Work with Dr. Audra Stinchcomb, PhD, RPh, FAAPS, FAIMBE,
SMNAI | NotedSource
Dr. Audra Stinchcomb is a distinguished academician and
researcher with extensive expertise in pharmaceutics and
drug delivery. She earned her Bachelor of Science in
Pharmacy in 1989, followed by a Ph.D. in Pharmaceutics and
Drug Delivery in 1995. Dr. Stinchcomb further honed her
skills through a postdoctoral fellowship in
Biopharmaceutical Sciences and Pharmaceutical Chemistry at
the University of California, San Francisco, completing
her training in 1996. Her career has been marked by
significant contributions as a Professor at both the
University of Maryland, Baltimore, and the University of
Kentucky. Dr. Stinchcomb holds prestigious fellowships
including FAAPS, FAIMBE, and SMNAI, underscoring her
leadership and impact in the scientific community.
https://cv.notedsource.io/me/7NLGKPXR
Dr. Audra Stinchcomb, PhD, RPh, FAAPS, FAIMBE, SMNAI
Professor, School of Pharmacy, University of Maryland, Baltimore and serial entrepreneur in complex drug products, including transdermal, topical, nasal & oromucosal
Research Expertise
Complex Drug Products
About
Dr. Audra Stinchcomb is a distinguished
academician and researcher with extensive
expertise in pharmaceutics and drug delivery.
She earned her Bachelor of Science in Pharmacy
in 1989, followed by a Ph.D. in Pharmaceutics
and Drug Delivery in 1995. Dr. Stinchcomb
further honed her skills through a
postdoctoral fellowship in Biopharmaceutical
Sciences and Pharmaceutical Chemistry at the
University of California, San Francisco,
completing her training in 1996. Her career
has been marked by significant contributions
as a Professor at both the University of
Maryland, Baltimore, and the University of
Kentucky. Dr. Stinchcomb holds prestigious
fellowships including FAAPS, FAIMBE, and
SMNAI, underscoring her leadership and impact
in the scientific community.
Publications
Challenges and Opportunities in
dermal/transdermal Delivery
Therapeutic Delivery
2010
Transdermal cannabidiol reduces
inflammation and pain‐related behaviours
in a rat model of arthritis
European Journal of Pain
2015
Microneedles permit transdermal delivery
of a skin-impermeant medication to humans
Proceedings of the National Academy of
Sciences
2008
Characterization of the permeability
barrier of human skin in vivo
Proceedings of the National Academy of
Sciences
1997
Chain Drives
Industrial Machinery Repair
2003
Human skin permeation of
Δ8-tetrahydrocannabinol, cannabidiol and
cannabinol
Journal of Pharmacy and
Pharmacology
2004
Unique treatment potential of cannabidiol
for the prevention of relapse to drug use:
preclinical proof of principle
Neuropsychopharmacology
2018
Cannabidiol bioavailability after nasal
and transdermal application: effect of
permeation enhancers
Drug Development and Industrial
Pharmacy
2010
Cannabidiol-Based Prodrugs: Synthesis and
Bioevaluation
Unknown Venue
Programmable transdermal drug delivery of
nicotine using carbon nanotube membranes
Proceedings of the National Academy of
Sciences
2010
Transdermal delivery of cannabidiol
attenuates binge alcohol-induced
neurodegeneration in a rodent model of an
alcohol use disorder
Pharmacology Biochemistry and
Behavior
2013
Human Skin Sermeation of 3-O-Alkyl
Carbamate Prodrugs of Naltrexone
Journal of Pharmaceutical
Sciences
2009
Layer-by-layer surface modification of
polyethersulfone membranes using
polyelectrolytes and AgCl/TiO 2 xerogels
Journal of Membrane Science
2015
In vitro experiment optimization for
measuring tetrahydrocannabinol skin
permeation
International Journal of
Pharmaceutics
2002
Immunocontraceptive compositions
containing sperm antigens, and methods of
