Muqddas Tariq

Post-Doctoral fellow, NYU Grossman school of medicine.

Research Expertise

Stem cell biology
RNA biology
Epitranscriptome modifications
m6A
Cell Biology
Biotechnology
Biochemistry
Molecular Biology
Infectious Diseases
Virology
Genetics
Molecular Medicine
Immunology
Developmental Biology

About

I am Muqddas Tariq, currently working as a postdoctoral fellow in the Ronald O. Perelman Department of Dermatology, NYU Langone Medical Center since October 2023. I am from Pakistan and obtained my Ph.D. from the Guangzhou Institutes of Biomedicine & Health (GIBH), Chinese Academy of Sciences (CAS), majoring in Cell Biology. As part of my Ph.D. projects, I worked in the area of stem cell and regenerative biology and acquired the necessary skill set relevant to cell/molecular biology, RNA binding protein interactome analysis, and epitranscriptome modifications. Until now, I have contributed to 17 publications (including research and review articles), 10 of which emerged during my Ph.D. tenure at GIBH.  During my doctoral study, I have been working on a project that led to the development of a new methodology, named RICK (RNA Interactome capture using ClicK chemistry), for systemic capturing of the newly transcribed RNA binding proteins (RBPs) in cancer and mESCs. The working principle of this methodology is based upon the incorporation of 5-ethynyluridine (EU) into newly transcribed RNAs followed by click chemistry. Parts of the work were later published in ***Nature Methods ***2018 (my credit as a 2nd author) and ***Nature Protocols*** 2021 (my credit as a co-first author). Apart from establishing the RICK methodology, I generated three induced pluripotent stem cells (iPSCs) lines from a Parkinson’s disease patient with mutant *PARKIN*. Part of this work was then published in ***Stem Cell Research*** 2020. Moreover, I also worked on a project aimed at identifying N6-methyladenosine (m6A)-based mRNA binding exclusive RBPs *in vivo* using *Mettl3* KO and WT mESCs. My efforts led to defining an m6A interactome (containing some novel binders and repellants) that was not identified previously. This work was still in progress when I left the lab in my capacity as an “Associate researcher” (the position I got hired for after my graduation in 2020 during the COVID-19 surge in China).

Legacy Map

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Publications

Capturing the interactome of newly transcribed RNA
Nature Methods
2018
CXCL13/CXCR5 signaling axis in cancer
Life Sciences
2019
Role of viral and host factors in interferon based therapy of hepatitis C virus infection
Virology Journal
2013
Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2
Nucleic Acids Research
2020
Current and future therapies for hepatitis C virus infection: from viral proteins to host targets
Archives of Virology
2013
Correlation of OAS1 Gene Polymorphism at Exon 7 Splice Accepter Site with Interferon-Based Therapy of HCV Infection in Pakistan
Viral Immunology
2014
Transcript Analysis of P2X Receptors in PBMCs of Chronic HCV Patients: An Insight into Antiviral Treatment Response and HCV-Induced Pathogenesis
Viral Immunology
2013
β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus
Science Advances
2020
The mTORC1‐eIF4F axis controls paused pluripotency
EMBO reports
2021
Capture of the newly transcribed RNA interactome using click chemistry
Nature Protocols
2021
Intricacies in the cross talk between metabolic enzymes, RNA, and protein translation
Journal of Molecular Cell Biology
2019
NOX4 induces oxidative stress and apoptosis through upregulation of caspases 3 and 9 and downregulation of TIGAR in HCV-infected Huh-7 cells
Future Virology
2013
Generation of three induced pluripotent stem cell lines from a Parkinson's disease patient with mutant PARKIN (p. C253Y)
Stem Cell Research
2020
A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism
iScience
2022
Investigation of biomarkers in peripheral blood cells of Pakistani chronic HCV patients with genotype 3a: an assessment of HCV-induced pathogenesis
Future Virology
2014
coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins
Unknown Venue
2023
Development of murine models to study Hepatitis C virus induced liver pathogenesis
Indian Journal of Virology
2013

Education

Experience

NYU Grossman school of medicine

Postdoc / OctoberPresent

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