Kalpita R. Karan
Ph.D. with a over 8 years of experience in human genetics and molecular biology. Presently, pushing pre-clinical discovery pipelines in human gene therapy at Weill Cornell Medicine.
Research Expertise
About
Publications
Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations
Mitochondrion / Jul 01, 2021
Trumpff, C., Michelson, J., Lagranha, C. J., Taleon, V., Karan, K. R., Sturm, G., Lindqvist, D., Fernström, J., Moser, D., Kaufman, B. A., & Picard, M. (2021). Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations. Mitochondrion, 59, 225–245. https://doi.org/10.1016/j.mito.2021.04.002
Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
eLife / Oct 26, 2021
Rausser, S., Trumpff, C., McGill, M. A., Junker, A., Wang, W., Ho, S.-H., Mitchell, A., Karan, K. R., Monk, C., Segerstrom, S. C., Reed, R. G., & Picard, M. (2021). Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.70899
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Communications Biology / Jan 12, 2023
Sturm, G., Karan, K. R., Monzel, A. S., Santhanam, B., Taivassalo, T., Bris, C., Ware, S. A., Cross, M., Towheed, A., Higgins-Chen, A., McManus, M. J., Cardenas, A., Lin, J., Epel, E. S., Rahman, S., Vissing, J., Grassi, B., Levine, M., Horvath, S., … Picard, M. (2023). OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases. Communications Biology, 6(1). https://doi.org/10.1038/s42003-022-04303-x
Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood
Brain, Behavior, & Immunity - Health / May 01, 2020
Karan, K. R., Trumpff, C., McGill, M. A., Thomas, J. E., Sturm, G., Lauriola, V., Sloan, R. P., Rohleder, N., Kaufman, B. A., Marsland, A. L., & Picard, M. (2020). Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood. Brain, Behavior, & Immunity - Health, 5, 100080. https://doi.org/10.1016/j.bbih.2020.100080
A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
Scientific Data / Dec 03, 2022
Sturm, G., Monzel, A. S., Karan, K. R., Michelson, J., Ware, S. A., Cardenas, A., Lin, J., Bris, C., Santhanam, B., Murphy, M. P., Levine, M. E., Horvath, S., Belsky, D. W., Wang, S., Procaccio, V., Kaufman, B. A., Hirano, M., & Picard, M. (2022). A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations. Scientific Data, 9(1). https://doi.org/10.1038/s41597-022-01852-y
Rare SLC1A1 variants in hot water epilepsy
Human Genetics / Mar 21, 2017
Karan, K. R., Satishchandra, P., Sinha, S., & Anand, A. (2017). Rare SLC1A1 variants in hot water epilepsy. Human Genetics, 136(6), 693–703. https://doi.org/10.1007/s00439-017-1778-7
Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging
Psychoneuroendocrinology / Sep 01, 2023
Bobba-Alves, N., Sturm, G., Lin, J., Ware, S. A., Karan, K. R., Monzel, A. S., Bris, C., Procaccio, V., Lenaers, G., Higgins-Chen, A., Levine, M., Horvath, S., Santhanam, B. S., Kaufman, B. A., Hirano, M., Epel, E., & Picard, M. (2023). Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging. Psychoneuroendocrinology, 155, 106322. https://doi.org/10.1016/j.psyneuen.2023.106322
Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
Scientific Reports / Jun 02, 2021
Bindra, S., McGill, M. A., Triplett, M. K., Tyagi, A., Thaker, P. H., Dahmoush, L., Goodheart, M. J., Ogden, R. T., Owusu-Ansah, E., R Karan, K., Cole, S., Sood, A. K., Lutgendorf, S. K., & Picard, M. (2021). Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-89934-6
Dynamic behavior of cell-free mitochondrial DNA in human saliva
Psychoneuroendocrinology / Sep 01, 2022
Trumpff, C., Rausser, S., Haahr, R., Karan, K. R., Gouspillou, G., Puterman, E., Kirschbaum, C., & Picard, M. (2022). Dynamic behavior of cell-free mitochondrial DNA in human saliva. Psychoneuroendocrinology, 143, 105852. https://doi.org/10.1016/j.psyneuen.2022.105852
Complete Mitochondrial Genome Analysis and Clinical Documentation of a Five-Generational Indian Family with Mitochondrial 1555A>G Mutation and Postlingual Hearing Loss
Annals of Human Genetics / Mar 24, 2014
Subathra, M., Selvakumari, M., Ramesh, A., Ramakrishnan, R., Karan, K. R., Kaur, M., Manikandan, M., & Srikumari Srisailapathy, C. R. (2014). Complete Mitochondrial Genome Analysis and Clinical Documentation of a Five-Generational Indian Family with Mitochondrial 1555A>G Mutation and Postlingual Hearing Loss: m.1555A>G Mutation and Hearing Loss in India. Annals of Human Genetics, 78(3), 217–234. Portico. https://doi.org/10.1111/ahg.12061
Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging
Feb 23, 2022
Bobba-Alves, N., Sturm, G., Lin, J., Ware, S. A., Karan, K. R., Monzel, A. S., Bris, C., Procaccio, V., Lenaers, G., Higgins-Chen, A., Levine, M., Horvath, S., Santhanam, B. S., Kaufman, B. A., Hirano, M., Epel, E., & Picard, M. (2022). Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging. https://doi.org/10.1101/2022.02.22.481548
OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
Nov 30, 2021