use (JD Bleil et al, US)
Biofutur
1998
Determining Dermal Absorption Parameters
in Vivo From Tape Strip Data
Pharmaceutical Research
2002
Chemical Uptake Into Human Stratum Corneum
In Vivo from Volatile and Non-Volatile
Solvents
Pharmaceutical Research
1999
Diclofenac delays micropore closure
following microneedle treatment in human
subjects
Journal of Controlled Release
2012
Straight-Chain Naltrexone Ester Prodrugs:
Diffusion and Concurrent Esterase
Biotransformation in Human Skin
Journal of Pharmaceutical
Sciences
2002
Current aspects of formulation efforts and
pore lifetime related to microneedle
treatment of skin
Expert Opinion on Drug Delivery
2010
Simultaneous Transdermal Delivery of
Buprenorphine Hydrochloride and Naltrexone
Hydrochloride by Iontophoresis
Unknown Venue
Transdermal Delivery of Naltrexol and Skin
Permeability Lifetime after Microneedle
Treatment in Hairless Guinea Pigs
Journal of Pharmaceutical
Sciences
2010
Flux Across of Microneedle-treated Skin is
Increased by Increasing Charge of
Naltrexone and Naltrexol In Vitro
Pharmaceutical Research
2008
In vitro/in vivo correlation studies for
transdermal Δ8-THC development
Journal of Pharmaceutical
Sciences
2004
Diclofenac Enables Prolonged Delivery of
Naltrexone Through Microneedle-Treated
Skin
Pharmaceutical Research
2011
Transdermal drug delivery
Drug Delivery Systems, Second
Edition
2003
In vitro permeation of a pegylated
naltrexone prodrug across
microneedle-treated skin
Journal of Controlled Release
2010
Development of Opioid Transdermal Delivery
Systems
Opiate Receptors and Antagonists
2009
Enhancement of transdermal delivery of
6-β-naltrexol via a codrug linked to
hydroxybupropion
Journal of Controlled Release
2006
Permeation of Buprenorphine and Its
3-Alkyl-Ester Prodrugs Through Human Skin
Pharmaceutical Research
1996
Diclofenac Enables Unprecedented Week-Long
Microneedle-Enhanced Delivery of a Skin
Impermeable Medication in Humans
Pharmaceutical Research
2013
Transdermal Delivery of the Synthetic
Cannabinoid WIN 55,212-2: In Vitro/in Vivo
Correlation
Pharmaceutical Research
2004
A fully validated LC–MS/MS method for
simultaneous determination of nicotine and
its metabolite cotinine in human serum and
its application to a pharmacokinetic study
after using nicotine transdermal delivery
systems with standard heat application in
adult smokers
Journal of Chromatography B
2016
Vehicle Composition Influence on the
Microneedle-Enhanced Transdermal Flux of
Naltrexone Hydrochloride
Pharmaceutical Research
2010
Towards mimicking natural protein channels
with aligned carbon nanotube membranes for
active drug delivery
Life Sciences
2010
Synthesis and hydrolytic behavior of two
novel tripartate codrugs of naltrexone and
6β-naltrexol with hydroxybupropion as
potential alcohol abuse and smoking
cessation agents
Bioorganic & Medicinal
Chemistry
2006
In Vitro/in Vivo Correlation of
Transdermal Naltrexone Prodrugs in
Hairless Guinea Pigs
Pharmaceutical Research
2005
Transdermal Drug Delivery System
Regulatory Issues
Transdermal Drug Delivery Systems
2002
In vitro – in vivo correlations for
nicotine transdermal delivery systems
evaluated by both in vitro skin permeation
(IVPT) and in vivo serum pharmacokinetics
under the influence of transient heat
application
Journal of Controlled Release
2018
A duplex “Gemini” prodrug of naltrexone
for transdermal delivery
Journal of Controlled Release
2004
Pharmacokinetic and Pharmacodynamic
Profile of Supratherapeutic Oral Doses of
Δ9‐THC in Cannabis Users
The Journal of Clinical
Pharmacology
2013
Transdermal Delivery of Naltrexone and its
Active Metabolite 6-β-Naltrexol in Human
Skin in Vitro and Guinea Pigs in Vivo
