Elena Ostrakhovitch

Scientist II at University of Kentucky, Department of Neurology with publication on cell metabolism, redox regulation and cell death

Research Expertise

cell biology
cell reprogramming
metal toxicity
redox regulation

About

. I received training at the Institute of Physiological Chemistry I, Medical school, Heinrich-Heine-University, Düsseldorf. My mentors were Professor Afanas’ev I.B., Professor Korkina L.G., Professor Helmut Sies, and Dr.  Lars-Oliver Klotz. Later I received training at the University of Western Ontario, Canada. My supervisors were Professor Cherian at the Department of Pathology and Professor Li at the Department of Biochemistry. I was Staff Scientist at the non-profit Research institute in Aging and Cancer, Irvine, California, where I spent 7 years as a research scientist focusing on the role of redox-active hydrogen sulfide in redox homeostasis in cancer and age-associated molecular changes. I relished the scientific freedom and the opportunity to mentor junior scientists. I have become interested in age-associated neurodegeneration. I left the staff scientist position and moved to Kentucky University in Lexington, KY. I accepted a postdoctoral scholar appointment with the Department of Neurology to study early molecular changes linked to Parkinson’s disease development. In 2021 I accepted the Scientist II position at Buck institute on research on aging. Under the supervision of Professor Melov, I work on understanding the mechanisms of senescence, lysosmal dysfunction, role of autophagy in cellular senescence and targeting of senescent cells with senolytics, and the development of organoids as an in vitro model of muscle atrophy in aging. In 2023, I moved back to Lexington, KY where I accepted the position of Scientist II to continue the research on alpha-synuclein and its role in neurodegenerative diseases such as Parkinson’s disease and multiple system atrophy (MSA). I am highly motivated to develop new approaches to solve the most challenging problems we face in modern-day science. I continue learning and integrating new technologies. I have experience in lab and project management, coordination of collaborations, and organization of meetings. I have extensive experience in experimental design, laboratory maintenance, and scientific data analysis. I published:  4 book chapters, 6 review articles, and over 41 original research articles. That statement is validated by my publication record, which can be easily found at [https://www.ncbi.nlm.nih.gov/pubmed](https://www.ncbi.nlm.nih.gov/pubmed)

Legacy Map

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Publications

Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals
Biochemical Pharmacology
2001
Oxidative stress in rheumatoid arthritis leukocytes: suppression by rutin and other antioxidants and chelators 1 1Abbreviations: CL, chemiluminescence; DF, desferrioxamine; DHR, dihydrorhodamine; FA, Fanconi anemia; HBSS, Hanks’ balanced salt solution; NMMA, NG-monomethyl l-arginine; NO, nitric oxide; PMA, 12-O-myristate 13-acetate; PMN, polymorphonuclear; RA, rheumatoid arthritis, and SOD, superoxide dismutase.
Biochemical Pharmacology
2001
Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: Mechanisms and consequences
Archives of Biochemistry and Biophysics
2007
Copper Ions Strongly Activate the Phosphoinositide-3-Kinase/Akt Pathway Independent of the Generation of Reactive Oxygen Species
Archives of Biochemistry and Biophysics
2002
Interaction of metallothionein with tumor suppressor p53 protein
FEBS Letters
2006
Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells
Apoptosis
2005
Homocysteine and age-associated disorders
Ageing Research Reviews
2019
Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: The lack of effect of ERK in p53 mediated copper induced apoptosis
Journal of Cellular Biochemistry
2005
P53 mediated regulation of metallothionein transcription in breast cancer cells
Journal of Cellular Biochemistry
2007
Homocysteine in Chronic Kidney Disease
Advances in Clinical Chemistry
2015
Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc
Archives of Biochemistry and Biophysics
2004
Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S–Nampt
Experimental Cell Research
2015
Directed differentiation of embryonic P19 cells and neural stem cells into neural lineage on conducting PEDOT–PEG and ITO glass substrates
Archives of Biochemistry and Biophysics
2012
A H2S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells
PLoS ONE
2014
The role of redox environment in neurogenic development
Archives of Biochemistry and Biophysics
2013
Tin
Handbook on the Toxicology of Metals
2022
The role of SLAM family receptors in immune cell signalingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.
Biochemistry and Cell Biology
2006
Direct enzymatic reduction of lucigenin decreases lucigenin‐amplified chemiluminescence produced by superoxide ion
Luminescence
2001
Mammalian Numb-interacting Protein 1/Dual Oxidase Maturation Factor 1 Directs Neuronal Fate in Stem Cells
Journal of Biological Chemistry
2010
Tin
Handbook on the Toxicology of Metals
2007
p53-mediated regulation of neuronal differentiation via regulation of dual oxidase maturation factor 1
Neuroscience Letters
2011
NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics
Breast Cancer Research and Treatment
2009
Basal and copper-induced expression of metallothionein isoform 1,2 and 3 genes in epithelial cancer cells: The role of tumor suppressor p53
Journal of Trace Elements in Medicine and Biology
2016
Cancer cells recovering from damage exhibit mitochondrial restructuring and increased aerobic glycolysis
Biochemical and Biophysical Research Communications
2014
Replicative senescence is distinguishable from DNA damage-induced senescence by increased methylation of promoter of rDNA and reduced expression of rRNA
Mechanisms of Ageing and Development
2019
SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux
Cellular Signalling
2009
Interplay between Numb and Notch in epithelial cancers: Role for dual oxidase maturation factor
European Journal of Cancer
2009
3-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation
Experimental Cell Research
2019
Analysis of circulating metabolites to differentiate Parkinson’s disease and essential tremor
Neuroscience Letters
2022
Tin
Handbook on the Toxicology of Metals
2015
Hydrogen sulfide facilitates reprogramming and trans-differentiation in 3D dermal fibroblast
PLOS ONE
2020
Highlight section: Copper and zinc in cell signaling and disease
Archives of Biochemistry and Biophysics
2007
Figure 3: Effect of flavones on the aggregation of alpha-synuclein.
Unknown Venue
Reduced alpha‐synuclein in cerebrospinal fluid in synucleinopathies: Evidence from a meta‐analysis
Movement Disorders
2014
In the wake of neural progenitors
Archives of Biochemistry and Biophysics
2013

Education

PhD, Chemistry (kinetics and catalysis) / November, 1994

Moscow

MBA, administration

Washington DC, District of Columbia, United States of America

Experience

The University of Kentucky, College of Medicine Department of Neurology

Scientist II

Buck Institute for Research on Aging

Scientist II

The University of Kentucky, College of Medicine Department of Neurology

Postdoc

Frontiers in Bioscience, Research Institute in Aging and Cancer

Staff scientist

The University of Western Ontario, London ON, Canada

Heinrich-Heine-University, Institute of Physiological Chemistry I

research scientist

Russian State Medical University, Department of Molecular Biology

Sr. Scientist

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