Cyril Eleftheriou

Principal Scientist, Expert in Neuroscience and Bioengineering

Research Expertise

Neuroscience
vision
machine-learning
nanomedicine
biomaterials

About

Resourceful and highly enthusiastic research scientist with a diverse cultural and multidisciplinary background. A valuable team player having contributed to scientific research on fundamental and translational projects in the UK, Italy and the USA. I’m also an effective communicator who enjoys collaborating with, training and learning from colleagues. I have focused my career around four heavily interconnected fields: Visual Neuroscience, Neuro-electronic interfacing, retinal rescue and microscopy. Visual Neuroscience: Focused on elucidated the intricacies of the visual system, I have investigated retinal and cortical circuits using a variety of approaches, including in vivo electrophysiology, ex vivo optophysiology/Multi-electrode arrays, and immunohistochemistry. My contributions focused mostly on the influence of melanopsin signaling in retinal coding. Neuro-electronic interfacing: Dedicated to the seamless integration of neural tissue (neurons, glia, vascular system) with computational equipment (electrodes, nano-particles, optogenetics, chemogenetics), I have investigated the biophysical, molecular and ultra-structural properties of this interface in both fundamental and translational projects. Retinal rescue: Dedicated to the study and treatment of retinal dystrophies, I have worked on an array of degeneration models (Diabetic Retinopathy, P23H, CRX, RD1, RS1, RD10, RCS), and investigated cutting edge treatment strategies (optogenetics, nano-particles, bio-electronic prostheses, low molecular weight compounds, biologics). Microscopy: For the past 15 years, I have been at the forefront of developing cutting-edge structural and neurophysiological imaging techniques. These innovative assays have been successfully applied across a diverse spectrum of scales: from investigating intricate biological interactions at the nanoscopic level using electron microscopy to mapping the complex neuro-glio-vascular interactions of hundreds of retinal cells through multiphoton imaging.

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Publications

Restoration of Vision with Ectopic Expression of Human Rod Opsin
Current Biology
2015
Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy
Nature Nanotechnology
2020
Semiconductor Nanorod–Carbon Nanotube Biomimetic Films for Wire-Free Photostimulation of Blind Retinas
Nano Letters
2014
An Induced Pluripotent Stem Cell Model of Hypoplastic Left Heart Syndrome (HLHS) Reveals Multiple Expression and Functional Differences in HLHS-Derived Cardiac Myocytes
Stem Cells Translational Medicine
2014
Neuronal firing modulation by a membrane-targeted photoswitch
Nature Nanotechnology
2020
Photoreceptive retinal ganglion cells control the information rate of the optic nerve
Proceedings of the National Academy of Sciences
2018
Retina-specific targeting of pericytes reveals structural diversity and enables control of capillary blood flow
Unknown Venue
2020
Of neurons and pericytes: The neuro-vascular approach to diabetic retinopathy
Visual Neuroscience
2020
Melanopsin Driven Light Responses Across a Large Fraction of Retinal Ganglion Cells in a Dystrophic Retina
Frontiers in Neuroscience
2020
AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43
Unknown Venue
2021
Carbon nanotube electrodes for retinal implants: a study of structural and functional integration over time
Unknown Venue
2016
Optogenetic Stimulation of Cholinergic Amacrine Cells Improves Capillary Blood Flow in Diabetic Retinopathy
Investigative Opthalmology & Visual Science
2020
Restoration of vision with ectopic expression of human rod opsin
The Lancet
2017
Retinoschisin deficiency induces persistent aberrant waves of activity affecting neuroglial signaling in the retina
Unknown Venue
2021
A Membrane-Targeted Photoswitch Potently Modulates Neuronal Firing
Unknown Venue
2019
A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness
Nature Materials
2017
Mechanisms for Discomfort Glare in Central Vision
Investigative Ophthalmology & Visual Science
2014
Structure, Function, and Pathology of Bruch's Membrane
Retina
2013
Carbon nanotube electrodes for retinal implants: A study of structural and functional integration over time
Biomaterials
2017
Optogenetic Modulation of Intracellular Signalling and Transcription: Focus on Neuronal Plasticity
Journal of Experimental Neuroscience
2017
Melanopsin-Derived Visual Responses under Light Adapted Conditions in the Mouse dLGN
PLOS ONE
2015
Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn
Proceedings of the National Academy of Sciences
2015
Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones
Journal of Neurophysiology
2015

Education

Newcastle University

PhD, Neuroscience / July, 2013

Newcastle upon Tyne

University of Manchester

Masters, Neuroscience and AI / June, 2007

Manchester

Experience

Novartis

Principal Scientist / November, 2022Present

Gene therapy, Optical Coherence Tomography, Machine Learning, Programming, Microelectrode array, Retina, Translational Medicine, Confocal Microscopy

Burke Neurological Instiute

Director of Imaging Core / May, 2019November, 2022

Confocal Microscopy, histology, Immunohistochemistry, retinal function, hemodynamics, neuroplasticity, neuroscience

Italian Institute of Technology

Postdoctoral Scholar / November, 2016October, 2018

Neurosurgery, Optogenetics, Gene therapy, Super Resolution Microscopy, Visual Neuroscience, Neuroplasticity, Matlab, Programming, Machine Learning

University of Manchester

Postdoctoral Researcher / September, 2013June, 2016

Neuroscience, Retinal plasticity, visual function, confocal microscopy, micro-electrode array, programming, automation

Newcastle University

Postdoctoral Researcher / April, 2012September, 2013

Neuroscience, retinal plasticity, neurotech, neural implants, nanotechnology, electron microscopy, confocal microscopy, bioengineering, programming, automation

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