Kalpita R. Karan

Ph.D. with a over 8 years of experience in human genetics and molecular biology. Presently, pushing pre-clinical discovery pipelines in human gene therapy at Weill Cornell Medicine.

Research Expertise

AAV Gene therapy
Alzheimer's
Human Genetics
Mitochondria
Aging
Cell Biology
Molecular Biology
Molecular Medicine
Nephrology
Statistics and Probability
Statistics, Probability and Uncertainty
Education
Computer Science Applications
Library and Information Sciences
Information Systems
Genetics
Genetics (clinical)
Biological Psychiatry
Endocrine and Autonomic Systems
Endocrinology, Diabetes and Metabolism
Psychiatry and Mental health
Endocrinology
Drug Discovery
Neurology (clinical)
Pediatrics, Perinatology and Child Health

About

PROFESSIONAL SUMMARY ■ Trained molecular geneticist with 10+ years of scientific and technical expertise in genetics and molecular biology. ■ Actively contributing to CNS gene therapy, specifically focused on Alzheimer’s disease. ■ Carry a vision that nucleic acid-based therapeutics are solutions to numerous health problems. ■ Believe that stress, inflammation, and disease risk are highly correlated and should be a focus of the therapeutic strategy.

Publications

Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations

Mitochondrion / Jul 01, 2021

Trumpff, C., Michelson, J., Lagranha, C. J., Taleon, V., Karan, K. R., Sturm, G., Lindqvist, D., Fernström, J., Moser, D., Kaufman, B. A., & Picard, M. (2021). Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations. Mitochondrion, 59, 225–245. https://doi.org/10.1016/j.mito.2021.04.002

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

eLife / Oct 26, 2021

Rausser, S., Trumpff, C., McGill, M. A., Junker, A., Wang, W., Ho, S.-H., Mitchell, A., Karan, K. R., Monk, C., Segerstrom, S. C., Reed, R. G., & Picard, M. (2021). Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.70899

OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases

Communications Biology / Jan 12, 2023

Sturm, G., Karan, K. R., Monzel, A. S., Santhanam, B., Taivassalo, T., Bris, C., Ware, S. A., Cross, M., Towheed, A., Higgins-Chen, A., McManus, M. J., Cardenas, A., Lin, J., Epel, E. S., Rahman, S., Vissing, J., Grassi, B., Levine, M., Horvath, S., … Picard, M. (2023). OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases. Communications Biology, 6(1). https://doi.org/10.1038/s42003-022-04303-x

Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood

Brain, Behavior, & Immunity - Health / May 01, 2020

Karan, K. R., Trumpff, C., McGill, M. A., Thomas, J. E., Sturm, G., Lauriola, V., Sloan, R. P., Rohleder, N., Kaufman, B. A., Marsland, A. L., & Picard, M. (2020). Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood. Brain, Behavior, & Immunity - Health, 5, 100080. https://doi.org/10.1016/j.bbih.2020.100080

A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations

Scientific Data / Dec 03, 2022

Sturm, G., Monzel, A. S., Karan, K. R., Michelson, J., Ware, S. A., Cardenas, A., Lin, J., Bris, C., Santhanam, B., Murphy, M. P., Levine, M. E., Horvath, S., Belsky, D. W., Wang, S., Procaccio, V., Kaufman, B. A., Hirano, M., & Picard, M. (2022). A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations. Scientific Data, 9(1). https://doi.org/10.1038/s41597-022-01852-y

Rare SLC1A1 variants in hot water epilepsy

Human Genetics / Mar 21, 2017

Karan, K. R., Satishchandra, P., Sinha, S., & Anand, A. (2017). Rare SLC1A1 variants in hot water epilepsy. Human Genetics, 136(6), 693–703. https://doi.org/10.1007/s00439-017-1778-7

Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging

Psychoneuroendocrinology / Sep 01, 2023

Bobba-Alves, N., Sturm, G., Lin, J., Ware, S. A., Karan, K. R., Monzel, A. S., Bris, C., Procaccio, V., Lenaers, G., Higgins-Chen, A., Levine, M., Horvath, S., Santhanam, B. S., Kaufman, B. A., Hirano, M., Epel, E., & Picard, M. (2023). Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging. Psychoneuroendocrinology, 155, 106322. https://doi.org/10.1016/j.psyneuen.2023.106322

Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors

Scientific Reports / Jun 02, 2021

Bindra, S., McGill, M. A., Triplett, M. K., Tyagi, A., Thaker, P. H., Dahmoush, L., Goodheart, M. J., Ogden, R. T., Owusu-Ansah, E., R Karan, K., Cole, S., Sood, A. K., Lutgendorf, S. K., & Picard, M. (2021). Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-89934-6

Dynamic behavior of cell-free mitochondrial DNA in human saliva

Psychoneuroendocrinology / Sep 01, 2022

Trumpff, C., Rausser, S., Haahr, R., Karan, K. R., Gouspillou, G., Puterman, E., Kirschbaum, C., & Picard, M. (2022). Dynamic behavior of cell-free mitochondrial DNA in human saliva. Psychoneuroendocrinology, 143, 105852. https://doi.org/10.1016/j.psyneuen.2022.105852

Complete Mitochondrial Genome Analysis and Clinical Documentation of a Five-Generational Indian Family with Mitochondrial 1555A>G Mutation and Postlingual Hearing Loss

Annals of Human Genetics / Mar 24, 2014

Subathra, M., Selvakumari, M., Ramesh, A., Ramakrishnan, R., Karan, K. R., Kaur, M., Manikandan, M., & Srikumari Srisailapathy, C. R. (2014). Complete Mitochondrial Genome Analysis and Clinical Documentation of a Five-Generational Indian Family with Mitochondrial 1555A>G Mutation and Postlingual Hearing Loss: m.1555A>G Mutation and Hearing Loss in India. Annals of Human Genetics, 78(3), 217–234. Portico. https://doi.org/10.1111/ahg.12061

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

Feb 23, 2022

Bobba-Alves, N., Sturm, G., Lin, J., Ware, S. A., Karan, K. R., Monzel, A. S., Bris, C., Procaccio, V., Lenaers, G., Higgins-Chen, A., Levine, M., Horvath, S., Santhanam, B. S., Kaufman, B. A., Hirano, M., Epel, E., & Picard, M. (2022). Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging. https://doi.org/10.1101/2022.02.22.481548

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

Nov 30, 2021

Sturm, G., Karan, K. R., Monzel, A., Santhanam, B. S., Taivassalo, T., Bris, C., Ware, S. A., Cross, M., Towheed, A., Higgins-Chen, A., McManus, M. J., Cardenas, A., Lin, J., Epel, E. S., Rahman, S., Vissing, J., Grassi, B., Levine, M., Horvath, S., … Picard, M. (2021). OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases. https://doi.org/10.1101/2021.11.29.470428

A genetic locus for sensory epilepsy precipitated by contact with hot water maps to chromosome 9p24.3-p23

Journal of Genetics / Jun 01, 2018

Karan, K. R., Satishchandra, P., Sinha, S., & Anand, A. (2018). A genetic locus for sensory epilepsy precipitated by contact with hot water maps to chromosome 9p24.3-p23. Journal of Genetics, 97(2), 391–398. https://doi.org/10.1007/s12041-018-0947-3

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects

Journal of Molecular Medicine / May 30, 2022

Karan, K. R., Trumpff, C., Cross, M., Engelstad, K. M., Marsland, A. L., McGuire, P. J., Hirano, M., & Picard, M. (2022). Leukocyte cytokine responses in adult patients with mitochondrial DNA defects. Journal of Molecular Medicine, 100(6), 963–971. https://doi.org/10.1007/s00109-022-02206-2

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

Oct 16, 2020

Rausser, S., Trumpff, C., McGill, M. A., Junker, A., Wang, W., Ho, S., Mitchell, A., Karan, K. R., Monk, C., Segerstrom, S. C., Reed, R. G., & Picard, M. (2020). Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures. https://doi.org/10.1101/2020.10.16.342923

Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

Feb 04, 2023

Zhou, W., Karan, K. R., Gu, W., Klein, H.-U., Sturm, G., De Jager, P. L., Bennett, D. A., Hirano, M., Picard, M., & Mills, R. E. (2023). Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts. https://doi.org/10.1101/2023.02.03.527065

Hot Water Epilepsy

Journal of Pediatric Epilepsy / Dec 01, 2019

Torres, A. R., Aquino-Cabrera, M., & Mohanty, M. (2019). Hot Water Epilepsy. Journal of Pediatric Epilepsy, 08(04), 100–102. https://doi.org/10.1055/s-0039-1700947

Corrigendum to “Dynamic behavior of cell-free mitochondrial DNA in human saliva” [Psychoneuroendocrinology 143 (2022) 105852]

Psychoneuroendocrinology / Oct 01, 2022

Trumpff, C., Rausser, S., Haahr, R., Karan, K. R., Gouspillou, G., Puterman, E., Kirschbaum, C., & Picard, M. (2022). Corrigendum to “Dynamic behavior of cell-free mitochondrial DNA in human saliva” [Psychoneuroendocrinology 143 (2022) 105852]. Psychoneuroendocrinology, 144, 105884. https://doi.org/10.1016/j.psyneuen.2022.105884

Mitochondrial respiratory capacity regulates acute LPS-stimulated inflammatory signatures in human blood

Psychoneuroendocrinology / Sep 01, 2019

Karan, K. R., Trumpff, C., McGill, M. A., Thomas, J. E., Sturm, G., Lauriola, V., Rohleder, N., Sloan, R. P., & Picard, M. (2019). Mitochondrial respiratory capacity regulates acute LPS-stimulated inflammatory signatures in human blood. Psychoneuroendocrinology, 107, 11. https://doi.org/10.1016/j.psyneuen.2019.07.029

Daily and weekly within-person stability of neuroendocrine, metabolic, and immune biomarkers: An intensive longitudinal exploratory study

Psychoneuroendocrinology / Sep 01, 2019

Trumpff, C., Rausser, S., Juster, R.-P., Mitchell, A., Ahmad, S., Karan, K., Sturm, G., McGill, M., Kirschbaum, C., & Picard, M. (2019). Daily and weekly within-person stability of neuroendocrine, metabolic, and immune biomarkers: An intensive longitudinal exploratory study. Psychoneuroendocrinology, 107, 32–33. https://doi.org/10.1016/j.psyneuen.2019.07.092

Mitochondrial modulation of LPS-induced inflammation and glucocorticoid sensitivity in human blood

Psychoneuroendocrinology / Feb 01, 2019

Karan, K. R., Trumpff, C., Sturm, G., Thomas, J. E., McGill, M. A., Rohleder, N., Sloan, R. P., & Picard, M. (2019). Mitochondrial modulation of LPS-induced inflammation and glucocorticoid sensitivity in human blood. Psychoneuroendocrinology, 100, S49–S50. https://doi.org/10.1016/j.psyneuen.2018.12.170

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects

Dec 16, 2021

Karan, K. R., Trumpff, C., Cross, M., Englestad, K. M., Marsland, A. L., McGuire, P., Hirano, M., & Picard, M. (2021). Leukocyte cytokine responses in adult patients with mitochondrial DNA defects. https://doi.org/10.1101/2021.12.13.472449

A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

Nov 13, 2021

Sturm, G., Monzel, A. S., Karan, K. R., Michelson, J., Ware, S. A., Cardenas, A., Lin, J., Bris, C., Santhanam, B., Murphy, M. P., Levine, M. E., Horvath, S., Belsky, D. W., Wang, S., Procaccio, V., Kaufman, B. A., Hirano, M., & Picard, M. (2021). A Multi-Omics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations. https://doi.org/10.1101/2021.11.12.468448

Education

Ph.D, Human Molecular Genetics / September, 2016

Bangalore

Vellore Institute of Technology University

M.Sc, Biomedical Genetics / 2008

Vellore

Experience

Weill Cornell Medicine

Research Associate / November, 2021Present

Columbia University

Postdoctoral Scientist / July, 2017September, 2021

Jawaharlal Nehru Centre for Advanced Scientific Research

Research Associate / July, 2016January, 2017

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