Journal of Pharmaceutical
Sciences
2005
In vivo evaluation of 3-O-alkyl ester
transdermal prodrugs of naltrexone in
hairless guinea pigs
Journal of Controlled Release
2005
Abuse-resistant opioid prodrugs that
demonstrate oral overdose protection
The Journal of Pain
2012
Human Skin Permeation of Branched-Chain
3-O-Alkyl Ester and Carbonate Prodrugs of
Naltrexone
Pharmaceutical Research
2005
Physicochemical Evaluation, in Vitro Human
Skin Diffusion, and Concurrent
Biotransformation of 3-O-Alkyl Carbonate
Prodrugs of Naltrexone
Pharmaceutical Research
2004
Fluvastatin as a Micropore Lifetime
Enhancer for Sustained Delivery Across
Microneedle-Treated Skin
Journal of Pharmaceutical
Sciences
2014
Further characterization of benzodiazepine
receptor differences in long-sleep and
short-sleep mice
Life Sciences
1988
Automation of patent classification
World Patent Information
2002
Transdermal Delivery of Bupropion and its
Active Metabolite, Hydroxybupropion: A
Prodrug Strategy as an Alternative
Approach
Journal of Pharmaceutical
Sciences
2009
Development and validation of a liquid
chromatography–mass spectrometry method
for the quantitation of naltrexone and
6β-naltrexol in guinea pig plasma
Journal of Chromatography B
2004
Transdermal permeation of WIN 55,212-2 and
CP 55,940 in human skin in vitro
International Journal of
Pharmaceutics
2004
On the Road to Development of an in Vitro
Permeation Test (IVPT) Model to Compare
Heat Effects on Transdermal Delivery
Systems: Exploratory Studies with Nicotine
and Fentanyl
Pharmaceutical Research
2017
Quantification of anandamide,
oleoylethanolamide and
palmitoylethanolamide in rodent brain
tissue using high performance liquid
chromatography–electrospray mass
spectroscopy
Journal of Pharmaceutical
Analysis
2014
The effects of ethanol and Ro 15–4513 on
elevated plus-maze and rotarod performance
in long-sleep and short-sleep mice
Alcohol
1989
Cutaneous Pharmacokinetics of Acyclovir
Cream 5% Products: Evaluating
Bioequivalence with an In Vitro Permeation
Test and an Adaptation of Scaled Average
Bioequivalence
Pharmaceutical Research
2020
In vivo evaluation of a transdermal codrug
of 6-β-naltrexol linked to
hydroxybupropion in hairless guinea pigs
European Journal of Pharmaceutical
Sciences
2008
In Vitro Release Studies on Matrix Type
Transdermal Drug Delivery Systems of
Naltrexone and Its Acetyl Prodrug
Drug Development and Industrial
Pharmacy
2005
Minimally invasive technique for measuring
transdermal glucose with a fluorescent
biosensor
Analytical and Bioanalytical
Chemistry
2018
Bioconversion of Naltrexone and Its
3-O-Alkyl-Ester Prodrugs in a Human Skin
Equivalent
Journal of Pharmaceutical
Sciences
2005
Liquid chromatographic–mass spectrometric
quantitation of Δ9-tetrahydrocannabinol
and two metabolites in pharmacokinetic
study plasma samples
Journal of Chromatography B
2004
Microneedle-Assisted Skin Permeation by
Nontoxic Bioengineerable Gas Vesicle
Nanoparticles
Molecular Pharmaceutics
2017
Estimation of Maximum Transdermal Flux of
Nonionized Xenobiotics from Basic
Physicochemical Determinants
Molecular Pharmaceutics
2012
A Solubility and Related Physicochemical
Property Comparison of Buprenorphine and
Its 3-Alkyl Esters
Pharmaceutical Research
1995
Intranasal Delivery of Recombinant Human
Parathyroid Hormone [hPTH (1–34)],
Teriparatide in Rats
Endocrine Research
2004
Development of a Codrug Approach for
Sustained Drug Delivery Across
Microneedle-Treated Skin
Journal of Pharmaceutical
Sciences
2013
Intranasal absorption of
Δ9-tetrahydrocannabinol and WIN55,212-2
mesylate in rats
European Journal of Pharmaceutics and
Biopharmaceutics
2007
Permeation of WIN 55,212-2, a potent
