Jordan Woehl, Ph.D.

Scripps Research/Calibr

San Diego, California, United States of America

Research Expertise

Biochemistry
Molecular Biophysics

About

Jordan Woehl is a highly educated and experienced scientist with a passion for biochemistry and molecular biophysics. He received his Bachelor of Science degree in Medicinal Chemistry from the University of Missouri in 2011, where he gained a strong foundation in the principles and techniques of chemistry. He then pursued a Master of Science degree in Cell and Molecular Biology from the University of Missouri–Kansas City, where he focused on understanding the molecular mechanisms of cellular processes. Continuing his academic journey, Jordan obtained his Ph.D. in Biochemistry and Molecular Biophysics from Kansas State University in 2017. During his doctoral studies, he conducted research on the structure and function of proteins, gaining expertise in techniques such as X-ray crystallography, mass spectrometry, and protein purification. After completing his Ph.D., Jordan continued to expand his knowledge and skills through postdoctoral training at Scripps Research. Here he focused on studying viral proteins and their interactions with the host immune system. Jordan then transitioned to the industry, working as an Analytical Scientist at the International AIDS Vaccine Initiative. In this role, he utilized his expertise in protein analysis to support the development of biologics for various infectious diseases. Currently, Jordan is a Senior Staff Scientist at Scripps Research/Calibr, where he leads a team of researchers in the development of antibody based therapeutics. He is dedicated to advancing scientific knowledge and making a positive impact on human health through his work. In addition to his professional accomplishments, Jordan is also passionate about mentoring and teaching the next generation of scientists. He has served as a mentor to undergraduate and graduate students, helping them develop their research skills and pursue their own scientific passions. Overall, Jordan Woehl is a dedicated and highly skilled scientist with a strong background in biochemistry and molecular biophysics. His education and experience make him a valuable asset to any research team, and his passion for advancing scientific understanding makes him a valuable contributor to the field.

Publications

The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase
The Journal of Immunology
2014
1H, 15N, and 13C resonance assignments of Staphylococcus aureus extracellular adherence protein domain 4
Biomolecular NMR Assignments
2016
The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein
Protein Science
2017
Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins
Molecular Immunology
2015
Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins
Protein Science
2017
An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses
ACS Chemical Biology
2020
An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen
Proceedings of the National Academy of Sciences
2020
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Proceedings of the National Academy of Sciences
2019
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
Proceedings of the National Academy of Sciences
2022
Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells
ACS Central Science
2021
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
Journal of the American Chemical Society
2020
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
Science
2020
Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways
iScience
2022
Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies
PLOS Pathogens
2023
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins
Science Translational Medicine
2024
Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution
Science Signaling
2023
Fully synthetic platform to rapidly generate tetravalent bispecific nanobody–based immunoglobulins
Proceedings of the National Academy of Sciences
2023

Education

University of Missouri

B.S., Medicinal Chemistry / May, 2011

Columbia, Missouri, United States of America

University of Missouri–Kansas City

M.S., Cell and Molecular Biology / May, 2013

Kansas City, Missouri, United States of America

Kansas State University

Ph.D., Biochemistry and Molecular Biophysics / May, 2017

Manhattan, Kansas, United States of America

Experience

Scripps Research

Postdoctoral Fellow / June, 2017March, 2020

• Elucidate the host and/or microbiome targets of anti-proteolytic proteins produced in response to distal gut inflammation • Development of covalent neutrophil elastase inhibitor/biochemical probe through small molecule sulfonyl fluoride/fluorosulfate screen • Development and mechanistic understanding of small molecule inhibitor(s) of streptopain from S. pyogenes; followed by a high-throughput lead optimization strategy using SuFEx-based chemistry

International AIDS Vaccine Initiative

Analytical Scientist I/II / April, 2020October, 2023

• Characterization of protein/antibody preparations using biophysical methodology • Determination of kinetic properties of antibody/antigen interactions • Antigen screening through novel, synthetic yeast-display antibody and nanobody libraries • Affinity maturation of neutralizing antibodies through yeast-display methods • Development of fluorescent pseudovirus system for library-on-library screening

Scripps Research/Calibr

Sr. Staff Scientist / October, 2023Present

• Characterization of protein/antibody preparations using biophysical methodology • Determination of kinetic properties of antibody/antigen interactions • Antigen screening through novel, synthetic yeast-display antibody and nanobody libraries • Affinity maturation of neutralizing antibodies through yeast-display methods

Links & Social Media

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