Jerome Ferrance

Scientist with an Engineering Degree

Research Expertise

Biomedical Engineering
Condensed Matter Physics
Bioengineering
Genetics
Pathology and Forensic Medicine
Electronic, Optical and Magnetic Materials
Biochemistry
Analytical Chemistry
Spectroscopy
Environmental Chemistry
Electrochemistry
Atomic and Molecular Physics, and Optics
Modeling and Simulation
Molecular Biology
Organic Chemistry
Clinical Biochemistry
Biochemistry (medical)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry
Instrumentation
Medical Laboratory Technology
Computer Science Applications
Colloid and Surface Chemistry
Catalysis
Ceramics and Composites
Biophysics
Cell Biology
Applied Microbiology and Biotechnology
Biotechnology
Atmospheric Science
Space and Planetary Science
Oncology
Cancer Research

About

I run a research and consulting business focused on solving problems in the bioanalytical, microfluidic, and nanotechnology sectors.  Having an extensive background from research and education in multiple disciplines, I generate outside-the-box solutions to meet client needs.  Work for recent clients has included training on DNA analysis for identification and diagnostic purposes, immunoassay improvements, evaluation of new instrumentation for soil testing, evaluation of material coatings for products in petroleum storage applications, utilization of chemical bath deposition methods, photovoltaic cell development, integration of carbon nanotubes into photovoltaic devices, and development of photonic and microfluidic devices for integration with THz spectroscopy analysis.  As part of my work, I prepare proposals and collaborate with clients to prepare proposals for government and private agencies to secure funding for cutting edge technology development.