cannabinoid receptor agonist, across human
tracheo-bronchial tissue in vitro and rat
nasal epithelium in vivo
Journal of Pharmacy and
Pharmacology
2006
Near-Infrared Spectrometry for the
Quantification of Dermal Absorption of
Econazole Nitrate and 4-Cyanophenol
Pharmaceutical Research
2006
Microneedle-Assisted Percutaneous Delivery
of Naltrexone Hydrochloride in Yucatan
Minipig: In Vitro–In Vivo Correlation
Molecular Pharmaceutics
2013
Effect of Formulation pH on Transport of
Naltrexone Species and Pore Closure in
Microneedle-Enhanced Transdermal Drug
Delivery
Molecular Pharmaceutics
2013
Simultaneous Quantification of Anandamide
and Other Endocannabinoids in Dorsal Vagal
Complex of Rat Brainstem by LC–MS
Chromatographia
2008
Near Infrared Spectrometry for the
Quantification of Human Dermal Absorption
of Econazole Nitrate and Estradiol
Pharmaceutical Research
2006
Programmable transdermal delivery of
nicotine in hairless guinea pigs using
carbon nanotube membrane pumps
Journal of Pharmaceutical
Sciences
2012
Novel 3-O-pegylated carboxylate and
3-O-pegylated carbamate prodrugs of
naltrexone for microneedle-enhanced
transdermal delivery
Bioorganic & Medicinal Chemistry
Letters
2010
Carbon Nanotube Membranes for use in the
Transdermal Treatment of Nicotine
Addiction and Opioid Withdrawal Symptoms
Substance Abuse: Research and
Treatment
2009
Transdermal Prodrug Concepts: Permeation
of Buprenorphine and Its Alkyl Esters
through Hairless Mouse Skin and Influence
of Vehicles.
Biological and Pharmaceutical
Bulletin
1996
Evaluation of in vitro/in vivo
correlations for three fentanyl
transdermal delivery systems using in
vitro skin permeation testing and human
pharmacokinetic studies under the
influence of transient heat application
Journal of Controlled Release
2022
Effect of Controlled Heat Application on
Topical Diclofenac Formulations Evaluated
by In Vitro Permeation Tests (IVPT) Using
Porcine and Human Skin
Pharmaceutical Research
2020
US Patent History
World Patent Information
2007
LC–MS method for the estimation of Δ8-THC
and 11-nor-Δ8-THC-9-COOH in plasma
Journal of Pharmaceutical and
Biomedical Analysis
2005
Xenobiotic Bioconversion in Human
Epidermis Models
Pharmaceutical Research
2003
Naltrexone Salt Selection for Enhanced
Transdermal Permeation Through
Microneedle-Treated Skin
Journal of Pharmaceutical
Sciences
2012
Prodrugs and codrugs as strategies for
improving percutaneous absorption
Expert Review of Dermatology
2008
The Sensitivity of In Vitro Permeation
Tests to Chemical Penetration Enhancer
Concentration Changes in Fentanyl
Transdermal Delivery Systems
AAPS PharmSciTech
2018
Programmable Transdermal Clonidine
Delivery Through Voltage-Gated Carbon
Nanotube Membranes
Journal of Pharmaceutical
Sciences
2014
In Vitro Skin Diffusion Study of Pure
Forskolin versus a Forskolin-Containing
Plectranthus barbatus Root Extract
Journal of Natural Products
2009
Binge Alcohol Exposure Transiently Changes
the Endocannabinoid System: A Potential
Target to Prevent Alcohol-Induced
Neurodegeneration
Brain Sciences
2017
Education
BSPharm, Pharmacy / May, 1989
Boulder/Denver, Colorado, United
States of America
Ph.D., Pharmaceutics and Drug Delivery / April, 1995
Ann Arbor, Michigan, United States
of America
University of California, San Francisco
Postdoc, Biopharmaceutical Sciences and Pharmaceutical Chemistry / April, 1996
San Francisco, California, United
States of America
Experience
University of Maryland, Baltimore
Professor / November, 2011 — Present
Director of Pharmaceutical and Industrial Fellowships
University of Kentucky
Professor / April, 2001 — October, 2011
Links & Social Media
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