Kalpita R. Karan

Ph.D. with a over 8 years of experience in human genetics and molecular biology. Presently, pushing pre-clinical discovery pipelines in human gene therapy at Weill Cornell Medicine.

Research Expertise

AAV Gene therapy
Alzheimer's
Human Genetics
Mitochondria
Aging
Cell Biology
Molecular Biology
Molecular Medicine
Nephrology
Statistics and Probability
Statistics, Probability and Uncertainty
Education
Computer Science Applications
Library and Information Sciences
Information Systems
Genetics
Genetics (clinical)
Biological Psychiatry
Endocrine and Autonomic Systems
Endocrinology, Diabetes and Metabolism
Psychiatry and Mental health
Endocrinology
Drug Discovery
Neurology (clinical)
Pediatrics, Perinatology and Child Health

About

PROFESSIONAL SUMMARY ■ Trained molecular geneticist with 10+ years of scientific and technical expertise in genetics and molecular biology. ■ Actively contributing to CNS gene therapy, specifically focused on Alzheimer’s disease. ■ Carry a vision that nucleic acid-based therapeutics are solutions to numerous health problems. ■ Believe that stress, inflammation, and disease risk are highly correlated and should be a focus of the therapeutic strategy.

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Publications

Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations
Mitochondrion
2021
Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
eLife
2021
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Communications Biology
2023
Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood
Brain, Behavior, & Immunity - Health
2020
A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
Scientific Data
2022
Rare SLC1A1 variants in hot water epilepsy
Human Genetics
2017
Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging
Psychoneuroendocrinology
2023
Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
Scientific Reports
2021
Dynamic behavior of cell-free mitochondrial DNA in human saliva
Psychoneuroendocrinology
2022
Complete Mitochondrial Genome Analysis and Clinical Documentation of a Five-Generational Indian Family with Mitochondrial 1555A>G Mutation and Postlingual Hearing Loss
Annals of Human Genetics
2014
Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging
Unknown Venue
2022
OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
Unknown Venue
2021
A genetic locus for sensory epilepsy precipitated by contact with hot water maps to chromosome 9p24.3-p23
Journal of Genetics
2018
Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Journal of Molecular Medicine
2022
Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Unknown Venue
2020
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
Unknown Venue
2023
Hot Water Epilepsy
Journal of Pediatric Epilepsy
2019
Corrigendum to “Dynamic behavior of cell-free mitochondrial DNA in human saliva” [Psychoneuroendocrinology 143 (2022) 105852]
Psychoneuroendocrinology
2022
Mitochondrial respiratory capacity regulates acute LPS-stimulated inflammatory signatures in human blood
Psychoneuroendocrinology
2019
Daily and weekly within-person stability of neuroendocrine, metabolic, and immune biomarkers: An intensive longitudinal exploratory study
Psychoneuroendocrinology
2019
Mitochondrial modulation of LPS-induced inflammation and glucocorticoid sensitivity in human blood
Psychoneuroendocrinology
2019
Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Unknown Venue
2021
A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations
Unknown Venue
2021

Education

Ph.D, Human Molecular Genetics / September, 2016

Bangalore

Vellore Institute of Technology University

M.Sc, Biomedical Genetics / 2008

Vellore

Experience

Weill Cornell Medicine

Research Associate / November, 2021Present

Columbia University

Postdoctoral Scientist / July, 2017September, 2021

Jawaharlal Nehru Centre for Advanced Scientific Research

Research Associate / July, 2016January, 2017

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