Murli Manohar

Boyce Thompson Institute, Cornell University

Research Expertise

Inter-specific interactions
Chemical signaling
Biopesticides
Plant Science
Ecology, Evolution, Behavior and Systematics
Genetics
Molecular Biology
Molecular Medicine
Genetics (clinical)
Virology
Microbiology
Immunology
Parasitology
Physiology
Agronomy and Crop Science
Ecology
Biochemistry
Biotechnology
Food Science
Polymers and Plastics
Materials Chemistry
Environmental Chemistry

About

Instrumental in leading the development of Ascribe technology from start-up to successful execution. Skilled in identifying and capitalizing on emerging technologies and executing R&D strategic objectives to accelerate the product development process and increase customer centricity across different markets. Excel in overseeing cross-function projects with substantial R&D budgets to transform scientific discoveries into market-ready products. Tech leader and inventor with solid business acumen, holding patents for successful start-up and market-ready products. Expert at developing high-performing teams for commercializing new, differentiated, and disruptive products. Experienced researcher with effective communication and interpersonal skills; known for expanding business by collaborating with industry leaders, academic researchers, and contract research organizations. Passionate about driving innovation and delivering impactful results for business growth and market expansion. As a Ph.D. in Biochemistry, Molecular Biology, and Plant Science, I bring a strong background and expertise in agriculture and biopharmaceutical research. But more than that, I am driven by a deep passion for advancing Agtech, Foodtech, and Biotech solutions. My mission is to harness the power of nature to create sustainable and effective products that can enhance plant and human health.

Legacy Map

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Publications

Conserved nematode signalling molecules elicit plant defenses and pathogen resistance
Nature Communications
2015
Identification of multiple salicylic acid-binding proteins using two high throughput screens
Frontiers in Plant Science
2015
Plant cation/H+ exchangers (CAXs): biological functions and genetic manipulations
Plant Biology
2011
Chickpea breeding and management
Unknown Venue
2007
Lentil
Unknown Venue
2007
Aspirin’s Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses
Molecular Medicine
2015
Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid
PLOS Pathogens
2016
Plant metabolism of nematode pheromones mediates plant-nematode interactions
Nature Communications
2020
Human GAPDH Is a Target of Aspirin’s Primary Metabolite Salicylic Acid and Its Derivatives
PLOS ONE
2015
Calcium transport from source to sink: understanding the mechanism(s) of acquisition, translocation, and accumulation for crop biofortification
Acta Physiologiae Plantarum
2014
Uses, consumption and utilization.
Chickpea breeding and management
2007
Members of the abscisic acid co‐receptor PP2C protein family mediate salicylic acid–abscisic acid crosstalk
Plant Direct
2017
Uses and Consumption
Lentil
2007
Plant and Human MORC Proteins Have DNA-Modifying Activities Similar to Type II Topoisomerases, but Require One or More Additional Factors for Full Activity
Molecular Plant-Microbe Interactions®
2017
Lentil Growers and Production Systems around the World
Lentil
2007
Chickpea Biofortification for Cytokinin Dehydrogenase via Genome Editing to Enhance Abiotic-Biotic Stress Tolerance and Food Security
Frontiers in Genetics
2022
The GHKL ATPase MORC1 Modulates Species-Specific Plant Immunity in Solanaceae
Molecular Plant-Microbe Interactions®
2015
Nematode Signaling Molecules Are Extensively Metabolized by Animals, Plants, and Microorganisms
ACS Chemical Biology
2021
Epigenomics as Potential Tools for Enhancing Magnitude of Breeding Approaches for Developing Climate Resilient Chickpea
Frontiers in Genetics
2022
Expression of mouse small interfering RNAs in lettuce using artificial microRNA technology
BioTechniques
2020
Efficacy of Ascaroside #18 Treatments in Control of Salmonella enterica on Alfalfa and Fenugreek Seeds and Sprouts
Journal of Food Protection
2023
Synthesis and characterization of microporous polymer microspheres with strong cation-exchange character
Reactive and Functional Polymers
2012
The fate of enterohemorrhagic Escherichia coli on alfalfa and fenugreek seeds and sprouts as affected by ascaroside #18 treatments
Food Bioscience
2024
Cover Image
Journal of Phytopathology
2019
Nematode ascaroside enhances resistance in a broad spectrum of plant–pathogen systems
Journal of Phytopathology
2019
Heterodimerization of Arabidopsis calcium/proton exchangers contributes to regulation of guard cell dynamics and plant defense responses
Journal of Experimental Botany
2017
The Compromised Recognition of Turnip Crinkle Virus1 Subfamily of Microrchidia ATPases Regulates Disease Resistance in Barley to Biotrophic and Necrotrophic Pathogens
Plant Physiology
2014
Characterization of Arabidopsis Ca2+/H+ Exchanger CAX3
Biochemistry
2011
The expression of the open reading frame of Arabidopsis CAX1, but not its cDNA, confers metal tolerance in yeast
Plant Biology
2010
Zebrafish (Danio rerio) Endomembrane Antiporter Similar to a Yeast Cation/H+ Transporter Is Required for Neural Crest Development
Biochemistry
2010