Sturm, G., Karan, K. R., Monzel, A., Santhanam, B. S., Taivassalo, T., Bris, C., Ware, S. A., Cross, M., Towheed, A., Higgins-Chen, A., McManus, M. J., Cardenas, A., Lin, J., Epel, E. S., Rahman, S., Vissing, J., Grassi, B., Levine, M., Horvath, S., … Picard, M. (2021). OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases. https://doi.org/10.1101/2021.11.29.470428
A genetic locus for sensory epilepsy precipitated by contact with hot water maps to chromosome 9p24.3-p23
Journal of Genetics / Jun 01, 2018
Karan, K. R., Satishchandra, P., Sinha, S., & Anand, A. (2018). A genetic locus for sensory epilepsy precipitated by contact with hot water maps to chromosome 9p24.3-p23. Journal of Genetics, 97(2), 391–398. https://doi.org/10.1007/s12041-018-0947-3
Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Journal of Molecular Medicine / May 30, 2022
Karan, K. R., Trumpff, C., Cross, M., Engelstad, K. M., Marsland, A. L., McGuire, P. J., Hirano, M., & Picard, M. (2022). Leukocyte cytokine responses in adult patients with mitochondrial DNA defects. Journal of Molecular Medicine, 100(6), 963–971. https://doi.org/10.1007/s00109-022-02206-2
Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Oct 16, 2020
Rausser, S., Trumpff, C., McGill, M. A., Junker, A., Wang, W., Ho, S., Mitchell, A., Karan, K. R., Monk, C., Segerstrom, S. C., Reed, R. G., & Picard, M. (2020). Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures. https://doi.org/10.1101/2020.10.16.342923
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
Feb 04, 2023
Zhou, W., Karan, K. R., Gu, W., Klein, H.-U., Sturm, G., De Jager, P. L., Bennett, D. A., Hirano, M., Picard, M., & Mills, R. E. (2023). Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts. https://doi.org/10.1101/2023.02.03.527065
Hot Water Epilepsy
Journal of Pediatric Epilepsy / Dec 01, 2019
Torres, A. R., Aquino-Cabrera, M., & Mohanty, M. (2019). Hot Water Epilepsy. Journal of Pediatric Epilepsy, 08(04), 100–102. https://doi.org/10.1055/s-0039-1700947
Corrigendum to “Dynamic behavior of cell-free mitochondrial DNA in human saliva” [Psychoneuroendocrinology 143 (2022) 105852]
Psychoneuroendocrinology / Oct 01, 2022
Trumpff, C., Rausser, S., Haahr, R., Karan, K. R., Gouspillou, G., Puterman, E., Kirschbaum, C., & Picard, M. (2022). Corrigendum to “Dynamic behavior of cell-free mitochondrial DNA in human saliva” [Psychoneuroendocrinology 143 (2022) 105852]. Psychoneuroendocrinology, 144, 105884. https://doi.org/10.1016/j.psyneuen.2022.105884
Mitochondrial respiratory capacity regulates acute LPS-stimulated inflammatory signatures in human blood
Psychoneuroendocrinology / Sep 01, 2019
Karan, K. R., Trumpff, C., McGill, M. A., Thomas, J. E., Sturm, G., Lauriola, V., Rohleder, N., Sloan, R. P., & Picard, M. (2019). Mitochondrial respiratory capacity regulates acute LPS-stimulated inflammatory signatures in human blood. Psychoneuroendocrinology, 107, 11. https://doi.org/10.1016/j.psyneuen.2019.07.029
Daily and weekly within-person stability of neuroendocrine, metabolic, and immune biomarkers: An intensive longitudinal exploratory study
Psychoneuroendocrinology / Sep 01, 2019
Trumpff, C., Rausser, S., Juster, R.-P., Mitchell, A., Ahmad, S., Karan, K., Sturm, G., McGill, M., Kirschbaum, C., & Picard, M. (2019). Daily and weekly within-person stability of neuroendocrine, metabolic, and immune biomarkers: An intensive longitudinal exploratory study. Psychoneuroendocrinology, 107, 32–33. https://doi.org/10.1016/j.psyneuen.2019.07.092
Mitochondrial modulation of LPS-induced inflammation and glucocorticoid sensitivity in human blood
Psychoneuroendocrinology / Feb 01, 2019
Karan, K. R., Trumpff, C., Sturm, G., Thomas, J. E., McGill, M. A., Rohleder, N., Sloan, R. P., & Picard, M. (2019). Mitochondrial modulation of LPS-induced inflammation and glucocorticoid sensitivity in human blood. Psychoneuroendocrinology, 100, S49–S50. https://doi.org/10.1016/j.psyneuen.2018.12.170
Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Dec 16, 2021
Karan, K. R., Trumpff, C., Cross, M., Englestad, K. M., Marsland, A. L., McGuire, P., Hirano, M., & Picard, M. (2021). Leukocyte cytokine responses in adult patients with mitochondrial DNA defects. https://doi.org/10.1101/2021.12.13.472449
A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations
Nov 13, 2021
Sturm, G., Monzel, A. S., Karan, K. R., Michelson, J., Ware, S. A., Cardenas, A., Lin, J., Bris, C., Santhanam, B., Murphy, M. P., Levine, M. E., Horvath, S., Belsky, D. W., Wang, S., Procaccio, V., Kaufman, B. A., Hirano, M., & Picard, M. (2021). A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations. https://doi.org/10.1101/2021.11.12.468448
Education
Ph.D, Human Molecular Genetics / September, 2016
Vellore Institute of Technology University
M.Sc, Biomedical Genetics / 2008
Experience
Weill Cornell Medicine
Research Associate / November, 2021 — Present
Columbia University
Postdoctoral Scientist / July, 2017 — September, 2021
Jawaharlal Nehru Centre for Advanced Scientific Research
Research Associate / July, 2016 — January, 2017
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