idea to development, user survey design and analysis, and defining product scope.

Legacy Map

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Publications

Vitamin D and regulation of vascular cell function
American Journal of Physiology-Heart and Circulatory Physiology
2018
Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)2D3
PLOS ONE
2017
Optimizing the Cell Painting assay for image-based profiling
Nature Protocols
2023
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations
Unknown Venue
2022
1,25(OH)2D3regulates the proangiogenic activity of pericyte through VDR‐mediated modulation of VEGF production and signaling of VEGF and PDGF receptors
FASEB BioAdvances
2019
Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature
PLOS ONE
2017
Bcl-2 Expression in Pericytes and Astrocytes Impacts Vascular Development and Homeostasis
Scientific Reports
2019
Time‐lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition
Journal of Biophotonics
2018
Endothelium Expression of Bcl-2 Is Essential for Normal and Pathological Ocular Vascularization
PLOS ONE
2015
2020 BioImage Analysis Survey: Community experiences and needs for the future
Biological Imaging
2021
Modulation of Vascular Cell Function by Bim Expression
International Journal of Cell Biology
2013
Quantitative assessment of retinopathy using multi-parameter image analysis
Journal of Medical Signals & Sensors
2016
A biologist’s guide to planning and performing quantitative bioimaging experiments
PLOS Biology
2023
Assessing the performance of the Cell Painting assay across different imaging systems
Unknown Venue
2023
Vitamin D Receptor Expression Limits the Angiogenic and Inflammatory Properties of Retinal Endothelial Cells
Cells
2023
Vitamin D attenuates proangiogenic properties of pericytes through increased production of VEGF (679.1)
The FASEB Journal
2014
Vitamin D Receptor Expression is Essential for the Antiangiogenic Activity of Vitamin D
The FASEB Journal
2016
Expression of Bim in Retinal Endothelial Cells or Pericytes is Essential for Normal Regression of the Fetal Vasculature
The FASEB Journal
2016
Bcl‐2 Expression in Endothelial Cells Impacts Retinal Vascularization and Choroidal Neovascularization
The FASEB Journal
2015
Neurosymbolic System Profiling: A Template-Based Approach
Unknown Venue
2023
Ensuring Quality in Thyroid Cancer Surgery
US Endocrinology
2017

Education

University of Wisconsin, Madison

PhD, Cellular and Molecular Biology / August, 2017

Madison, Wisconsin, United States of America

Experience

Broad Institute

Postdoctoral Researcher / September, 2019March, 2022

▪ Co-led the image analysis effort (pilot experiments) of the JUMP-Cell Painting Consortium ▪ Actively contributed to the community engagement and driving biological projects of the Center for Open BioImage Analysis (COBA) ▪ Designed and executed image analysis workflow for collaborative projects ▪ Provided expertise and consultation to the community through office hours and image.sc forum ▪ Prepared and conducted workshops and training materials for image analysis and CellProfiler

Icahn School of Medicine at Mount Sinai

Associate Scientist / October, 2018September, 2019

▪ Trained users on the basics of microscopy, quantitative imaging, and various types of microscopes usage ▪ Provided experimental design, troubleshooting, and image analysis services ▪ Prepared training materials and seminars ▪ Managed and executed several internal core facility projects

University of Madison, WI

Postdoctoral Research Associate / September, 2017September, 2018

▪ Trained new students and managed trainees and technicians in the lab ▪ Performed analysis utilizing techniques including mammalian cell culture, flow cytometry, protein isolation, SDS-PAGE, immunoblotting, transient transfection, stable cell-line generation using viral vectors, luciferase assays, ELISA, fluorescence microscopy, angiogenesis assays ▪ Prepared manuscripts, presentations, and helped in writing grants ▪ Participated in meetings with principal investigator and research staff to evaluate and interpret data, develop new methodologies, and evaluate and update research protocols ▪ Actively participated in research, data analysis, and report writing for collaboration research projects

Dewpoint Therapeutics

Data Scientist / April, 2022February, 2024

▪Lead data analysis for internal high-throughput and high-content experiments ▪ Design and develop image analysis workflows ▪ Develop algorithms for analyzing profiles extracted from images ▪ Develop reports and deliver results to the stakeholders ▪ Product owner for an internal software application ▪ Help Business Development unit to assess available platforms for image analysis and morphological profiling ▪ Manage tissue analysis efforts using Jira

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