Education

Texas A&M University

Biochemistry, Plant Biology, Biotechnology, Molecular Biology / May, 2012

College Station, Texas, United States of America

Indian Institute of Technology Roorkee

M.S, Biotechnology / May, 2005

Roorkee

B.S, Agriculture / May, 2003

Allahabad

Experience

Ascribe Bioscience Inc.

CTO / February, 2019Present

Execute the company's technological roadmap in alignment with business goals and vision. Collaborate with cross-functional teams to drive innovation and enhance crop protection products. Analyze market trends and competitive landscape to identify new technological advancements and product differentiation opportunities. ● Built strong partnerships with Ag-tech firms, investors, academic scholars, and growers. ● Controlled research and development budget of more than $10M to drive innovation into tangible outcomes. ● Developed independent research laboratory and managed R&D, multi-national field tests, and commercialization plans. ● Conducted market research to enhance product offerings and align with customer requirements.

Boyce Thompson Institute for Plant Research

Senior Scientist / September, 2012November, 2020

Supported multidisciplinary teams in assessing complex data sets, identifying patterns, and drawing meaningful conclusions. Led design and execution of experiments, ensuring adherence to scientific protocols and research methodologies. Facilitated collaborative research projects and leveraged resources for mutual benefit. ● Recognized as the inventor of several technologies, delivering a foundation for establishing Ascribe Bioscience. ● Uncovered unique processes of plant and animal responses to external stresses. ● Earned promotion to Senior Scientist in 2017 based on excellent performance. ● Expert in the fields of Molecular Biology, Plant Biotechnology, Crop Protection, and Gene Editing. ● Authored revolutionary research publications in Agriculture, Molecular Biology, Biochemistry, Biotechnology, and Natural Chemistry.

Baylor College of Medicine

Graduate Research Assistant/Postdoctoral Associate / May, 2008September, 2012

The objective was to study and optimize CAX-mediated biofortification and phytoremediation in plants. My research investigated the physiological functions, structure-function relationship, and inter- and intra-molecular interactions of calcium transporters cation/proton exchangers known as CAX in plants. My research used Saccharomyces cerevisiae (yeast) as the model system to study CAX transporters and established membrane fractionation and enrichment techniques to evaluate the real-time movement of metals between membranes. Moreover, I also characterized new calcium transporters from both plants and animals. Other experience: Hands-on experience in executing potency assays (binding assays, In vitro, In vivo). Hands-on experience in RNAi technology (Designing, cloning, and heterologous expression of siRNA in plants targeting animal mRNA).

The University of Texas Health Science Center at Houston School of Public Health

Visiting Research Student / September, 2010September, 2012

My work objective was to express and purify CAX (Calcium transporter) proteins through heterologous expression and determine their three-dimensional structure using X-ray crystallography. The work involved cloning 15+ CAX proteins from different plant species in E. coli and yeast expression vectors. It also included optimizing and expressing protein production, screening and solubilizing proteins using detergents, and purifying functional proteins through affinity chromatography. The metal transport activity of purified proteins was evaluated by reconstituting the proteins in proteoliposomes, isothermal titration calorimetry (ITC), and in inverted vesicles prepared from protein-expressing E. coli cells. The purified protein underwent crystallization screening to assess the effectiveness of methods, reagents, and other variables in producing high-quality crystals of CAX proteins for 3D structure analysis.

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