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Publications

Chitosan Stabilized Single Walled Carbon Nanotube Strings for Biosensor Development
Journal of Nanoscience and Nanotechnology
2016
Enhanced recovery of spermatozoa and comprehensive lysis of epithelial cells from sexual assault samples having a low cell counts or aged up to one year
Forensic Science International: Genetics
2014
Liquid chromatography-mass spectrometry interface for detection of extraterrestrial organics
2014 IEEE Aerospace Conference
2014
Organics Analyzer for Sampling Icy Surfaces: A liquid chromatograph-mass spectrometer for future in situ small body missions
2013 IEEE Aerospace Conference
2013
Portable sub-terahertz resonance spectrometer combined with microfluidic sample cell
SPIE Proceedings
2013
Sub-terahertz resonance spectroscopy of biological macromolecules and cells
SPIE Proceedings
2013
Effect of Nanocrystals on the Photoresponse of Carbon Nanotube Strings
Journal of Nanoelectronics and Optoelectronics
2012
Microchip extraction of catecholamines using a boronic acid functional affinity monolith
Analytica Chimica Acta
2011
Nanomaterials enabled fiber optic networks
2011 IEEE Avionics, Fiber- Optics and Photonics Technology Conference
2011
Photo-Induced Current Changes in Carbon Nanotube Films Incorporating CdSe Nanocrystals
Journal of Nanoelectronics and Optoelectronics
2011
Single‐walled Carbon Nanotube Strings for Biosensor Development
Electroanalysis
2011
Solid phase extraction of DNA from biological samples in a post-based, high surface area poly(methyl methacrylate) (PMMA) microdevice
Lab on a Chip
2011
A simple method for the evaluation of microfluidic architecture using flow quantitation via a multiplexed fluidic resistance measurement
Lab on a Chip
2010
An integrated microfluidic device for DNA purification and PCR amplification of STR fragments
Forensic Science International: Genetics
2010
Characterization of dynamic solid phase DNA extraction from blood with magnetically controlled silica beads
The Analyst
2010
Development of a micro-total analysis system (μ-TAS) for the determination of catecholamines
Analytical and Bioanalytical Chemistry
2010
Dual-Domain Microchip-Based Process for Volume Reduction Solid Phase Extraction of Nucleic Acids from Dilute, Large Volume Biological Samples
Analytical Chemistry
2010
Integration of a Precolumn Fluorogenic Reaction, Separation, and Detection of Reduced Glutathione
Analytical Chemistry
2010
Solvent effects on the electrical and optical properties of composite carbon nanotube/MEH-PPV films
Journal of Nanoparticle Research
2009
An automated micro-solid phase extraction device involving integrated \high-pressure microvalves for genetic sample preparation
Biomedical Microdevices
2009
Chitosan-Coated Silica as a Solid Phase for RNA Purification in a Microfluidic Device
Analytical Chemistry
2009
Genotyping of α-thalassemia deletions using multiplex polymerase chain reactions and gold nanoparticle-filled capillary electrophoresis
Journal of Chromatography A
2009
Protein determination by microchip capillary electrophoresis using an asymmetric squarylium dye: Noncovalent labeling and nonequilibrium measurement of association constants
ELECTROPHORESIS
2008
Quantification of SMN1 and SMN2 genes by capillary electrophoresis for diagnosis of spinal muscular atrophy
ELECTROPHORESIS
2008
Single nucleotide polymorphism detection in the hMSH2 gene using conformation‐sensitive CE
ELECTROPHORESIS
2008
Towards an integrated microfluidic device for spaceflight clinical diagnostics
Journal of Chromatography A
2008
A Low-Cost, Low-Power Consumption, Miniature Laser-Induced Fluorescence System for DNA Detection on a Microfluidic Device
Clinics in Laboratory Medicine
2007
An active microfluidic system packaging technology
Sensors and Actuators B: Chemical
2007
Expedited, Chemically Enhanced Sperm Cell Recovery from Cotton Swabs for Rape Kit Analysis*
Journal of Forensic Sciences
2007
Gellan beads as a transparent media for protein immobilization and affinity capture
Journal of Chromatography A
2007
Microfluidic chip-based protein capture from human whole blood using octadecyl (C18) silica beads for nucleic acid analysis from large volume samples
Journal of Chromatography A
2007
Microfluidic-Based DNA Purification in a Two-Stage, Dual-Phase Microchip Containing a Reversed-Phase and a Photopolymerized Monolith
Analytical Chemistry
2007
On‐line sample stacking and short‐end injection CE for the determination of fluoxetine and norfluoxetine in plasma: Method development and validation using experimental designs
ELECTROPHORESIS
2007
A Low-Cost, Low-Power, Consumption Miniature Laser-Induced Fluorescence System for DNA Detection on a Microfluidic Device
JALA: Journal of the Association for Laboratory Automation
2006
A fully integrated microfluidic genetic analysis system with sample-in–answer-out capability
Proceedings of the National Academy of Sciences
2006
A microchip sensor for calcium determination
Analytical and Bioanalytical Chemistry
2006
A Simple, Valveless Microfluidic Sample Preparation Device for Extraction and Amplification of DNA from Nanoliter-Volume Samples
Analytical Chemistry
2006
Chitosan as a Polymer for pH-Induced DNA Capture in a Totally Aqueous System
Analytical Chemistry
2006
DNA Extraction Using a Tetramethyl Orthosilicate-Grafted Photopolymerized Monolithic Solid Phase
Analytical Chemistry
2006
Enhanced Elution of Sperm from Cotton Swabs Via Enzymatic Digestion for Rape Kit Analysis*
Journal of Forensic Sciences
2006
Extraction of C-reactive protein from serum on a microfluidic chip
Analytica Chimica Acta
2006
Method for determining intracapillary solution temperatures: Application to sample zone heating for enhanced fluorescent labeling of proteins
ELECTROPHORESIS
2006
Microchip‐Based Cell Lysis and DNA Extraction from Sperm Cells for Application to Forensic Analysis
Journal of Forensic Sciences
2006
Microchip-Based Macroporous Silica Sol−Gel Monolith for Efficient Isolation of DNA from Clinical Samples
Analytical Chemistry
2006
Protein digestion and phosphopeptide enrichment on a glass microchip
Analytica Chimica Acta
2006
Quenching of the Electrochemiluminescence of Tris(2,2‘-bipyridine)ruthenium(II) by Ferrocene and Its Potential Application to Quantitative DNA Detection
Journal of the American Chemical Society
2006
Use of a capillary electrophoresis instrument with laser-induced fluorescence detection for DNA quantitation
Journal of Chromatography A
2006
Extrinsic Fabry−Perot Interferometry for Noncontact Temperature Control of Nanoliter-Volume Enzymatic Reactions in Glass Microchips
Analytical Chemistry
2005
Glass microfluidic devices with thin membrane voltage junctions for electrospray mass spectrometry
Lab on a Chip
2005
Pressure Injection on a Valved Microdevice for Electrophoretic Analysis of Submicroliter Samples
Analytical Chemistry
2005
Separation of Sperm and Epithelial Cells in a Microfabricated Device:  Potential Application to Forensic Analysis of Sexual Assault Evidence
Analytical Chemistry
2004
The performance of a microchip-based fiber optic detection technique for the determination of Ca2+ ions in urine
Sensors and Actuators B: Chemical
2005
Microchip Laser-Induced Fluorescence Detection of Proteins at Submicrogram per Milliliter Levels Mediated by Dynamic Labeling under Pseudonative Conditions
Analytical Chemistry
2004
The design and testing of a silica sol–gel-based hybridization array
Journal of Non-Crystalline Solids
2004
A microchip-based proteolytic digestion system driven by electroosmotic pumping
Lab on a Chip
2003
Capillary electrophoresis with laser-induced fluorescence detection for laboratory diagnosis of galactosemia
Journal of Chromatography A
2003
Developments toward a complete micro-total analysis system for Duchenne muscular dystrophy diagnosis
Analytica Chimica Acta
2003
Microchip-Based Purification of DNA from Biological Samples
Analytical Chemistry
2003
An innovative separation platform: electrophoretic microchip technology
Handbook of Modern Pharmaceutical Analysis
2001
Exploiting sensitive laser‐induced fluorescence detection on electrophoretic microchips for executing rapid clinical diagnostics
Luminescence
2001
Polymerase Chain Reaction in Polymeric Microchips: DNA Amplification in Less Than 240 Seconds
Analytical Biochemistry
2001
Analysis of metabolic fluxes in batch and continuous cultures of Bacillus subtilis
Biotechnology and Bioengineering
1993
Utilization of glucose and amino acids in insect cell cultures: Quantifying the metabolic flows within the primary pathways and medium development
Biotechnology and Bioengineering
1993
Testing of Ion Exchange Solid Phase Extraction Media for Extraterrestrial In Situ Sample Preparation on Liquid Samples
ACS Earth and Space Chemistry
2023
Solid phase extraction on reverse phase chromatographic media subjected to stresses expected for extraterrestrial implementation
The Analyst
2022
Sub-terahertz vibrational spectroscopy of ovarian cancer and normal control tissue for molecular diagnostic technology
Cancer Biomarkers
2019

Education

Ph.D., Chemical Engineering / August, 1996

Pittsburgh, Pennsylvania, United States of America

Experience

J2F Engineering

Sole Proprietor / June, 2010Present

My own Research and consulting company

Vibratess, LLC

President / January, 2021Present

A small spectroscopy development company

University of Virginia

Research Assistant Professor / March, 2003June, 2010

Ran analytical biochemical/microfluidic laboratory

Pettit Applied Technologies

Director of Scientific Operations / February, 2007June, 2010

Development of new technologies and methods

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